LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Book ; Online ; Thesis: Study of genetic and epigenetic determinants of gene expression regulation for both SL genes in response to estrogen in common carp (Cyprinus carpio)

Valenzuela Nieto, Guillermo Eduardo [Verfasser] / Kausel, Gudrun [Akademischer Betreuer]

2019

Author's details	Guillermo Eduardo Valenzuela Nieto ; Betreuer: Gudrun Kausel
Keywords	Landwirtschaft, Veterinärmedizin ; Agriculture, Veterinary Science
Subject code	sg630
Language	English
Publisher	Universitätsbibliothek Regensburg
Publishing place	Regensburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

Aguado, Julio / Amarilla, Alberto A / Taherian Fard, Atefeh / Albornoz, Eduardo A / Tyshkovskiy, Alexander / Schwabenland, Marius / Chaggar, Harman K / Modhiran, Naphak / Gómez-Inclán, Cecilia / Javed, Ibrahim / Baradar, Alireza A / Liang, Benjamin / Peng, Lianli / Dharmaratne, Malindrie / Pietrogrande, Giovanni / Padmanabhan, Pranesh / Freney, Morgan E / Parry, Rhys / Sng, Julian D J /

Isaacs, Ariel / Khromykh, Alexander A / Valenzuela Nieto, Guillermo / Rojas-Fernandez, Alejandro / Davis, Thomas P / Prinz, Marco / Bengsch, Bertram / Gladyshev, Vadim N / Woodruff, Trent M / Mar, Jessica C / Watterson, Daniel / Wolvetang, Ernst J

Nature aging

2023 Volume 3, Issue 12, Page(s) 1561–1575

Abstract: Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on ... ...

Abstract	Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on neuropathologies is unknown. Here we show that senescent cells accumulate in aged human brain organoids and that senolytics reduce age-related inflammation and rejuvenate transcriptomic aging clocks. In postmortem brains of patients with severe COVID-19 we observed increased senescent cell accumulation compared with age-matched controls. Exposure of human brain organoids to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced cellular senescence, and transcriptomic analysis revealed a unique SARS-CoV-2 inflammatory signature. Senolytic treatment of infected brain organoids blocked viral replication and prevented senescence in distinct neuronal populations. In human-ACE2-overexpressing mice, senolytics improved COVID-19 clinical outcomes, promoted dopaminergic neuron survival and alleviated viral and proinflammatory gene expression. Collectively our results demonstrate an important role for cellular senescence in driving brain aging and SARS-CoV-2-induced neuropathology, and a therapeutic benefit of senolytic treatments.
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; COVID-19 ; Senotherapeutics ; SARS-CoV-2 ; Aging ; Brain
Chemical Substances	Senotherapeutics
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-023-00519-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Venoarterial extracorporeal membrane oxygenation in heart surgery post-operative pediatric patients: A retrospective study at Christus Muguerza Hospital, Monterrey, Mexico.

Vargas-Camacho, Gerardo / Contreras-Cepeda, Verónica / Gómez-Gutierrez, Rene / Quezada-Valenzuela, Guillermo / Nieto-Sanjuanero, Adriana / Santos-Guzmán, Jesús / González-Salazar, Francisco

SAGE open medicine

2020 Volume 8, Page(s) 2050312120910353

Abstract: Objectives: Extracorporeal membrane oxygenation is a life support procedure developed to offer cardiorespiratory support when conventional therapies have failed. The purpose of this study is to describe the findings during the first years using ... ...

