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  1. Article ; Online: Potential Use of Radiolabeled Antibodies for Imaging and Treatment of COVID-19.

    Dadachova, Ekaterina

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2021  Volume 62, Issue 7, Page(s) 1020

    MeSH term(s) COVID-19 ; Diagnostic Imaging ; Humans ; Immunoconjugates ; Radioimmunotherapy ; SARS-CoV-2
    Chemical Substances Immunoconjugates
    Language English
    Publishing date 2021-05-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.120.261874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  2. Article ; Online: Melanin - protecting and enhancing the earliest life on Earth: Comment on "Insoluble organic matter in chondrites: Archetypal melanin-like PAH-based multifunctionality at the origin of life?" by Marco d'Ischia et al.

    Dadachova, Ekaterina

    Physics of life reviews

    2021  Volume 38, Page(s) 127–128

    MeSH term(s) Earth, Planet ; Melanins ; Meteoroids
    Chemical Substances Melanins
    Language English
    Publishing date 2021-05-27
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Comment
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2021.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Radioimmunotherapy for the treatment of infectious diseases: a comprehensive update.

    Carvalho, Jorge Luis Costa / Dadachova, Ekaterina

    Expert review of anti-infective therapy

    2023  Volume 21, Issue 4, Page(s) 365–374

    Abstract: Introduction: Corona Virus Disease of 2019 (COVID-19) pandemic has renewed interest in monoclonal antibodies for treating infectious diseases. During last two decades experimental data has been accumulated showing the potential of radioimmunotherapy ( ... ...

    Abstract Introduction: Corona Virus Disease of 2019 (COVID-19) pandemic has renewed interest in monoclonal antibodies for treating infectious diseases. During last two decades experimental data has been accumulated showing the potential of radioimmunotherapy (RIT) of infectious diseases. In addition, COVID-19 pandemic has created a novel landscape for opportunistic fungal infections in post-COVID-19 patients resulting from severe immune suppression.
    Areas covered: We analyze recent results on targeting "pan-antigens" shared by fungal pathogens in mouse models and in healthy dogs; on developing RIT of prosthetic joint infections (PJI); examine RIT as potential human immunodeficiency virus (HIV) cure strategy and analyze its mechanisms and safety. Literature review was performed using PubMed and Google Scholar and includes relevant articles from 2000 to 2022.
    Expert opinion: Some of the RIT of infection applications can, hopefully, be moved into the clinic earlier than others after preclinical development: (1) RIT of opportunistic fungal infections might contribute to saving lives as current antifungal drugs do not work in severely immunocompromised patients; (2) RIT of patients with PJI. Success of RIT in these patients will allow to expand the application of RIT to other similarly vulnerable patients' populations such as cancer patients with weakened immune system and organ transplant recipients.
    MeSH term(s) Mice ; Humans ; Animals ; Dogs ; Radioimmunotherapy/methods ; Pandemics ; COVID-19 ; Mycoses ; Communicable Diseases/therapy
    Language English
    Publishing date 2023-03-02
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2023.2184345
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6106: Show issues Location:
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  4. Article ; Online: Future Vistas in Alpha Therapy of Infectious Diseases.

    Dadachova, Ekaterina

    Journal of medical imaging and radiation sciences

    2019  Volume 50, Issue 4 Suppl 1, Page(s) S49–S52

    MeSH term(s) Alpha Particles/therapeutic use ; Bacterial Infections/radiotherapy ; Communicable Diseases/radiotherapy ; HIV Infections/radiotherapy ; Humans ; Mycoses/radiotherapy ; Opportunistic Infections/radiotherapy ; Radioimmunotherapy/methods ; Radioimmunotherapy/trends
    Keywords covid19
    Language English
    Publishing date 2019-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2019.06.052
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2541: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives.

    Dadachova, Ekaterina / Rangel, Drauzio E N

    Frontiers in medicine

    2022  Volume 9, Page(s) 819702

    Abstract: COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging ... ...

