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Article ; Online: New prebiotics by ketone donation.

Satoh, Takumi

Trends in endocrinology and metabolism: TEM

2023 Volume 34, Issue 7, Page(s) 414–425

Abstract: Integrity of the microbiome is an essential element for human gut health. 3-Hydroxybutyrate (3HB) secreted into the gut lumen has gained attention as a regulator of gut physiology, including stem cell expansion. In this opinion, I propose new prebiotics ... ...

Abstract	Integrity of the microbiome is an essential element for human gut health. 3-Hydroxybutyrate (3HB) secreted into the gut lumen has gained attention as a regulator of gut physiology, including stem cell expansion. In this opinion, I propose new prebiotics leading to gut health by use of a ketone (3HB) donor. When exogenous 3HB is supplied through ketone donation, it has the potential to markedly improve gut health by altering the gut microbiome and systemic metabolic status. Poly-hydroxybutyrate (PHB) donates 3HB and primarily influences microbiota, making it an effective prebiotic for improving the gut environment. Thus, exogenous 3HB donation to the lumen of the gut may aid gut health by maintaining the integrity of microbiome.
MeSH term(s)	Humans ; Prebiotics ; Hydroxybutyrates/metabolism ; 3-Hydroxybutyric Acid/metabolism ; Microbiota ; Gastrointestinal Microbiome
Chemical Substances	Prebiotics ; Hydroxybutyrates ; 3-Hydroxybutyric Acid (TZP1275679)
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2023.05.001
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Article ; Online: Bird evolution by insulin resistance.

Satoh, Takumi

Trends in endocrinology and metabolism: TEM

2021 Volume 32, Issue 10, Page(s) 803–813

Abstract: Drift of oxygen concentrations in the atmosphere was one of the main drivers of the evolution of vertebrates. The drop in oxygen concentrations at the Permian-Triassic (PT) boundary may have been the biggest challenge to vertebrates. This hypoxic ... ...

Abstract	Drift of oxygen concentrations in the atmosphere was one of the main drivers of the evolution of vertebrates. The drop in oxygen concentrations at the Permian-Triassic (PT) boundary may have been the biggest challenge to vertebrates. This hypoxic condition forced theropods to lose certain genes to maximize their efficiency of oxygen usage. Recent studies show that omentin and insulin-sensitive glucose transporter 4 (GLUT4) are missing in the bird genome. Since these gene products play essential roles in maintaining insulin sensitivity, this loss forced theropods to become insulin resistant. Insulin resistance may have been the key to allowing theropods to become hyperathletic under hypoxic conditions and to outcompete mammals during the Triassic period. A second challenge was the gradual increase in oxygen concentrations during the late Jurassic, Cretaceous, and Tertiary periods when reactive oxygen species (ROS) leakage from mitochondria became a problem. Since the simplest solution was the expansion of body size, some theropods became bigger to reduce ROS leakage per volume. Another solution was the development of a constitutively active countermeasure against ROS. A recent study shows that Neoaves have constitutively active nuclear factor erythroid 2-related factor 2 (NRF2) due to deletion of the C-terminal part of the KEAP1 protein, thus allowing Neoaves to express antioxidant enzymes to overcome ROS leakage.
MeSH term(s)	Animals ; Birds/metabolism ; Humans ; Insulin Resistance/genetics ; Insulins ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Oxygen ; Reactive Oxygen Species/metabolism
Chemical Substances	Insulins ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Oxygen (S88TT14065)
Language	English
Publishing date	2021-08-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1042384-9
ISSN	1879-3061 ; 1043-2760
ISSN (online)	1879-3061
ISSN	1043-2760
DOI	10.1016/j.tem.2021.07.007
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Article: Pharmacokinetic Analysis of Zonarol, a Marine Algal Hydroquinone, in Mice Using HPLC with Fluorescence Detection.

Fei, Jiyao / Yamada, Sohsuke / Satoh, Takumi / Koyama, Tomoyuki

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Zonarol, which was discovered in the brown ... ...

Abstract	Zonarol, which was discovered in the brown algae
Language	English
Publishing date	2023-06-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12061013
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Article ; Online: Effects of psychogenic stress on oxidative stress and antioxidant capacity at different growth stages of rats: Experimental study.

Lee, Sangun / Itagaki, Atsunori / Satoh, Atsuko / Sugimoto, Issei / Saito, Takumi / Shibukawa, Yoshihiko / Tatehana, Haruka

PloS one

2024 Volume 19, Issue 4, Page(s) e0287421

Abstract: This study examined the psychogenic stress (PS) effects on changes in oxidative stress and the antioxidant capacity of an organism at different growth stages. The experimental animals were male Wistar rats of five different ages from growth periods (GPs) ...

