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  1. Article ; Online: Infections Caused by Free-Living Amoebae.

    Kofman, Aaron / Guarner, Jeannette

    Journal of clinical microbiology

    2021  Volume 60, Issue 1, Page(s) e0022821

    Abstract: Infections caused by Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris result in a variety of clinical manifestations in humans. These amoebae are found in water and soil worldwide. ...

    Abstract Infections caused by Naegleria fowleri, Acanthamoeba spp., and Balamuthia mandrillaris result in a variety of clinical manifestations in humans. These amoebae are found in water and soil worldwide.
    MeSH term(s) Acanthamoeba ; Amebiasis/diagnosis ; Amoeba ; Balamuthia mandrillaris ; Humans ; Naegleria fowleri
    Language English
    Publishing date 2021-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.00228-21
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    Zs.A 1188: Show issues Location:
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  2. Article ; Online: Potential COVID-19 Endgame Scenarios: Eradication, Elimination, Cohabitation, or Conflagration?

    Kofman, Aaron / Kantor, Rami / Adashi, Eli Y

    JAMA

    2021  Volume 326, Issue 4, Page(s) 303–304

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Disease Eradication ; Endemic Diseases ; Global Health ; Humans
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.11042
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  3. Article ; Online: Lassa Fever in Travelers from West Africa, 1969-2016.

    Kofman, Aaron / Choi, Mary J / Rollin, Pierre E

    Emerging infectious diseases

    2019  Volume 25, Issue 2, Page(s) 245–248

    Abstract: Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non-Lassa-endemic countries from West Africa. We describe a retrospective review performed through ... ...

    Abstract Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non-Lassa-endemic countries from West Africa. We describe a retrospective review performed through literature search of clinical and epidemiologic characteristics of all imported Lassa fever cases worldwide during 1969-2016. Our findings demonstrate that approximately half of imported cases had distinctive clinical features (defined as fever and >1 of the following: pharyngitis, sore throat, tonsillitis, conjunctivitis, oropharyngeal ulcers, or proteinuria). Delays in clinical suspicion of this diagnosis were common. In addition, no secondary transmission of Lassa fever to contacts of patients with low-risk exposures occurred, and infection of high-risk contacts was rare. Future public health investigations of such cases should focus on timely recognition of distinctive clinical features, earlier treatment of patients, and targeted public health responses focused on high-risk contacts.
    MeSH term(s) Adolescent ; Adult ; Africa, Western/epidemiology ; Aged ; History, 20th Century ; History, 21st Century ; Humans ; Lassa Fever/epidemiology ; Lassa Fever/history ; Lassa Fever/transmission ; Lassa Fever/virology ; Middle Aged ; Public Health Surveillance ; Risk Factors ; Seasons ; Travel ; Travel-Related Illness ; Young Adult
    Language English
    Publishing date 2019-02-02
    Publishing country United States
    Document type Historical Article ; Journal Article ; Meta-Analysis
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2502.180836
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    Zs.A 4778: Show issues Location:
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  4. Article ; Online: Strategies to prevent catheter-associated urinary tract infections in acute-care hospitals: 2022 Update.

    Patel, Payal K / Advani, Sonali D / Kofman, Aaron D / Lo, Evelyn / Maragakis, Lisa L / Pegues, David A / Pettis, Ann Marie / Saint, Sanjay / Trautner, Barbara / Yokoe, Deborah S / Meddings, Jennifer

    Infection control and hospital epidemiology

    2023  Volume 44, Issue 8, Page(s) 1209–1231

    Abstract: The intent of this document is to highlight practical recommendations in a concise format designed to assist physicians, nurses, and infection preventionists at acute-care hospitals in implementing and prioritizing their catheter-associated urinary tract ...

    Abstract The intent of this document is to highlight practical recommendations in a concise format designed to assist physicians, nurses, and infection preventionists at acute-care hospitals in implementing and prioritizing their catheter-associated urinary tract infection (CAUTI) prevention efforts. This document updates the
    MeSH term(s) United States ; Humans ; Infection Control ; Physicians ; Catheters ; Hospitals
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2023.137
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  5. Article ; Online: Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination.

    Kainulainen, Markus H / Harmon, Jessica R / Whitesell, Amy N / Bergeron, Éric / Karaaslan, Elif / Cossaboom, Caitlin M / Malenfant, Jason H / Kofman, Aaron / Montgomery, Joel M / Choi, Mary J / Albariño, César G / Spiropoulou, Christina F

    Emerging microbes & infections

    2023  Volume 12, Issue 2, Page(s) 2265660

    Abstract: Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re- ...

    Abstract Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-emerged causing more than 160 confirmed and probable cases. This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine.
    MeSH term(s) Humans ; Hemorrhagic Fever, Ebola/prevention & control ; Antibodies, Viral ; Ebolavirus/genetics ; Vaccination ; Glycoproteins/genetics
    Chemical Substances Antibodies, Viral ; Glycoproteins
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2265660
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  6. Article ; Online: Lassa Fever in Travelers from West Africa, 1969–2016

    Aaron Kofman / Mary J. Choi / Pierre E. Rollin

    Emerging Infectious Diseases, Vol 25, Iss 2, Pp 236-

    2019  Volume 239

    Abstract: Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non–Lassa-endemic countries from West Africa. We describe a retrospective review performed through ... ...