Abstract	Objectives: Extracorporeal membrane oxygenation is a life support procedure developed to offer cardiorespiratory support when conventional therapies have failed. The purpose of this study is to describe the findings during the first years using venoarterial extracorporeal membrane oxygenation in pediatric patients after cardiovascular surgery at Christus Muguerza High Specialty Hospital in Monterrey, Mexico. Methods: This is a retrospective, observational, and descriptive study. The files of congenital heart surgery post-operative pediatric patients, who were treated with venoarterial extracorporeal membrane oxygenation from January 2013 to December 2015, were reviewed. Results: A total of 11 patients were reviewed, of which 7 (63.8%) were neonates and 4 (36.7%) were in pediatric age. The most common diagnoses were transposition of great vessels, pulmonary stenosis, and tetralogy of Fallot. Survival rate was 54.5% and average life span was 6.3 days; the main complications were sepsis (36.3%), acute renal failure (36.3%), and severe cerebral hemorrhage (9.1%). The main causes of death were multi-organ dysfunction syndrome (27.3%) and cerebral hemorrhage (18.2%). Conclusion: The mortality rates found are very similar to those found in a meta-analysis report published in 2013 and the main complication and causes of death are also very similar to the majority of extracorporeal membrane oxygenation reports for these kinds of patients. Although the results are encouraging, early sepsis detection, prevention of cerebral hemorrhage, and renal function monitoring must be improved.
Language	English
Publishing date	2020-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2735399-0
ISSN	2050-3121
ISSN	2050-3121
DOI	10.1177/2050312120910353
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Serological Profile Of Specific Antibodies Against Dominant Antigens Of SARS-CoV-2 In Chilean COVID-19 Patients.

Cereceda, Karina / Gonzalez-Stegmaier, Roxana / Briones, Jose Luis / Selman, Carolina / Aguirre, Adam / Valenzuela-Nieto, Guillermo / Caglevic, Christian / Gazitua, Raimundo / Rojas-Fernandez, Alejandro / Villaroel-Espíndola, Franz

bioRxiv

Abstract: Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has been a pandemic since March 2020. Currently, the virus has infected more than 50 million people worldwide and more than half a million in Chile. For many coronaviruses, Spike (S) and ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has been a pandemic since March 2020. Currently, the virus has infected more than 50 million people worldwide and more than half a million in Chile. For many coronaviruses, Spike (S) and Nucleocapsid (N) proteins are described as major antigenic molecules, inducing seroconversion and production of neutralizing antibodies. In this work, we evaluated the presence in serum of IgM, IgA and IgG antibodies against N and S proteins of SARS-CoV-2 using western blot, and developed an ELISA test for the qualitative characterization of COVID-19 patients. Patients with an active infection or who have recovered from COVID-19 showed specific immunoblotting patterns for the recombinants S protein and its domains S1 and S2, as well as for the N protein of SARS-CoV-2. Anti-N antibodies were more frequently detected than anti-S or anti-S1-RBD antibodies. People who were never exposed to SARS-CoV-2 did not show reactivity. Finally, indirect ELISA assays using N and S1-RBD proteins, alone or in combination, were established with variable sensitivity and specificity depending on the antigen bound to the solid phase. Overall, Spike showed higher specificity than the nucleocapsid, and comparable sensitivity for both antigens. Both approaches confirmed the seroconversion after infection and allowed us to implement the analysis of antibodies in blood for research purposes in a local facility.
Keywords	covid19
Language	English
Publishing date	2021-02-05
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.02.05.429566
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: A nanobody recognizes a unique conserved epitope and potently neutralizes SARS-CoV-2 omicron variants.

Modhiran, Naphak / Lauer, Simon Malte / Amarilla, Alberto A / Hewins, Peter / Lopes van den Broek, Sara Irene / Low, Yu Shang / Thakur, Nazia / Liang, Benjamin / Nieto, Guillermo Valenzuela / Jung, James / Paramitha, Devina / Isaacs, Ariel / Sng, Julian D J / Song, David / Jørgensen, Jesper Tranekjær / Cheuquemilla, Yorka / Bürger, Jörg / Andersen, Ida Vang / Himelreichs, Johanna /

Jara, Ronald / MacLoughlin, Ronan / Miranda-Chacon, Zaray / Chana-Cuevas, Pedro / Kramer, Vasko / Spahn, Christian / Mielke, Thorsten / Khromykh, Alexander A / Munro, Trent / Jones, Martina L / Young, Paul R / Chappell, Keith / Bailey, Dalan / Kjaer, Andreas / Herth, Matthias Manfred / Jurado, Kellie Ann / Schwefel, David / Rojas-Fernandez, Alejandro / Watterson, Daniel

