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Article: Ameliorative effects of Kyung-Ok-Ko and its mixture with

Kim, Minseo / Kim, Hyun-Sook / Oh, Joohee / Zhou, Xiangqin / Ahn, SongHee / Koo, Youngtae / Kim, Hyun-Jung / Jang, Jiwon

Frontiers in nutrition

2023 Volume 10, Page(s) 1171346

Abstract: Introduction: Kyung-Ok-Ko (KOK) is a popular traditional medicine used as a natural alternative ...

Abstract	Introduction: Kyung-Ok-Ko (KOK) is a popular traditional medicine used as a natural alternative to hormone replacement therapy for treating postmenopausal symptoms in Asia. Methods: OVX rats were daily oral administrated with KOK and KOK + Results: The 12-week treatment with KOK and KOK + Conclusion: This is the first
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1171346
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Article ; Online: The efficacy, effectiveness, and safety of Kyung-ok-ko: A narrative review.

Kim, Ji-Woo / Geum, Ji-Hye / Ha, Won-Bae / Woo, Hyeon-Jun / Han, Yun-Hee / Park, Shin-Hyeok / Lee, Jung-Han

Medicine

2022 Volume 101, Issue 45, Page(s) e31311

Abstract: Kyung-ok-ko (KOK), a traditional medicinal formula in East Asia, has been recently studied across ...

Abstract	Kyung-ok-ko (KOK), a traditional medicinal formula in East Asia, has been recently studied across various fields. However, comprehensive reviews of clinical applications of KOK targeting clinical and experimental studies are lacking. Therefore, the application of KOK is being limited to the range of tonic medicines. To overcome this limitation, we aim to investigate the effectiveness, mechanism, and safety of KOK to obtain evidence regarding its effects in clinical applications. We searched for clinical and experimental articles in 11 databases (PubMed, Cochrane Library, Excerpta Medica dataBASE, China National Knowledge Infrastructure, Google Scholar, Research Information Sharing Service, Oriental Medicine Advanced Searching Integrated System, Koreanstudies Information Service System, Korean Medical Database, DBpia, and ScienceON). We selected 54 studies based on the inclusion criteria. Three clinical studies used KOK for a consumptive disease and health promotion. Fifty-one experimental studies reported the antioxidant activity, neuroprotective activity, anticancer effect, anti-inflammatory activity, immunological activity, growth promotion, impacts on cardiovascular system diseases, gastrointestinal system diseases, respiratory system diseases, and metabolic bone disease, hepatoprotective function, and antifatigue function of KOK, which were considered effective and safe in consumptive, chronic, metabolic, inflammatory, and immune diseases. We identified the effectiveness of KOK in the treatment of a wide range of diseases. However, further clinical studies are warranted in the future.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/therapeutic use ; Medicine, East Asian Traditional ; China ; Far East
Chemical Substances	kyung-ok-ko ; Drugs, Chinese Herbal
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031311
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Article ; Online: Administration of Kyung-Ok-Ko reduces stress-induced depressive behaviors in mice through inhibition of inflammation pathway.

Liu, Quan Feng / Park, Sun-Woo / Kim, Young-Mi / Song, Sue-Jin / Chin, Young-Won / Pak, Sok Cheon / Jeon, Songhee / Koo, Byung-Soo

Journal of ethnopharmacology

2020 Volume 265, Page(s) 113441

Abstract: Ethnopharmacological relevance: Kyung-Ok-Ko (KOK), a traditional medicinal formula composed ...

