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  1. Article ; Online: The Crosstalk between Nephropathy and Coagulation Disorder: Pathogenesis, Treatment, and Dilemmas.

    Qiu, Zhiwei / Pang, Xiaocong / Xiang, Qian / Cui, Yimin

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 11, Page(s) 1793–1811

    Abstract: Abstract: The interaction between the kidney and the coagulation system greatly affects each other because of the abundant vessel distribution and blood perfusion in the kidney. Clinically, the risks of complicated thrombosis and bleeding have become ... ...

    Abstract Abstract: The interaction between the kidney and the coagulation system greatly affects each other because of the abundant vessel distribution and blood perfusion in the kidney. Clinically, the risks of complicated thrombosis and bleeding have become important concerns in the treatment of nephropathies, especially nephrotic syndrome, CKD, ESKD, and patients with nephropathy undergoing RRTs. Adverse effects of anticoagulant or procoagulant therapies in patients with nephropathy, especially anticoagulation-related nephropathy, heparin-induced thrombocytopenia, and bleeding, seriously worsen the prognosis of patients, which have become challenges for clinicians. Over the decades, the interaction between the kidney and the coagulation system has been widely studied. However, the effects of the kidney on the coagulation system have not been systematically investigated. Although some coagulation-related proteins and signaling pathways have been shown to improve coagulation abnormalities while avoiding additional kidney damage in certain kidney diseases, their potential as anticoagulation targets in nephropathy requires further investigation. Here, we review the progression of research on the crosstalk between the coagulation system and kidney diseases and systematically analyze the significance and shortcomings of previous studies to provide new sight into future research. In addition, we highlight the status of clinical treatment for coagulation disorder and nephropathy caused by each other, indicating guidance for the formulation of therapeutic strategies or drug development.
    MeSH term(s) Humans ; Blood Coagulation Disorders/complications ; Blood Coagulation Disorders/drug therapy ; Anticoagulants/adverse effects ; Kidney ; Nephrotic Syndrome/drug therapy ; Thrombosis/complications ; Blood Coagulation Factors ; Hemorrhage ; Heparin/adverse effects
    Chemical Substances Anticoagulants ; Blood Coagulation Factors ; Heparin (9005-49-6)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  2. Article ; Online: IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities.

    He, Xu / Wedn, Abdalla / Wang, Jian / Gu, Yanlun / Liu, Hongjin / Zhang, Juqi / Lin, Zhiqiang / Zhou, Renpeng / Pang, Xiaocong / Cui, Yimin

    Pharmacological research

    2024  Volume 201, Page(s) 107063

    Abstract: Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways to defend the host. Recent studies have revealed additional regulatory ... ...

    Abstract Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways to defend the host. Recent studies have revealed additional regulatory functions of STING beyond its innate immune-related activities, including the regulation of cellular metabolism, DNA repair, cellular senescence, autophagy and various cell deaths. These findings highlight the broader implications of STING in cellular physiology beyond its role in innate immunity. Currently, approximately 10 STING agonists have entered the clinical stage. Unlike inhibitors, which have a maximum inhibition limit, agonists have the potential for infinite amplification. STING signaling is a complex process that requires precise regulation of STING to ensure balanced immune responses and prevent detrimental autoinflammation. Recent research on the structural mechanism of STING autoinhibition and its negative regulation by adaptor protein complex 1 (AP-1) provides valuable insights into its different effects under physiological and pathological conditions, offering a new perspective for developing immune regulatory drugs. Herein, we present a comprehensive overview of the regulatory functions and molecular mechanisms of STING beyond innate immune regulation, along with updated details of its structural mechanisms. We discuss the implications of these complex regulations in various diseases, emphasizing the importance and feasibility of targeting the immunity-dependent or immunity-independent functions of STING. Moreover, we highlight the current trend in drug development and key points for clinical research, basic research, and translational research related to STING.
    MeSH term(s) Autophagy ; Cell Death ; Cellular Senescence ; Immunity, Innate ; Nucleotidyltransferases
    Chemical Substances Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2024.107063
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    Zs.A 721: Show issues Location:
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  3. Article ; Online: Continuous tuning of pulse parameters in a soliton fiber laser by adjusting the effect of nonlinear polarization rotation: publisher's note.

