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Article ; Online: Dihydroisotanshinone I and BMAL-SIRT1 Pathway in an In Vitro 6-OHDA-Induced Model of Parkinson's Disease.

Su, Hui-Chen / Sun, Yuan-Ting / Yang, Ming-Yu / Wu, Ching-Yuan / Hsu, Cheng-Ming

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Danshen has been widely used for the treatment of central nervous system diseases. We investigated the effect of dihydroisotanshinone I (DT), a compound extracted from Danshen, as well as the corresponding mechanisms in an in vitro-based 6-OHDA-induced ... ...

Abstract	Danshen has been widely used for the treatment of central nervous system diseases. We investigated the effect of dihydroisotanshinone I (DT), a compound extracted from Danshen, as well as the corresponding mechanisms in an in vitro-based 6-OHDA-induced Parkinson's disease (PD) model. SH-SY5Y human neuroblastoma cell lines were pretreated with 6-hydroxydopamine (6-OHDA) and challenged with DT. Subsequently, the cell viability and levels of reactive oxygen species (ROS) and caspase-3 were analyzed. The effect of DT on the 6-OHDA-treated SH-SY5Y cells and the expression of the core circadian clock genes were measured using a real-time quantitative polymerase chain reaction. Our results indicated that DT attenuated the 6-OHDA-induced cell death in the SH-SY5Y cells and suppressed ROS and caspase-3. Moreover, DT reversed both the RNA and protein levels of
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Reactive Oxygen Species/metabolism ; Oxidopamine/pharmacology ; Caspase 3/genetics ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; ARNTL Transcription Factors/genetics ; Cell Line, Tumor ; Neuroblastoma/metabolism ; Apoptosis ; Neuroprotective Agents/pharmacology
Chemical Substances	Reactive Oxygen Species ; dihydroisotanshinone I (20958-18-3) ; Oxidopamine (8HW4YBZ748) ; Caspase 3 (EC 3.4.22.-) ; Sirtuin 1 (EC 3.5.1.-) ; ARNTL Transcription Factors ; Neuroprotective Agents ; SIRT1 protein, human (EC 3.5.1.-)
Language	English
Publishing date	2023-07-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241311088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hole-Transporting Materials based on Oligo(hetero)aryls with a Naphthodithiophene Core - Succinct Synthesis by Twofold Direct C-H Olefination.

Hsu, Chia-Chi / Lee, Kun-Mu / Wu, Xiao-Wei / Lin, Li / Yu, Wei-Lun / Liu, Ching-Yuan

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 Volume 30, Issue 10, Page(s) e202302552

Abstract: This work demonstrated the first synthetic application of direct C-H olefinations in the step-saving preparation of various hole-transporting materials (HTM) for efficient perovskite solar cells (PSC). Cross-dehydrogenative couplings of ... ...

Abstract	This work demonstrated the first synthetic application of direct C-H olefinations in the step-saving preparation of various hole-transporting materials (HTM) for efficient perovskite solar cells (PSC). Cross-dehydrogenative couplings of naphthodithiophene (NDT) with vinyl arenes under palladium-catalysis facilely generated various new oligo(hetero)aryls with internal alkenes. Reaction conditions were optimized, which gave the product isolated yields of up to 71 % with high (E)-stereoselectivity. These readily accessible NDT core-based small molecules involving olefin as π-spacers displayed immediate power conversion efficiencies of up to 17.2 % without a device oxidation process that is required for the commercially available spiro-OMeTAD and most other existing HTMs while fabricated in corresponding PSC devices.
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202302552
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Induction of ferroptosis and apoptosis in endometrial cancer cells by dihydroisotanshinone I.

Wu, Ching-Yuan / Yang, Yao-Hsu / Lin, Yu-Shih / Shu, Li-Hsin / Liu, Hung-Te / Wu, Yu-Huei / Wu, Yu-Heng

Heliyon

2023 Volume 9, Issue 11, Page(s) e21652

Abstract: Danshen, also known ... ...

Abstract	Danshen, also known as
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21652
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dihydroisotanshinone I and BMAL-SIRT1 Pathway in an In Vitro 6-OHDA-Induced Model of Parkinson’s Disease

