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Article ; Online: Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration.

Pascual-Carreras, Eudald / Marín-Barba, Marta / Castillo-Lara, Sergio / Coronel-Córdoba, Pablo / Magri, Marta Silvia / Wheeler, Grant N / Gómez-Skarmeta, Jose Luis / Abril, Josep F / Saló, Emili / Adell, Teresa

Nature communications

2023 Volume 14, Issue 1, Page(s) 298

Abstract: For successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail ... ...

Abstract	For successful regeneration, the identity of the missing tissue must be specified according to the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this process; the same field of cells can regrow a head or a tail according to the missing body part. After amputation, the differential activation of the Wnt/β-catenin signal specifies anterior versus posterior identity. Initially, both wnt1 and notum (Wnt inhibitor) are expressed in all wounds, but 48 hours later they are restricted to posterior or anterior facing wounds, respectively, by an unknown mechanism. Here we show that 12 hours after amputation, the chromatin accessibility of cells in the wound region changes according to the polarity of the pre-existing tissue in a Wnt/β-catenin-dependent manner. Genomic analyses suggest that homeobox transcription factors and chromatin-remodeling proteins are direct Wnt/β-catenin targets, which trigger the expression of posterior effectors. Finally, we identify FoxG as a wnt1 up-stream regulator, probably via binding to its first intron enhancer region.
MeSH term(s)	Animals ; Planarians/physiology ; Wnt Proteins/genetics ; Wnt Proteins/metabolism ; Chromatin Assembly and Disassembly ; beta Catenin/genetics ; beta Catenin/metabolism ; Body Patterning/genetics
Chemical Substances	Wnt Proteins ; beta Catenin
Language	English
Publishing date	2023-01-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-35937-y
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Article ; Conference proceedings: COVID-19 vaccination-related intestinal ischaemia

Gomez, D. Vazquez / Cami, M. Marques / Villellas, F. Vilardell / Velasco, N. Zaragoza / Salas, I. Miguel / Bayas Pástor, D. C. / Pascual, I. / Aleix, L. Verges / Lladó, F. González-Huix / De Rubinat, M. Planella

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765105
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Conference proceedings: Endoscopic management of Mirizzi Syndrome: a case series

Gomez, D. Vazquez / Velasco, N. Zaragoza / Miranda, M. Albuquerque / Comas, E. Pijoan / Salas, I. Miguel / Monclus, N. Torres / Pástor, D. C. Bayas / Pascual, I. / Aleix, L. Verges / Lladó, F. González-Huix

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765356
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Conference proceedings: False gastric subepithelial lesion: Endoscopic Ultrasonography (EUS) as an essential tool

Pástor, D. C. Bayas / Gomez, D. Vazquez / Pascual, I. / Aleix, L. Verges / Monclus, N. Torres / Torres, V. G. / Salas, I. Miguel / Velasco, N. Zaragoza / Comas, E. Pijoan / De Rubinat, M. Planella / Lladó, F. González-Huix

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765839
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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Conference proceedings: Use of fully covered self-expandable metal stents in management of difficult common bile duct stones: a case series

Velasco, N. Zaragoza / Miranda, M. Alburquerque / Salas, I. Miguel / Comas, E. Pijoan / Pástor, D. C. Bayas / Gomez, D. Vazquez / García, A. L. Vargas / Pascual, I. / Monclus, N. Torres / De Rubinat, M. Planella / Lladó, F. González-Huix

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765696
Database	Thieme publisher's database

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Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Conference proceedings: Successful endoscopic treatment for Mirizzi Syndrome type III under stent use and cholangioscopy-assisted intraluminal lithotripsy

Gomez, D. Vazquez / Velasco, N. Zaragoza / Miranda, M. Albuquerque / Comas, E. Pijoan / Salas, I. Miguel / Monclus, N. Torres / Bayas Pástor, D. C. / Pascual, I. / Aleix, L. Verges / Lladó, F. González-Huix

Endoscopy

2023 Volume 55, Issue S 02

Event/congress	ESGE Days 2023, Dublin, Ireland, 2023-04-20
Language	English
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	80120-3
ISSN	1438-8812 ; 0013-726X
ISSN (online)	1438-8812
ISSN	0013-726X
DOI	10.1055/s-0043-1765761
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 669: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 162: Show issues

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Article ; Online: Prognostic value of intrinsic subtypes in hormone-receptor-positive metastatic breast cancer: systematic review and meta-analysis.