    Zhang, Xintong / Guo, Haozhe / He, Wenbin / Wang, Xiaocong / Huang, Qi / Zheng, Yu / Yin, Ruochen / Huang, Zhiyuan / Jiang, Xin / Xu, Lixin / Leng, Yuxin / Pang, Meng

    Optics letters

    2024  Volume 49, Issue 6, Page(s) 1611

    Abstract: This publisher's note contains a correction to Opt. Lett.49, 674 (2024)10.1364/OL.509981. ...

    Abstract This publisher's note contains a correction to Opt. Lett.49, 674 (2024)10.1364/OL.509981.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.521523
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  4. Article ; Online: Platelet factor 4(PF4) and its multiple roles in diseases.

    Liu, Zhiyan / Li, Longtu / Zhang, Hanxu / Pang, Xiaocong / Qiu, Zhiwei / Xiang, Qian / Cui, Yimin

    Blood reviews

    2023  Volume 64, Page(s) 101155

    Abstract: Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has attracted wide attention due to its role in novel coronavirus vaccine-19 (COVID-9)- ... ...

    Abstract Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has attracted wide attention due to its role in novel coronavirus vaccine-19 (COVID-9)-induced immune thrombotic thrombocytopenia (VITT) and cognitive impairments. The electrostatic interaction between PF4 and negatively charged molecules is vital in the progression of VITT, which is similar to HIT. Emerging evidence suggests its multiple roles in hematopoietic and angiogenic inhibition, platelet coagulation interference, host inflammatory response promotion, vascular inhibition, and antitumor properties. The emerging pharmacological effects of PF4 may help deepen the exploration of its mechanism, thus accelerating the development of targeted therapies. However, due to its pleiotropic properties, the development of drugs targeting PF4 is at an early stage and faces many challenges. Herein, we discussed the characteristics and biological functions of PF4, summarized PF4-mediated signaling pathways, and discussed its multiple roles in diseases to inform novel approaches for successful clinical translational research.
    MeSH term(s) Humans ; Platelet Factor 4/metabolism ; COVID-19 Vaccines/adverse effects ; Heparin ; Thrombocytopenia/etiology ; Immunoglobulin G ; Immunologic Factors/adverse effects
    Chemical Substances Platelet Factor 4 (37270-94-3) ; COVID-19 Vaccines ; Heparin (9005-49-6) ; Immunoglobulin G ; Immunologic Factors
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101155
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    Zs.A 2207: Show issues Location:
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  5. Article ; Online: Immune thrombocytopenia of haematological immune-related adverse events in cancer immunotherapy: Most and mighty.

    Pang, Xiaocong / Su, Xian / Zhang, Zhuo / Cui, Yimin

    European journal of cancer (Oxford, England : 1990)

    2020  Volume 131, Page(s) 16–17

    MeSH term(s) Humans ; Immunologic Factors ; Immunotherapy ; Neoplasms ; Purpura, Thrombocytopenic, Idiopathic ; Thrombocytopenia
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-04-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2020.02.042
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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  6. Article ; Online: R-LIO

    Kai Chen / Kai Zhan / Fan Pang / Xiaocong Yang / Da Zhang

    Sustainability, Vol 14, Iss 10833, p

    Rotating Lidar Inertial Odometry and Mapping

    2022  Volume 10833

    Abstract: In this paper, we propose a novel simultaneous localization and mapping algorithm, R-LIO, which combines rotating multi-line lidar and inertial measurement unit. R-LIO can achieve real-time and high-precision pose estimation and map-building. R-LIO is ... ...

    Abstract In this paper, we propose a novel simultaneous localization and mapping algorithm, R-LIO, which combines rotating multi-line lidar and inertial measurement unit. R-LIO can achieve real-time and high-precision pose estimation and map-building. R-LIO is mainly composed of four sequential modules, namely nonlinear motion distortion compensation module, frame-to-frame point cloud matching module based on normal distribution transformation by self-adaptive grid, frame-to-submap point cloud matching module based on line and surface feature, and loop closure detection module based on submap-to-submap point cloud matching. R-LIO is tested on public datasets and private datasets, and it is compared quantitatively and qualitatively to the four well-known methods. The test results show that R-LIO has a comparable localization accuracy to well-known algorithms as LIO-SAM, FAST-LIO2, and Faster-LIO in non-rotating lidar data. The standard algorithms cannot function normally with rotating lidar data. Compared with non-rotating lidar data, R-LIO can improve localization and mapping accuracy in rotating lidar data.
    Keywords SLAM ; rotating lidar ; motion distortion compensation ; self-adaptive grid ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer

    Xiaocong Pang / Xiaojiao Sun / Yanlun Gu / Xu He / Kan Gong / Song Song / Jixin Zhang / Jie Xia / Zhenming Liu / Yimin Cui

    Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-

    2023  Volume 4

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Discovery of C19-9 as a novel non-RGD inhibitor of αvβ3 to overcome enzalutamide resistance in castration-resistant prostate cancer.

    Pang, Xiaocong / Sun, Xiaojiao / Gu, Yanlun / He, Xu / Gong, Kan / Song, Song / Zhang, Jixin / Xia, Jie / Liu, Zhenming / Cui, Yimin

    Signal transduction and targeted therapy

    2023  Volume 8, Issue 1, Page(s) 60

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/genetics ; Benzamides/pharmacology ; Phenylthiohydantoin/pharmacology ; Phenylthiohydantoin/therapeutic use ; Nitriles
    Chemical Substances enzalutamide (93T0T9GKNU) ; Benzamides ; Phenylthiohydantoin (2010-15-3) ; Nitriles
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-022-01236-z
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  9. Article ; Online: Immune Thrombocytopenia-A Neglected Adverse Event of PD-1 and PD-L1 Inhibitors in Clinical Trials.

    Pang, Xiaocong / Su, Xian / Cui, Yimin

    JAMA oncology

    2019  Volume 5, Issue 11, Page(s) 1640–1641

    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.3599
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  10. Article: Steam chamber expanding processes and bottom water invading characteristics during steam flooding in heavy oil reservoirs

    Pang, Zhanxi / Wang, Luting / Yin, Fanghao / Lyu, Xiaocong

    Energy. 2021 Nov. 01, v. 234

    2021  

    Abstract: It is very important to quantitatively analyze steam chamber expanding and bottom water invading during steam flooding. Firstly, a novel method was established to identify the moment of water invading based on the energy conservation law. Then, a series ... ...

    Abstract It is very important to quantitatively analyze steam chamber expanding and bottom water invading during steam flooding. Firstly, a novel method was established to identify the moment of water invading based on the energy conservation law. Then, a series of experiments were carried out to research the effect of steam flooding through 3D physical simulation and oil-component analysis. The results showed that water invading was recognized through the inflection point of tangent slope of temperature vs. time. Steam mainly migrated in upper layer and hot water moved downwards into bottom layer. The four stages of steam flooding were corresponding to the growth processes of steam chamber, such as expanding, advancing, channeling and overriding. The ultimate oil recovery factor was only 36.00%. The shape of water coning deformed from a triangle to a trapezoid. Finally, the dimensionless volume of water coning was about 32.29%. During steam flooding, the content of oil components gradually changed due to the effect of distillation. The content of light hydrocarbon was higher at the front of steam chamber. However, heavy components mainly occupied the swept zone of steam flooding. The results are important in exploitation practice aiming at heavy oil reservoirs with bottom water.
    Keywords distillation ; energy ; energy conservation ; oils ; steam ; temperature
    Language English
    Dates of publication 2021-1101
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2021.121214
    Database NAL-Catalogue (AGRICOLA)

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