Abstract	Ethnopharmacological relevance: Kyung-Ok-Ko (KOK), a traditional medicinal formula composed of Rehmannia glutinosa (Gaertn.) DC, Poria cocos (Schw.) Wolf, Korean Red Panax ginseng C.A.Mey, and honey, has been used to treat amnesia and dementia. KOK has also been shown to ameliorate transient cerebral global ischemia-induced brain damage, but the antidepressant-like effect of KOK has not been examined. Aim of the study: This study examined the antidepressant-like effect of KOK in an immobilization-induced stress mouse and its mechanisms of action. Materials and methods: The animals in the stress group were immobilized for two hours a day for two weeks. KOK at a dose of 1 g/kg/day was administered orally to the stressed mice for two weeks in advance of their immobilization. A forced swimming test was performed to analyze their depressive behaviors. To examine the anti-inflammatory or antioxidative effects of KOK, the murine macrophage cell line, RAW 264.7 cells and human neuroblastoma cell, SH-SY5Y cells, were treated with lipopolysaccharide (LPS) and hydrogen peroxide, respectively. Result: The KOK extract showed no significant toxicity when the cells were treated with a KOK extract at 5, 10, 25, 50, and 100 μg/mL. The KOK ethanol extract reduced LPS-induced TNF-α production, inducible nitric oxide (iNOS) mRNA level, and the levels of MAPK and p38 phosphorylation in RAW 264.7 cells. KOK also suppressed H Conclusion: KOK might be useful for the treatment of depression caused by environmental and lifestyle-related stress.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/toxicity ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/pharmacology ; Antidepressive Agents/toxicity ; Behavior, Animal/drug effects ; Cell Line, Tumor ; Depression/drug therapy ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/toxicity ; Humans ; Inflammation/drug therapy ; Inflammation/pathology ; Lipopolysaccharides ; Macrophages/drug effects ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred ICR ; Nitric Oxide/metabolism ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Stress, Psychological/drug therapy
Chemical Substances	Anti-Inflammatory Agents ; Antidepressive Agents ; Drugs, Chinese Herbal ; Lipopolysaccharides ; Reactive Oxygen Species ; kyung-ok-ko ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2020-10-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113441
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Article: Administration of Kyung-Ok-Ko reduces stress-induced depressive behaviors in mice through inhibition of inflammation pathway

Liu, Quan Feng / Park, Sun-Woo / Kim, Young-Mi / Song, Sue-jin / Chin, Young-Won / Pak, Sok Cheon / Jeon, Songhee / Koo, Byung-Soo

Journal of ethnopharmacology. 2021 Jan. 30, v. 265

2021

Abstract: Kyung-Ok-Ko (KOK), a traditional medicinal formula composed of Rehmannia glutinosa (Gaertn.) DC ...

Abstract	Kyung-Ok-Ko (KOK), a traditional medicinal formula composed of Rehmannia glutinosa (Gaertn.) DC, Poria cocos (Schw.) Wolf, Korean Red Panax ginseng C.A.Mey, and honey, has been used to treat amnesia and dementia. KOK has also been shown to ameliorate transient cerebral global ischemia-induced brain damage, but the antidepressant-like effect of KOK has not been examined.This study examined the antidepressant-like effect of KOK in an immobilization-induced stress mouse and its mechanisms of action.The animals in the stress group were immobilized for two hours a day for two weeks. KOK at a dose of 1 g/kg/day was administered orally to the stressed mice for two weeks in advance of their immobilization. A forced swimming test was performed to analyze their depressive behaviors. To examine the anti-inflammatory or antioxidative effects of KOK, the murine macrophage cell line, RAW 264.7 cells and human neuroblastoma cell, SH-SY5Y cells, were treated with lipopolysaccharide (LPS) and hydrogen peroxide, respectively.The KOK extract showed no significant toxicity when the cells were treated with a KOK extract at 5, 10, 25, 50, and 100 μg/mL. The KOK ethanol extract reduced LPS-induced TNF-α production, inducible nitric oxide (iNOS) mRNA level, and the levels of MAPK and p38 phosphorylation in RAW 264.7 cells. KOK also suppressed H₂O₂-induced cell death and the production of reactive oxygen species (ROS) in SH-SY5Y cells. In the forced swimming test, KOK induced a decrease in immobility and an increase in climbing activity. Finally, the administration of KOK reversed the up-regulation of IkB-α phosphorylation in the stressed mouse cortex.KOK might be useful for the treatment of depression caused by environmental and lifestyle-related stress.
Keywords	Panax ginseng ; Poria ; Rehmannia glutinosa ; amnesia ; brain damage ; cell death ; cell lines ; dementia ; ethanol ; gene expression ; honey ; humans ; hydrogen peroxide ; inflammation ; lipopolysaccharides ; macrophages ; mice ; nitric oxide ; phosphorylation ; toxicity ; traditional medicine
Language	English
Dates of publication	2021-0130
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113441
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats.

Lee, Min Jung / Jang, Minhee / Bae, Chun-Sik / Park, Kyoung-Sun / Kim, Hak-Jae / Lee, Sanghyun / Lee, Sang Won / Kim, Young Ock / Cho, Ik-Hyun

Rejuvenation research

2016 Volume 19, Issue 6, Page(s) 456–466

Abstract: A traditional herbal prescription Kyung-Ok-Ko (KOK), composed of Rehmannia glutinosa Liboschitz var ...

