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Article ; Online: Potential Endotype Transition for Coronavirus Disease 2019-Related Sepsis With Longitudinal Transcriptome Profiling.

Ren, Xinyong

2021 Volume 49, Issue 7, Page(s) e719–e720

MeSH term(s)	COVID-19 ; Gene Expression Profiling ; Humans ; SARS-CoV-2 ; Sepsis/genetics
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/CCM.0000000000004975
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Zs.A 1261: Show issues

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Article ; Online: Anode-Free Sodium Metal Pouch Cell Using Cu

Zhang, Wu / Zheng, Jiale / Ren, Ziang / Wang, Juncheng / Luo, Jianmin / Wang, Yao / Tao, Xinyong / Liu, Tiefeng

Advanced materials (Deerfield Beach, Fla.)

2024 Volume 36, Issue 15, Page(s) e2310347

Abstract: Anode-free sodium metal battery (AFSMB) promises high energy density but suffers from the difficulty of maintaining high cycling stability. Nonuniform sodium (Na) deposition on the current collector is largely responsible for capacity decay in the ... ...

Abstract	Anode-free sodium metal battery (AFSMB) promises high energy density but suffers from the difficulty of maintaining high cycling stability. Nonuniform sodium (Na) deposition on the current collector is largely responsible for capacity decay in the cycling process of AFSMB. Here, a unique copper phosphide (Cu
Language	English
Publishing date	2024-01-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310347
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Stable Operation of Lithium Metal Batteries with Aggressive Cathode Chemistries at 4.9 V.

Piao, Zhihong / Ren, Hong-Rui / Lu, Gongxun / Jia, Kai / Tan, Junyang / Wu, Xinru / Zhuang, Zhaofeng / Han, Zhiyuan / Li, Chuang / Gao, Runhua / Tao, Xinyong / Zhou, Guangmin / Cheng, Hui-Ming

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 15, Page(s) e202300966

Abstract: High-voltage lithium metal batteries (LMBs) pose severe challenges for the matching of electrolytes with aggressive electrodes, especially at low temperatures. Here, we report a rational modification of the ... ...

Abstract	High-voltage lithium metal batteries (LMBs) pose severe challenges for the matching of electrolytes with aggressive electrodes, especially at low temperatures. Here, we report a rational modification of the Li
Language	English
Publishing date	2023-03-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202300966
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Article ; Online: Design, Synthesis, and Evaluation of a Set of Carboxylic Acid and Phosphate Prodrugs Derived from HBV Capsid Protein Allosteric Modulator NVR 3-778.

Ji, Xiangkai / Jiang, Xiangyi / Kobayashi, Chisa / Ren, Yujie / Hu, Lide / Gao, Zhen / Kang, Dongwei / Jia, Ruifang / Zhang, Xujie / Zhao, Shujie / Watashi, Koichi / Liu, Xinyong / Zhan, Peng

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 18

Abstract: Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator ( ... ...

Abstract	Hepatitis B virus (HBV) capsid protein (Cp) is necessary for viral replication and the maintenance of viral persistence, having become an attractive target of anti-HBV drugs. To improve the water solubility of HBV capsid protein allosteric modulator (CpAM) NVR 3-778, a series of novel carboxylic acid and phosphate prodrugs were designed and synthesized using a prodrug strategy. In vitro HBV replication assay showed that these prodrugs maintained favorable antiviral potency (EC50 = 0.28−0.42 µM), which was comparable to that of NVR 3-778 (EC50 = 0.38 µM). More importantly, the cytotoxicity of prodrug N8 (CC50 > 256 µM) was significantly reduced compared to NVR 3-778 (CC50 = 13.65 ± 0.21 µM). In addition, the water solubility of prodrug N6 was hundreds of times better than that of NVR 3-778 in three phosphate buffers with various pH levels (2.0, 7.0, 7.4). In addition, N6 demonstrated excellent plasma and blood stability in vitro and good pharmacokinetic properties in rats. Finally, the hemisuccinate prodrug N6 significantly improved the candidate drug NVR 3-778’s water solubility and increased metabolic stability while maintaining its antiviral efficacy.
MeSH term(s)	Animals ; Antiviral Agents/chemistry ; Benzamides ; Capsid Proteins/chemistry ; Carboxylic Acids/metabolism ; Carboxylic Acids/pharmacology ; Hepatitis B virus/metabolism ; Phosphates/metabolism ; Piperidines ; Prodrugs/chemistry ; Rats ; Water/metabolism
Chemical Substances	Antiviral Agents ; Benzamides ; Capsid Proteins ; Carboxylic Acids ; NVR 3-778 ; Phosphates ; Piperidines ; Prodrugs ; Water (059QF0KO0R)
Language	English
Publishing date	2022-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27185987
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Zs.MO 81: Show issues

