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  1. Article ; Online: Prospective role of NSAIDs with antiviral properties for pharmacological management of postsurgical procedures during COVID-19.

    Nainu, Firzan / Mamada, Sukamto S / Emran, Talha B

    International journal of surgery (London, England)

    2023  Volume 109, Issue 2, Page(s) 109–111

    MeSH term(s) Humans ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; COVID-19 ; Antiviral Agents ; SARS-CoV-2
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Antiviral Agents
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Apoptosis and Phagocytosis as Antiviral Mechanisms.

    Nainu, Firzan / Ophinni, Youdiil / Shiratsuchi, Akiko / Nakanishi, Yoshinobu

    Sub-cellular biochemistry

    2023  Volume 106, Page(s) 77–112

    Abstract: Viruses are infectious entities that make use of the replication machinery of their hosts to produce more progenies, causing disease and sometimes death. To counter viral infection, metazoan hosts are equipped with various defense mechanisms, from the ... ...

    Abstract Viruses are infectious entities that make use of the replication machinery of their hosts to produce more progenies, causing disease and sometimes death. To counter viral infection, metazoan hosts are equipped with various defense mechanisms, from the rapid-evoking innate immune responses to the most advanced adaptive immune responses. Previous research demonstrated that cells in fruit flies and mice infected with Drosophila C virus and influenza, respectively, undergo apoptosis, which triggers the engulfment of apoptotic virus-infected cells by phagocytes. This process involves the recognition of eat-me signals on the surface of virus-infected cells by receptors of specialized phagocytes, such as macrophages and neutrophils in mice and hemocytes in fruit flies, to facilitate the phagocytic elimination of virus-infected cells. Inhibition of phagocytosis led to severe pathologies and death in both species, indicating that apoptosis-dependent phagocytosis of virus-infected cells is a conserved antiviral mechanism in multicellular organisms. Indeed, our understanding of the mechanisms underlying apoptosis-dependent phagocytosis of virus-infected cells has shed a new perspective on how hosts defend themselves against viral infection. This chapter explores the mechanisms of this process and its potential for developing new treatments for viral diseases.
    MeSH term(s) Animals ; Mice ; Phagocytosis/physiology ; Phagocytes/physiology ; Immunity, Innate ; Virus Diseases ; Apoptosis/physiology ; Antiviral Agents
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-031-40086-5_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Model organisms in experimental pharmacology and drug discovery 2022.

    Nainu, Firzan / Jota Baptista, Catarina / Faustino-Rocha, Ana / Oliveira, Paula Alexandra

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1143934

    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1143934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Drosophila melanogaster

    Nainu, Firzan / Salim, Emil / Emran, Talha Bin / Sharma, Rohit

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 939813

    MeSH term(s) Animals ; Drosophila melanogaster ; Insect Vectors ; Models, Animal ; Parasites
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.939813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Inflammation-Mediated Responses in the Development of Neurodegenerative Diseases.

    Nainu, Firzan / Mamada, Sukamto S / Harapan, Harapan / Emran, Talha Bin

    Advances in experimental medicine and biology

    2023  Volume 1411, Page(s) 39–70

    Abstract: Since its first description over a century ago, neurodegenerative diseases (NDDs) have impaired the lives of millions of people worldwide. As one of the major threats to human health, NDDs are characterized by progressive loss of neuronal structure and ... ...

    Abstract Since its first description over a century ago, neurodegenerative diseases (NDDs) have impaired the lives of millions of people worldwide. As one of the major threats to human health, NDDs are characterized by progressive loss of neuronal structure and function, leading to the impaired function of the CNS. While the precise mechanisms underlying the emergence of NDDs remains elusive, association of neuroinflammation with the emergence of NDDs has been suggested. The immune system is tightly controlled to maintain homeostatic milieu and failure in doing so has been shown catastrophic. Here, we review current concepts on the cellular and molecular drivers responsible in the induction of neuroinflammation and how such event further promotes neuronal damage leading to neurodegeneration. Experimental data generated from cell culture and animal studies, gross and molecular pathologies of human CNS samples, and genome-wide association study are discussed to provide deeper insights into the mechanistic details of neuroinflammation and its roles in the emergence of NDDs.
    MeSH term(s) Animals ; Humans ; Neurodegenerative Diseases/genetics ; Neuroinflammatory Diseases ; Genome-Wide Association Study ; Inflammation
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-19-7376-5_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Molecular Insight into the Pharmacological Potential of

    Fatimawali / Tallei, Trina Ekawati / Kepel, Billy Johnson / Bodhi, Widdhi / Manampiring, Aaltje Ellen / Nainu, Firzan

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 11

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Clerodendrum/metabolism ; Network Pharmacology ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Insulin/metabolism ; Drugs, Chinese Herbal/therapeutic use
    Chemical Substances Insulin ; Drugs, Chinese Herbal
    Language English
    Publishing date 2023-10-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59111899
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Fruit fly for anticancer drug discovery and repurposing.

    Nainu, Firzan / Salim, Emil / As'ad, Muh Fadhil / Chandran, Deepak / Dhama, Kuldeep / Rabaan, Ali A / Emran, Talha B

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 2, Page(s) 337–342

    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000222
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Immunopharmacological considerations of general anaesthetics for surgical procedures in the times of COVID-19: Correspondence.

    Nainu, Firzan / Frediansyah, Andri / Salim, Emil / Chandran, Deepak / Dhama, Kuldeep / Rabaan, Ali A / Harapan, Harapan / Emran, Talha Bin

    Annals of medicine and surgery (2012)

    2023  Volume 85, Issue 5, Page(s) 2232–2236

    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2745440-X
    ISSN 2049-0801
    ISSN 2049-0801
    DOI 10.1097/MS9.0000000000000555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Drosophila melanogaster as a Versatile Model for Studying Medically Important Insect Vector-Borne Parasites

    Firzan Nainu / Emil Salim / Talha Bin Emran / Rohit Sharma

    Frontiers in Cellular and Infection Microbiology, Vol

    2022  Volume 12

    Keywords fruit fly ; model organism ; infection ; parasite biology ; drug discovery ; drug repurposing ; Microbiology ; QR1-502
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Potential Application of

    Nainu, Firzan / Rahmatika, Dini / Emran, Talha Bin / Harapan, Harapan

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 588561

    Keywords covid19
    Language English
    Publishing date 2020-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.588561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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