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  1. Book: Ryan's Retina

    Sadda, Srinivas R. / Schachat, Andrew P. / Wilkinson, Charles P. / Hinton, David R. / Wiedemann, Peter / Freund, K. Bailey / Sarraf, David

    2022  

    Language English
    Size 3112 p.
    Edition 7
    Publisher Elsevier LTD
    Document type Book
    Note PDA Manuell_16
    Format 245 x 304 x 168
    ISBN 9780323722131 ; 032372213X
    Database PDA

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  2. Book: Oxford handbook of rheumatology

    Clunie, Gavin P. R. / Wilkinson, Nick / Nikiphorou, Elena / Jadon, Deepak

    (Oxford handbooks)

    2018  

    Author's details Gavin Clunie, Nick Wilkinson, Elena Nikiphorou, Deepak Jadon
    Series title Oxford handbooks
    Keywords Rheumatic Diseases
    Language English
    Size xxii, 755 Seiten, Illustrationen
    Edition Fourth edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019786280
    ISBN 978-0-19-872825-2 ; 9780191043932 ; 0-19-872825-5 ; 0191043931
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Support for the fasting endurance hypothesis of partial migration in a nearshore seabird

    Wilkinson, Bradley P. / Jodice, Patrick G. R.

    Ecosphere. 2023 Feb., v. 14, no. 2 p.e4365-

    2023  

    Abstract: Partial migration occurs when only a fraction of a population migrates instead of all individuals. Considered an evolutionary precursor to full migration, understanding why some individuals choose to undertake migration while others do not may serve to ... ...

    Abstract Partial migration occurs when only a fraction of a population migrates instead of all individuals. Considered an evolutionary precursor to full migration, understanding why some individuals choose to undertake migration while others do not may serve to inform general migratory theory. While several hypotheses currently exist for explaining the maintenance of partial migration, empirical support for many is limited. To address this gap, we analyzed GPS data acquired from brown pelicans (Pelecanus occidentalis; n = 74), a partially migratory seabird, nesting on six colonies in the South Atlantic Bight over the course of four autumn migrations. We estimated that approximately 74% of pelicans nesting within the study area may be migratory on an annual basis, with the remainder staying within the surrounding marine ecoregion year‐round. Mean date of migration initiation was 9 November, although movements occurred from September to December. Results from Cox's proportional hazards modeling indicated significant positive and negative effects of sea surface temperatures and body condition on migration rate, respectively. We suggest that the ontogenetic migration of the primary forage species of brown pelicans from estuarine to pelagic environments causes a seasonal reduction in prey and that pelicans in poor body condition are unable to meet the energetic demands potentially associated with this decrease in prey availability (i.e., the fasting endurance hypothesis of partial migration). Although we did not find evidence for a density‐dependent migratory response, the effects of intraspecific competition on migration in pelicans also appear to warrant consideration.
    Keywords Pelecanus occidentalis ; autumn ; body condition ; ecoregions ; estuaries ; forage ; intraspecific competition ; migratory behavior ; ontogeny ; seabirds
    Language English
    Dates of publication 2023-02
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2572257-8
    ISSN 2150-8925
    ISSN 2150-8925
    DOI 10.1002/ecs2.4365
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Metabolomic profiling of wild rooibos (Aspalathus linearis) ecotypes and their antioxidant-derived phytopharmaceutical potential.

    Wilkinson, C / Brooks, J / Stander, M A / Malgas, R / Roodt-Wilding, R / Makunga, N P

    Metabolomics : Official journal of the Metabolomic Society

    2024  Volume 20, Issue 3, Page(s) 45

    Abstract: Introduction: Aspalathus linearis (commonly known as rooibos) is endemic to the Cape Floristic Region of South Africa and is a popular herbal drink and skin phytotherapeutic ingredient, with health benefits derived primarily from its unique phenolic ... ...

