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  1. Book: Vida de D. Gregorio Guadaña

    Enríquez Gómez, Antonio / Martínez Sánchez, Jesús

    1980  

    Author's details Antonio Enríquez Gómez. Ed. Jesús Martínez Sánchez
    Language Undetermined
    Size 146 S
    Publisher Legasa
    Publishing place Madrid
    Document type Book
    ISBN 8485701070 ; 9788485701070
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article: Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19.

    Martínez-Sánchez, Gregorio / Schwartz, Adriana / Donna, Vincenzo Di

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 5

    Abstract: 1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical ... ...

    Abstract (1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
    Keywords covid19
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9050389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Inhibition of Peroxidation Potential and Protein Oxidative Damage by Metal Mangiferin Complexes

    Alberto J. Nuñez-Selles / Lauro Nuevas-Paz / Gregorio Martínez-Sánchez

    Applied Sciences, Vol 12, Iss 2240, p

    2022  Volume 2240

    Abstract: Background: Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands. Whereas flavonoids have been extensively studied, xanthones ...

    Abstract Background: Metal coordination complexes of polyphenolic compounds have been claimed to have better antioxidant and protection against protein oxidative damage effects than the isolated ligands. Whereas flavonoids have been extensively studied, xanthones such as mangiferin are lacking extensive research. Methods: Cu (II), Zn (II), and Se (IV) mangiferin complexes were synthesized with different stoichiometric ratios. Products were isolated by preparative chromatography and subjected to spectral analysis by FT-IR, HPLC-DAD, and HPLC-ESI-MS. The inhibition effects on peroxidation potential and protein oxidative damage were determined for all the metal–MF complexes. Results: Eight metal–MF complexes were isolated. Cu (II)–MF complexes did not improve MF antioxidant/protective effects; Zn (II) complexes (stoichiometric ratio 1:2) antioxidant/protective effects had no significant differences to MF; Zn (II)– and Se (IV)–MF complexes (stoichiometric ratio 1:3) showed the best inhibition effects on peroxidation potential (49.06% and 32.08%, respectively), and on the protection against protein oxidative damage (14.49% and 20.81%, respectively). Conclusions: The antioxidant/protective effects of Se (IV)– and Zn (II)–MF coordination complexes were significantly improved as compared to isolated MF, when the reaction between the metal salt and MF was performed with a stoichiometric ratio 1:3.
    Keywords oxidative stress ; protein oxidative damage ; mangiferin ; metal–mangiferin complexes ; antioxidant therapy ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Biblioteca mundial sobre ozonoterapia, una herramienta para la investigación

    Gregorio Martínez-Sánchez

    Revista Cubana de Farmacia, Vol 49, Iss 1, Pp 188-

    2015  Volume 192

    Keywords Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
    Language Spanish
    Publishing date 2015-03-01T00:00:00Z
    Publisher ECIMED
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

    Gregorio Martínez-Sánchez / Adriana Schwartz / Vincenzo Di Donna

    Antioxidants, Vol 9, Iss 389, p

    2020  Volume 389

    Abstract: 1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical ... ...

    Abstract (1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
    Keywords ozone therapy 1 ; SARS-CoV-2 ; Keap1/Nrf2/ARE pathway ; NF-κ B ; Nrf2 ; Therapeutics. Pharmacology ; RM1-950 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Influence of Blood Rheology and Turbulence Models in the Numerical Simulation of Aneurysms.

    Brambila-Solórzano, Alberto / Méndez-Lavielle, Federico / Naude, Jorge Luis / Martínez-Sánchez, Gregorio Josué / García-Rebolledo, Azael / Hernández, Benjamín / Escobar-Del Pozo, Carlos

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: An aneurysm is a vascular malformation that can be classified according to its location (cerebral, aortic) or shape (saccular, fusiform, and mycotic). Recently, the study of blood flow interaction with aneurysms has gained attention from physicians and ... ...

    Abstract An aneurysm is a vascular malformation that can be classified according to its location (cerebral, aortic) or shape (saccular, fusiform, and mycotic). Recently, the study of blood flow interaction with aneurysms has gained attention from physicians and engineers. Shear stresses, oscillatory shear index (OSI), gradient oscillatory number (GON), and residence time have been used as variables to describe the hemodynamics as well as the origin and evolution of aneurysms. However, the causes and hemodynamic conditions that promote their growth are still under debate. The present work presents numerical simulations of three types of aneurysms: two aortic and one cerebral. Simulation results showed that the blood rheology is not relevant for aortic aneurysms. However, for the cerebral aneurysm case, blood rheology could play a relevant role in the hemodynamics. The evaluated turbulence models showed equivalent results in both cases. Lastly, a simulation considering the fluid-structure interaction (FSI) showed that this phenomenon is the dominant factor for aneurysm simulation.
    Language English
    Publishing date 2023-10-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10101170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

    Martínez-Sánchez, Gregorio / Schwartz, Adriana / Di Donna, Vincenzo

    Antioxidants. 2020 May 06, v. 9, no. 5

    2020  

    Abstract: 1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical ... ...

    Abstract (1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antioxidants ; byproducts ; clinical trials ; free radicals ; homeostasis ; inflammation ; interleukin-1beta ; interleukin-6 ; mechanism of action ; models ; oxidative stress ; ozone ; therapeutics ; transcription factor NF-kappa B ; China
    Language English
    Dates of publication 2020-0506
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9050389
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

    Martínez-Sánchez, Gregorio / Schwartz, Adriana / Donna, Vincenzo Di

    Abstract: 1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical ... ...

    Abstract (1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κ B/Nrf2 pathways and IL-6/IL-1ß expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κ B/Nrf2 balance and IL-6 and IL-1ß expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #854062
    Database COVID19

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  9. Article ; Online: La ozonoterapia gana evidencias científicas en el campo clínico

    Gregorio Martínez-Sánchez

    Revista Cubana de Farmacia, Vol 47, Iss 1, Pp 1-

    2013  Volume 4

    Keywords Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R
    Language Spanish
    Publishing date 2013-03-01T00:00:00Z
    Publisher Editorial Ciencias Médicas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: La ozonoterapia gana evidencias científicas en el campo clínico Ozone therapy gains scientific evidence in the clinical field

    Gregorio Martínez-Sánchez

    Revista Cubana de Farmacia, Vol 47, Iss 1, Pp 1-

    2013  Volume 4

    Keywords Therapeutics. Pharmacology ; RM1-950 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language Spanish
    Publishing date 2013-03-01T00:00:00Z
    Publisher Editorial Ciencias Médicas
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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