Abstract	This study examined the psychogenic stress (PS) effects on changes in oxidative stress and the antioxidant capacity of an organism at different growth stages. The experimental animals were male Wistar rats of five different ages from growth periods (GPs) to old age. The growth stages were randomly classified into control (C) and experimental (PS) groups. The PS was performed using restraint and water immersion once daily for 3 h for 4 weeks. Reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) were measured before and after the experiment. In addition, the liver and adrenal glands were removed, and the wet weight was measured. The d-ROM and BAP of all growth stages given PS increased significantly. The d-ROM in the C group without PS increased significantly in GPs while decreased significantly in old-aged rats. In addition, the BAP of the C group in GP and early adulthood were all significantly elevated. There were significant differences in organ weights between the C and PS groups at all growth stages. Oxidative stress and antioxidant capacity differed depending on the organism's developmental status and growth stage, and PS also showed different effects. In particular, the variability in oxidative stress was remarkable, suggesting that the effect of PS was more significant in the organism's immature organs.
MeSH term(s)	Animals ; Oxidative Stress ; Antioxidants/metabolism ; Male ; Rats, Wistar ; Rats ; Stress, Psychological/metabolism ; Reactive Oxygen Species/metabolism ; Liver/metabolism ; Organ Size ; Adrenal Glands/metabolism ; Adrenal Glands/growth & development
Chemical Substances	Antioxidants ; Reactive Oxygen Species
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0287421
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome.

Satoh, Takumi / Trudler, Dorit / Oh, Chang-Ki / Lipton, Stuart A

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 1

Abstract: Rosemary ( ...

Abstract	Rosemary (
Language	English
Publishing date	2022-01-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11010124
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Article: Relationship between muscle echo intensity on ultrasound and isokinetic strength of the three superficial quadriceps femoris muscles in healthy young adults.

Yamauchi, Tomoyuki / Yamada, Takumi / Satoh, Yoshinao

Journal of physical therapy science

2021 Volume 33, Issue 4, Page(s) 334–338

Abstract: Purpose] The purpose of this study was to clarify the relationship between muscle echo intensity measured with ultrasound and the isokinetic strength of each of the three superficial quadriceps femoris muscles in healthy young adults. [Participants and ... ...

Abstract	[Purpose] The purpose of this study was to clarify the relationship between muscle echo intensity measured with ultrasound and the isokinetic strength of each of the three superficial quadriceps femoris muscles in healthy young adults. [Participants and Methods] We measured the echo intensity of the three superficial muscles of the quadriceps femoris in 25 healthy adults (10 males and 15 females; mean age, 22.3 years) using ultrasound. Moreover, we obtained the maximum force during isokinetic knee extension at 60°/s using an isokinetic dynamometer. [Results] In males and females, a significant negative correlation between echo intensity and muscle strength was found in the VM (r=-0.65 and r=-0.63, respectively). [Conclusion] In both males and females, only the muscle echo intensity of the vastus medialis was found to have a negative correlation with the maximum force during isokinetic knee extension at 60°/s. Our data lay the foundation for simplifying and rationally performing the measurement of muscle echo intensity of the quadriceps femoris. And it would therefore be sufficient to only measure the VM to clarify a relationship between EI and maximum isokinetic force in the quadriceps.
Language	English
Publishing date	2021-04-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2038898-6
ISSN	0915-5287
ISSN	0915-5287
DOI	10.1589/jpts.33.334
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Article: Pulmonary artery pressure-perfusion relation during exercise in patients with chronic thromboembolic pulmonary hypertension using pulmonary arteriography and right-heart catheterization.

Goda, Ayumi / Takeuchi, Kaori / Kikuchi, Hanako / Inami, Takumi / Kohno, Takashi / Soejima, Kyoko / Satoh, Toru

International journal of cardiology. Heart & vasculature

2023 Volume 48, Page(s) 101252

Abstract: Background: In pulmonary hypertension (PH), pulmonary artery pressure (PAP) does not increase to pulmonary perfusion (PP) ... 50% for the early detection of PP disorders. The relationship between PP ... ...

Abstract	Background: In pulmonary hypertension (PH), pulmonary artery pressure (PAP) does not increase to pulmonary perfusion (PP) < 50%. During exercise, PAP may be increased even at PP > 50% for the early detection of PP disorders. The relationship between PP estimated by pulmonary angiography (PAG) and PAP was evaluated in patients with chronic thromboembolic PH (CTEPH) treated by balloon pulmonary angioplasty with near-normal PH. Methods: Thirty-one patients (age 60 ± 11 years) with CTEPH underwent catheterization at rest and during exercise. Each segmental PP was determined by visualization of its segmental pulmonary artery and graded from 0 to 3 in the PAG. PP was estimated as the percentage PAG (%PAG) score-%summed total of all segmental PP/the full score-54. Results: The mean PAP (mPAP) increased from 28 ± 6 mmHg to 46 ± 10 mmHg during exercise. Transpulmonary pressure gradient, the value of mPAP with the pulmonary artery wedge pressure substituted at peak exercise, was negatively correlated with %PAG score (rs = -0.56, p < 0.001) and elevated at > 50% PP. Conclusions: The PAP-PP relationship at peak exercise was correlated, shifting from the relationship at rest, and the PAP started to rise with PP > 50%.
Language	English
Publishing date	2023-08-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2818464-6
ISSN	2352-9067
ISSN	2352-9067
DOI	10.1016/j.ijcha.2023.101252
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Article ; Online: Transition from Intravenous Epoprostenol to Treprostinil Due to Intolerable Side Effects in Patients With Pulmonary Arterial Hypertension.