    Abstract Introduction: Aspalathus linearis (commonly known as rooibos) is endemic to the Cape Floristic Region of South Africa and is a popular herbal drink and skin phytotherapeutic ingredient, with health benefits derived primarily from its unique phenolic content. Several, seemingly habitat-specific ecotypes from the Cederberg (Western Cape) and Northern Cape have morphological, ecological, genetic and biochemical differences.
    Objectives and methods: Despite the commercial popularity of the cultivated variety, the uncultivated ecotypes are largely understudied. To address gaps in knowledge about the biochemical constituency, ultra-performance liquid chromatography-mass spectrometry analysis of fifteen populations was performed, enabling high-throughput metabolomic fingerprinting of 50% (v/v) methanolic extracts. Antioxidant screening of selected populations was performed via three assays and antimicrobial activity on two microbial species was assessed. The metabolomic results were corroborated with total phenolic and flavonoid screening of the extracts.
    Results and discussion: Site-specific chemical lineages of rooibos ecotypes were confirmed via multivariate data analyses. Important features identified via PLS-DA disclosed higher relative abundances of certain tentative metabolites (e.g., rutin, aspalathin and apiin) present in the Dobbelaarskop, Blomfontein, Welbedacht and Eselbank sites, in comparison to other locations. Several unknown novel metabolites (e.g., m/z 155.0369, 231.0513, 443.1197, 695.2883) are responsible for metabolomic separation of the populations, four of which showed higher amounts of key metabolites and were thus selected for bioactivity analysis. The Welbedacht and Eselbank site 2 populations consistently displayed higher antioxidant activities, with 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activities of 679.894 ± 3.427 µmol Trolox/g dry matter and 635.066 ± 5.140 µmol Trolox/g dry matter, respectively, in correlation with a high number of phenolic and flavonoid compounds. The contribution of the individual metabolites to the pharmacological effectiveness of rooibos remains unknown and as such, further structural elucidation and phytopharmacological testing is thus urgently needed.
    MeSH term(s) Aspalathus ; Antioxidants ; Ecotype ; Metabolomics ; Flavonoids ; Phenols
    Chemical Substances Antioxidants ; Flavonoids ; Phenols
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250617-2
    ISSN 1573-3890 ; 1573-3882
    ISSN (online) 1573-3890
    ISSN 1573-3882
    DOI 10.1007/s11306-024-02103-4
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  5. Book: Predictive methods in percutaneous absorption

    Moss, Gary P. / Gullick, Darren R. / Wilkinson, Simon C.

    2015  

    Author's details Gary P. Moss ; Darren R. Gullick ; Simon C. Wilkinson
    Keywords Percutaneous absorption ; Transdermal drug delivery ; Diffusion modelling ; Skin permeability ; Quantitative structure-activity relationships (QSARs ; Artificial membranes ; Hautresorption ; Permeabilität ; Kutane Applikation ; Pharmakodynamik ; Mathematisches Modell ; Computersimulation
    Subject Simulation ; Computer ; Simulationstechnik ; Systemsimulation ; Digitale Simulation ; Computermodell ; Rechnersimulation ; Perkutane Verabreichung ; Perkutane Applikation ; Perkutane Therapie ; Epikutane Applikation ; Durchlässigkeit ; Haut
    Subject code 612.79101518
    Language English
    Size XV, 199 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT018815898
    ISBN 978-3-662-47370-2 ; 978-3-662-47371-9 ; 3-662-47370-4 ; 3-662-47371-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 4061 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Headache, Confusion, and Hearing Loss.

    Jebaraj, Abigail P / Wilkinson, Samuel W / Nydegger, Jacob R / Seay, Meagan D

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  Volume 43, Issue 1, Page(s) e40

    MeSH term(s) Humans ; Hearing Loss/diagnosis ; Confusion ; Headache/diagnosis ; Headache/etiology
    Language English
    Publishing date 2023-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001804
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    Zs.A 1670: Show issues Location:
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  7. Article ; Online: Physical activity levels in female breast cancer patients and survivors in Ekurhuleni, South Africa.

    Wilkinson, R / Smith, L

    South African journal of sports medicine

    2023  Volume 35, Issue 1, Page(s) v35i1a16001

    Abstract: ... of significance set at 95% (p < 0.05).: Results: One hundred female breast cancer patients and survivors ...

    Abstract Background: By using complementary therapies, such as exercise rehabilitation during and after cancer treatment, breast cancer patients and survivors can improve their quality of life and overall health while also negating the deleterious effects of breast cancer and its treatment.
    Objectives: The aim of this study was to determine the physical activity levels of female breast cancer patients and survivors in Ekurhuleni, South Africa.
    Methods: The International Global Physical Activity Questionnaire (2002) determined participants' physical activity levels during work, travel and leisure. The questionnaire was disseminated to medical facilities in hard copy format and online via the Google Forms platform. Statistics were computed using the Statistical Package for Social Science (SPSS) with the level of significance set at 95% (p < 0.05).
    Results: One hundred female breast cancer patients and survivors with a mean age of 55 years from Ekurhuleni, South Africa participated in this study. The findings reflected that most participants (59%) were meeting the American College of Sports Medicine's physical activity guidelines when considering activity done during work, travel and leisure. No significant difference was seen in physical activity participation between breast cancer patients and breast cancer survivors, or those attending private and public facilities.
    Conclusion: For the breast cancer patient, physical activity and exercise may be a promising and effective adjuvant treatment both during and after anticancer therapies, improving quality of life, playing a role in increasing treatment tolerance, mitigating a range of symptoms and side effects brought on by cancer diagnosis and treatments and enhancing outcomes.
    Language English
    Publishing date 2023-10-05
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2475947-8
    ISSN 2078-516X ; 2078-516X
    ISSN (online) 2078-516X
    ISSN 2078-516X
    DOI 10.17159/2078-516X/2023/v35i1a16001
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  8. Article ; Online: Support for the fasting endurance hypothesis of partial migration in a nearshore seabird

    Bradley P. Wilkinson / Patrick G. R. Jodice

    Ecosphere, Vol 14, Iss 2, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Partial migration occurs when only a fraction of a population migrates instead of all individuals. Considered an evolutionary precursor to full migration, understanding why some individuals choose to undertake migration while others do not may ... ...

