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  1. Article ; Online: Redefining the biological and pathophysiological role of dimethylarginine dimethylaminohydrolase 2.

    Nair, Pramod C / Mangoni, Arduino A / Rodionov, Roman N

    Trends in molecular medicine

    2024  

    Abstract: The enzyme dimethylarginine dimethylaminohydrolase (DDAH) 1 metabolizes asymmetric dimethylarginine (ADMA), a critical endogenous cardiovascular risk factor. In the past two decades, there has been significant controversy about whether DDAH2, the other ... ...

    Abstract The enzyme dimethylarginine dimethylaminohydrolase (DDAH) 1 metabolizes asymmetric dimethylarginine (ADMA), a critical endogenous cardiovascular risk factor. In the past two decades, there has been significant controversy about whether DDAH2, the other DDAH isoform, is also able to directly metabolize ADMA. There has been evidence that DDAH2 regulates several critical processes involved in cardiovascular and immune homeostasis. However, the molecular mechanisms underpinning these effects are unclear. In this opinion, we discuss the previous and current knowledge of ADMA metabolism by DDAH in light of a recent consortium study, which convincingly demonstrated that DDAH2 is not capable of metabolizing ADMA, unlike DDAH1. Thus, further research in this field is needed to uncover the molecular mechanisms of DDAH2 and its role in various disorders.
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phosphodiesterase-5 Inhibitors and Survival in Men With Coronary Artery Disease.

    Maas, Renke / Rodionov, Roman N

    Journal of the American College of Cardiology

    2021  Volume 77, Issue 12, Page(s) 1551–1553

    MeSH term(s) Coronary Artery Disease/drug therapy ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Erectile Dysfunction ; Humans ; Male ; Phosphodiesterase 5 Inhibitors ; Sildenafil Citrate
    Chemical Substances Phosphodiesterase 5 Inhibitors ; Sildenafil Citrate (BW9B0ZE037) ; Cyclic Nucleotide Phosphodiesterases, Type 5 (EC 3.1.4.35)
    Language English
    Publishing date 2021-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2021.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Evaluation of the Value of Histological Examination for the Prediction of Genetic Thoracic Proximal Aortopathies.

    Mahlmann, Adrian / Rodionov, Roman N / Behrendt, Christian-Alexander / Leip, Jennifer Lynne / Lackner, Helmut Karl / Eraqi, Mohamed / Elzanaty, Nesma / Ghazy, Tamer

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071838
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  4. Article ; Online: Correction: COVID-19 and Therapeutic Apheresis.

    Tselmin, Sergey / Julius, Ulrich / Jarzebska, Natalia / Rodionov, Roman N

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 8, Page(s) e5

    Language English
    Publishing date 2022-09-02
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1930-9384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 and Therapeutic Apheresis.

    Tselmin, Sergey / Julius, Ulrich / Jarzebska, Natalia / Rodionov, Roman N

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 8, Page(s) 571–577

    Abstract: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is an unprecedented challenge for the global community. The pathogenesis of COVID-19, its complications and long term sequelae (so called Long/Post-COVID) include, in addition to the direct virus- ... ...

    Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is an unprecedented challenge for the global community. The pathogenesis of COVID-19, its complications and long term sequelae (so called Long/Post-COVID) include, in addition to the direct virus-induced tissues injury, multiple secondary processes, such as autoimmune response, impairment of microcirculation, and hyperinflammation. Similar pathological processes, but in the settings of neurological, cardiovascular, rheumatological, nephrological, and dermatological diseases can be successfully treated by powerful methods of Therapeutic Apheresis (TA). We describe here the rationale and the initial attempts of TA treatment in severe cases of acute COVID-19. We next review the evidence for the role of autoimmunity, microcirculatory changes and inflammation in pathogenesis of Long/Post COVID and the rationale for targeting those pathogenic processes by different methods of TA. Finally, we discuss the impact of COVID-19 pandemic on patients, who undergo regular TA treatments due to their underlying chronic conditions, with the specific focus on the patients with inherited lipid diseases being treated at the Dresden University Apheresis Center.
    MeSH term(s) Blood Component Removal ; COVID-19/complications ; COVID-19/therapy ; Humans ; Microcirculation ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-08-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1864-9482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Correction: COVID-19 and Therapeutic Apheresis

    Tselmin, Sergey / Julius, Ulrich / Jarzebska, Natalia / Rodionov, Roman N.

