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  1. Article: Quantum Computing and the Future of Neurodegeneration and Mental Health Research.

    Stefano, George B

    Brain sciences

    2024  Volume 14, Issue 1

    Abstract: Quantum computing and supercomputing are two distinct approaches that can be used to solve complex computational problems [ ... ]. ...

    Abstract Quantum computing and supercomputing are two distinct approaches that can be used to solve complex computational problems [...].
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Artificial Intelligence as a Tool for the Diagnosis and Treatment of Neurodegenerative Diseases.

    Stefano, George B

    Brain sciences

    2023  Volume 13, Issue 6

    Abstract: While humans have much in common biologically with other mammalian species, they are largely distinguished by their innate intelligence, specifically, their ability to generate complex and sophisticated tools [ ... ]. ...

    Abstract While humans have much in common biologically with other mammalian species, they are largely distinguished by their innate intelligence, specifically, their ability to generate complex and sophisticated tools [...].
    Language English
    Publishing date 2023-06-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13060938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Biomedical significance of nitric oxide

    Stefano, George B.

    2006  

    Author's details ed. by George B. Stefano
    Language English
    Size 478 S. : Ill., graph. Darst.
    Publisher Medical Science International
    Publishing place Warsaw u.a.
    Publishing country Poland
    Document type Book
    HBZ-ID HT015186712
    ISBN 978-83-909231-4-7 ; 83-909231-4-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 2767 order for loan Magazin

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  4. Article ; Online: Historical Insight into Infections and Disorders Associated with Neurological and Psychiatric Sequelae Similar to Long COVID.

    Stefano, George B

    Medical science monitor : international medical journal of experimental and clinical research

    2021  Volume 27, Page(s) e931447

    Abstract: Long-term sequelae of coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now recognized. However, there is still a lack of consensus regarding the terminology for this emerging ... ...

    Abstract Long-term sequelae of coronavirus disease 2019 (COVID-19) due to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are now recognized. However, there is still a lack of consensus regarding the terminology for this emerging chronic clinical syndrome, which includes long COVID, chronic COVID syndrome, post-COVID-19 syndrome, post-acute COVID-19, and long-hauler COVID-19. In this review, I will use the term "long COVID". A review of the medical history and epidemiology of past pandemics and epidemics in modern literature review identifies common long-term post-infectious disorders, with the common finding of altered cognition. In the brain, the cerebral hypoxia induced by SARS-CoV-2 infection may be caused by mitochondrial dysfunction, resulting in "brain fog". Historically, the common symptom of altered cognition has been reported during earlier pandemics, which include the influenza pandemics of 1889 and 1892 (Russian flu), the Spanish flu pandemic (1918-1919), encephalitis lethargica, diphtheria, and myalgic encephalomyelitis (chronic fatigue syndrome or post-viral fatigue syndrome). There are similarities between chronic fatigue syndrome and the "brain fog" described in long COVID. During past viral epidemics and pandemics, a commonality of neural targets may have increased viral survival by conformational matching. The neurological and psychiatric sequelae of SARS-CoV-2 infection, or long COVID, may have emerged from neural effects that have emerged from an invertebrate and vertebrate virosphere. This review aims to present a historical overview of infections and disorders associated with neurological and psychiatric sequelae that have shown similarities with long COVID.
    MeSH term(s) Brain/virology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/metabolism ; COVID-19/physiopathology ; COVID-19/psychology ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/virology ; History, 21st Century ; Humans ; Influenza Pandemic, 1918-1919 ; Pandemics ; SARS-CoV-2/enzymology ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism
    Language English
    Publishing date 2021-02-26
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.931447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4924: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The foundations of mind-body medicine: Love, good relationships, and happiness modulate stress and promote health.