    Abstract Lassa virus is a rodentborne arenavirus responsible for human cases of Lassa fever, a viral hemorrhagic fever, in West Africa and in travelers arriving to non–Lassa-endemic countries from West Africa. We describe a retrospective review performed through literature search of clinical and epidemiologic characteristics of all imported Lassa fever cases worldwide during 1969–2016. Our findings demonstrate that approximately half of imported cases had distinctive clinical features (defined as fever and >1 of the following: pharyngitis, sore throat, tonsillitis, conjunctivitis, oropharyngeal ulcers, or proteinuria). Delays in clinical suspicion of this diagnosis were common. In addition, no secondary transmission of Lassa fever to contacts of patients with low-risk exposures occurred, and infection of high-risk contacts was rare. Future public health investigations of such cases should focus on timely recognition of distinctive clinical features, earlier treatment of patients, and targeted public health responses focused on high-risk contacts.
    Keywords Lassa fever ; travel medicine ; zoonotic diseases ; viruses ; West Africa ; zoonoses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Subject code 610
    Language English
    Publishing date 2019-02-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report.

    Kofman, Aaron D / Sizemore, Emma K / Detelich, Joshua F / Albrecht, Benjamin / Piantadosi, Anne L

    BMC infectious diseases

    2020  Volume 20, Issue 1, Page(s) 716

    Abstract: Background: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age.: Case ... ...

    Abstract Background: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age.
    Case presentation: The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5.
    Conclusion: MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.
    MeSH term(s) Adult ; Aspirin/administration & dosage ; Aspirin/therapeutic use ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Cough/complications ; Diarrhea/complications ; Dyspnea/complications ; Female ; Fever/complications ; Humans ; Immunoglobulins, Intravenous/administration & dosage ; Immunoglobulins, Intravenous/therapeutic use ; Pandemics ; Pharyngitis/complications ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Polymerase Chain Reaction ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/complications ; Systemic Inflammatory Response Syndrome/drug therapy ; Systemic Inflammatory Response Syndrome/virology ; Treatment Outcome ; Vomiting/complications
    Chemical Substances Immunoglobulins, Intravenous ; Aspirin (R16CO5Y76E)
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-020-05439-z
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  8. Article ; Online: Pre-exposure prophylaxis for the primary prevention of HIV in at-risk women: empowerment and equity revisited.

    Kofman, Aaron / Adashi, Eli Y

    AIDS reviews

    2014  Volume 16, Issue 3, Page(s) 134–143

    Abstract: Women continue to bear a disproportionate burden of the HIV epidemic's impact. The last three years have witnessed the explosive emergence of pre-exposure prophylaxis as a viable, woman-initiated, and woman-controlled candidate for the primary prevention ...

    Abstract Women continue to bear a disproportionate burden of the HIV epidemic's impact. The last three years have witnessed the explosive emergence of pre-exposure prophylaxis as a viable, woman-initiated, and woman-controlled candidate for the primary prevention of HIV in women. These developments have proven particularly significant for at-risk women in environments where negotiation of safe sex is difficult. In this review, we trace the recent evolution of the pre-exposure prophylaxis vision for women, delineate the clinical trials that made it all possible, and discuss ongoing efforts required for its full actualization.
    MeSH term(s) Female ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; HIV Infections/psychology ; Humans ; Negotiating ; Power (Psychology) ; Pre-Exposure Prophylaxis ; Risk Factors ; Safe Sex ; United States/epidemiology
    Language English
    Publishing date 2014-07
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 2086783-9
    ISSN 1698-6997 ; 1139-6121
    ISSN (online) 1698-6997
    ISSN 1139-6121
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    Zs.A 5711: Show issues Location:
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  9. Article ; Online: Revisiting the minimum incubation period of Zaire ebolavirus.

    Kofman, Aaron D / Haberling, Dana L / Mbuyi, Gisele / Martel, Lise D / Whitesell, Amy N / Van Herp, Michel / Makaya, Gerry / Corvil, Salomon / Abedi, Aaron Aruna / Ngoma, Patrick Mavungu / Mbuyi, Francis / Mossoko, Mathias / Koivogui, Enogo / Soke, Norbert / Gbamou, Nouonan / Fonjungo, Peter N / Keita, Lamine / Keita, Sakoba / Shoemaker, Trevor R /
    Richards, Guy A / Montgomery, Joel M / Breman, Joel G / Geisbert, Thomas W / Choi, Mary J / Rollin, Pierre E

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 10, Page(s) 1111–1112

    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00506-6
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    Zs.A 5743: Show issues Location:
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  10. Article ; Online: Continued increases in the incidence of healthcare-associated infection (HAI) during the second year of the coronavirus disease 2019 (COVID-19) pandemic.

    Lastinger, Lindsey M / Alvarez, Carlos R / Kofman, Aaron / Konnor, Rebecca Y / Kuhar, David T / Nkwata, Allan / Patel, Prachi R / Pattabiraman, Vaishnavi / Xu, Sunny Y / Dudeck, Margaret A

    Infection control and hospital epidemiology

    2022  Volume 44, Issue 6, Page(s) 997–1001

    Abstract: Data from the National Healthcare Safety Network were analyzed to assess the impact of COVID-19 on the incidence of healthcare-associated infections (HAI) during 2021. Standardized infection ratios were significantly higher than those during the ... ...

    Abstract Data from the National Healthcare Safety Network were analyzed to assess the impact of COVID-19 on the incidence of healthcare-associated infections (HAI) during 2021. Standardized infection ratios were significantly higher than those during the prepandemic period, particularly during 2021-Q1 and 2021-Q3. The incidence of HAI was elevated during periods of high COVID-19 hospitalizations.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Incidence ; Pandemics ; Cross Infection/epidemiology ; Delivery of Health Care
    Language English
    Publishing date 2022-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2022.116
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