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  1. Article: Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats.

    Jin, Zhixing / Wang, Li / Zhu, Zhiling

    Evidence-based complementary and alternative medicine : eCAM

    2015  Volume 2015, Page(s) 208514

    Abstract: Objective. To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development ... induced by GuiXiong Xiaoyi Wan. The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ ...

    Abstract Objective. To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development of endometriosis in a rat model. Methods. Sprague-Dawley rats with surgically induced endometriosis were randomly treated with low-dose GXXYW, high-dose GXXYW, or vehicle (negative control) for 28 days. Immunohistochemistry was used to assess cell proliferation in the lesions. The terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP biotin nick end labelling (TUNEL) method was performed to analyse the apoptosis induced by GuiXiong Xiaoyi Wan. The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ lymphocytes in the spleens of the rats were evaluated using flow cytometric analysis. Results. Treatment with GXXYW significantly decreased the lesion size, inhibited cell proliferation, and induced apoptosis in endometriotic tissue. The spleens of GXXYW-treated rats also demonstrated a significant increase in the percentage of CD4+ lymphocytes and a significant decrease in the percentage of CD8+ lymphocytes. Conclusions. These results suggest that, in a rat model, GXXYW may be effective in the suppression of the growth of endometriosis, possibly through the inhibition of cell proliferation, the induction of apoptosis of endometriotic cells, and the regulation of the immune system.
    Language English
    Publishing date 2015-01-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2015/208514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats

    Zhixing Jin / Li Wang / Zhiling Zhu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2015  Volume 2015

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats

    Zhixing Jin / Li Wang / Zhiling Zhu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2015  Volume 2015

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Effect of GuiXiong Xiaoyi Wan in Treatment of Endometriosis on Rats

    Zhixing Jin / Li Wang / Zhiling Zhu

    Evidence-Based Complementary and Alternative Medicine, Vol

    2015  Volume 2015

    Abstract: Objective. To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development ... induced by GuiXiong Xiaoyi Wan. The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ ...

    Abstract Objective. To evaluate the effect of GuiXiong Xiaoyi Wan (GXXYW) on the development of endometriosis in a rat model. Methods. Sprague-Dawley rats with surgically induced endometriosis were randomly treated with low-dose GXXYW, high-dose GXXYW, or vehicle (negative control) for 28 days. Immunohistochemistry was used to assess cell proliferation in the lesions. The terminal deoxynucleotidyl transferase- (TdT-) mediated dUTP biotin nick end labelling (TUNEL) method was performed to analyse the apoptosis induced by GuiXiong Xiaoyi Wan. The percentages of CD3+ lymphocytes, CD4+ lymphocytes, and CD8+ lymphocytes in the spleens of the rats were evaluated using flow cytometric analysis. Results. Treatment with GXXYW significantly decreased the lesion size, inhibited cell proliferation, and induced apoptosis in endometriotic tissue. The spleens of GXXYW-treated rats also demonstrated a significant increase in the percentage of CD4+ lymphocytes and a significant decrease in the percentage of CD8+ lymphocytes. Conclusions. These results suggest that, in a rat model, GXXYW may be effective in the suppression of the growth of endometriosis, possibly through the inhibition of cell proliferation, the induction of apoptosis of endometriotic cells, and the regulation of the immune system.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 630
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Integrated Bioinformatics and Experimental Validation to Identify a Disulfidptosis-Related lncRNA Model for Prognostic Prediction in Papillary Renal Cell Carcinoma.

    Zhu, Yidong / Jin, Xiaoyi / Liu, Jun

    Combinatorial chemistry & high throughput screening

    2024  

    Abstract: Aims: This study aimed to construct a prognostic model for papillary renal cell carcinoma (pRCC) utilizing disulfidptosis-associated long non-coding RNAs (lncRNAs). Additionally, it investigated the potential of these lncRNAs in predicting immune ... ...