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Article ; Online: The current progress in the use of boron as a platform for novel antiviral drug design.

Wang, Shuo / Ren, Yujie / Wang, Zhao / Jiang, Xiangyi / Xu, Shujing / Zhang, Xujie / Zhao, Shujie / Zalloum, Waleed A / Liu, Xinyong / Zhan, Peng

Expert opinion on drug discovery

2022 , Page(s) 1–12

Abstract: Introduction: Boron has attracted extensive interest due to several FDA-approved boron-containing drugs and other pharmacological agents in clinical trials. As a semimetal, it has peculiar biochemical characteristics which could be utilized in designing ...

Abstract	Introduction: Boron has attracted extensive interest due to several FDA-approved boron-containing drugs and other pharmacological agents in clinical trials. As a semimetal, it has peculiar biochemical characteristics which could be utilized in designing novel drugs against drug-resistant viruses. Emerging and reemerging viral pandemics are major threats to human health. Accordingly, we aim to comprehensively review the current status of antiviral boron-containing compounds. Areas covered: This review focuses on the utilization of boron to design molecules against viruses from two perspectives: (i) single boron atom-containing compounds acting on miscellaneous viral targets and (ii) boron clusters. The peculiar properties of antiviral boron-containing compounds and their diverse binding modes with viral targets are described in detail in this review. Expert opinion: Compounds bearing boronic acid can interact with viral targets by forming covalent or robust hydrogen bonds. This feature is valuable for combating resistant viruses. Furthermore, boron clusters can form dihydrogen bonds and bear features such as three-dimensional aromaticity, hydrophobicity, and biological stability. All these features demonstrated boron as a probable essential element with immense potential for drug design.
Language	English
Publishing date	2022-12-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2259618-5
ISSN	1746-045X ; 1746-0441
ISSN (online)	1746-045X
ISSN	1746-0441
DOI	10.1080/17460441.2023.2153829
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Zs.A 6388: Show issues

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Article ; Online: Discovery and optimization of benzenesulfonamides-based hepatitis B virus capsid modulators via contemporary medicinal chemistry strategies.

Ren, Yujie / Ma, Yue / Cherukupalli, Srinivasulu / Tavis, John E / Menéndez-Arias, Luis / Liu, Xinyong / Zhan, Peng

European journal of medicinal chemistry

2020 Volume 206, Page(s) 112714

Abstract: Hepatitis B is a vaccine-preventable, but potentially life-threatening liver infection caused by the Hepatitis B virus (HBV). It represents an important health burden, with 257 million active cases globally. Current HBV treatments using nucleos(t)ide ... ...

