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Article ; Online: Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major Herbs.

Zhong, Linda Li Dan / Lam, Wai Ching / Yang, Wei / Chan, Kam Wa / Sze, Stephen Cho Wing / Miao, Jiangxia / Yung, Ken Kin Lam / Bian, Zhaoxiang / Wong, Vivian Taam

The American journal of Chinese medicine

2020 Volume 48, Issue 5, Page(s) 1051–1071

Abstract: COVID-19 has been declared a pandemic by WHO on March 11, 2020. No specific treatment and vaccine with documented safety and efficacy for the disease have been established. Hence it is of utmost importance to identify more therapeutics such as Chinese ... ...

Abstract	COVID-19 has been declared a pandemic by WHO on March 11, 2020. No specific treatment and vaccine with documented safety and efficacy for the disease have been established. Hence it is of utmost importance to identify more therapeutics such as Chinese medicine formulae to meet the urgent need. Qing Fei Pai Du Tang (QFPDT), a Chinese medicine formula consisting of 21 herbs from five classical formulae has been reported to be efficacious on COVID-19 in 10 provinces in mainland China. QFPDT could prevent the progression from mild cases and shorten the average duration of symptoms and hospital stay. It has been recommended in the 6th and 7th versions of Clinical Practice Guideline on COVID-19 in China. The basic scientific studies, supported by network pharmacology, on the possible therapeutic targets of QFPDT and its constituent herbs including
MeSH term(s)	Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/history ; Betacoronavirus/drug effects ; Betacoronavirus/physiology ; COVID-19 ; China ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/history ; History, Ancient ; Humans ; Medicine in Literature ; Medicine, Chinese Traditional ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
Chemical Substances	Antiviral Agents ; Drugs, Chinese Herbal
Keywords	covid19
Language	English
Publishing date	2020-05-07
Publishing country	Singapore
Document type	Historical Article ; Journal Article ; Review
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X20500512
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Article: Correction: Effects of Chinese medicine for COVID-19 rehabilitation: a multicenter observational study.

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 120

Language	English
Publishing date	2022-10-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00674-9
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Article: Effects of Chinese medicine for COVID-19 rehabilitation: a multicenter observational study.

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 99

Abstract: Objectives: This study aimed to evaluate the effects of Chinese Medicine (CM) on the health condition of the post-COVID-19 patients, particularly with the CM Syndrome diagnosis and Body Constitutions (BC), as well as related clinical characteristics.: ...

Abstract	Objectives: This study aimed to evaluate the effects of Chinese Medicine (CM) on the health condition of the post-COVID-19 patients, particularly with the CM Syndrome diagnosis and Body Constitutions (BC), as well as related clinical characteristics. Methods: 150 participants who had COVID-19 and discharged from Hong Kong public hospitals were recruited. They were provided with three to six months of CM treatments, during which assessments were made per month and at follow-up on their CM syndromes, BC, lung functions, and other medical conditions. This study was divided into two parts: (1) Retrospective survey: medical history of participants during COVID-19 hospitalization was collected during the baseline visit; (2) Prospective observation and assessments: clinical symptoms, lung functions, and BC status were evaluated in participants receiving CM treatment based on syndrome differentiation and clinical symptoms. Results: The median hospitalization period was 16 days. Symptoms were presented in 145 (96.6%) patients at the day they were diagnosed with COVID-19. Fever, fatigue, and dry cough were the most common symptoms, exhibiting in 59.3% (89 of 150), 55.3% (83 of 150), and 46% (70 of 150) participants, respectively. Among the 150 post-COVID patients, majority (71.3%) were of the two particular post-COVID CM Syndromes (Qi Deficiency of Lung and Spleen, and Qi and Yin Deficiency). Upon CM treatment, there was an observable increase in participants reaching a balanced BC (i.e. healthy body conditions). The increase was observed to be more prominent in those without the particular CM Syndromes compared to those with the CM Syndromes. Main clinical symptoms in participants with the CM Syndromes decreased upon CM treatment. Occurrence of fatigue also dropped after CM treatment though not all accompanied clinical symptoms were resolved fully. Further to the improvement in terms of CM assessments, lung functions of the participants were found to show improvement after treatment. Both the performance in 6MWT and scores in the LFQ improved upon CM treatments (P < 0.05). Conclusion: This study provided evidence for individualized CM treatment on COVID-19 rehabilitation concerning the clinical symptoms improvements, lung functions improvement, and achieving a balanced BC. It is believed that CM may be a key to further promote rehabilitation and resolution of residual symptoms. Long-term large scale follow-up studies on sub-categorising post-COVID patients according to different CM syndromes would be required to further elucidate treatment of persistent symptoms that may be associated with long-COVID.
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00654-z
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Article ; Online: Correction