Abstract	A traditional herbal prescription Kyung-Ok-Ko (KOK), composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquilaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in Oriental medicine as an invigorant for age-related diseases, such as amnesia and stroke. However, the beneficial value of KOK on uterine dysfunction related to hyperandrogenism is largely unknown. We investigated the effect of KOK (2.0 g/kg/day, per os) on endometrial abnormalities in a dehydroepiandrosterone (DHEA, subcutaneous)-induced polycystic ovary syndrome (PCOS) rat model. Preadministration of KOK significantly (p<0.05) decreased the elevated body weight, uterus weight, and endometrial thickness by PCOS induction, corresponding to reduced apoptosis and the infiltration of immune cells (CD4
MeSH term(s)	Animals ; Apoptosis/drug effects ; CD4-Positive T-Lymphocytes/drug effects ; Dehydroepiandrosterone/pharmacology ; Disease Models, Animal ; Drugs, Chinese Herbal/therapeutic use ; Female ; Inflammation Mediators/metabolism ; Organ Size/drug effects ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/immunology ; Rats ; Rats, Sprague-Dawley ; Uterus/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Inflammation Mediators ; kyung-ok-ko ; Dehydroepiandrosterone (459AG36T1B)
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2150779-X
ISSN	1557-8577 ; 1549-1684
ISSN (online)	1557-8577
ISSN	1549-1684
DOI	10.1089/rej.2015.1787
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Zs.A 5215: Show issues

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Article ; Online: Anti-platelet and anti-thrombotic effect of a traditional herbal medicine Kyung-Ok-Ko.

Kim, Tae-Ho / Lee, Kyoung Mee / Hong, Nam Doo / Jung, Yi-Sook

Journal of ethnopharmacology

2016 Volume 178, Page(s) 172–179

Abstract: Ethnopharmacological relevance: Kyung-Ok-Ko (KOK), a traditional herbal prescription, contains six ...

Abstract	Ethnopharmacological relevance: Kyung-Ok-Ko (KOK), a traditional herbal prescription, contains six main ingredients; Rehmannia glutinosa var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey. KOK has been widely taken as a traditional oriental medicine for improving blood circulation or age-related symptoms, such as dementia and stroke. However, the effect of KOK on platelet activity has not been clarified. Materials and methods: To evaluate the effect of KOK on platelet function, we evaluated its effect on functional markers of platelet activation such as aggregation and shape change. As a mechanism study for the effect of KOK, we examined its effect on granule secretion, intracellular Ca(2+) increase, and PLCγ and Akt activation. To investigate the effect of orally administered KOK (0.5, 1, 2 g/kg), we examined its ex vivo effect on platelet aggregation in rat, and its in vivo anti-thrombotic effect in mice thromboembolism model. Furthermore, the effect of KOK on bleeding time was examined to estimate its potential side effect. Results: KOK (0.3, 1, 3, 10 mg/ml) inhibited collagen-induced platelet aggregation and shape change in rat platelets in a concentration-dependent manner. The mechanism for the anti-platelet effect of KOK seems to involve the inhibition of ATP release, intracellular Ca(2+) elevation, and the phosphorylation of PLCγ and Akt. In rat ex vivo study, KOK (2 g/kg, p.o. for 1 day, and 0.5, 1, 2 g/kg, p.o. for 7 days) also had significant inhibitory effects on collagen-induced platelet aggregation. In addition, KOK showed a significant protective effect against thrombosis attack in mice. The prolongation of bleeding time by KOK was much less than that by ASA, suggesting a beneficial potential of KOK than ASA in view of side effect. Conclusions: These findings suggest that KOK elicits remarkable anti-platelet and anti-thrombotic effects with less side effect of bleeding, and therefore, it may have a therapeutic potential for the prevention of platelet-associated cardiovascular diseases.
MeSH term(s)	Animals ; Bleeding Time/methods ; Blood Platelets/drug effects ; Drugs, Chinese Herbal/pharmacology ; Herbal Medicine/methods ; Male ; Medicine, East Asian Traditional/methods ; Medicine, Traditional/methods ; Mice ; Mice, Inbred ICR ; Phytotherapy/methods ; Plant Extracts/pharmacology ; Plants, Medicinal/chemistry ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Platelet Function Tests/methods ; Rats ; Rats, Sprague-Dawley ; Thrombosis/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Plant Extracts ; Platelet Aggregation Inhibitors ; kyung-ok-ko
Language	English
Publishing date	2016-02-03
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.11.040
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The efficacy and safety of Kyung-Ok-Ko on cancer-related fatigue in lung cancer patients: Study protocol for a randomized, patients-assessor blind, placebo-controlled, parallel-group, single-center trial.