Schettini, F / Martínez-Sáez, O / Falato, C / De Santo, I / Conte, B / Garcia-Fructuoso, I / Gomez-Bravo, R / Seguí, E / Chic, N / Brasó-Maristany, F / Paré, L / Vidal, M / Adamo, B / Muñoz, M / Pascual, T / Ciruelos, E / Perou, C M / Carey, L A / Prat, A

ESMO open

2023 Volume 8, Issue 3, Page(s) 101214

Abstract: Background: In hormone receptor-positive (HoR+) breast cancer (BC), gene expression analysis identifies luminal A (LumA), luminal B (LumB), human epidermal growth factor receptor 2 (HER2)-enriched (HER2-E), basal-like (BL) intrinsic subtypes and a ... ...

Abstract	Background: In hormone receptor-positive (HoR+) breast cancer (BC), gene expression analysis identifies luminal A (LumA), luminal B (LumB), human epidermal growth factor receptor 2 (HER2)-enriched (HER2-E), basal-like (BL) intrinsic subtypes and a normal-like group. This classification has an established prognostic value in early-stage HoR+ BC. Here, we carried out a trial-level meta-analysis to determine the prognostic ability of subtypes in metastatic BC (MBC). Materials and methods: We systematically reviewed all the available prospective phase II/III trials in HoR+ MBC where subtype was assessed. The primary endpoint was progression-free survival (PFS)/time to progression (TTP) of the LumA subtype compared to non-LumA. Secondary endpoints were PFS/TTP of each individual subtype, according to treatment, menopausal and HER2 status and overall survival (OS). The random-effect model was applied, and heterogeneity assessed through Cochran's Q and I Results: Seven studies were included (2536 patients). Non-LumA represented 55.2% and was associated with worse PFS/TTP than LumA [hazard ratio (HR) 1.77, P < 0.001, I Conclusions: In HoR+ MBC, non-LumA disease is associated with poorer PFS/TTP and OS than LumA, independently of HER2, treatment and menopausal status. Future trials in HoR+ MBC should consider this clinically relevant biological classification.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/drug therapy ; Prognosis ; Prospective Studies ; Antineoplastic Agents/therapeutic use ; Proportional Hazards Models
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ISSN	2059-7029
ISSN (online)	2059-7029
DOI	10.1016/j.esmoop.2023.101214
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Article ; Online: Analysis of the Complexity of Palliative Care for Cancer Patients.

Mocha Campillo, Fátima / Comín Orce, Ana María / Monreal Cepero, María Luna / Trincado Cobos, Pablo / Gómez Mugarza, Pablo / Barriendos Sanz, Susana / Pascual de la Fuente, Natalia / Ruffini Egea, Sofia / Martínez Trufero, Javier

The American journal of hospice & palliative care

2024 , Page(s) 10499091241247169

Abstract: Introduction: The Spanish National Health System has defined complexity as a set of factors of increased difficulty that require the intervention of a palliative care team: Methods: This study is a descriptive, observational, and cross-sectional ... ...

Abstract	Introduction: The Spanish National Health System has defined complexity as a set of factors of increased difficulty that require the intervention of a palliative care team Methods: This study is a descriptive, observational, and cross-sectional analysis that included patients diagnosed with advanced oncological pathology undergoing palliative treatment who were admitted to the Medical Oncology ward of the Miguel Servet University Hospital between March and April 2023. Result: A total of 100 patients were selected for the study. According to the IDC-Pal, 68% of patients were classified as highly complex, 26% of patients were complex and only 6% of patients were classified as non-complex. The presence of pain ( Discussion: This study has shown that a high proportion of hospitalized palliative care cancer patients have high complexity, suggesting a good matching of healthcare resources to patient complexity. Four factors related to complexity have been identified, namely pain, nausea and vomiting, depression and a bedridden functional state. The presence of any of the 4 factors could help healthcare professionals to identify patients for early specialized palliative care.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1074344-3
ISSN	1938-2715 ; 1049-9091
ISSN (online)	1938-2715
ISSN	1049-9091
DOI	10.1177/10499091241247169
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Article ; Online: Potenciales biomarcadores predictores de mortalidad en pacientes COVID-19 en el Servicio de Urgencias.