Chinese Medicine, Vol 17, Iss 1, Pp 1-

Effects of Chinese medicine for COVID-19 rehabilitation: a multicenter observational study

2022 Volume 2

Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of Chinese medicine for COVID-19 rehabilitation

Chinese Medicine, Vol 17, Iss 1, Pp 1-

a multicenter observational study

2022 Volume 24

Abstract: Abstract Objectives This study aimed to evaluate the effects of Chinese Medicine (CM) on the health condition of the post-COVID-19 patients, particularly with the CM Syndrome diagnosis and Body Constitutions (BC), as well as related clinical ... ...

Abstract	Abstract Objectives This study aimed to evaluate the effects of Chinese Medicine (CM) on the health condition of the post-COVID-19 patients, particularly with the CM Syndrome diagnosis and Body Constitutions (BC), as well as related clinical characteristics. Methods 150 participants who had COVID-19 and discharged from Hong Kong public hospitals were recruited. They were provided with three to six months of CM treatments, during which assessments were made per month and at follow-up on their CM syndromes, BC, lung functions, and other medical conditions. This study was divided into two parts: (1) Retrospective survey: medical history of participants during COVID-19 hospitalization was collected during the baseline visit; (2) Prospective observation and assessments: clinical symptoms, lung functions, and BC status were evaluated in participants receiving CM treatment based on syndrome differentiation and clinical symptoms. Results The median hospitalization period was 16 days. Symptoms were presented in 145 (96.6%) patients at the day they were diagnosed with COVID-19. Fever, fatigue, and dry cough were the most common symptoms, exhibiting in 59.3% (89 of 150), 55.3% (83 of 150), and 46% (70 of 150) participants, respectively. Among the 150 post-COVID patients, majority (71.3%) were of the two particular post-COVID CM Syndromes (Qi Deficiency of Lung and Spleen, and Qi and Yin Deficiency). Upon CM treatment, there was an observable increase in participants reaching a balanced BC (i.e. healthy body conditions). The increase was observed to be more prominent in those without the particular CM Syndromes compared to those with the CM Syndromes. Main clinical symptoms in participants with the CM Syndromes decreased upon CM treatment. Occurrence of fatigue also dropped after CM treatment though not all accompanied clinical symptoms were resolved fully. Further to the improvement in terms of CM assessments, lung functions of the participants were found to show improvement after treatment. Both the performance in 6MWT ...
Keywords	Covid-19 ; Rehabilitation ; Observational study ; Chinese Medicine ; Respiratory system ; Lung function ; Other systems of medicine ; RZ201-999
Subject code	150
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Potential Targets for Treatment of Coronavirus Disease 2019 (COVID-19): A Review of Qing-Fei-Pai-Du-Tang and Its Major Herbs

Zhong, Linda Li Dan / Lam, Wai Ching / Yang, Wei / Chan, Kam Wa / Sze, Stephen Cho Wing / Miao, Jiangxia / Yung, Ken Kin Lam / Bian, Zhaoxiang / Wong, Vivian Taam

Am J Chin Med

Abstract	COVID-19 has been declared a pandemic by WHO on March 11, 2020. No specific treatment and vaccine with documented safety and efficacy for the disease have been established. Hence it is of utmost importance to identify more therapeutics such as Chinese medicine formulae to meet the urgent need. Qing Fei Pai Du Tang (QFPDT), a Chinese medicine formula consisting of 21 herbs from five classical formulae has been reported to be efficacious on COVID-19 in 10 provinces in mainland China. QFPDT could prevent the progression from mild cases and shorten the average duration of symptoms and hospital stay. It has been recommended in the 6th and 7th versions of Clinical Practice Guideline on COVID-19 in China. The basic scientific studies, supported by network pharmacology, on the possible therapeutic targets of QFPDT and its constituent herbs including Ephedra sinica, Bupleurum chinense, Pogostemon cablin, Cinnamomum cassia, Scutellaria baicalensis were reviewed. The anti-oxidation, immuno-modulation and antiviral mechanisms through different pathways were collated. Two clusters of actions identified were cytokine storm prevention and angiotensin converting enzyme 2 (ACE2) receptor binding regulation. The multi-target mechanisms of QFPDT for treating viral infection in general and COVID-19 in particular were validated. While large scale clinical studies on QFPDT are being conducted in China, one should use real world data for exploration of integrative treatment with inclusion of pharmacokinetic, pharmacodynamic and herb-drug interaction studies.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #647145
Database	COVID19

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Article: Consensus-based recommendations for case report in Chinese medicine (CARC).

