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  1. Article ; Online: Anesthesia and the neurobiology of consciousness.

    Mashour, George A

    Neuron

    2024  

    Abstract: ... In the ... ...

    Abstract In the 19
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2024.03.002
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Ketamine and the paradox of anaesthetic state transitions.

    Mashour, George A

    British journal of anaesthesia

    2023  Volume 132, Issue 2, Page(s) 224–226

    Abstract: Administration of subanaesthetic doses of ketamine during isoflurane anaesthesia has been shown in animals to deepen the anaesthetised state, while accelerating emergence. Duan and colleagues have now shown that the addition of subanaesthetic doses of ... ...

    Abstract Administration of subanaesthetic doses of ketamine during isoflurane anaesthesia has been shown in animals to deepen the anaesthetised state, while accelerating emergence. Duan and colleagues have now shown that the addition of subanaesthetic doses of esketamine to isoflurane has a similar effect of increasing the burst suppression ratio, while accelerating emergence. Using c-Fos expression and fibre photometry, they show that esketamine activates glutamatergic neurones in the paraventricular nucleus of the thalamus, a structure that regulates wakefulness. Chemogenetic inhibition of these neurones attenuates the arousal-promoting effects, suggesting a causal role of the paraventricular nucleus of the thalamus in esketamine-mediated acceleration of recovery from anaesthesia.
    MeSH term(s) Animals ; Ketamine/pharmacology ; Isoflurane/pharmacology ; Anesthetics ; Anesthesia
    Chemical Substances Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; Isoflurane (CYS9AKD70P) ; Anesthetics
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Editorial
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2023.11.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Consciousness.

    Mashour, George A

    Anesthesia and analgesia

    2022  Volume 134, Issue 6, Page(s) 1118–1125

    MeSH term(s) Consciousness
    Language English
    Publishing date 2022-05-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000005983
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  4. Article ; Online: Ketamine Analgesia and Psychedelia: Can We Dissociate Dissociation?

    Mashour, George A

    Anesthesiology

    2022  Volume 136, Issue 5, Page(s) 675–677

    MeSH term(s) Analgesia ; Humans ; Ketamine/therapeutic use ; Pain ; Pain Management
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000004172
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  5. Book: Neurologic outcomes of surgery and anesthesia

    Mashour, George A. / Avidan, Michael

    2013  

    Author's details ed. by George A. Mashour ; Michael S. Avidan
    Keywords Nervous System Diseases / etiology ; Postoperative Complications ; Anesthesia / adverse effects
    Language English
    Size XII, 139 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017772548
    ISBN 978-0-19-989572-4 ; 978-0-19-998593-7 ; 978-0-19-998594-4 ; 0-19-989572-4 ; 0-19-998593-6 ; 0-19-998594-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2582 available for loan (reading room) Lesesaal EG

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  6. Book: Neuroscientific foundations of anesthesiology

    Mashour, George A. / Lydic, Ralph

    2011  

    Author's details ed. by George A. Mashour ; Ralph Lydic
    Keywords Anesthesia ; Anesthetics / pharmacology ; Nervous System Physiological Phenomena
    Language English
    Size XII, 283 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index ; Brain anatomy of relevance to the anesthesiologist -- Cellular and molecular effects of general anesthetics in the brain -- The shared circuits of sleep and anesthesia -- Thalamocortical system and anesthetic-induced unconsciousness -- Anesthetic modulation of memory processing in the medial temporal lobe -- Neuroimaging changes associated with human acute and chronic pain -- Spinal cord targets of relevance to the anesthesiologist -- Anesthetic-induced immobility -- Mechanisms of spinal analgesia -- Peripheral nervous system : anatomy and function -- The neurobiology of incisional pain -- Sequelae of nerve injury : neuropathic pain and complex regional pain syndrome -- The autonomic nervous system -- Anesthetic pharmacology of the autonomic nervous system -- Review of neuromuscular junction anatomy and function -- Pharmacology of neuromuscular blockers -- Anesthesia and disorders of the neuromuscular system -- Anesthesia-mediated neurotoxicity -- Post-operative cognitive disorders -- Anesthesia and neurodegenerative disorders
    HBZ-ID HT017091354
    ISBN 978-0-19-539824-3 ; 0-19-539824-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 184 order for loan Magazin

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  7. Book: Consciousness, awareness, and anesthesia

    Mashour, George A.

    2010  

    Author's details ed. by George A. Mashour
    Keywords Anesthesia, General / adverse effects ; Awareness / drug effects ; Consciousness / drug effects ; Intraoperative Complications
    Language English
    Size X, 262 S., [1] Bl. : Ill., graph. Darst., 26 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016342196
    ISBN 978-0-521-51822-2 ; 0-521-51822-9
    Database Catalogue ZB MED Medicine, Health

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    2010 A 2273 order for loan Magazin

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  8. Article: Propofol Disrupts the Functional Core-Matrix Architecture of the Thalamus in Humans.

    Huang, Zirui / Mashour, George A / Hudetz, Anthony G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, ... ...

    Abstract Research into the role of thalamocortical circuits in anesthesia-induced unconsciousness is difficult due to anatomical and functional complexity. Prior neuroimaging studies have examined either the thalamus as a whole or focused on specific subregions, overlooking the distinct neuronal subtypes like core and matrix cells. We conducted a study of heathy volunteers and functional magnetic resonance imaging during conscious baseline, deep sedation, and recovery. We advanced the functional gradient mapping technique to delineate the functional geometry of thalamocortical circuits, within a framework of the unimodal-transmodal functional axis of the cortex. We observed a significant shift in this geometry during unconsciousness, marked by the dominance of unimodal over transmodal geometry. This alteration was closely linked to the spatial variations in the density of matrix cells within the thalamus. This research bridges cellular and systems-level understanding, highlighting the crucial role of thalamic core-matrix functional architecture in understanding the neural mechanisms of states of consciousness.
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.23.576934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Unconscious processes

    Mashour, George A.

    (International anesthesiology clinics ; 46,3)

    2008  

    Author's details ed. by George A. Mashour
    Series title International anesthesiology clinics ; 46,3
    Collection
    Language English
    Size XIV, 205 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT015655570
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 243 -46,3- verfügbar in Königswinter Königswinter

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  10. Article ; Online: General anesthesia and the cortical stranglehold on consciousness.

    Pal, Dinesh / Mashour, George A

    Neuron

    2022  Volume 110, Issue 12, Page(s) 1891–1893

    Abstract: In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these ... ...

    Abstract In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness.
    MeSH term(s) Anesthesia, General ; Anesthetics, General/pharmacology ; Animals ; Consciousness/physiology ; Electroencephalography ; Mice ; Neurons/physiology ; Unconsciousness/chemically induced
    Chemical Substances Anesthetics, General
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2022.05.014
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