    Abstract Aims: This study aimed to construct a prognostic model for papillary renal cell carcinoma (pRCC) utilizing disulfidptosis-associated long non-coding RNAs (lncRNAs). Additionally, it investigated the potential of these lncRNAs in predicting immune responses and drug sensitivity in pRCC.
    Background: LncRNAs have been implicated in the progression and prognosis of pRCC. Recently, disulfidptosis, an emerging form of regulated cell death, has shown potential as a therapeutic approach for cancer. However, the potential association between disulfidptosis-related lncRNAs and pRCC remains unclear.
    Methods: We analyzed transcriptome profiling and clinical data of pRCC patients from The Cancer Genome Atlas database. Using Pearson correlation analysis, we identified lncRNAs associated with disulfidptosis. Based on the identified disulfidptosis-related lncRNAs that were correlated with overall survival (OS), we constructed a novel prediction model using the least absolute shrinkage and selection operator, univariable Cox regression, and multivariable Cox regression analyses. The model's utility was assessed through Kaplan-Meier survival, receiver operating characteristics, and principal component analyses. Moreover, functional analysis helped identify potential prognostic mechanisms, and the prediction of chemical drugs for pRCC was also performed. Finally, qRT-PCR validated the expression of prognostic lncRNAs in pRCC cells and patient samples.
    Results: Our prediction model was based on nine disulfidptosis-related lncRNAs. Evaluation and validation analyses demonstrated that the model had excellent, consistent, and independent prognostic value for pRCC patients, with area under the curve (AUC) values of 0.954, 0.910, and 0.830 for 1-, 3-, and 5-year OS, respectively. Through functional analysis, we discovered a significant correlation between the identified prognostic signature and immunity. Additionally, in terms of chemotherapy sensitivity, our analysis indicated that the low-risk group exhibited higher sensitivity to sunitinib and pazopanib. Furthermore, the expression patterns of the identified lncRNAs were validated in samples obtained from pRCC cells and patients.
    Conclusion: This study successfully established and validated a novel disulfidptosis-related prediction model. The findings suggest the potential involvement of immune-related pathways in lncRNA signature-associated survival. This model holds promise for differentiating prognosis and improving personalized therapeutic strategies for pRCC in clinical practice.
    Language English
    Publishing date 2024-04-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/0113862073303084240403051346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5577: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Dietary quercetin protects Cherax quadricarinatus against white spot syndrome virus infection.

    Gong, Jing / Pan, Xiaoyi / Zhou, Xiujuan / Zhu, Fei

    Journal of invertebrate pathology

    2023  Volume 198, Page(s) 107931

    Abstract: Quercetin is a plant flavonoid with a molecular formula ... ...

    Abstract Quercetin is a plant flavonoid with a molecular formula C
    MeSH term(s) Animals ; Astacoidea ; White spot syndrome virus 1 ; Quercetin/pharmacology ; Quercetin/metabolism ; Immunity, Innate/genetics ; Hemocytes
    Chemical Substances Quercetin (9IKM0I5T1E)
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390885-9
    ISSN 1096-0805 ; 0022-2011
    ISSN (online) 1096-0805
    ISSN 0022-2011
    DOI 10.1016/j.jip.2023.107931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 958: Show issues Location:
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  7. Article ; Online: Consequences of COVID-19 on the cardiovascular and renal systems.

    Zhu, Yuan / Zhang, Xiaoyi / Peng, Zhiyong

    Sleep medicine

    2022  Volume 100, Page(s) 31–38

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Cardiovascular System ; Cardiovascular Diseases/epidemiology
    Language English
    Publishing date 2022-08-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2022.07.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5315: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 635: Show issues

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  8. Article ; Online: Assessing Preferences and Perceived Restorative Qualities of Break Spaces for Nurses in China.

    Zhu, Xiaoyi / Shepley, Mardelle McCuskey

    HERD

    2022  Volume 15, Issue 3, Page(s) 126–142

    Abstract: Objective: This study investigated Chinese nurses' preferences for (a) proximity of break areas, (b) functionality of break areas, (c) amenities, and (d) nature-related environmental features.: Background: While nurses in China need support to ... ...