Fu, Shu-Fei / Cheng, Chung-Wah / Zhang, Li / Zhong, Linda Li-Dan / Kun, Wai / Lin, Jia / Zhang, Bo-Li / Wang, Yong-Yan / Shang, Hong-Cai / Bian, Zhao-Xiang

Chinese journal of integrative medicine

2016 Volume 22, Issue 1, Page(s) 73–79

Abstract: Case reports are valuable clinical evidence in traditional Chinese medicine (TCM). However, the general reporting quality is suboptimal. A working group comprising 20 members was set up to develop systematic recommendations on case report in Chinese ... ...

Abstract	Case reports are valuable clinical evidence in traditional Chinese medicine (TCM). However, the general reporting quality is suboptimal. A working group comprising 20 members was set up to develop systematic recommendations on case report in Chinese medicine (CARC). The working group (CARC group) developed a primary checklist based on reviewing the general reporting quality of case reports in TCM and thorough internal discussion. Two-round consensus process had been carried out among clinical experts, evidence-based medicine methodologists, medical journal editors and clinical practitioners with designated questionnaire embedded with the primary checklist. In total, 118 participants from 17 provinces of China and Korea completed the questionnaires. Their feedback was analyzed and discussed by the CARC group. The checklist was amended accordingly, and the final version, comprising 16-item, is presented here. Under the framework of CARC recommendations, the reporting quality of case reports in TCM can be improved.
MeSH term(s)	Consensus ; Female ; Health Planning Guidelines ; Humans ; Male ; Medical Records ; Medicine, Chinese Traditional ; Research Report
Language	English
Publishing date	2016-01
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-015-2121-6
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Article: Urgent need to improve the quality of case report in traditional Chinese medicine: Assessment on reporting quality of 3,417 cases.

Fu, Shu-Fei / Kun, Wai / Zeng, Xiao-Xi / Zhang, Li / Cheng, Chung-Wah / Song, Lisa / Zhong, Linda Li-Dan / Lin, Jia / Wang, Yong-Yan / Shang, Hong-Cai / Bian, Zhao-Xia

Chinese journal of integrative medicine

2016 Volume 22, Issue 6, Page(s) 473–480

Abstract: Objective: To survey the reporting quality of traditional Chinese medicine (TCM) case reports published in recent years and understand the common problems. The assessment results would lay the foundation for the development of recommendations for case ... ...

Abstract	Objective: To survey the reporting quality of traditional Chinese medicine (TCM) case reports published in recent years and understand the common problems. The assessment results would lay the foundation for the development of recommendations for case report in Chinese medicine. Methods: This survey determined the reporting quality of cases with Chinese herbal decoction, Chinese proprietary medicine, acupuncture, moxibustion and other traditional therapies published in 20 core medical journals of China by searching the China Academic Journals Full-text Database from 2006 to 2010. Fifty survey items in 16 domains were used to determine the reporting quality. One point was assigned to each item (Yes=1 point; No=0 point), and total score was 50 points. The domain of treatment was assessed independently, ranging from 2 to 9 items for different TCM interventions. Results: The total of 1,858 case reports, covering 3,417 cases were included to analyze from 13 out of 20 core medical journals of China. There were 74.8% of them did not identify the nature of study in title, while 73.9% did not comprise an abstract. Incomplete reporting was found in discussions/ comment, and only 38.9% had made recommendations or take-away messages. Figures and tables were infrequently used. Three cases cited the full names of patients, but without declaring that any consent was obtained. Over 90% reported the symptoms and signs of TCM, and characteristics on tongue and pulse, but less than 50% did mention other medical history and diagnostic rationale. More than 90% treatments of the included cases were herbal decoction, with clear reporting on the ingredients and dosages. However, the reporting rate of the dosages of each ingredient was just 48.4%. Almost none reported the quality control of crude herbs, manufacturers and lot numbers of herbal proprietary medicine. Besides, advices and precautions on diet, emotions and living were rare to be illustrated. Conclusion: Systematic reporting recommendations are urged to develop for improving the contents and format of case reports in TCM.
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Outcome Assessment (Health Care) ; Periodicals as Topic ; Quality Assurance, Health Care ; Research Report/standards
Language	English
Publishing date	2016-06
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2171254-2
ISSN	1993-0402 ; 1672-0415
ISSN (online)	1993-0402
ISSN	1672-0415
DOI	10.1007/s11655-015-2250-y
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Article ; Online: Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan.