Abstract	Hepatitis B is a vaccine-preventable, but potentially life-threatening liver infection caused by the Hepatitis B virus (HBV). It represents an important health burden, with 257 million active cases globally. Current HBV treatments using nucleos(t)ide analogs and pegylated interferons cannot alleviate the situation completely since they are unable to cure the infection or reduce the amount of viral covalently closed circular DNA (cccDNA). The HBV core protein is a small protein of 183 amino acids that participates in multiple essential functions in the HBV replicative cycle. Capsid assembly modulators that target the core protein are being developed. Sulfonamides are synthetic functional groups, found in several drugs. Herein, we provide a concise report focusing on the sulfamoylbenzamides as HBV capsid modulators, and medicinal chemistry strategies used in their design and development.
MeSH term(s)	Capsid/drug effects ; Capsid/metabolism ; Chemistry, Pharmaceutical/methods ; Drug Design ; Hepatitis B virus/drug effects ; Hepatitis B virus/metabolism ; Humans ; Sulfonamides/chemistry ; Sulfonamides/pharmacology ; Benzenesulfonamides
Chemical Substances	Sulfonamides
Language	English
Publishing date	2020-08-05
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2020.112714
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Zs.B 784: Show issues

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Article ; Online: Design, synthesis, and biological evaluation of novel sulfamoylbenzamide derivatives as HBV capsid assembly modulators.

Wang, Shuo / Ren, Yujie / Li, Qilan / Wang, Ya / Jiang, Xiangyi / Xu, Shujing / Zhang, Xujie / Zhao, Shujie / Bradley, Daniel P / Woodson, Molly E / Zhao, Fabao / Wu, Shuo / Li, Yuhuan / Tian, Ye / Liu, Xinyong / Tavis, John E / Zhan, Peng

Bioorganic chemistry

2022 Volume 129, Page(s) 106192

Abstract: Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to demonstrate antiviral activity in patients infected with HBV. However, ... ...

Abstract	Capsid assembly modulators (CAMs) represent a novel class of antiviral agents targeting hepatitis B virus (HBV) capsid to disrupt the assembly process. NVR 3-778 is the first CAM to demonstrate antiviral activity in patients infected with HBV. However, the relatively low aqueous solubility and moderate activity in the human body halted further development of NVR 3-778. To improve the anti-HBV activity and the drug-like properties of NVR 3-778, we designed and synthesized a series of NVR 3-778 derivatives. Notably, phenylboronic acid-bearing compound 7b (EC
MeSH term(s)	Humans ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Benzamides/pharmacology ; Capsid/drug effects ; Capsid/metabolism ; Capsid Proteins/metabolism ; Hepatitis B virus/drug effects ; Hepatitis B virus/physiology ; Virus Assembly/drug effects ; Drug Design
Chemical Substances	Antiviral Agents ; Benzamides ; Capsid Proteins ; NVR 3-778
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2022.106192
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Zs.A 4207: Show issues

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Article ; Online: Design, synthesis and evaluation of heteroaryldihydropyrimidine analogues bearing spiro ring as hepatitis B virus capsid protein inhibitors.

Ma, Yue / Zhao, Shujie / Ren, Yujie / Cherukupalli, Srinivasulu / Li, Qilan / Woodson, Molly E / Bradley, Daniel P / Tavis, John E / Liu, Xinyong / Zhan, Peng

European journal of medicinal chemistry

2021 Volume 225, Page(s) 113780

Abstract: GLS4, a potent antiviral drug candidate, has been widely studied and entered into phase II clinical trials. Nevertheless, the therapeutic application of GLS4 is limited due to poor water solubility, short half-life, and low bioavailability. In order to ... ...