Hui-Chen Su / Yuan-Ting Sun / Ming-Yu Yang / Ching-Yuan Wu / Cheng-Ming Hsu

International Journal of Molecular Sciences, Vol 24, Iss 11088, p

2023 Volume 11088

Abstract	Danshen has been widely used for the treatment of central nervous system diseases. We investigated the effect of dihydroisotanshinone I (DT), a compound extracted from Danshen, as well as the corresponding mechanisms in an in vitro-based 6-OHDA-induced Parkinson’s disease (PD) model. SH-SY5Y human neuroblastoma cell lines were pretreated with 6-hydroxydopamine (6-OHDA) and challenged with DT. Subsequently, the cell viability and levels of reactive oxygen species (ROS) and caspase-3 were analyzed. The effect of DT on the 6-OHDA-treated SH-SY5Y cells and the expression of the core circadian clock genes were measured using a real-time quantitative polymerase chain reaction. Our results indicated that DT attenuated the 6-OHDA-induced cell death in the SH-SY5Y cells and suppressed ROS and caspase-3. Moreover, DT reversed both the RNA and protein levels of BMAL1 and SIRT1 in the 6-OHDA-treated SH-SY5Y cells. Additionally, the SIRT1 inhibitor attenuated the effect of DT on BMAL1 and reduced the cell viability. The DT and SIRT1 activators activated SIRT1 and BMAL1 , and then reduced the death of the SH-SY5Y cells damaged by 6-OHDA. SIRT1 silencing was enhanced by DT and resulted in a BMAL1 downregulation and a reduction in cell viability. In conclusion, our investigation suggested that DT reduces cell apoptosis, including an antioxidative effect due to a reduction in ROS, and regulates the circadian genes by enhancing SIRT1 and suppressing BMAL1. DT may possess novel therapeutic potential for PD in the future, but further in vivo studies are still needed.
Keywords	Idiopathic Parkinson’s disease ; Danshen ; Dihydroisotanshinone I ; 6-OHDA ; SIRT1 ; BMAL1 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Left ventricular assist device exchange from HeartMate II to HeartMate 3 in an Asian patient-a case report and literature review.

Chang, Hsiao-Huang / Kuo, Tzu-Ting / Chen, Po-Lin / Kuo, Chia-Cheng / Kuo, Ching-Yuan / Wu, Nai-Yuan

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 82

Abstract: Background: Pump exchange surgery of left ventricular assist device (LVAD) has been demonstrated in several studies; however, information for Asian patients was limited.: Case presentation: A 63-year-old man underwent a pump upgrade from HeartMate II ...

Abstract	Background: Pump exchange surgery of left ventricular assist device (LVAD) has been demonstrated in several studies; however, information for Asian patients was limited. Case presentation: A 63-year-old man underwent a pump upgrade from HeartMate II to HeartMate 3 for driveline damage through limited left anterior thoracotomy and lower partial sternotomy. He did not experience any hemodynamic adverse events or device malfunction during postoperative follow-ups of 12 months. We also reviewed all published cases with HeartMate II exchange to HeartMate 3. Conclusions: The case demonstrated that it was safe and feasible to perform HMII LVAD exchange to HM3 through a limited approach for Asian patients.
MeSH term(s)	Male ; Humans ; Middle Aged ; Heart-Assist Devices/adverse effects ; Postoperative Period ; Sternotomy
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02133-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 6-shogaol is a potential treatment for Head and Neck Squamous Cell Carcinoma.

Hsu, Cheng-Ming / Su, Hui-Chen / Yang, Ming-Yu / Tsai, Yao-Te / Tsai, Ming-Shao / Yang, Yao-Hsu / Wu, Ching-Yuan / Chang, Shun-Fu

International journal of medical sciences

2023 Volume 20, Issue 2, Page(s) 238–246

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Catechols/pharmacology ; Catechols/therapeutic use ; Apoptosis ; Head and Neck Neoplasms/drug therapy
Chemical Substances	shogaol (83DNB5FIRF) ; Catechols
Language	English
Publishing date	2023-01-22
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.80542
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Developing and Testing the Negative Mentoring Experience Questionnaire (NMEQ) for Nurses

Ching-Yuan Huang / Tsung-Chin Wu / Rhay-Hung Weng / Chiu- Hsia Hung / Tzu-En Lin / Yu-Chen Tsai

SAGE Open, Vol

2023 Volume 13

Abstract: Many nurse managers actively developed mentoring programs to shorten the acclimation period of new nurses in hospitals. The main aim was to develop a negative mentoring experience questionnaire (NMEQ) and test its validity and reliability. A cross- ... ...

Abstract	Many nurse managers actively developed mentoring programs to shorten the acclimation period of new nurses in hospitals. The main aim was to develop a negative mentoring experience questionnaire (NMEQ) and test its validity and reliability. A cross-sectional study was employed. This study adopted questionnaire-survey method with new nurses of Taiwanese hospitals. In the main study, this study adopted reliability analysis, content, validity, construct validity and criterion-related validity analysis. 255 participants were collected, with 87.93% response rate. A total of 29 items of five-dimension scale of NMEQ were proposed: four nursing manager items, four institutional items, three other medical staff items, 12 mentor items, and six mentee items. Each dimension demonstrated a reliability of 0.72 to 0.96. Exploratory factor analysis and Confirmatory factor analysis results indicated that NMEQ had acceptable convergent and discriminate validity. Correlation analysis indicated this scale and mentoring function scale exhibited a significantly negative correlation ( p < .05). NMEQ is reliable and valid for hospital nurses. It also can help clinical nursing managers to clarify the possible negative experiences and strengthen the adaptability and mental health of new staff nurses in mentoring programs. Nursing policy planners can use NMEQ to measure the negative experience of new nurses, monitor the performance of mentoring program, and further revise mentoring policies.
Keywords	History of scholarship and learning. The humanities ; AZ20-999 ; Social Sciences ; H
Subject code	150
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Genetic Differentiation of the Bloodsucking Midge

Ching, Yung-Hao / Kuo, Yuan-Chen / Su, Ming-Ching / Wang, Szu-Chieh / Lin, Chuen-Fu / Tu, Wu-Chun / Lin, Ming-Der

Insects

2024 Volume 15, Issue 1

Abstract: ... ...