Hu, Dong-Dong / Han, Quan-Bin / Zhong, Linda Li-Dan / Li, Yan-Hong / Lin, Cheng-Yuan / Ho, Hing-Man / Zhang, Man / Lin, Shu-Hai / Zhao, Ling / Huang, Tao / Mi, Hong / Tan, Hong-Sheng / Xu, Hong-Xi / Bian, Zhao-Xiang

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2015 Volume 1000, Page(s) 136–146

Abstract: Ma-Zi-Ren-Wan (MZRW) is a classic Chinese formula which has been used to treat human constipation in China for over 2000 years. In order to make good and rational use of this formula in the future, this paper presents the first attempt to track the ... ...

Abstract	Ma-Zi-Ren-Wan (MZRW) is a classic Chinese formula which has been used to treat human constipation in China for over 2000 years. In order to make good and rational use of this formula in the future, this paper presents the first attempt to track the pharmacokinetic features of MZRW in rat using rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Ten chemical components of MZRW, namely, rhein, emodin, aloe emodin, hesperidin, naringin, amygdalin, albiflorin, paeoniflorin, magnolol and honokiol, were simultaneously determined in rat plasma after a single oral administration (10g/kg body weight) of MZRW to rats. Geniposide and liquiritin were used as internal standards. The separation was performed on a Waters ACQUITY BEH C18 column (100mm×2.1mm, 1.7μm). The detection was conducted by multiple-reaction monitoring (MRM) in negative ionization mode. Two highest abundant MRM transitions without interference were optimized for each analyte. This method was well validated in terms of linearity, precision, accuracy, recovery, matrix effect and stability. All calibration curves had good linearity (r(2)>0.995) over the concentration range from 3.9 to 125.0ng/mL for emodin, 3.9-500.0ng/mL for amygdalin, 2.0-4000.0ng/mL for naringin and hesperidin, 3.9-2000.0ng/mL for magnolol, 7.8-2000.0ng/mL for rhein and 3.9-4000.0ng/mL for albiflorin, paeoniflorin, aloe emodin and honokiol. The intra-day and inter-day precision (relative standard deviation) was within 15%, the accuracy (relative error) ranged from -13.6% to 15.1%, and the lower limit of quantification in plasma ranged between 2.0ng/mL and 7.8ng/mL. Extraction recovery, matrix effect and stability were satisfactory. The validated method was successfully applied to a pharmacokinetic study of these ten compounds after oral administration of MZRW to rats. The pharmacokinetic parameters of each compound can facilitate clinical studies in the future.
MeSH term(s)	Animals ; Anthraquinones/blood ; Anthraquinones/chemistry ; Anthraquinones/pharmacokinetics ; Biphenyl Compounds ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacokinetics ; Flavonoids/blood ; Flavonoids/chemistry ; Flavonoids/pharmacokinetics ; Glycosides/blood ; Glycosides/chemistry ; Glycosides/pharmacokinetics ; Lignans ; Linear Models ; Male ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods
Chemical Substances	Anthraquinones ; Biphenyl Compounds ; Drugs, Chinese Herbal ; Flavonoids ; Glycosides ; Lignans ; magnolol (001E35HGVF) ; honokiol (11513CCO0N)
Language	English
Publishing date	2015-09-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2015.07.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.

Abnet, Christian C / Wang, Zhaoming / Song, Xin / Hu, Nan / Zhou, Fu-You / Freedman, Neal D / Li, Xue-Min / Yu, Kai / Shu, Xiao-Ou / Yuan, Jian-Min / Zheng, Wei / Dawsey, Sanford M / Liao, Linda M / Lee, Maxwell P / Ding, Ti / Qiao, You-Lin / Gao, Yu-Tang / Koh, Woon-Puay / Xiang, Yong-Bing /