    Abstract Abstract Partial migration occurs when only a fraction of a population migrates instead of all individuals. Considered an evolutionary precursor to full migration, understanding why some individuals choose to undertake migration while others do not may serve to inform general migratory theory. While several hypotheses currently exist for explaining the maintenance of partial migration, empirical support for many is limited. To address this gap, we analyzed GPS data acquired from brown pelicans (Pelecanus occidentalis; n = 74), a partially migratory seabird, nesting on six colonies in the South Atlantic Bight over the course of four autumn migrations. We estimated that approximately 74% of pelicans nesting within the study area may be migratory on an annual basis, with the remainder staying within the surrounding marine ecoregion year‐round. Mean date of migration initiation was 9 November, although movements occurred from September to December. Results from Cox's proportional hazards modeling indicated significant positive and negative effects of sea surface temperatures and body condition on migration rate, respectively. We suggest that the ontogenetic migration of the primary forage species of brown pelicans from estuarine to pelagic environments causes a seasonal reduction in prey and that pelicans in poor body condition are unable to meet the energetic demands potentially associated with this decrease in prey availability (i.e., the fasting endurance hypothesis of partial migration). Although we did not find evidence for a density‐dependent migratory response, the effects of intraspecific competition on migration in pelicans also appear to warrant consideration.
    Keywords body condition ; movement behavior ; resource abundance ; seabird ; telemetry ; Ecology ; QH540-549.5
    Subject code 337
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Immune interaction between SARS-CoV-2 and

    Booysen, Petro / Wilkinson, Katalin A / Sheerin, Dylan / Waters, Robyn / Coussens, Anna K / Wilkinson, Robert J

    Frontiers in immunology

    2023  Volume 14, Page(s) 1254206

    Abstract: SARS-CoV-2 ... ...

    Abstract SARS-CoV-2 and
    MeSH term(s) Humans ; Animals ; Mice ; Mycobacterium tuberculosis ; SARS-CoV-2 ; COVID-19 ; Coinfection ; Tuberculosis/prevention & control
    Language English
    Publishing date 2023-09-27
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1254206
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  10. Article ; Online: Mismatch between trochlear coronal alignment of arthritic knees and currently available prosthesis: a morphological analysis of 4116 knees and 45 implant designs.

    Rosa, Sergio Barroso / Hazratwala, Kaushik / Wilkinson, Matthew P R

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2022  Volume 31, Issue 8, Page(s) 3116–3123

    Abstract: Purpose: In up to a fifth of total knee replacements (TKR), surgeons are not capable of achieving good clinical and functional results. Despite comprehensive diagnostic workup, an underlying cause is not always identified in these patients. The purpose ... ...

    Abstract Purpose: In up to a fifth of total knee replacements (TKR), surgeons are not capable of achieving good clinical and functional results. Despite comprehensive diagnostic workup, an underlying cause is not always identified in these patients. The purpose of this study is to compare native and prosthetic trochlear anatomies, to evaluate a potential source of morphologic mismatch and theoretically, of poor clinical outcomes.
    Methods: Native trochlear angles of 4116 knee CTs from 360 Knee Systems database of arthritic pre-operative TKR patients were evaluated. A semi-automated tridimensional analysis was performed to define the native trochlear angle in the coronal plane (NTA) among other 142 parameters. An active search was conducted to identify currently available TKR models; prosthetic trochlear orientation in the coronal plane (PTA) was extracted from the technical data provided by manufacturers.
    Results: The mean native trochlear angle (NTA) was 1.6° ± 6.6° (valgus) with a range from - 23.8° (varus) to 30.3°(valgus). A valgus NTA was present in 60.6% of the knees and 39.4% of them had a varus NTA. 89 TKR models were identified; trochlear details were available for 45 of them, of which 93% were designed with a valgus orientation of the prosthetic trochlear angle (PTA) and 6.9% showed a neutral (0°) PTA. Varus alignment of PTA was not present in any system. Angular numeric values for PTA were available for 34 models; these ranged from 0° to 15° of valgus, with a median value of 6.18° (SD ± 2.88°).
    Conclusion: This study shows a significant mismatch between native and prosthetic trochlear angles. A relevant proportion of the studied knees (41.45%) fall out of the trochlear angle range of currently available implants; representing a potential source for biomechanical imbalance. While further research is warranted to fully understand the clinical implications of the present study, manufacturers may need to take these findings into account for future implant designs.
    Level of evidence: Level III, retrospective cohort study.
    MeSH term(s) Humans ; Retrospective Studies ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Knee/surgery ; Arthroplasty, Replacement, Knee/methods ; Knee Prosthesis ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery
    Language English
    Publishing date 2022-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1007/s00167-022-07251-5
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