Kim, Kwan-Il / Kong, Moonkyo / Lee, Seung Hyeun / Lee, Beom-Joon

Medicine

2019 Volume 98, Issue 44, Page(s) e17717

Abstract: ... Kyung-Ok-Ko is used for improving fatigue or weak physical constitution. It is known to be effective ... in immune activation, reducing fatigue, and enhancing cognitive function. Although Kyung-Ok-Ko is clinically used ... Therefore, we aimed to investigate the efficacy and safety of Kyung-Ok-Ko.: Methods: This is a randomized, placebo ...

Abstract	Background: Cancer-related fatigue (CRF) is a major symptom experienced by lung cancer patients receiving chemotherapy and radiation therapy. Since CRF has a multidimensional influence on cancer patients, they may experience physical weakening, a decline in cognitive function, and depression from emotional consequences. Kyung-Ok-Ko is used for improving fatigue or weak physical constitution. It is known to be effective in immune activation, reducing fatigue, and enhancing cognitive function. Although Kyung-Ok-Ko is clinically used for the treatment of CRF, its efficacy and safety against CRF in lung cancer patients are yet to be studied. Therefore, we aimed to investigate the efficacy and safety of Kyung-Ok-Ko. Methods: This is a randomized, placebo-controlled, patients-assessor blind, parallel-group, single-center clinical trial. Lung cancer patients with CRF, after termination of chemo or radiation therapies, are randomized in a 1:1 ratio to receive either Kyung-Ok-Ko or placebo for 6 weeks. The primary outcome is Brief Fatigue Inventory (BFI). The secondary outcomes include Visual Analog Fatigue Scale (VAFS), Functional Assessment of Cancer Therapy (FACIT) Fatigue scale, Hospital Anxiety Depression Scale (HADS), Montreal Cognitive Assessment Korean version (MoCA-K), and Korean pattern identification questionnaire. Adverse events are evaluated by Common Terminology Criteria for Adverse Events (CTCAE). All outcomes and adverse events are assessed at the baseline, mid-treatment, post-treatment, and at 1-month follow-up. Discussion: This study investigates whether Kyung-Ok-Ko can alleviate CRF in lung cancer patients. The results of this study will provide clinical evidence for the application of Kyung-Ok-Ko in the treatment of CRF in lung cancer patients. Trial registration: Korean Clinical Trial Registry (http://cris.nih.go.kr; registration number: KCT000666).Trial status: Currently, participant recruitment is ongoing.
MeSH term(s)	Adult ; Drugs, Chinese Herbal/therapeutic use ; Fatigue/drug therapy ; Fatigue/etiology ; Female ; Humans ; Lung Neoplasms/complications ; Male ; Randomized Controlled Trials as Topic ; Single-Blind Method ; Treatment Outcome ; Young Adult
Chemical Substances	Drugs, Chinese Herbal ; kyung-ok-ko
Language	English
Publishing date	2019-11-05
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000017717
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Article: Effect of a Traditional Herbal Prescription, Kyung-Ok-Ko, on Male Mouse Spermatogenic Ability after Heat-Induced Damage.

Hwang, Deok-Sang / Kim, Hyo Geun / Park, Sodam / Hong, Nam Doo / Ryu, Jong Hoon / Oh, Myung Sook

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 950829

Abstract: Kyung-Ok-Ko (KOK), a well-known traditional Korean medicinal formula, has long been used ...