iScience

2023 Volume 26, Issue 7, Page(s) 107085

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Omicron variant sub-lineages spread rapidly worldwide, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) Omicron variant sub-lineages spread rapidly worldwide, mostly due to their immune-evasive properties. This has put a significant part of the population at risk for severe disease and underscores the need for effective anti-SARS-CoV-2 agents against emergent strains in vulnerable patients. Camelid nanobodies are attractive therapeutic candidates due to their high stability, ease of large-scale production, and potential for delivery via inhalation. Here, we characterize the receptor binding domain (RBD)-specific nanobody W25 and show superior neutralization activity toward Omicron sub-lineages in comparison to all other SARS-CoV2 variants. Structure analysis of W25 in complex with the SARS-CoV2 spike glycoprotein shows that W25 engages an RBD epitope not covered by any of the antibodies previously approved for emergency use.
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107085
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Venoarterial extracorporeal membrane oxygenation in heart surgery post-operative pediatric patients

Gerardo Vargas-Camacho / Verónica Contreras-Cepeda / Rene Gómez-Gutierrez / Guillermo Quezada-Valenzuela / Adriana Nieto-Sanjuanero / Jesús Santos-Guzmán / Francisco González-Salazar

SAGE Open Medicine, Vol

A retrospective study at Christus Muguerza Hospital, Monterrey, Mexico

2020 Volume 8

Abstract	Objectives: Extracorporeal membrane oxygenation is a life support procedure developed to offer cardiorespiratory support when conventional therapies have failed. The purpose of this study is to describe the findings during the first years using venoarterial extracorporeal membrane oxygenation in pediatric patients after cardiovascular surgery at Christus Muguerza High Specialty Hospital in Monterrey, Mexico. Methods: This is a retrospective, observational, and descriptive study. The files of congenital heart surgery post-operative pediatric patients, who were treated with venoarterial extracorporeal membrane oxygenation from January 2013 to December 2015, were reviewed. Results: A total of 11 patients were reviewed, of which 7 (63.8%) were neonates and 4 (36.7%) were in pediatric age. The most common diagnoses were transposition of great vessels, pulmonary stenosis, and tetralogy of Fallot. Survival rate was 54.5% and average life span was 6.3 days; the main complications were sepsis (36.3%), acute renal failure (36.3%), and severe cerebral hemorrhage (9.1%). The main causes of death were multi-organ dysfunction syndrome (27.3%) and cerebral hemorrhage (18.2%). Conclusion: The mortality rates found are very similar to those found in a meta-analysis report published in 2013 and the main complication and causes of death are also very similar to the majority of extracorporeal membrane oxygenation reports for these kinds of patients. Although the results are encouraging, early sepsis detection, prevention of cerebral hemorrhage, and renal function monitoring must be improved.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody.

Valenzuela Nieto, Guillermo / Jara, Ronald / Watterson, Daniel / Modhiran, Naphak / Amarilla, Alberto A / Himelreichs, Johanna / Khromykh, Alexander A / Salinas-Rebolledo, Constanza / Pinto, Teresa / Cheuquemilla, Yorka / Margolles, Yago / López González Del Rey, Natalia / Miranda-Chacon, Zaray / Cuevas, Alexei / Berking, Anne / Deride, Camila / González-Moraga, Sebastián / Mancilla, Héctor / Maturana, Daniel /

Langer, Andreas / Toledo, Juan Pablo / Müller, Ananda / Uberti, Benjamín / Krall, Paola / Ehrenfeld, Pamela / Blesa, Javier / Chana-Cuevas, Pedro / Rehren, German / Schwefel, David / Fernandez, Luis Ángel / Rojas-Fernandez, Alejandro

Scientific reports

2021 Volume 11, Issue 1, Page(s) 3318

Abstract: Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains critical. Effective diagnosis, treatment, and prophylactic measures are urgently required to meet ...

