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  1. Article: Potential Zoonotic Origins of SARS-CoV-2 and Insights for Preventing Future Pandemics Through One Health Approach.

    Konda, Muralikrishna / Dodda, Balasunder / Konala, Venu Madhav / Naramala, Srikanth / Adapa, Sreedhar

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8932

    Abstract: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Zoonotic diseases are infections that are transmitted from animals ...

    Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Zoonotic diseases are infections that are transmitted from animals to humans. COVID-19 caused by SARS-CoV-2 most likely originated in bats and transmitted to humans through a possible intermediate host. Based on published research so far, pangolins are considered the most likely intermediate hosts. Further studies are needed on different wild animal species, including pangolins that are sold at the same wet market or similar wet markets before concluding pangolins as definitive intermediate hosts. SARS-CoV-2 is capable of reverse zoonosis as well. Additional research is needed to understand the pathogenicity of the virus, especially in companion animals, modes of transmission, incubation period, contagious period, and zoonotic potential. Interdisciplinary one health approach handles these mosaic issues of emerging threats by integrating professionals from multiple disciplines like human medicine, veterinary medicine, environmental health, and social sciences. Given that the future outbreak of zoonotic diseases is inevitable, importance must be given for swift identification of the pathogen, source, and transmission methods. Countries should invest in identifying the hot spots for the origin of zoonotic diseases, enhance diagnostic capabilities, and rapid containment measures at local, regional, and national levels. The threat posed by emerging infectious diseases in modern-days also needs combined efforts internationally where a single discipline or nation cannot handle the burden alone.
    Keywords covid19
    Language English
    Publishing date 2020-06-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Potential Zoonotic Origins of SARS-CoV-2 and Insights for Preventing Future Pandemics Through One Health Approach

    Konda, Muralikrishna / Dodda, Balasunder / Konala, Venu Madhav / Naramala, Srikanth / Adapa, Sreedhar

    Cureus

    Abstract: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Zoonotic diseases are infections that are transmitted from animals ... ...

    Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Zoonotic diseases are infections that are transmitted from animals to humans COVID-19 caused by SARS-CoV-2 most likely originated in bats and transmitted to humans through a possible intermediate host Based on published research so far, pangolins are considered the most likely intermediate hosts Further studies are needed on different wild animal species, including pangolins that are sold at the same wet market or similar wet markets before concluding pangolins as definitive intermediate hosts SARS-CoV-2 is capable of reverse zoonosis as well Additional research is needed to understand the pathogenicity of the virus, especially in companion animals, modes of transmission, incubation period, contagious period, and zoonotic potential Interdisciplinary one health approach handles these mosaic issues of emerging threats by integrating professionals from multiple disciplines like human medicine, veterinary medicine, environmental health, and social sciences Given that the future outbreak of zoonotic diseases is inevitable, importance must be given for swift identification of the pathogen, source, and transmission methods Countries should invest in identifying the hot spots for the origin of zoonotic diseases, enhance diagnostic capabilities, and rapid containment measures at local, regional, and national levels The threat posed by emerging infectious diseases in modern-days also needs combined efforts internationally where a single discipline or nation cannot handle the burden alone
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #696018
    Database COVID19

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  3. Article ; Online: Effects of lactate on beef heart mitochondrial oxygen consumption and muscle darkening.

    Ramanathan, Ranjith / Mancini, Richard A / Konda, Muralikrishna Reddy

    Journal of agricultural and food chemistry

    2009  Volume 57, Issue 4, Page(s) 1550–1555

    Abstract: The mechanism of lactate-induced beef color darkening is unclear. Our objective was to evaluate the ability of mitochondria isolated from bovine cardiac muscle to utilize lactate as a fuel for respiration. Addition of lactate (4, 8, and 16 mM) to ... ...

    Abstract The mechanism of lactate-induced beef color darkening is unclear. Our objective was to evaluate the ability of mitochondria isolated from bovine cardiac muscle to utilize lactate as a fuel for respiration. Addition of lactate (4, 8, and 16 mM) to isolated bovine cardiac mitochondria resulted in state IV oxygen consumption at pH 7.2 and 25 degrees C measured using a Clark oxygen electrode. Combining mitochondria with lactate, LDH, and NAD increased state IV oxygen consumption compared with that of lactate alone (p < 0.05). Moreover, oxygen consumption resulting from the addition of lactate-LDH-NAD (0.2 mM each) was comparable to oxygen consumption resulting from the direct addition of NADH (0.2 mM) to mitochondria at pH 7.2. Rotenone reduced (p < 0.05) lactate-mediated darkening in bovine cardiac muscle homogenates. Lactate-induced beef color darkening may be due to increased oxygen consumption by mitochondria, which out-competes myoglobin for oxygen and results in dark colored muscle.
    MeSH term(s) Animals ; Cattle ; Color ; Lactic Acid/pharmacology ; Meat ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Myocardium/chemistry ; Myocardium/metabolism ; Myoglobin/metabolism ; Oxygen Consumption/drug effects ; Rotenone/pharmacology
    Chemical Substances Myoglobin ; Rotenone (03L9OT429T) ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2009-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/jf802933p
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Audio / Video: Effects of Lactate on Beef Heart Mitochondrial Oxygen Consumption and Muscle Darkening

    Ramanathan, Ranjith / Mancini, Richard A / Konda, Muralikrishna Reddy

    Journal of agricultural and food chemistry. 2009 Feb. 25, v. 57, no. 4

    2009  

    Abstract: The mechanism of lactate-induced beef color darkening is unclear. Our objective was to evaluate the ability of mitochondria isolated from bovine cardiac muscle to utilize lactate as a fuel for respiration. Addition of lactate (4, 8, and 16 mM) to ... ...

    Abstract The mechanism of lactate-induced beef color darkening is unclear. Our objective was to evaluate the ability of mitochondria isolated from bovine cardiac muscle to utilize lactate as a fuel for respiration. Addition of lactate (4, 8, and 16 mM) to isolated bovine cardiac mitochondria resulted in state IV oxygen consumption at pH 7.2 and 25 °C measured using a Clark oxygen electrode. Combining mitochondria with lactate, LDH, and NAD increased state IV oxygen consumption compared with that of lactate alone (p < 0.05). Moreover, oxygen consumption resulting from the addition of lactate-LDH-NAD (0.2 mM each) was comparable to oxygen consumption resulting from the direct addition of NADH (0.2 mM) to mitochondria at pH 7.2. Rotenone reduced (p < 0.05) lactate-mediated darkening in bovine cardiac muscle homogenates. Lactate-induced beef color darkening may be due to increased oxygen consumption by mitochondria, which out-competes myoglobin for oxygen and results in dark colored muscle.
    Keywords beef cattle ; heart ; food additives ; lactic acid ; myocardium ; postmortem changes ; mitochondria ; oxygen consumption ; color ; beef quality ; lactate dehydrogenase ; NAD (coenzyme)
    Language English
    Dates of publication 2009-0225
    Size p. 1550-1555.
    Document type Article ; Audio / Video
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/jf802933p
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1185: Show issues

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  5. Article: Effects of lactate on ground lamb colour stability and mitochondria-mediated metmyoglobin reduction

    Ramanathan, Ranjith / Mancini, Richard A / Joseph, Poulson / Yin, Shuang / Tatiyaborworntham, Nantawat / Petersson, Katherine H / Sun, Qun / Konda, Muralikrishna R

    Food chemistry. 2011 May 1, v. 126, no. 1

    2011  

    Abstract: Previous research suggests that lactate’s colour stabilizing effect in beef is through NADH production and antioxidant activity. However, no research has assessed lactate’s role in lamb colour. Hence, our objectives were to evaluate the effects of ... ...

    Abstract Previous research suggests that lactate’s colour stabilizing effect in beef is through NADH production and antioxidant activity. However, no research has assessed lactate’s role in lamb colour. Hence, our objectives were to evaluate the effects of lactate on lamb surface discolouration, oxygen consumption, and metmyoglobin reduction. In experiment 1, lactate (final meat concentration=2.5%w/w) was added to ground lamb (n=20 carcasses) and patties were stored for 3days at 1°C in PVC packaging. Surface colour (CIE L∗ and a∗) and metmyoglobin reducing activity of ground lamb patties were measured. Addition of lactate improved colour stability and metmyoglobin reducing activity (p<0.05). In experiment 2, mitochondria were isolated from lamb longissimus muscle (n=3). Addition of lactate–LDH–NAD to mitochondria resulted in significant oxygen consumption and metmyoglobin reduction compared with mitochondrial controls without lactate (p<0.05). Lactate can improve the colour stability of lamb, possibly by increasing metmyoglobin reducing activity.
    Keywords NAD (coenzyme) ; antioxidant activity ; beef ; color ; discoloration ; lactates ; lambs ; longissimus muscle ; meat carcasses ; mitochondria ; oxygen consumption ; patties
    Language English
    Dates of publication 2011-0501
    Size p. 166-171.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2010.10.093
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  6. Article: Potential Zoonotic Origins of SARS-CoV-2 and Insights for Preventing Future Pandemics Through One Health Approach. LID - e8932

    Konda, M. / Dodda, B. / Konala, V. M. / Naramala, S. / Adapa, S.

    Cureus

    Abstract: ... Konda, Muralikrishna ...

    Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Zoonotic diseases are infections that are transmitted from animals to humans COVID-19 caused by SARS-CoV-2 most likely originated in bats and transmitted to humans through a possible intermediate host Based on published research so far, pangolins are considered the most likely intermediate hosts Further studies are needed on different wild animal species, including pangolins that are sold at the same wet market or similar wet markets before concluding pangolins as definitive intermediate hosts SARS-CoV-2 is capable of reverse zoonosis as well Additional research is needed to understand the pathogenicity of the virus, especially in companion animals, modes of transmission, incubation period, contagious period, and zoonotic potential Interdisciplinary one health approach handles these mosaic issues of emerging threats by integrating professionals from multiple disciplines like human medicine, veterinary medicine, environmental health, and social sciences Given that the future outbreak of zoonotic diseases is inevitable, importance must be given for swift identification of the pathogen, source, and transmission methods Countries should invest in identifying the hot spots for the origin of zoonotic diseases, enhance diagnostic capabilities, and rapid containment measures at local, regional, and national levels The threat posed by emerging infectious diseases in modern-days also needs combined efforts internationally where a single discipline or nation cannot handle the burden alone FAU - Konda, Muralikrishna
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #854602
    Database COVID19

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