Pascual Gómez, N F / Monge Lobo, I / Granero Cremades, I / Figuerola Tejerina, A / Ramasco Rueda, F / von Wernitz Teleki, A / Arrabal Campos, F M / Sanz de Benito, M A

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia

2020 Volume 33, Issue 4, Page(s) 267–273

Abstract: Objective: Identify which biomarkers performed in the first emergency analysis help to stratify COVID-19 patients according to mortality risk.: Methods: Observational, descriptive and cross-sectional study performed with data collected from patients ... ...

Title translation	Potential biomarkers predictors of mortality in COVID-19 patients in the Emergency Department.
Abstract	Objective: Identify which biomarkers performed in the first emergency analysis help to stratify COVID-19 patients according to mortality risk. Methods: Observational, descriptive and cross-sectional study performed with data collected from patients with suspected COVID-19 in the Emergency Department from February 24 to March 16, 2020. The univariate and multivariate study was performed to find independent mortality markers and calculate risk by building a severity score. Results: A total of 163 patients were included, of whom 33 died and 29 of them were positive for the COVID-19 PCR test. We obtained as possible factors to conform the Mortality Risk Score age> 75 years ((adjusted OR = 12,347, 95% CI: 4,138-36,845 p = 0.001), total leukocytes> 11,000 cells / mm3 (adjusted OR = 2,649, 95% CI: 0.879-7.981 p = 0.083), glucose> 126 mg / dL (adjusted OR = 3.716, 95% CI: 1.247-11.074 p = 0.018) and creatinine> 1.1 mg / dL (adjusted OR = 2.566, 95% CI: 0.889- 7.403, p = 0.081) This score was called COVEB (COVID, Age, Basic analytical profile) with an AUC 0.874 (95% CI: 0.816-0.933, p <0.001; Cut-off point = 1 (sensitivity = 89.66 % (95% CI: 72.6% -97.8%), specificity = 75.59% (95% CI: 67.2% -82.8%). A score <1 has a negative predictive value = 100% (95% CI: 93.51% -100%) and a positive predictive value = 18.59% (95% CI: 12.82% -25.59%). Conclusions: Clinical severity scales, kidney function biomarkers, white blood cell count parameters, the total neutrophils / total lymphocytes ratio and procalcitonin are early risk factors for mortality. The variables age, glucose, creatinine and total leukocytes stand out as the best predictors of mortality. A COVEB score <1 indicates with a 100% probability that the patient with suspected COVID-19 will not die in the next 30 days.
MeSH term(s)	Age Factors ; Aged ; Analysis of Variance ; Area Under Curve ; Betacoronavirus ; Biomarkers/blood ; Blood Glucose/analysis ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Creatinine/blood ; Cross-Sectional Studies ; Emergency Service, Hospital ; Female ; Humans ; Hypertension/mortality ; Leukocyte Count ; Male ; Odds Ratio ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Predictive Value of Tests ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Assessment/methods ; SARS-CoV-2 ; Sensitivity and Specificity
Chemical Substances	Biomarkers ; Blood Glucose ; Creatinine (AYI8EX34EU)
Keywords	covid19
Language	Spanish
Publishing date	2020-07-13
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	1018135-0
ISSN	1988-9518 ; 0214-3429
ISSN (online)	1988-9518
ISSN	0214-3429
DOI	10.37201/req/060.2020
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Article: Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study.

Muñoz-Gómez, Ana / Fernández-Cruz, Ana / Lavilla-Olleros, Cristina / Giner-Galvañ, Vicente / Ausín-García, Cristina / Wikman, Philip / Bendala-Estrada, Alejandro D / Vargas, Juan A / Rubio-Rivas, Manuel / Laureiro, Jaime / Fernández-Bermúdez, Daniel / Buonaiuto, Verónica A / Arenas de Larriva, Antonio P / Pascual-Pérez, María de Los Reyes / Alcalá-Pedrajas, José N / Labirua-Iturburu Ruiz, Ane / Hernández-Milián, Almudena / Gómez Del Mazo, Marta / Antequera, Beatriz /

Mella-Pérez, Carmen / Navas-Alcántara, María de la Sierra / Soto-Delgado, Juan F / Gámez-Mancera, Rosa M / Sardiña-González, Cristina / Meijide-Míguez, Héctor / Ramos-Rincón, José M / Gómez-Huelgas, Ricardo / On Behalf Of The Semi-Covid-Network

Journal of clinical medicine

2021 Volume 10, Issue 20

Abstract: We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients ... ...

Abstract	We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242];
Language	English
Publishing date	2021-10-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10204678
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