Abstract	Kyung-Ok-Ko (KOK), a well-known traditional Korean medicinal formula, has long been used to invigorate the essential qi. This use of KOK may be associated with reproductive ability as a more modern concept. The protective effect of KOK was evaluated against deterioration of testicular function induced by heat exposure in male mice. Male fertility was disrupted by scrotal heat stress at 43°C for 5 weeks. KOK (0.25, 0.50, and 2.00 g/kg/day) was administered orally at 3 h after the stress. To evaluate the protective effect of KOK, body weight, testicular weight, sperm count, sperm motility, and histopathological changes in the testes were evaluated. KOK-treated mice significantly recovered their general health, as evidenced by body weight. KOK-treated mice also showed significantly higher testes weights, sperm counts, and sperm motility than did the heat stress group. KOK-treated mice significantly recovered the morphological appearance of the seminiferous tubules and seminiferous epithelium. Furthermore, KOK-treated mice significantly increased antioxidant enzyme activities and reduced the protein expressions of apoptosis in the testes. KOK significantly protects against heat-induced damage to testicular function in male mice by inhibiting oxidative stress and apoptosis, indicating that KOK may be an effective agent for treatment of heat-induced male infertility.
Language	English
Publishing date	2015-10-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/950829
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Article ; Online: Correction: Won-Kyung Cho; et al. Epimedium Koreanum Nakai Displays Broad Spectrum of Antiviral Activity In Vitro and In Vivo by Inducing Cellular Antiviral State. Viruses 2015, 7, 352⁻377.

Cho, Won-Kyung / Weeratunga, Prasanna / Lee, Byeong-Hoon / Park, Jun-Seol / Kim, Chul-Joong / Ma, Jin Yeul / Lee, Jong-Soo

Viruses

2018 Volume 10, Issue 6

Abstract: The authors wish to make the following change to their paper [1].[ ... ]. ...

Abstract	The authors wish to make the following change to their paper [1].[...].
Language	English
Publishing date	2018--04
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v10060304
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Article ; Online: Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats.

Jang, Minhee / Lee, Min Jung / Lee, Jin Moo / Bae, Chun-Sik / Kim, Sung-Hoon / Ryu, Jong Hoon / Cho, Ik-Hyun

PloS one

2014 Volume 9, Issue 2, Page(s) e87623

Abstract: Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var ...

Abstract	Kyung-Ok-Ko (KOK), a traditional herbal prescription composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquillaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in traditional Oriental medicine as a vitalizing medicine or as the prescription for patients with age-associated disorders such as amnesia and stroke. However, the potential protective value of KOK for the treatment of polycystic ovarian syndrome (PCOS) is largely unknown. We investigated whether pre-administration (daily from 2 hours before PCOS induction) and post-administration (daily after induction of PCOS) of KOK (0.5, 1.0, and 2.0 g/kg/day, p.o.) could have a protective effect in a dehydroepiandrosterone (DHEA, s.c.)-induced PCOS rat model. Pre-administration of KOK significantly decreased the elevated body weight and ovary weight, elevated size and number of follicular cysts, elevated level of serum glucose, and estradiol after DHEA injection. KOK reduced the elevated percentage of CD8 (+) T lymphocytes in lymph nodes, the elevated mRNA expression of CD11b and CD3 in ovaries, and infiltration of macrophages in ovarian tissue with PCOS. KOK diminished the increased mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α), chemokines (IL-8, MCP-1), and iNOS in the ovaries, and increased the reduced mRNA expression of growth factors (EGF, TGF-β) by DHEA injection. Post-administration of KOK also improved the DHEA-induced PCOS-like symptoms, generally similar to those evident from pre-administration of KOK. KOK may effectively prevent and improve DHEA-induced PCOS via anti-inflammatory action, indicating its preventive and therapeutic potential for suppressing PCOS.
MeSH term(s)	Animals ; Blood Glucose/metabolism ; Body Weight/drug effects ; Dehydroepiandrosterone ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/toxicity ; Estradiol/blood ; Estrous Cycle/drug effects ; Fasting/blood ; Female ; Inflammation Mediators/metabolism ; Insulin/blood ; Lymph Nodes/drug effects ; Lymph Nodes/metabolism ; Lymph Nodes/pathology ; Medicine, East Asian Traditional ; Organ Size/drug effects ; Ovary/drug effects ; Ovary/pathology ; Phytotherapy ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/toxicity ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/pathology ; Polycystic Ovary Syndrome/prevention & control ; Progesterone/blood ; Rats ; Rats, Sprague-Dawley ; T-Lymphocytes/drug effects ; T-Lymphocytes/metabolism
Chemical Substances	Blood Glucose ; Drugs, Chinese Herbal ; Inflammation Mediators ; Insulin ; Plant Extracts ; kyung-ok-ko ; Dehydroepiandrosterone (459AG36T1B) ; Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E)
Language	English
Publishing date	2014-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0087623
Database	MEDical Literature Analysis and Retrieval System OnLINE

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