    Esch, Tobias / Stefano, George B / Michaelsen, Maren M

    Stress and health : journal of the International Society for the Investigation of Stress

    2024  , Page(s) e3387

    Abstract: Although stress is an everyday fact of life, it can lead to poor health outcomes, particularly when intense or prolonged. However, humans have unique cognitive abilities and thus may be able to combat stress by engaging critical psychological defence ... ...

    Abstract Although stress is an everyday fact of life, it can lead to poor health outcomes, particularly when intense or prolonged. However, humans have unique cognitive abilities and thus may be able to combat stress by engaging critical psychological defence mechanisms. In this review, we discuss the field of mind-body medicine, which focuses on improving our understanding of the mechanisms underlying this response and developing interventions that might be used to limit the effects of chronic stress. We review the findings of past and current research in this field that has focused on the impact of psychological, emotional, and behavioural factors, including love, social connectedness, and happiness on human health and the amelioration of pain as well as other signs and symptoms of disease. While these studies have not yet led to confirmed, quantifiable conclusions, the overall weight of evidence suggests that happiness (defined as a personal sense of well-being) may be directly associated with improved health parameters and reductions in debilitating symptoms. Collectively, these findings suggest that interventions designed to promote stress mitigation, notably those that encourage social activity, may lead to significant improvements in human health.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2042041-9
    ISSN 1532-2998 ; 1532-3005
    ISSN (online) 1532-2998
    ISSN 1532-3005
    DOI 10.1002/smi.3387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2060: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The BERN Framework of Mind-Body Medicine: Integrating Self-Care, Health Promotion, Resilience, and Applied Neuroscience.

    Esch, Tobias / Stefano, George B

    Frontiers in integrative neuroscience

    2022  Volume 16, Page(s) 913573

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452962-X
    ISSN 1662-5145
    ISSN 1662-5145
    DOI 10.3389/fnint.2022.913573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Viruses Broaden the Definition of Life by Genomic Incorporation of Artificial Intelligence and Machine Learning Processes.

    Stefano, George B / Kream, Richard M

    Current neuropharmacology

    2022  Volume 20, Issue 10, Page(s) 1888–1893

    Abstract: Viruses have been classified as non-living because they require a cellular host to support their replicative processes. Empirical investigations have significantly advanced our understanding of the many strategies employed by viruses to usurp and divert ... ...

    Abstract Viruses have been classified as non-living because they require a cellular host to support their replicative processes. Empirical investigations have significantly advanced our understanding of the many strategies employed by viruses to usurp and divert host regulatory and metabolic processes to drive the synthesis and release of infectious particles. The recent emergence of SARS-CoV-2 has permitted us to evaluate and discuss a potentially novel classification of viruses as living entities. The ability of SARS CoV-2 to engender comprehensive regulatory control of integrative cellular processes is strongly suggestive of an inherently dynamic informational registry that is programmatically encoded by linear ssRNA sequences responding to distinct evolutionary constraints. Responses to positive evolutionary constraints have resulted in a single-stranded RNA viral genome that occupies a threedimensional space defined by conserved base-paring resulting from a complex pattern of both secondary and tertiary structures. Additionally, regulatory control of virus-mediated infectious processes relies on extensive protein-protein interactions that drive conformational matching and shape recognition events to provide a functional link between complementary viral and host nucleic acid and protein domains. We also recognize that the seamless integration of complex replicative processes is highly dependent on the precise temporal matching of complementary nucleotide sequences and their corresponding structural and non-structural viral proteins. Interestingly, the deployment of concerted transcriptional and translational activities within targeted cellular domains may be modeled by artificial intelligence (AI) strategies that are inherently fluid, self-correcting, and adaptive at accommodating temporal changes in host defense mechanisms. An in-depth understanding of multiple self-correcting AIassociated viral processes will most certainly lead to novel therapeutic development platforms, notably the design of efficacious neuropharmacological agents to treat chronic CNS syndromes associated with long-COVID. In summary, it appears that viruses, notably SARS-CoV-2, are very much alive due to acquired genetic advantages that are intimately entrained to existential host processes via evolutionarily constrained AI-associated learning paradigms.
    MeSH term(s) Artificial Intelligence ; COVID-19/complications ; Genomics ; Humans ; Machine Learning ; SARS-CoV-2/genetics ; Viruses ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2022-04-18
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X20666220420121746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Mobility Coupled with Motivation Promotes Survival: The Evolution of Cognition as an Adaptive Strategy.