    Abstract Objective: This study investigated Chinese nurses' preferences for (a) proximity of break areas, (b) functionality of break areas, (c) amenities, and (d) nature-related environmental features.
    Background: While nurses in China need support to adequately perform their jobs, little is known about how restorative spaces impact their mental and physical health.
    Methods: Data were collected through interviews (
    Results: Nurses preferred the break room to be close to nursing stations; to have visual privacy from patients; and to provide space and facilities for drinking, taking naps, dining, and chatting with colleagues. Balconies and windows were shown to have a significant restorative effect. Well-designed break areas were perceived to have positive impacts on nurse perceived levels of well-being and increase nurses' satisfaction levels with their work environment.
    Conclusion: The study outcomes emphasize the importance of restorative spaces for inpatient nurses and recommend including natural elements in the break rooms.
    MeSH term(s) China ; Humans ; Job Satisfaction ; Nursing Staff, Hospital ; Nursing Stations ; Privacy ; Surveys and Questionnaires ; Workplace
    Language English
    Publishing date 2022-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2525547-2
    ISSN 2167-5112 ; 1937-5867
    ISSN (online) 2167-5112
    ISSN 1937-5867
    DOI 10.1177/19375867221075837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Rapid detection of four major HFMD-associated enteroviruses by multiplex HiFi-LAMP assays.

    Zhang, Xiaoling / Zhao, Yongjuan / Zhu, Xiaoyi / Tian, Weimin / Zhang, Chiyu

    Analytical and bioanalytical chemistry

    2024  Volume 416, Issue 8, Page(s) 1971–1982

    Abstract: Hand, foot, and mouth disease (HFMD) caused by various enteroviruses is a major public health concern globally. Human enterovirus 71(EVA71), coxsackievirus A16 (CVA16), coxsackievirus A6 (CVA6), and coxsackievirus A10 (CVA10) are four major enteroviruses ...

    Abstract Hand, foot, and mouth disease (HFMD) caused by various enteroviruses is a major public health concern globally. Human enterovirus 71(EVA71), coxsackievirus A16 (CVA16), coxsackievirus A6 (CVA6), and coxsackievirus A10 (CVA10) are four major enteroviruses responsible for HFMD. Rapid, accurate, and specific point-of-care (POC) detection of the four enteroviruses is crucial for the prevention and control of HFMD. Here, we developed two multiplex high-fidelity DNA polymerase loop-mediated isothermal amplification (mHiFi-LAMP) assays for simultaneous detection of EVA71, CVA16, CVA6, and CVA10. The assays have good specificity and exhibit high sensitivity, with limits of detection (LOD) of 11.2, 49.6, 11.4, and 20.5 copies per 25 μL reaction for EVA71, CVA16, CVA6, and CVA10, respectively. The mHiFi-LAMP assays showed an excellent clinical performance (sensitivity 100.0%, specificity 83.3%, n = 47) when compared with four singleplex RT-qPCR assays (sensitivity 93.1%, specificity 100%). In particular, the HiFi-LAMP assays exhibited better performance (sensitivity 100.0%, specificity 100%) for CVA16 and CVA6 than the RT-qPCR assays (sensitivity 75.0-92.3%, specificity 100%). Furthermore, the mHiFi-LAMP assays detected all clinical samples positive for the four enteroviruses within 30 min, obviously shorter than about 1-1.5 h by the RT-qPCR assays. The new mHiFi-LAMP assays can be used as a robust point-of-care testing (POCT) tool to facilitate surveillance of HFMD at rural and remote communities and resource-limited settings.
    MeSH term(s) Humans ; Hand, Foot and Mouth Disease/diagnosis ; Enterovirus/genetics ; Enterovirus A, Human/genetics ; Molecular Diagnostic Techniques ; China/epidemiology ; Phylogeny ; Nucleic Acid Amplification Techniques
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-024-05197-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Bibliometric analysis and evaluation of publications on non-

    Wang, Menghui / Fang, Hui / Zhou, Chulin / Ouyang, Yaobin / Yu, Chenfeng / Zhang, Yang / Zhu, Xiaoyi / Xie, Chuan / Deng, Qiliang

    Future microbiology

    2024  

    Abstract: Aim: ...

    Abstract Aim:
    Language English
    Publishing date 2024-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2254620-0
    ISSN 1746-0921 ; 1746-0913
    ISSN (online) 1746-0921
    ISSN 1746-0913
    DOI 10.2217/fmb-2024-0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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