Tang, Ze-Zhong / Fan, Jin-Hu / Chung, Charles C / Wang, Chaoyu / Wheeler, William / Yeager, Meredith / Yuenger, Jeff / Hutchinson, Amy / Jacobs, Kevin B / Giffen, Carol A / Burdett, Laurie / Fraumeni, Joseph F / Tucker, Margaret A / Chow, Wong-Ho / Zhao, Xue-Ke / Li, Jiang-Man / Li, Ai-Li / Sun, Liang-Dan / Wei, Wu / Li, Ji-Lin / Zhang, Peng / Li, Hong-Lei / Cui, Wen-Yan / Wang, Wei-Peng / Liu, Zhi-Cai / Yang, Xia / Fu, Wen-Jing / Cui, Ji-Li / Lin, Hong-Li / Zhu, Wen-Liang / Liu, Min / Chen, Xi / Chen, Jie / Guo, Li / Han, Jing-Jing / Zhou, Sheng-Li / Huang, Jia / Wu, Yue / Yuan, Chao / Huang, Jing / Ji, Ai-Fang / Kul, Jian-Wei / Fan, Zhong-Min / Wang, Jian-Po / Zhang, Dong-Yun / Zhang, Lian-Qun / Zhang, Wei / Chen, Yuan-Fang / Ren, Jing-Li / Li, Xiu-Min / Dong, Jin-Cheng / Xing, Guo-Lan / Guo, Zhi-Gang / Yang, Jian-Xue / Mao, Yi-Ming / Yuan, Yuan / Guo, Er-Tao / Hou, Zhi-Chao / Liu, Jing / Li, Yan / Tang, Sa / Chang, Jia / Peng, Xiu-Qin / Han, Min / Yin, Wan-Li / Liu, Ya-Li / Hu, Yan-Long / Liu, Yu / Yang, Liu-Qin / Zhu, Fu-Guo / Yang, Xiu-Feng / Feng, Xiao-Shan / Wang, Zhou / Li, Yin / Gao, She-Gan / Liu, Hai-Lin / Yuan, Ling / Jin, Yan / Zhang, Yan-Rui / Sheyhidin, Ilyar / Li, Feng / Chen, Bao-Ping / Ren, Shu-Wei / Liu, Bin / Li, Dan / Zhang, Gao-Fu / Yue, Wen-Bin / Feng, Chang-Wei / Qige, Qirenwang / Zhao, Jian-Ting / Yang, Wen-Jun / Lei, Guang-Yan / Chen, Long-Qi / Li, En-Min / Xu, Li-Yan / Wu, Zhi-Yong / Bao, Zhi-Qin / Chen, Ji-Li / Li, Xian-Chang / Zhuang, Xiang / Zhou, Ying-Fa / Zuo, Xian-Bo / Dong, Zi-Ming / Wang, Lu-Wen / Fan, Xue-Pin / Wang, Jin / Zhou, Qi / Ma, Guo-Shun / Zhang, Qin-Xian / Liu, Hai / Jian, Xin-Ying / Lian, Sin-Yong / Wang, Jin-Sheng / Chang, Fu-Bao / Lu, Chang-Dong / Miao, Jian-Jun / Chen, Zhi-Guo / Wang, Ran / Guo, Ming / Fan, Zeng-Lin / Tao, Ping / Liu, Tai-Jing / Wei, Jin-Chang / Kong, Qing-Peng / Fan, Lei / Wang, Xian-Zeng / Gao, Fu-Sheng / Wang, Tian-Yun / Xie, Dong / Wang, Li / Chen, Shu-Qing / Yang, Wan-Cai / Hong, Jun-Yan / Wang, Liang / Qiu, Song-Liang / Goldstein, Alisa M / Yuan, Zhi-Qing / Chanock, Stephen J / Zhang, Xue-Jun / Taylor, Philip R / Wang, Li-Dong

Human molecular genetics

2012 Volume 21, Issue 9, Page(s) 2132–2141

Abstract: Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously ... ...

Abstract	Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P< 5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.29 (1.19-1.40) and P= 7.63 × 10(-10). An imputation analysis of 4304 SNPs at 2q33 suggested a single association signal, and the strongest imputed SNP associations were similar to those from the genotyped SNPs. We conducted an ancestral recombination graph analysis with 53 SNPs to identify one or more haplotypes that harbor the variants directly responsible for the detected association signal. This showed that the five SNPs exist in a single haplotype along with 45 imputed SNPs in strong linkage disequilibrium, and the strongest candidate was rs10201587, one of the genotyped SNPs. Our meta-analysis found genome-wide significant SNPs at 2q33 that map to the CASP8/ALS2CR12/TRAK2 gene region. Variants in CASP8 have been extensively studied across a spectrum of cancers with mixed results. The locus we identified appears to be distinct from the widely studied rs3834129 and rs1045485 SNPs in CASP8. Future studies of esophageal and other cancers should focus on comprehensive sequencing of this 2q33 locus and functional analysis of rs13016963 and rs10201587 and other strongly correlated variants.
MeSH term(s)	Asian Continental Ancestry Group/genetics ; Carcinoma, Squamous Cell/genetics ; China ; Chromosomes, Human, Pair 10/genetics ; Chromosomes, Human, Pair 2/genetics ; Esophageal Neoplasms/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Genome-Wide Association Study ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide ; Recombination, Genetic
Language	English
Publishing date	2012-02-08
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/dds029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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