    Stefano, George B / Kream, Richard M / Esch, Tobias

    Biology

    2023  Volume 12, Issue 1

    Abstract: Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling ... ...

    Abstract Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling pathways. While dopamine remains the preeminent catecholamine in invertebrate neural systems, epinephrine is the major product of catecholamine synthetic pathways in vertebrate species. Given that the enzymatic steps leading to the generation of morphine are similar to those constraining the evolutionary adaptation of the biosynthesis of catecholamines, we hypothesize that the emergence of these more advanced signaling pathways was based on conservation and selective "retrofitting" of pre-existing enzyme activities. This is consistent with observations that support the recruitment of enzymatically synthesized tetrahydrobiopterin (BH4), which is a cofactor for tyrosine hydroxylase, the enzyme responsible for dopamine production. BH4 is also an electron donor involved in the production of nitric oxide (NO). The links that coordinate BH4-mediated NO and catecholaminergic-mediated processes provide these systems with the capacity to regulate numerous downstream signaling pathways. We hypothesize that the evolution of catecholamine signaling pathways in animal species depends on the acquisition of a mobile lifestyle and motivationally driven feeding, sexual, and self-protective responses.
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12010080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Reassessment of the blood-brain barrier: a potential target for viral entry into the immune-privileged brain.

    Stefano, George B / Büttiker, Pascal / Kream, Richard M

    Germs

    2022  Volume 12, Issue 1, Page(s) 99–101

    Language English
    Publishing date 2022-03-31
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2649305-6
    ISSN 2248-2997
    ISSN 2248-2997
    DOI 10.18683/germs.2022.1310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mobility Coupled with Motivation Promotes Survival: The Evolution of Cognition as an Adaptive Strategy

    Stefano, George B. / Kream, Richard M. / Esch, Tobias

    Biology (Basel). 2023 Jan. 03, v. 12, no. 1

    2023  

    Abstract: Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling ... ...

    Abstract Morphine plays a critical regulatory role in both simple and complex plant species. Dopamine is a critical chemical intermediate in the morphine biosynthetic pathway and may have served as a primordial agonist in developing catecholamine signaling pathways. While dopamine remains the preeminent catecholamine in invertebrate neural systems, epinephrine is the major product of catecholamine synthetic pathways in vertebrate species. Given that the enzymatic steps leading to the generation of morphine are similar to those constraining the evolutionary adaptation of the biosynthesis of catecholamines, we hypothesize that the emergence of these more advanced signaling pathways was based on conservation and selective “retrofitting” of pre-existing enzyme activities. This is consistent with observations that support the recruitment of enzymatically synthesized tetrahydrobiopterin (BH4), which is a cofactor for tyrosine hydroxylase, the enzyme responsible for dopamine production. BH4 is also an electron donor involved in the production of nitric oxide (NO). The links that coordinate BH4-mediated NO and catecholaminergic-mediated processes provide these systems with the capacity to regulate numerous downstream signaling pathways. We hypothesize that the evolution of catecholamine signaling pathways in animal species depends on the acquisition of a mobile lifestyle and motivationally driven feeding, sexual, and self-protective responses.
    Keywords agonists ; biochemical pathways ; biosynthesis ; cognition ; dopamine ; epinephrine ; evolutionary adaptation ; invertebrates ; lifestyle ; morphine ; motivation ; nitric oxide ; tyrosine 3-monooxygenase ; vertebrates
    Language English
    Dates of publication 2023-0103
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12010080
    Database NAL-Catalogue (AGRICOLA)

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