Abstract	Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains critical. Effective diagnosis, treatment, and prophylactic measures are urgently required to meet global demand: recombinant antibodies fulfill these requirements and have marked clinical potential. Here, we describe the fast-tracked development of an alpaca Nanobody specific for the receptor-binding-domain (RBD) of the SARS-CoV-2 Spike protein with potential therapeutic applicability. We present a rapid method for nanobody isolation that includes an optimized immunization regimen coupled with VHH library E. coli surface display, which allows single-step selection of Nanobodies using a simple density gradient centrifugation of the bacterial library. The selected single and monomeric Nanobody, W25, binds to the SARS-CoV-2 S RBD with sub-nanomolar affinity and efficiently competes with ACE-2 receptor binding. Furthermore, W25 potently neutralizes SARS-CoV-2 wild type and the D614G variant with IC50 values in the nanomolar range, demonstrating its potential as antiviral agent.
MeSH term(s)	Angiotensin-Converting Enzyme 2/immunology ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antibody Affinity/genetics ; COVID-19/immunology ; COVID-19/virology ; Camelids, New World/immunology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Green Fluorescent Proteins/genetics ; HeLa Cells ; Humans ; Immunization ; Male ; Neutralization Tests ; Peptide Library ; Protein Binding/genetics ; SARS-CoV-2/chemistry ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Single-Domain Antibodies/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Transfection
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Peptide Library ; Single-Domain Antibodies ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Green Fluorescent Proteins (147336-22-9) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2021-02-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-82833-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity nanobody

Guillermo Valenzuela Nieto / Ronald Jara / Daniel Watterson / Naphak Modhiran / Alberto A. Amarilla / Johanna Himelreichs / Alexander A. Khromykh / Constanza Salinas-Rebolledo / Teresa Pinto / Yorka Cheuquemilla / Yago Margolles / Natalia López González del Rey / Zaray Miranda-Chacon / Alexei Cuevas / Anne Berking / Camila Deride / Sebastián González-Moraga / Héctor Mancilla / Daniel Maturana /

Andreas Langer / Juan Pablo Toledo / Ananda Müller / Benjamín Uberti / Paola Krall / Pamela Ehrenfeld / Javier Blesa / Pedro Chana-Cuevas / German Rehren / David Schwefel / Luis Ángel Fernandez / Alejandro Rojas-Fernandez

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 14

Abstract: Abstract Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains critical. Effective diagnosis, treatment, and prophylactic measures are urgently ... ...

Abstract	Abstract Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to reduce the burden placed on health systems, the situation remains critical. Effective diagnosis, treatment, and prophylactic measures are urgently required to meet global demand: recombinant antibodies fulfill these requirements and have marked clinical potential. Here, we describe the fast-tracked development of an alpaca Nanobody specific for the receptor-binding-domain (RBD) of the SARS-CoV-2 Spike protein with potential therapeutic applicability. We present a rapid method for nanobody isolation that includes an optimized immunization regimen coupled with VHH library E. coli surface display, which allows single-step selection of Nanobodies using a simple density gradient centrifugation of the bacterial library. The selected single and monomeric Nanobody, W25, binds to the SARS-CoV-2 S RBD with sub-nanomolar affinity and efficiently competes with ACE-2 receptor binding. Furthermore, W25 potently neutralizes SARS-CoV-2 wild type and the D614G variant with IC50 values in the nanomolar range, demonstrating its potential as antiviral agent.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Manejo exitoso de hernia diafragmática congénita con ECMO. Primer reporte de caso en México

Ulises Garza-Serna / René Daniel Gómez-Gutiérrez / Guillermo Quezada-Valenzuela / Bárbara Cárdenasdel Castillo / Verónica Contreras-Cepeda / Erik Alejandro Chávez-García / Adriana Nieto-Sanjuanero

Acta Pediátrica de México, Vol 38, Iss 6, Pp 378-

2017 Volume 385

Abstract: INTRODUCCIÓN: la hernia diafragmática congénita es una enfermedad que afecta a 1 de 3000 recién nacidos, con un alto índice de morbilidad y mortalidad, especialmente si se presenta con otras malformaciones como las anomalías congénitas cardiacas. El ... ...