Kikuchi, Hanako / Goda, Ayumi / Takeuchi, Kaori / Inami, Takumi / Kohno, Takashi / Soejima, Kyoko / Satoh, Toru

The American journal of cardiology

2023 Volume 206, Page(s) 31–34

Abstract: Intravenous epoprostenol improves exercise capacity and survival in patients with pulmonary arterial hypertension (PAH); however, it has side effects. Reviewing the side effects associated with epoprostenol and treprostinil is essential for improving the ...

Abstract	Intravenous epoprostenol improves exercise capacity and survival in patients with pulmonary arterial hypertension (PAH); however, it has side effects. Reviewing the side effects associated with epoprostenol and treprostinil is essential for improving the long-term treatment strategies for PAH. This retrospective review included patients with PAH who transitioned from intravenous epoprostenol to intravenous treprostinil owing to intolerable side effects, including high cardiac output symptoms, ascites, and thrombocytopenia. Of the 85 patients who received epoprostenol at our hospital between 2013 and 2021, 16 (11 women), with a median age of 33 (range 26 to 40) years (including 12 with idiopathic PAH, 3 with hereditary PAH, and 1 with connective tissue disease pulmonary hypertension), had to switch from intravenous epoprostenol to treprostinil owing to the side effects. After transitioning, epoprostenol-associated intolerable side effects, such as high cardiac output symptoms, ascites, and thrombocytopenia, were ameliorated. In conclusion, for patients with PAH who have intolerable side effects from epoprostenol and have difficulty in continuing treatment, switching from epoprostenol to treprostinil may be an option. Switching treatment leads to better adherence and improved long-term prostacyclin therapy.
MeSH term(s)	Humans ; Female ; Adult ; Epoprostenol/adverse effects ; Antihypertensive Agents/therapeutic use ; Pulmonary Arterial Hypertension/drug therapy ; Ascites ; Cardiac Output, High/chemically induced ; Cardiac Output, High/drug therapy ; Thrombocytopenia
Chemical Substances	treprostinil (RUM6K67ESG) ; Epoprostenol (DCR9Z582X0) ; Antihypertensive Agents
Language	English
Publishing date	2023-09-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2023.08.078
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Article ; Online: Distinct spatiotemporal distribution of Hsp90 under high-heat and mild-heat stress conditions in fission yeast.

Takasaki, Teruaki / Tomimoto, Naofumi / Ikehata, Takumi / Satoh, Ryosuke / Sugiura, Reiko

microPublication biology

2021 Volume 2021

Abstract: The molecular chaperone Hsp90 is highly conserved from bacteria to mammals. In fission yeast, Hsp90 is essential in many cellular processes and its expression is known to be increased by heat stress (HS). Here, we describe the distinct spatiotemporal ... ...

Abstract	The molecular chaperone Hsp90 is highly conserved from bacteria to mammals. In fission yeast, Hsp90 is essential in many cellular processes and its expression is known to be increased by heat stress (HS). Here, we describe the distinct spatiotemporal distribution of Hsp90 under high-heat stress (HHS: 45˚C) and mild-heat stress (MHS: 37˚C). Hsp90 is largely distributed in the cytoplasm under non-stressed conditions (27˚C). Under HHS, Hsp90 forms several cytoplasmic granules within 5 minutes, then the granules disappear within 60 minutes. Under MHS, Hsp90 forms fewer granules than under HHS within 5 minutes and strikingly the granules persist and grow in size. In addition, nuclear enrichment of Hsp90 was observed after 60 minutes under both HS conditions. Our data suggest that assembly/disassembly of Hsp90 granules is differentially regulated by temperatures.
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000388
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Article ; Online: Successful Management and Risk Stratification by Exercise Right Heart Catheterization Before Pregnancy in a Patient With Pulmonary Arterial Hypertension.

Yanagisawa, Yoshiaki / Goda, Ayumi / Takeuchi, Shinsuke / Takeuchi, Kaori / Kikuchi, Hanako / Inami, Takumi / Tanigaki, Shinji / Kohno, Takashi / Soejima, Kyoko / Satoh, Toru

CJC open

2023 Volume 5, Issue 4, Page(s) 312–314

Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Case Reports
ISSN	2589-790X
ISSN (online)	2589-790X
DOI	10.1016/j.cjco.2023.01.004
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