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  1. Article ; Online: Role of coronary computed tomography angiography to optimise percutaneous coronary intervention outcomes.

    Bouisset, Frederic / Ohashi, Hirofumi / Andreini, Daniele / Collet, Carlos

    Heart (British Cardiac Society)

    2023  

    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2023-322889
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Histopathologically confirmed intraplaque haemorrhage in a patient with unstable angina.

    Ohashi, Hirofumi / Ando, Hirohiko / Otsuka, Fumiyuki / Takashima, Hiroaki / Amano, Tetsuya

    European heart journal. Cardiovascular Imaging

    2022  Volume 23, Issue 4, Page(s) e165

    MeSH term(s) Angina, Unstable/diagnostic imaging ; Angina, Unstable/etiology ; Hemorrhage/diagnostic imaging ; Hemorrhage/etiology ; Humans
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeab295
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    Zs.A 5614: Show issues Location:
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  3. Article: Solicitation matters: Cultural differences in solicited and unsolicited support provision.

    Hashimoto, Hirofumi / Ohashi, Takuma / Yamaguchi, Susumu

    Frontiers in psychology

    2022  Volume 13, Page(s) 953260

    Abstract: Two studies aimed to examine cultural differences in social support provision, with or without solicitation, in Japan and the United States (US). In Study 1, we replicated a previous study with Japanese university students. We found that the Japanese ... ...

    Abstract Two studies aimed to examine cultural differences in social support provision, with or without solicitation, in Japan and the United States (US). In Study 1, we replicated a previous study with Japanese university students. We found that the Japanese participants did not provide social support when it was not solicited, as compared with when it was solicited. Furthermore, in Study 2, participants were asked to respond to a questionnaire regarding a hypothetical stressful situation experienced by a close other and to indicate their willingness to provide support. We confirmed our hypothesis that Japanese participants hesitate to provide unsolicited support to close others (such as family members or close friends), even when they recognize that the close others are in need, whereas the American participants do not hesitate to provide such support. Contrastingly, regarding solicited support, the Japanese and Americans were equally ready to provide support, as hypothesized. The cultural difference in social support resides in the provision of unsolicited support. These results suggest that differences in culturally appropriate responses to needy people are responsible for the difference in the provision of unsolicited vs. solicited social support.
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.953260
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  4. Article ; Online: Survey on experiences and attitudes of parents toward disclosing information to children with genetic syndromes and their siblings in Japan.

    Kaneko, Mikiko / Oba, Daiju / Ohashi, Hirofumi

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 15234

    Abstract: Many parents face the dilemma of when, how, and what to disclose to their children regarding their genetic conditions. The purpose of this study was to learn about the experiences of parents regarding disclosing information to their children with genetic ...

    Abstract Many parents face the dilemma of when, how, and what to disclose to their children regarding their genetic conditions. The purpose of this study was to learn about the experiences of parents regarding disclosing information to their children with genetic conditions. A questionnaire was sent to 378 parents of children and adolescents with the following genetic syndromes: 22q11.2 deletion syndrome, Beckwith-Wiedemann syndrome, Noonan syndrome, Russell-Silver syndrome, Kabuki syndrome, Williams syndrome, Prader-Willi syndrome, and Sotos syndrome. Findings were analyzed using descriptive statistics for multiple-choice questions. Of the parents surveyed, 158 (41.8%) responded to the questionnaires. The average age of children with genetic syndromes was 12 years. Sixty-seven parents had disclosed relevant information to their children, whereas 91 had not. Among them (who had disclosed information), out of 53 respondents who answered that their affected child had siblings, 50 had disclosed the genetic condition of the affected child to the siblings as well. Sixty-eight out of 91 respondents who had not told information to affected child were planning to disclose the information in the future. Many respondents who had disclosed information did not regret this. They felt good talking about genetic conditions, and had talked about genetic conditions with the affected children following disclosure. This study contributed to our understanding of the attitudes of parents towards disclosing information to children with genetic syndromes.
    MeSH term(s) Adolescent ; Child ; Disclosure ; Humans ; Japan ; Parents ; Siblings ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-19447-3
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  5. Article ; Online: Antiviral Activity of Micafungin and Its Derivatives against SARS-CoV-2 RNA Replication.

    Nakajima, Shogo / Ohashi, Hirofumi / Akazawa, Daisuke / Torii, Shiho / Suzuki, Rigel / Fukuhara, Takasuke / Watashi, Koichi

    Viruses

    2023  Volume 15, Issue 2

    Abstract: Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin ...

    Abstract Echinocandin antifungal drugs, including micafungin, anidulafungin, and caspofungin, have been recently reported to exhibit antiviral effects against various viruses such as flavivirus, alphavirus, and coronavirus. In this study, we focused on micafungin and its derivatives and analyzed their antiviral activities against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The micafungin derivatives Mi-2 and Mi-5 showed higher antiviral activity than micafungin, with 50% maximal inhibitory concentration (IC
    MeSH term(s) Humans ; Antiviral Agents/pharmacology ; COVID-19 ; Micafungin/pharmacology ; RNA Replication ; RNA, Viral ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Micafungin (R10H71BSWG) ; RNA, Viral
    Language English
    Publishing date 2023-02-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15020452
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  6. Article ; Online: Myocardial Infarction After Negative Invasive Physiological Assessment: Role of Atherosclerotic Phenotype and Translesional Pressure Gradient.

    Bouisset, Frederic / Lochy, Stijn / Vandeloo, Bert / Ohashi, Hirofumi / Tanaka, Kaoru / Rizzini, Maurizio Lodi / Collet, Carlos

    JACC. Cardiovascular interventions

    2023  Volume 16, Issue 11, Page(s) 1418–1419

    MeSH term(s) Humans ; Treatment Outcome ; Myocardial Infarction ; Atherosclerosis
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2023.02.028
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    Zs.A 6669: Show issues Location:
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  7. Article ; Online: A Small-for-Gestational-Age Infant with MIRAGE Syndrome Who Developed Heat Stroke and Rhabdomyolysis due to Severe Temperature Instability.

    Saito, Kana / Nakagawa, Ryota / Narumi, Satoshi / Ohashi, Hirofumi / Ishiguro, Akiko / Kabe, Kazuhiko

    Neonatology

    2023  Volume 120, Issue 3, Page(s) 390–394

    Abstract: MIRAGE syndrome is characterized by myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, and enteropathy. This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a ... ...

    Abstract MIRAGE syndrome is characterized by myelodysplasia, infection, restriction of growth, adrenal hypoplasia, genital phenotypes, and enteropathy. This report describes heat stroke and rhabdomyolysis caused by anhidrosis as a symptom of MIRAGE syndrome in a small-for-gestational-age (SGA) female neonate born at 32 weeks of gestation (birth weight, 911 g [-3.8 SD]). She developed severe temperature instability with anhidrosis, growth failure, mild developmental delay, hypothyroidism, and intractable enteropathy. On day 156, her temperature reached 42.0°C; her fever persisted for 2 h with prolonged irritability. Her serum creatine kinase level increased to a peak value of 12,716 (normal range, 43-321) IU/L. The clinical feature was diagnosed as rhabdomyolysis caused by heat stroke, which resulted from physical exertion with anhidrosis. Her SAMD9 variant was c.2945G>A, p. (Arg982His). Neonatologists should be aware of MIRAGE syndrome as a differential diagnosis of SGA with temperature instability.
    MeSH term(s) Humans ; Infant, Newborn ; Female ; Hypohidrosis ; Temperature ; Adrenal Insufficiency/genetics ; Infant, Small for Gestational Age ; Fetal Growth Retardation ; Heat Stroke ; Rhabdomyolysis/complications ; Rhabdomyolysis/diagnosis ; Intracellular Signaling Peptides and Proteins
    Chemical Substances SAMD9 protein, human ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2266911-5
    ISSN 1661-7819 ; 1661-7800
    ISSN (online) 1661-7819
    ISSN 1661-7800
    DOI 10.1159/000529762
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    Zs.A 391: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article: Bilateral Recurrent Laryngeal Nerve Paralysis Manifesting as Long COVID.

    Okuda, Hiroshi / Kunieda, Chikako / Shibata, Hirofumi / Ohashi, Toshimitsu / Ogawa, Takenori

    Cureus

    2022  Volume 14, Issue 8, Page(s) e27792

    Abstract: Management with ventilation is used for severe cases of coronavirus disease 2019 (COVID-19). After extubation, recurrent laryngeal nerve paralysis due to various factors may occur. Almost all cases of paralysis develop unilaterally; however, bilateral ... ...