    Abstract COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging modalities has always played an important role in diagnosis of infections and distinguishing them from the sterile inflammation. In addition to the clinically available radiopharmaceuticals there has been a decades-long effort to develop more specific imaging agents with some examples being radiolabeled antibiotics and antimicrobial peptides for bacterial imaging, radiolabeled anti-fungals for fungal infections imaging, radiolabeled pathogen-specific antibodies and molecular engineered constructs. In this opinion piece, we would like to discuss some examples of the work published in the last decade on developing nuclear imaging agents for bacterial, fungal, and viral infections in order to generate more interest among nuclear medicine community toward conducting clinical trials of these novel probes, as well as toward developing novel radiotracers for imaging infections.
    Language English
    Publishing date 2022-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.819702
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  6. Article ; Online: Targeted Radionuclide Therapy of Cancer and Infections.

    van der Wal, Bart C H / Dadachova, Ekaterina

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Targeted radionuclide therapy (TRT) has been burgeoning worldwide, with several radiopharmaceuticals for the treatment of metastatic cancers being approved for clinical use [ ... ]. ...

    Abstract Targeted radionuclide therapy (TRT) has been burgeoning worldwide, with several radiopharmaceuticals for the treatment of metastatic cancers being approved for clinical use [...].
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Radiopharmaceuticals/therapeutic use ; Neoplasms, Second Primary/drug therapy ; Radioisotopes/therapeutic use
    Chemical Substances Radiopharmaceuticals ; Radioisotopes
    Language English
    Publishing date 2023-05-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24109081
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  7. Article ; Online: Antibody-Mediated Depletion of Autoreactive T Lymphocytes through PD-1 Improves Disease Outcomes and Visualizes T Cell Activation in Experimental Autoimmune Encephalomyelitis.

    Frank, Connor / Salapa, Hannah E / Allen, Kevin J H / Levin, Michael C / Dawicki, Wojciech / Dadachova, Ekaterina

    Journal of immunology (Baltimore, Md. : 1950)

    2024  

    Abstract: Long-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target ... ...

    Abstract Long-term therapeutic outcomes of multiple sclerosis (MS) remain hindered by the chronic nature of immune cell stimulation toward self-antigens. Development of novel methods to target and deplete autoreactive T lymphocytes remains an attractive target for therapeutics for MS. We developed a programmed cell death 1 (PD-1)-targeted radiolabeled mAb and assessed its ability to deplete activated PD-1+ T lymphocytes in vitro and its ability to reduce disease burden of the myelin oligodendrocyte glycoprotein 35-55 experimental autoimmune encephalomyelitis (EAE) model in C57BL/6 mice. We also investigated the upregulation of PD-1 on infiltrating lymphocytes in an animal model of MS. Finally, we demonstrate the (to our knowledge) first reported positron-emission tomography/computed tomography imaging of activated PD-1+ cells in the EAE animal model of MS. We found that the 177Lu radioisotope-labeled anti-PD-1 mAb demonstrated significant in vitro cytotoxicity toward activated CD4+PD-1+ T lymphocytes and led to significant reduction in overall disease progression in the EAE animal model. Our results show high expression of PD-1 on infiltrating lymphocytes in the spinal cords of EAE diseased animals. Positron-emission tomography/computed tomography imaging of the anti-PD-1 mAb demonstrated significant uptake in the cervical draining lymph nodes highlighting accumulation of activated lymphocytes. Targeted depletion of T lymphocytes using T cell activation markers such as PD-1 may present a novel method to reduce autoimmune attack and inflammation in autoimmune diseases such as MS. Development of multimodal nuclear theranostic agents may present the opportunity to monitor T cell activation via imaging radioisotopes and simultaneously treat MS using therapeutic radioisotopes.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300751
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  8. Article ; Online: Highlights of the Latest Developments in Radiopharmaceuticals for Infection Imaging and Future Perspectives

    Ekaterina Dadachova / Drauzio E. N. Rangel

    Frontiers in Medicine, Vol

    2022  Volume 9

    Abstract: COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging ... ...

    Abstract COVID-19 pandemic has heightened the interest toward diagnosis and treatment of infectious diseases. Nuclear medicine with its powerful scintigraphic, single photon emission computer tomography (SPECT) and positron emission tomography (PET) imaging modalities has always played an important role in diagnosis of infections and distinguishing them from the sterile inflammation. In addition to the clinically available radiopharmaceuticals there has been a decades-long effort to develop more specific imaging agents with some examples being radiolabeled antibiotics and antimicrobial peptides for bacterial imaging, radiolabeled anti-fungals for fungal infections imaging, radiolabeled pathogen-specific antibodies and molecular engineered constructs. In this opinion piece, we would like to discuss some examples of the work published in the last decade on developing nuclear imaging agents for bacterial, fungal, and viral infections in order to generate more interest among nuclear medicine community toward conducting clinical trials of these novel probes, as well as toward developing novel radiotracers for imaging infections.
    Keywords infection imaging ; antibiotics ; anti-fungals ; antimicrobial peptides ; antibodies ; HIV ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Characterization of IGF2R Molecular Expression in Canine Osteosarcoma as Part of a Novel Comparative Oncology Approach.

    Boisclair, Charles / Dickinson, Ryan / Giri, Sabeena / Dadachova, Ekaterina / MacDonald-Dickinson, Valerie

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Progress in prognostic factors, treatments, and outcome for both canine and human osteosarcoma (OS) has been minimal over the last three decades. Surface overexpression of the cation independent mannose-6-phosphate/insulin-like growth factor receptor ... ...

    Abstract Progress in prognostic factors, treatments, and outcome for both canine and human osteosarcoma (OS) has been minimal over the last three decades. Surface overexpression of the cation independent mannose-6-phosphate/insulin-like growth factor receptor type 2 (IGF2R) has been proven to occur in human OS cells. Subsequently, radioimmunotherapy (RIT) targeting IGF2R has demonstrated promising preliminary results. The main aims of this study were to investigate the expression of IGF2R in spontaneously occurring canine OS cells using immunohistochemistry (IHC) on archived biopsy samples and to assess its prognostic significance. Thirty-four dogs were included in the study. All cases showed that 80-100% of OS cells stained positive for IGF2R. IGF2R overexpression alone was not shown to have prognostic significance using both visual and quantitative methods of IHC staining intensity. This study has established for the first time the consistent expression of IGF2R in spontaneously occurring canine OS. This comparative oncology approach will allow further investigation into RIT as a novel treatment modality; first in canines and then in humans with OS. In addition, further studies should be performed to assess the true prognostic significance of IGF2R overexpression.
    MeSH term(s) Animals ; Dogs ; Humans ; Bone Neoplasms/genetics ; Bone Neoplasms/veterinary ; Bone Neoplasms/metabolism ; Osteosarcoma/genetics ; Osteosarcoma/veterinary ; Osteosarcoma/metabolism ; Protein Binding ; Receptor, IGF Type 2/genetics ; Receptor, IGF Type 2/metabolism
    Chemical Substances Receptor, IGF Type 2
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031867
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  10. Article ; Online: Targeting Melanin in Melanoma with Radionuclide Therapy.

    Allen, Kevin J H / Malo, Mackenzie E / Jiao, Rubin / Dadachova, Ekaterina

    International journal of molecular sciences

    2022  Volume 23, Issue 17

    Abstract: Nearly 100,000 individuals are expected to be diagnosed with melanoma in the United States in 2022. Treatment options for late-stage metastatic disease up until the 2010s were few and offered only slight improvement to the overall survival. The ... ...

    Abstract Nearly 100,000 individuals are expected to be diagnosed with melanoma in the United States in 2022. Treatment options for late-stage metastatic disease up until the 2010s were few and offered only slight improvement to the overall survival. The introduction of B-RAF inhibitors and anti-CTLA4 and anti-PD-1/PD-L1 immunotherapies into standard of care brought measurable increases in the overall survival across all stages of melanoma. Despite the improvement in the survival statistics, patients treated with targeted therapies and immunotherapies are subject to very serious side effects, the development of drug resistance, and the high costs of treatment. This leaves room for the development of novel approaches as well as for the exploration of novel combination therapies for the treatment of metastatic melanoma. One such approach is targeting melanin pigment with radionuclide therapy. Advances in melanin-targeting radionuclide therapy of melanoma can be viewed from two spheres: (1) radioimmunotherapy (RIT) and (2) radiolabeled small molecules. The investigation of mechanisms of the action and efficacy of targeting melanin in melanoma treatment by RIT points to the involvement of the immune system such as complement dependent cytotoxicity. The combination of RIT with immunotherapy presents synergistic killing in mouse melanoma models. The field of radiolabeled small molecules is focused on radioiodinated compounds that have the ability to cross the cellular membranes to access intracellular melanin and can be applied in both therapy and imaging as theranostics. Clinical applications of targeting melanin with radionuclide therapies have produced encouraging results and clinical work is on-going. Continued work on targeting melanin with radionuclide therapy as a monotherapy, or possibly in combination with standard of care agents, has the potential to strengthen the current treatment options for melanoma patients.
    MeSH term(s) Animals ; Immunotherapy ; Melanins ; Melanoma/radiotherapy ; Mice ; Radioimmunotherapy/methods ; Radioisotopes/therapeutic use
    Chemical Substances Melanins ; Radioisotopes
    Language English
    Publishing date 2022-08-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23179520
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