Abstract	GLS4, a potent antiviral drug candidate, has been widely studied and entered into phase II clinical trials. Nevertheless, the therapeutic application of GLS4 is limited due to poor water solubility, short half-life, and low bioavailability. In order to improve the hydrophilicity and pharmacokinetic (PK) properties of GLS4, herein, we retained the dominant fragments, and used a scaffold hopping strategy to replace the easily metabolized morpholine ring of GLS4 with diverse sizes of spiro rings consisting of hydrogen bond donor and acceptor substituents. Potent in vitroanti-HBV activity and low cytotoxicity were observed for compound 4r (EC
MeSH term(s)	Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Capsid Proteins/antagonists & inhibitors ; Capsid Proteins/metabolism ; Dose-Response Relationship, Drug ; Drug Design ; Hepatitis B virus/chemistry ; Hepatitis B virus/drug effects ; Hepatitis B virus/metabolism ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Structure-Activity Relationship
Chemical Substances	Antiviral Agents ; Capsid Proteins ; Pyrimidines ; heteroaryldihydropyrimidine
Language	English
Publishing date	2021-08-19
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2021.113780
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Article: Removal of U(VI) from nuclear mining effluent by porous hydroxyapatite: Evaluation on characteristics, mechanisms and performance

Su, Minhua / Chen, Diyun / Hou, Li'an / Kong, Lingjun / Ren, Xinyong / Shi, Qingpu / Song, Gang / Tang, Jinfeng / Tsang, Daniel C.W / Zhang, Hongguo

Environmental pollution. 2019 July 11,

2019

Abstract: The effluents from nuclear mining processes contain relatively high content of radionuclides (such as uranium), which may seriously threaten the environment and human health. Herein, a novel adsorbent, porous hydroxyapatite, was prepared and proven ... ...

Abstract	The effluents from nuclear mining processes contain relatively high content of radionuclides (such as uranium), which may seriously threaten the environment and human health. Herein, a novel adsorbent, porous hydroxyapatite, was prepared and proven highly efficient for removal of uranyl ions (U(VI)) given its high U(VI) uptake capacity of 111.4 mg/g, fast adsorption kinetics, and the potential stabilization of adsorbed U(VI). A nearly complete removal of U(VI) was achieved by porous HAP under optimized conditions. Langmuir model could well describe the adsorption equilibrium. The data fit well with pseudo-second-order kinetic model, suggesting that U(VI) adsorption is primarily attributed to chemisorption with porous HAP. Intraparticle diffusion analysis showed that the intraparticle diffusion is the rate-limiting step for U(VI) adsorption by porous HAP. After removal by porous HAP, the adsorbed U(VI) ions were incorporated into tetragonal autunite, which has a low solubility (log Ksp: −48.36). Our findings demonstrate that the porous HAP can effectively remediate uranium contamination and holds great promise for environmental applications.
Keywords	adsorbents ; adsorption ; effluents ; human health ; hydroxyapatite ; kinetics ; mining ; radionuclides ; solubility ; sorption isotherms ; uranium ; uranyl ions
Language	English
Dates of publication	2019-0711
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2019.07.059
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Accelerated phosphorus recovery from aqueous solution onto decorated sewage sludge carbon.

Kong, Lingjun / Hu, Xingliang / Xie, Ziying / Ren, Xinyong / Long, Jianyou / Su, Minhua / Diao, Zenghui / Chen, Diyun / Shih, Kaimin / Hou, Li'an

Scientific reports

2018 Volume 8, Issue 1, Page(s) 13421

Abstract: In search of efficient phosphorus resource recovery and pollution remediation should be highly concerned due to the view of phosphorus nonrenewable and eutrophication. This work presented a new insight into conversion of sewage sludge into favorable ... ...

Abstract	In search of efficient phosphorus resource recovery and pollution remediation should be highly concerned due to the view of phosphorus nonrenewable and eutrophication. This work presented a new insight into conversion of sewage sludge into favorable carbonaceous adsorbent for accelerated removing and recovering phosphorus from aqueous solution, what addressed the issues of phosphorus recovery and pollution remediation as well as sludge disposal. Ca and water hyacinth were evolved to decorate sludge derived carbon. Effect of mass ratio of sludge, water hyacinth and calcium carbonate on the morphologies and adsorption kinetics was investigated. The adsorbents (SW-Ca-112) resulted from sludge in the presence of water hyacinth and CaCO
Language	English
Publishing date	2018-09-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-31750-6
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