Abstract	Forcipomyia
Language	English
Publishing date	2024-01-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662247-6
ISSN	2075-4450
ISSN	2075-4450
DOI	10.3390/insects15010023
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Article ; Online: Adherence to Statins Use and Risk of Dementia among Patients with Diabetes and Comorbid Hyperlipidemia.

Chang, Ching-Yuan / Lin, Fang-Ju / Hong, Jin-Liern / Wu, Chung-Hsuen

Inquiry : a journal of medical care organization, provision and financing

2021 Volume 58, Page(s) 469580211019201

Abstract: The results from previous observational studies and clinical trials about the neuroprotective benefits of statins use for the prevention of dementia are contradictory. It is unclear whether the neuroprotective benefits are experienced in a specific group ...

Abstract	The results from previous observational studies and clinical trials about the neuroprotective benefits of statins use for the prevention of dementia are contradictory. It is unclear whether the neuroprotective benefits are experienced in a specific group with a higher risk of dementia, such as patients with concurrent diabetes and hyperlipidemia. We aimed to examine the association between adherence to statins and the risk of dementia among patients with diabetes and comorbid hyperlipidemia. This was a retrospective study with a new user design. We used data from the Taiwan National Health Insurance Research Database to identify patients with diabetes and comorbid hyperlipidemia. The occurrence of dementia was the study outcome. The adherence to statins was the exposure, which was measured by the proportion of days covered (PDC) of statins. The good adherence included patients with ≥80% PDC of statins. Cox proportional hazards regression models were used to evaluate the association between adherence to statins and dementia. Among 18,125 included individuals with diabetes and comorbid hyperlipidemia, 33.5% had good adherence to statins. Compared to poor adherence to statins, good adherence to statins was not significantly associated with a reduced risk of dementia (hazard ratio = 0.94; 95%confidence interval = 0.70-1.24) among patients with diabetes and comorbid hyperlipidemia. Good adherence to statins was not found to be associated with the risk of dementia among patients with diabetes and comorbid hyperlipidemia in Taiwan. Future studies with a more diverse study population are needed to evaluate the neuroprotective effects of statins use on dementia prevention.
MeSH term(s)	Dementia/epidemiology ; Diabetes Mellitus/epidemiology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Hyperlipidemias/drug therapy ; Hyperlipidemias/epidemiology ; Retrospective Studies
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	42153-4
ISSN	1945-7243 ; 0046-9580
ISSN (online)	1945-7243
ISSN	0046-9580
DOI	10.1177/00469580211019201
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Article: Fluorinated graphene as a dual-functional anode to achieve dendrite-free and high-performance lithium metal batteries

Jamaluddin, Anif / Sin, Yu- Yu / Adhitama, Egy / Prayogi, Achmad / Wu, Yi-Ting / Chang, Jeng-Kuei / Su, Ching-Yuan

Carbon. 2022 Sept., v. 197

2022

Abstract: Lithium metal batteries (LMBs) are suffering from dendrite growth and a low coulombic efficiency (CE) during cycling. The use of the 3D structured current collector as lithium host and an artificial solid-electrolyte interphase (ASEI) layer were both ... ...

Abstract	Lithium metal batteries (LMBs) are suffering from dendrite growth and a low coulombic efficiency (CE) during cycling. The use of the 3D structured current collector as lithium host and an artificial solid-electrolyte interphase (ASEI) layer were both regarded as efficient methods to improve the anode performance. However, the reliable binder-free coating requires a controllable species (LiF) and conformability, which is still challenging. Herein, we propose a dual-functional coating layer that played the role of both lithium deposition host and the ASEI by predepositing fluorinated electrochemically exfoliated graphene (F-ECG) as a modifier on a working electrode in LMBs. With the ultra-strong interface and interlayer adhesion, the as-prepared coating layer could successfully prevent not only the peeling-off issue that usually happened in coating layers of carbon-based materials but also the expansion during charge/discharge cycles. Also, the LiF-rich film is constructed through the reaction of Li ions with the F species from F-ECG, exhibiting homogeneous Li plating/stripping without notable dendrite formation. As a result, the half-cell possesses a low nucleation overpotential (18 mV) and high stability for over 100 cycles with an average CE of 98.3%. The polarization profile shows remarkable performance for up to 250 h. Additionally, a full-cell LMB (NMC\|\|F-ECG) is demonstrated to achieve excellent capacity retention of up to 72% after 70 cycles. The LiF-rich dual-functional coating layer based on F-ECG as a modifier successfully improves the long-term stability of working electrodes, paving the way to realizing potential LMBs.
Keywords	adhesion ; anodes ; electrochemistry ; graphene ; lithium
Language	English
Dates of publication	2022-09
Size	p. 141-151.
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0008-6223
DOI	10.1016/j.carbon.2022.06.023
Database	NAL-Catalogue (AGRICOLA)

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