    Abstract Management with ventilation is used for severe cases of coronavirus disease 2019 (COVID-19). After extubation, recurrent laryngeal nerve paralysis due to various factors may occur. Almost all cases of paralysis develop unilaterally; however, bilateral recurrent laryngeal nerve paralysis occurs rarely. Such cases may be fatal due to upper air obstruction, and patients are forced to adhere to restrictions after a tracheotomy. The present case illustrates bilateral recurrent laryngeal nerve paralysis that occurred 48 hours after withdrawal from the ventilator. A 75-year-old woman with a history of hypertension came to our hospital with a history of fever and cough for five days. She was diagnosed with pneumonia due to COVID-19 via polymerase chain reaction using her saliva, and ground-glass opacity was found in both lung fields on chest X-ray and computed tomography (CT). Mechanical ventilation, steroids, remdesivir, and baricitinib were administered. The patient's fever and oxygenation status improved with these treatments, and she was weaned from the ventilator on the eighth day of hospitalization. She had no symptoms immediately. However, 48 hours after extubation, bilateral recurrent laryngeal nerve paralysis was suspected. Thus, oral intubation was immediately introduced and a tracheostomy was performed. Vocal cord movement disorders continued for eight weeks, and during that period, the patient displayed hoarseness and suffered from dysphagia. We considered that nerve disorders from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in addition to the compression by the endotracheal tube, caused bilateral recurrent laryngeal nerve paralysis. The neural injury by SARS-CoV-2 may prolong and manifest as "Long COVID."
    Language English
    Publishing date 2022-08-08
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.27792
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  9. Article ; Online: Metabolic profiling analysis of head and neck squamous cell carcinoma.

    Ohashi, Toshimitsu / Terazawa, Kosuke / Shibata, Hirofumi / Inoue, Norimitsu / Ogawa, Takenori

    Oral diseases

    2022  Volume 30, Issue 2, Page(s) 342–352

    Abstract: Objective: Tumor cells can acquire a large amount of energy and structural components by reprogramming energy metabolism; moreover, metabolic profiles slightly differ according to cancer type. This study compared and assessed the metabolic profile of ... ...

    Abstract Objective: Tumor cells can acquire a large amount of energy and structural components by reprogramming energy metabolism; moreover, metabolic profiles slightly differ according to cancer type. This study compared and assessed the metabolic profile of head and neck squamous cell carcinoma (HNSCC) and normal tissues, which were collected from patients without cancer.
    Subjects and methods: Overall, 23 patients with HNSCC and 6 patients without cancer were included in the analysis. Metabolomic profiles were analyzed using capillary electrophoresis-mass spectrometry. Gene expression was evaluated using real-time reverse transcription-polymerase chain reaction.
    Results: Glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle, and glutamine metabolism were upregulated in HNSCC tissues based on gene expression analysis. HNSCC could then have enhanced energy production and structural component. The levels of lactate, succinate, glutathione, 2-hydroxyglutarate, and S-adenosylmethionine, considered as oncometabolites, increased and these had accumulated in HNSCC tissues.
    Conclusions: The level of metabolites and the expression of enzymes differ between HNSCC and normal tissues. Reprogramming metabolism in HNSCC provides an energy source as well as structural components, creating a system that offers rapid proliferation, progression, and is less likely to be eliminated.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/genetics ; Metabolomics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
    Language English
    Publishing date 2022-11-28
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14432
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4427: Show issues Location:
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  10. Article ; Online: Immune-modified Glasgow prognostic score: A new prognostic marker for head and neck cancer.

    Terazawa, Kosuke / Ohashi, Toshimitsu / Shibata, Hirofumi / Ishihara, Takuma / Ogawa, Takenori

    Head & neck

    2022  Volume 44, Issue 11, Page(s) 2555–2563

    Abstract: Background: The modified Glasgow prognostic score (mGPS) includes C-reactive protein and serum albumin levels and is a useful prognostic tool for malignant tumors. The immune system affects cancer progression and recurrence and treatment response. We ... ...

    Abstract Background: The modified Glasgow prognostic score (mGPS) includes C-reactive protein and serum albumin levels and is a useful prognostic tool for malignant tumors. The immune system affects cancer progression and recurrence and treatment response. We hypothesized that increasing the lymphocyte count improves mGPS, and we created a new prognostic marker termed immune-mGPS (imGPS).
    Methods: This study included 461 patients with head and neck squamous cell carcinoma (HNSCC). The imGPS was calculated as the conventional mGPS with one additional point for a low lymphocyte count (<1250/μL).
    Results: Addition of the lymphocyte count to mGPS significantly increased the area under the time-dependent receiver operating characteristic curve for overall and progression-free survivals. The added predictive abilities of this tool were supported by improvement in both net reclassification and integrated discrimination.
    Conclusion: imGPS is a more accurate predictor of clinical outcome in patients with HNSCC than mGPS.
    MeSH term(s) C-Reactive Protein/metabolism ; Head and Neck Neoplasms/therapy ; Humans ; Prognosis ; Retrospective Studies ; Serum Albumin/metabolism ; Squamous Cell Carcinoma of Head and Neck/therapy
    Chemical Substances Serum Albumin ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27170
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    Zs.A 1493: Show issues Location:
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