    Hormone and Metabolic Research

    2022  Volume 54, Issue 08, Page(s) e5–e5

    Language English
    Publishing date 2022-08-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1930-9384
    Database Thieme publisher's database

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  7. Article ; Online: Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.

    Kozlova, Alena A / Vaganova, Anastasia N / Rodionov, Roman N / Gainetdinov, Raul R / Bernhardt, Nadine

    International journal of molecular sciences

    2022  Volume 23, Issue 19

    Abstract: The contribution of nitric oxide synthases (NOSs) to the pathophysiology of several neuropsychiatric disorders is recognized, but the role of their regulators, dimethylarginine dimethylaminohydrolases (DDAHs), is less understood. This study's objective ... ...

    Abstract The contribution of nitric oxide synthases (NOSs) to the pathophysiology of several neuropsychiatric disorders is recognized, but the role of their regulators, dimethylarginine dimethylaminohydrolases (DDAHs), is less understood. This study's objective was to estimate DDAH1 and DDAH2 associations with biological processes implicated in major psychiatric disorders using publicly accessible expression databases. Since co-expressed genes are more likely to be involved in the same biologic processes, we investigated co-expression patterns with DDAH1 and DDAH2 in the dorsolateral prefrontal cortex in psychiatric patients and control subjects. There were no significant differences in DDAH1 and DDAH2 expression levels in schizophrenia or bipolar disorder patients compared to controls. Meanwhile, the data suggest that in patients, DDAH1 and DDHA2 undergo a functional shift mirrored in changes in co-expressed gene patterns. This disarrangement appears in the loss of expression level correlations between DDAH1 or DDAH2 and genes associated with psychiatric disorders and reduced functional similarity of DDAH1 or DDAH2 co-expressed genes in the patient groups. Our findings evidence the possible involvement of DDAH1 and DDAH2 in neuropsychiatric disorder development, but the underlying mechanisms need experimental validation.
    MeSH term(s) Amidohydrolases/genetics ; Amidohydrolases/metabolism ; Arginine/metabolism ; Biological Products ; Humans ; Mental Disorders/genetics ; Nitric Oxide/metabolism ; Nitric Oxide Synthase
    Chemical Substances Biological Products ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F) ; Nitric Oxide Synthase (EC 1.14.13.39) ; Amidohydrolases (EC 3.5.-) ; dimethylargininase (EC 3.5.3.18)
    Language English
    Publishing date 2022-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms231911902
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  8. Article ; Online: Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets.

    Vaganova, Anastasia N / Shemyakova, Taisiia S / Lenskaia, Karina V / Rodionov, Roman N / Steenblock, Charlotte / Gainetdinov, Raul R

    Biomolecules

    2023  Volume 13, Issue 11

    Abstract: Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ... ...

    Abstract Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are involved in the pathogenesis of this disorder. Trace amine-associated receptor 1 (TAAR1) is expressed in endocrine organs, and it was revealed that TAAR1 may regulate insulin secretion in pancreatic islet β-cells. For instance, accumulating data demonstrate the positive effect of TAAR1 agonists on the dynamics of metabolic syndrome progression and MetS-associated disease development. The role of other TAARs (TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9) in the islet's function is much less studied. In this review, we summarize the evidence of TAARs' contribution to the metabolic syndrome pathogenesis and regulation of insulin secretion in pancreatic islets. Additionally, by the analysis of public transcriptomic data, we demonstrate that TAAR1 and other TAAR receptors are expressed in the pancreatic islets. We also explore associations between the expression of TAARs mRNA and other genes in studied samples and demonstrate the deregulation of TAARs' functional associations in patients with metabolic diseases compared to healthy donors.
    MeSH term(s) Humans ; Metabolic Syndrome/metabolism ; Insulin Secretion ; Amines/metabolism ; Signal Transduction ; Islets of Langerhans/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Amines ; TAAR5 protein, human ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-11-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13111618
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  9. Article ; Online: SARS-CoV-2-specicific humoral immunity in convalescent patients with mild COVID-19 is supported by CD4