Abstract	INTRODUCCIÓN: la hernia diafragmática congénita es una enfermedad que afecta a 1 de 3000 recién nacidos, con un alto índice de morbilidad y mortalidad, especialmente si se presenta con otras malformaciones como las anomalías congénitas cardiacas. El manejo del paciente con este padecimiento debe ser tratado de forma multidisciplinaria e incluir su evaluación prenatal y atención posnatal. OBJETIVO: reportar el primer caso exitoso en México de un paciente con hernia diafragmática congénita manejado con membrana de oxigenación extracorpórea. CASO CLÍNICO: paciente masculino de 37.5 semanas de gestación con diagnóstico prenatal de hernia diafragmática congénita a las 24 semanas de gestación sin otras anomalías congénitas; índice pulmón/ cabeza de 1.7. A las seis horas de nacido presentó saturación de oxígeno preductal de 78% y posductal a 58% con índice de oxigenación de 41, a pesar del tratamiento agresivo médico y ventilatorio, por lo que se necesitó la intervención e implementación de la membrana de circulación extracorpórea.
Keywords	hernia diafragmática congénita ; ECMO ; hipoplasia pulmonar ; cirugía fetal ; hipertensión pulmonar persistente del recién nacido ; Medicine ; R ; Pediatrics ; RJ1-570
Language	Spanish
Publishing date	2017-11-01T00:00:00Z
Publisher	Instituto Nacional de Pediatría
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Environmental and societal factors associated with COVID-19-related death in people with rheumatic disease: an observational study.

Izadi, Zara / Gianfrancesco, Milena A / Schmajuk, Gabriela / Jacobsohn, Lindsay / Katz, Patricia / Rush, Stephanie / Ja, Clairissa / Taylor, Tiffany / Shidara, Kie / Danila, Maria I / Wysham, Katherine D / Strangfeld, Anja / Mateus, Elsa F / Hyrich, Kimme L / Gossec, Laure / Carmona, Loreto / Lawson-Tovey, Saskia / Kearsley-Fleet, Lianne / Schaefer, Martin /

Al-Emadi, Samar / Sparks, Jeffrey A / Hsu, Tiffany Y-T / Patel, Naomi J / Wise, Leanna / Gilbert, Emily / Duarte-García, Alí / Valenzuela-Almada, Maria O / Ugarte-Gil, Manuel F / Ljung, Lotta / Scirè, Carlo A / Carrara, Greta / Hachulla, Eric / Richez, Christophe / Cacoub, Patrice / Thomas, Thierry / Santos, Maria J / Bernardes, Miguel / Hasseli, Rebecca / Regierer, Anne / Schulze-Koops, Hendrik / Müller-Ladner, Ulf / Pons-Estel, Guillermo / Tanten, Romina / Nieto, Romina E / Pisoni, Cecilia N / Tissera, Yohana S / Xavier, Ricardo / Lopes Marques, Claudia D / Pileggi, Gecilmara C S / Robinson, Philip C / Machado, Pedro M / Sirotich, Emily / Liew, Jean W / Hausmann, Jonathan S / Sufka, Paul / Grainger, Rebecca / Bhana, Suleman / Gore-Massy, Monique / Wallace, Zachary S / Yazdany, Jinoos

The Lancet. Rheumatology

2022 Volume 4, Issue 9, Page(s) e603–e613

Abstract: Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal ... ...

Abstract	Background: Differences in the distribution of individual-level clinical risk factors across regions do not fully explain the observed global disparities in COVID-19 outcomes. We aimed to investigate the associations between environmental and societal factors and country-level variations in mortality attributed to COVID-19 among people with rheumatic disease globally. Methods: In this observational study, we derived individual-level data on adults (aged 18-99 years) with rheumatic disease and a confirmed status of their highest COVID-19 severity level from the COVID-19 Global Rheumatology Alliance (GRA) registry, collected between March 12, 2020, and Aug 27, 2021. Environmental and societal factors were obtained from publicly available sources. The primary endpoint was mortality attributed to COVID-19. We used a multivariable logistic regression to evaluate independent associations between environmental and societal factors and death, after controlling for individual-level risk factors. We used a series of nested mixed-effects models to establish whether environmental and societal factors sufficiently explained country-level variations in death. Findings: 14 044 patients from 23 countries were included in the analyses. 10 178 (72·5%) individuals were female and 3866 (27·5%) were male, with a mean age of 54·4 years (SD 15·6). Air pollution (odds ratio 1·10 per 10 μg/m Interpretation: Our findings highlight the importance of environmental and societal factors as potential explanations of the observed regional disparities in COVID-19 outcomes among people with rheumatic disease and lay foundation for a new research agenda to address these disparities. Funding: American College of Rheumatology and European Alliance of Associations for Rheumatology.
Language	English
Publishing date	2022-07-25
Publishing country	England
Document type	Journal Article
ISSN	2665-9913
ISSN (online)	2665-9913
DOI	10.1016/S2665-9913(22)00192-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED