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  1. Book ; Online: Historical Background of Wang Yang-ming's Philosophy of Mind

    Dong, Ping

    2020  

    Abstract: This open access book offers comprehensive information on Wang Yang-ming's life, helping readers ... Wang Yang-ming's extraordinary life, his generous mind, deep thoughts and bright personality, inspiring ...

    Abstract This open access book offers comprehensive information on Wang Yang-ming's life, helping readers identify and grasp the foundations on which his philosophy was established. Though a great man, Wang had an extremely difficult life, full of many hardships. Based on various official histories, Wang's own writings, and his disciples' records, the book explores the legendary life of this ancient philosopher, who not only diligently pursued his objective of living as a sage, but also persistently sought the ideal state of a sage in ideology. The author also shares his own interpretations of the main aspects of Wang's philosophy using simple and straightforward language. This book will help readers understand and appreciate Wang Yang-ming's extraordinary life, his generous mind, deep thoughts and bright personality, inspiring them to pursue enriching lives. It offers a unique and insightful work for undergraduate students and all others interested in Wang's philosophy and life story
    Keywords Philosophy (General) ; Literature (General) ; Asien ; Philosophie ; Geschichte ; Wang, Yangming ; Philosophy of Mind ; Zeithintergrund
    Subject Historischer Hintergrund ; Geschichtlicher Hintergrund ; Mind ; Geist ; Philosophie des Geistes ; Philosophieren
    Size 1 electronic resource (199 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020589679
    ISBN 9789811530364 ; 981153036X
    DOI 10.1007/978-981-15-3036-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Historical Background of Wang Yang-ming’s Philosophy of Mind

    Dong, Ping

    From the Perspective of his Life Story

    2020  

    Author's details by Ping Dong
    Keywords Philosophy, Asian ; Oriental literature ; Asien ; Philosophie ; Geschichte ; Wang, Yangming ; Philosophy of Mind ; Zeithintergrund
    Subject Historischer Hintergrund ; Geschichtlicher Hintergrund ; Mind ; Geist ; Philosophie des Geistes ; Philosophieren
    Subject code 181
    Language English
    Size 1 Online-Ressource (X, 199 p. 1 illus)
    Edition 1st ed. 2020
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online
    HBZ-ID HT020468204
    ISBN 978-981-15-3036-4 ; 9789811530357 ; 9789811530371 ; 9789811530388 ; 981-15-3036-X ; 9811530351 ; 9811530378 ; 9811530386
    DOI 10.1007/978-981-15-3036-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Development of Yin-Yang ligand for cannabinoid receptors.

    Qiu, Yanli / Zhao, Yitian / Hu, Tao / Yang, Meifang / Li, Fei / Li, Cuixia / Gu, Weiliang / Yang, Xiaodi / Zhao, Suwen / Tao, Houchao

    Bioorganic chemistry

    2023  Volume 133, Page(s) 106377

    Abstract: ... effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer ... unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions ... activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality ...

    Abstract Cannabinoid receptors (CBs), including CB1 and CB2, are the key components of a lipid signaling endocannabinoid system (ECS). Development of synthetic cannabinoids has been attractive to modulate ECS functions. CB1 and CB2 are structurally closely related subtypes but with distinct functions. While most efforts focus on the development of selective ligands for single subtype to circumvent the undesired off-target effect, Yin-Yang ligands with opposite pharmacological activities simultaneously on two subtypes, offer unique therapeutic potential. Herein we report the development of a new Yin-Yang ligand which functions as an antagonist for CB1 and concurrently an agonist for CB2. We found that in the pyrazole-cored scaffold, the arm of N1-phenyl group could be a switch, modification of which yielded various ligands with distinct activities. As such, the ortho-morpholine substitution exerted the desired Yin-Yang bifunctionality which, based on the docking study and molecular dynamic simulation, was proposed to be resulted from the hydrogen bonding with S173 and S285 in CB1 and CB2, respectively. Our results demonstrated the feasibility of structure guided ligand evolution for challenging Yin-Yang ligand.
    MeSH term(s) Cannabinoids/pharmacology ; Cannabinoids/chemistry ; Endocannabinoids ; Ligands ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/chemistry ; Receptor, Cannabinoid, CB1/metabolism ; Receptors, Cannabinoid/chemistry ; Receptors, Cannabinoid/metabolism ; Yin-Yang
    Chemical Substances Cannabinoids ; Endocannabinoids ; Ligands ; Pyrazoles ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106377
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4207: Show issues Location:
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  4. Article ; Online: Yin Yang 1 impacts upon preeclampsia by regulating T

    Li, Haowen / Yu, Ling / Ding, Yiling / Nie, Yanting / Yang, Mengyuan

    Journal of immunotoxicology

    2023  Volume 20, Issue 1, Page(s) 2228420

    Abstract: ... The study here aimed to investigate the role of Yin Yang 1 (YY1) in PE, and to reveal any YY1-regulated ...

    Abstract Preeclampsia (PE) is a common obstetric syndrome with an unclear etiology and pathogenesis. The study here aimed to investigate the role of Yin Yang 1 (YY1) in PE, and to reveal any YY1-regulated mechanisms in PE. Peripheral blood, placenta, and endometrial tissues of PE patients, healthy volunteers, and patients who had undergone an elective Cesarean section and had a scarred uterus (control group) were collected for analyses. Rat PE models were established by lipopolysaccharide induction. Subsets of these rats were then made to over-express YY1. At 18 d after the PE was established, urine, blood, and placental tissues from all rats were collected. Levels of regulatory-T (T
    MeSH term(s) Humans ; Female ; Rats ; Pregnancy ; Animals ; Pre-Eclampsia ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; T-Lymphocytes, Regulatory ; Cesarean Section ; Yin-Yang ; Th17 Cells/metabolism ; Th17 Cells/pathology ; Placenta ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism ; RNA, Messenger/metabolism
    Chemical Substances Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Forkhead Transcription Factors ; RNA, Messenger
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205064-4
    ISSN 1547-6901 ; 1547-691X
    ISSN (online) 1547-6901
    ISSN 1547-691X
    DOI 10.1080/1547691X.2023.2228420
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Yang et al. Reply.

    Yang, Zhen-Qian / Shao, Zeng-Kai / Chen, Hua-Zhou / Mao, Xin-Rui / Ma, Ren-Min

    Physical review letters

    2021  Volume 127, Issue 20, Page(s) 209402

    Language English
    Publishing date 2021-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.209402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  6. Article ; Online: Sheng Yang He.

    Yang He, Sheng

    Current biology : CB

    2018  Volume 28, Issue 7, Page(s) R295–R296

    Abstract: Interview with Sheng Yang He, who studies the molecular biology of plant-pathogen interactions ...

    Abstract Interview with Sheng Yang He, who studies the molecular biology of plant-pathogen interactions at Michigan State University.
    Language English
    Publishing date 2018-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2018.02.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3208: Show issues Location:
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  7. Article ; Online: Erratum for Yang et al., "

    Yang, Hongxing / Hu, Shunli / Wang, Xiang / Chuang, Shaochuang / Jia, Weibin / Jiang, Jiandong

    Applied and environmental microbiology

    2020  Volume 86, Issue 12

    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/AEM.00957-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 201: Show issues Location:
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  8. Article ; Online: The role of transcription factor Yin Yang-1 in colorectal cancer.

    Shao, Zhiying / Yang, Wendong / Meng, Xiannan / Li, Minle / Hou, Pingfu / Li, Zhongwei / Chu, Sufang / Zheng, Junnian / Bai, Jin

    Cancer medicine

    2023  Volume 12, Issue 10, Page(s) 11177–11190

    Abstract: Background: Yin Yang-1 (YY1) is identified as a transcription factor with multiple functions ...

    Abstract Background: Yin Yang-1 (YY1) is identified as a transcription factor with multiple functions. However, the role of YY1 in tumorigenesis remains controversial and its regulatory effects may depend upon not only cancer types, but also its interacting partners, chromatin structure, and the context in which it acts. It has been detected that YY1 was highly expressed in colorectal cancer (CRC). Intriguingly, many YY1-repressed genes exhibit tumor suppressive potential while YY1 silencing is related to chemotherapy resistance. Therefore, it is crucial to meticulously explore YY1 protein structure and the dynamic alteration of its interactome in each cancer type. This review attempts to describe the structure of YY1, summarize the mechanism that influence the expression level of YY1 and also highlight the recent advances in our understanding of regulatory insights of YY1 functions in CRC.
    Methods: Related studies were identified through scoping search of PubMed, Web of science, Scopus and Emhase concerning the terms of "colorectal cancer", colorectal carcinoma" or CRC with "YY1". The retrieval strategy included title, abstract, and keywords with no language limitations. All the included articles were categorized depending on the mechanisms they explored.
    Results: In total, 170 articles were identified for further screening. After removing the duplication, not relevant outcomes and review articles, 34 were finally included in the review. Among them, 10 articles revealed the reasons of YY1 high expression in CRC, 13 articles explored YY1 function in CRC, and 11 articles fell into both aspects. In addition, we also summarized 10 clinical trials concerning the expression and activity of YY1 in various diseases, which offers a hint for future application.
    Conclusions: YY1 is highly expressed in CRC and broadly recognized as an oncogenic factor during the whole course of CRC. Sporadic controversial views are raised in term of CRC treatment, reminding us that future studies should take the influence of therapeutic regimens into concern.
    MeSH term(s) Humans ; Carcinogenesis/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Transcription Factors/genetics ; YY1 Transcription Factor/genetics ; YY1 Transcription Factor/metabolism
    Chemical Substances Transcription Factors ; YY1 Transcription Factor
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.5745
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference.

    Jiang, Hui / Li, Xiaoyu / Fan, Yang / Wang, Junjie / Xie, Yiyi / Yu, Peilin

    Journal of ethnopharmacology

    2024  Volume 328, Page(s) 118036

    Abstract: ... root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome ... mechanisms.: Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was ... Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma ...

    Abstract Ethnopharmacological relevance: The proper application of toxic medicines is one of the characteristics of traditional Chinese medicines, and the use of traditional Chinese medicines follows the principle of dialectical treatment. It is necessary to combine different "syndrome" or "disease" states with the toxicity of traditional Chinese medicines to form a reliable toxicity evaluation system. Fuzi, the lateral root of Aconitum carmichaelii Debx, is recognized as a panacea for kidney yang deficiency syndrome, however, its toxic effects significantly limit its clinical application.
    Aim of the study: Herein, our research aimed to explore the toxic effects of Fuzi on syndrome models, and tried to reveal the underlying mechanisms.
    Materials and methods: Firstly, the mouse model of kidney yang deficiency syndrome was established through intramuscular injection of 25 mg/kg hydrocortisone per day for 10 consecutive days. Then, the acute toxicity of Fuzi in normal mice and kidney yang deficiency model mice was explored. Finally, the plasma metabolite concentrations and liver CYP3A4 enzyme activity were analyzed to reveal the possible mechanisms of the different pharmacological and toxicological effects of Fuzi in individuals with different physical constitutions.
    Results: It was found that the treatment with Fuzi (138 g/kg) had serious toxic effects on kidney yang deficiency mice, leading to the death of 80% of the mice, whereas it showed no lethal toxicity in normal mice. This indicates that Fuzi induced greater toxicity in kidney yang deficiency mice than in normal ones. The liver CYP3A4 enzyme activity in kidney yang deficiency mice was decreased by 20% compared to the controls, resulting in slower metabolism of the toxic diester diterpenoid alkaloids in Fuzi.
    Conclusion: In conclusion, our study showed that changes of the metabolic enzyme activity in individuals with different syndromes led to different toxic effects of Chinese medicines, emphasizing the crucial importance of considering individual physical syndromes in the clinical application of traditional Chinese medicine, and the significance of conducting safety evaluations and dose predictions on animal models with specific syndromes for traditional Chinese medicines.
    MeSH term(s) Mice ; Animals ; Medicine, Chinese Traditional ; Yang Deficiency/chemically induced ; Yang Deficiency/drug therapy ; Cytochrome P-450 CYP3A ; Drugs, Chinese Herbal/pharmacology ; Diterpenes/toxicity ; Diterpenes/therapeutic use ; Kidney ; Aconitum
    Chemical Substances fuzi drug herbal ; Cytochrome P-450 CYP3A (EC 1.14.14.1) ; Drugs, Chinese Herbal ; Diterpenes
    Language English
    Publishing date 2024-03-08
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  10. Article ; Online: Correction: Liu, Y.; Yang, J. Hydrophobic Modification of ZrO

    Liu, Yan / Yang, Jing

    Gels (Basel, Switzerland)

    2022  Volume 9, Issue 1

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2022-12-30
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2813982-3
    ISSN 2310-2861 ; 2310-2861
    ISSN (online) 2310-2861
    ISSN 2310-2861
    DOI 10.3390/gels9010031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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