    Odendahl, Marcus / Endler, Iris / Haubold, Beate / Rodionov, Roman N / Bornstein, Stefan R / Tonn, Torsten

    Immunology letters

    2022  Volume 251-252, Page(s) 38–46

    Abstract: This study aimed at investigating the nature of SARS-CoV-2-specific immunity in patients with mild COVID-19 and sought to identify parameters most relevant for the generation of neutralizing antibody responses in convalescent COVID-19 patients. In the ... ...

    Abstract This study aimed at investigating the nature of SARS-CoV-2-specific immunity in patients with mild COVID-19 and sought to identify parameters most relevant for the generation of neutralizing antibody responses in convalescent COVID-19 patients. In the majority of the examined patients a cellular as well as humoral immune response directed to SARS-CoV-2 was detected. The finding of an anti-SARS-CoV-2-reactive cellular immune response in healthy individuals suggests a pre-existing immunity to various common cold HCoVs which share close homology with SARS-CoV-2. The humoral immunity to the S protein of SARS-CoV-2 detected in convalescent COVID-19 patients correlates with the presence of SARS-CoV-2-reactive CD4
    MeSH term(s) Humans ; Antibodies, Viral/blood ; CD4-Positive T-Lymphocytes/immunology ; COVID-19/immunology ; Immunity, Humoral ; Immunoglobulin G/blood ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-09-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2022.09.007
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  10. Article: mRNA Levels of Epithelial and Mesenchymal Markers in Lung Epithelial Cell Lines.

    Karetnikova, Ekaterina Sergeevna / Jarzebska, Natalia / Rodionov, Roman Nikolaevich / Rubets, Elena / Markov, Alexander Georgievich / Spieth, Peter Markus

    Reports of biochemistry & molecular biology

    2024  Volume 12, Issue 2, Page(s) 211–219

    Abstract: Background: Epithelial-mesenchymal transition (EMT) is an important physiologic process that determines the outcome of lung tissue healing after injury. Stimuli and molecular cascades inducing EMT lead to up-regulation of the mesenchymal-specific genes ... ...

    Abstract Background: Epithelial-mesenchymal transition (EMT) is an important physiologic process that determines the outcome of lung tissue healing after injury. Stimuli and molecular cascades inducing EMT lead to up-regulation of the mesenchymal-specific genes in the alveolar epithelial cells and to down-regulation of the genes coding for epithelial markers. Alveolar epithelial cell lines are commonly used as in vitro models to study processes occurring in the lung tissue. The aim of this study is to quantify and compare mRNA expression levels of epithelial and mesenchymal markers in a number of lung epithelial cell lines.
    Methods: Lung epithelial cell lines L2, R3/1 and RLE-6TN were cultured. Repeated mRNA isolation, reverse transcription, and quantitative PCR with primers to epithelial (E-cadherin, occludin, and ZO-2) and mesenchymal (α-SMA, collagen III, and vimentin) markers were performed.
    Results: First, our study revealed a higher level of epithelial transcripts in the RLE-6TN cell line compared to L2 and R3/1 cells. Secondly, we have found simultaneous mRNA expression of both epithelial (E-cadherin, occludin and ZO-2) and mesenchymal (α-SMA, collagen III and vimentin) markers in all cell lines studied.
    Conclusions: Our data indicate that at the transcriptional level the L2, R3/1, and RLE-6TN cell lines are at one of the intermediate stages of EMT, which opens new possibilities for the study of EMT on cell lines. Determination of the direction of changes in epithelial and mesenchymal markers will make it possible to establish the factors responsible for both EMT and reverse mesenchymal-epithelial transition.
    Language English
    Publishing date 2024-01-22
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2743890-9
    ISSN 2322-3480
    ISSN 2322-3480
    DOI 10.61186/rbmb.12.2.211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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