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Article: Evaluation of Implementation and Effectiveness of China's Antibiotic Stewardship in the First Affiliated Hospital of Sun Yat-sen University.

Zheng, Nianzhen / Li, Jian / Liu, Yang / Liao, Kang / Chen, Jie / Zhang, Chengcheng / Wen, Weiping

2023 Volume 12, Issue 4

Abstract: Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation ...

Abstract	Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China's antibiotic stewardship to improve and promote antimicrobial stewardship nationwide. The general surgery department of the study hospital was utilized to examine surgical site infection, and samples from across the hospital were used to identify bloodstream infection. Data was analyzed using descriptive analysis, the Mann-Kendall trend test, logit model and panel data model, and
Language	English
Publishing date	2023-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12040770
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Article ; Online: A Flexible Carbon Nanotube Sen-Memory Device.

Qu, Ting-Yu / Sun, Yun / Chen, Mao-Lin / Liu, Zhi-Bo / Zhu, Qian-Bing / Wang, Bing-Wei / Zhao, Tian-Yang / Liu, Chi / Tan, Jun / Qiu, Song / Li, Qing-Wen / Han, Zheng / Wang, Wei / Cheng, Hui-Ming / Sun, Dong-Ming

Advanced materials (Deerfield Beach, Fla.)

2020 Volume 32, Issue 9, Page(s) e1907288

Abstract: ... called "sen-memory", that exhibits the dual functionality of sensing and memory in a monolithic ...

Abstract	In a modern electronics system, charge-coupled devices and data storage devices are the two most indispensable components. Although there has been rapid and independent progress in their development during the last three decades, a cofunctionality of both sensing and memory at single-unit level is yet premature for flexible electronics. For wearable electronics that work in ultralow power conditions and involve strains, conventional sensing-and-memory systems suffer from low sensitivity and are not able to directly transform sensed information into sufficient memory. Here, a new transformative device is demonstrated, which is called "sen-memory", that exhibits the dual functionality of sensing and memory in a monolithic integrated circuit. The active channel of the device is formed by a carbon nanotube thin film and the floating gate is formed by a controllably oxidized aluminum nanoparticle array for electrical- and optical-programming. The device exhibits a high on-off current ratio of ≈10
Language	English
Publishing date	2020-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.201907288
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Article ; Online: The PROFILE of assessment program for internal medicine internship of Sun Yat-Sen University.

Yang, Da-Ya / Zhang, Kun-Song / Hou, Xun / Feng, Shao-Ting / Li, Hui-Yan / Liao, Xin-Xue / Liu, Jun / Kuang, Ming

Medical teacher

2018 Volume 41, Issue 5, Page(s) 603–605

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Clinical Competence ; Educational Measurement/methods ; Humans ; Internal Medicine/education ; Internship and Residency ; Problem-Based Learning ; Program Evaluation ; Schools, Medical ; Students, Medical
Language	English
Publishing date	2018-11-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424426-6
ISSN	1466-187X ; 0142-159X
ISSN (online)	1466-187X
ISSN	0142-159X
DOI	10.1080/0142159X.2018.1510177
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Article: Innovative Variance Corrected Sen’s Trend Test on Persistent Hydrometeorological Data

Wang, Wenpeng / Chen, Yuanfang / Liu, Bo / Zhao, Xu / Zhu, Yuelong

Water. 2019 Oct. 12, v. 11, no. 10

2019

Abstract: ... from the assumption of independence used by many statistical methods. A recently proposed Sen’s trend test claimed ... into the variance of the trend test statistic, whereby an innovative variance-corrected Sen’s trend test is ... corrected Sen’s trend test can effectively restore the inflated trend significance back to its nominal state ...

Abstract	Trend detection in observations helps one to identify anthropogenic forces on natural hydrological and climatic systems. Hydrometeorological data are often persistent over time that deviates from the assumption of independence used by many statistical methods. A recently proposed Sen’s trend test claimed to be free of this problem and thereby received widespread attention. However, both theoretical derivation and stochastic simulation of the current study implies that persistence inflates the trend significance, leading to false trends. To tackle this problem, we incorporate the feature of persistence into the variance of the trend test statistic, whereby an innovative variance-corrected Sen’s trend test is developed. Two theoretical variances of the trend test statistic are newly derived to account for short-term and long-term persistent behavior. The original variance for independent data is also corrected because of its negative bias. A stepwise procedure, including steps to specify the underlying persistent behavior and to test trend with new statistic, is outlined for performing the new test on factual data. Variance-corrected Sen’s trend test can effectively restore the inflated trend significance back to its nominal state. This study may call for the reassessment of published results of the original Sen’s trend test on data with persistence.
Keywords	hydrometeorology ; statistical analysis ; variance
Language	English
Dates of publication	2019-1012
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w11102119
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Article ; Online: Burnout and study engagement among medical students at Sun Yat-sen University, China: A cross-sectional study.

Liu, Hongchun / Yansane, Alfa Ibrahim / Zhang, Yurong / Fu, Haijun / Hong, Nanrui / Kalenderian, Elsbeth

Medicine

2018 Volume 97, Issue 15, Page(s) e0326

Abstract: This study aims to investigate burnout and study engagement among medical students at Sun Yat-sen ... University, China.A cross-sectional survey was conducted among undergraduate medical students of Sun Yat-sen ...

Abstract	This study aims to investigate burnout and study engagement among medical students at Sun Yat-sen University, China.A cross-sectional survey was conducted among undergraduate medical students of Sun Yat-sen University, China. A total of 453 undergraduate students completed a self-administered, structured questionnaire between January and February, 2016. Burnout and study engagement were measured using the Maslach Burnout Inventory-Student Survey (MBI-SS) and the UTRECHT Work Engagement Scale-Students (UWES-S), respectively. Subjects who scored high in emotional exhaustion subscale, high in cynicism subscale, and low in professional efficacy subscale simultaneously were graded as having high risk of burnout. Independent sample t tests and chi-square tests were used to compare the differences in burnout and work engagement between genders, majors, and grade levels.The means (standard deviations) of the MBI-SS subscales were 3.42 (1.45) for emotional exhaustion, 2.34 (1.64) for cynicism, and 3.04 (1.30) for professional efficacy. The means (standard deviations) of the UWES-S subscales were 3.13 (1.49) for vigor, 3.44 (1.47) for dedication and 3.00 (1.51) for absorption. Approximately 1 in 11 students experienced a high risk of burnout. There were no statistically significant gender differences in burnout and study engagement. There were also no statistically significant differences in burnout and study engagement subscales according to student major. Students in higher grades displayed increased burnout risk, higher mean burnout subscale score of cynicism, lower mean burnout subscale score of professional efficacy, and decreased mean study engagement subscale scores of dedication and absorption. There were strong correlations within study engagement subscales.Chinese medical students in this university experience a high level of burnout. Students at higher-grade level experience more burnout and decreased study engagement compared with students in lower level.
MeSH term(s)	Adolescent ; Adult ; Burnout, Professional/epidemiology ; Burnout, Professional/psychology ; China ; Cross-Sectional Studies ; Educational Status ; Female ; Humans ; Male ; Motivation ; Psychometrics/statistics & numerical data ; Statistics as Topic ; Students, Medical/psychology ; Surveys and Questionnaires ; Workload/psychology ; Young Adult
Language	English
Publishing date	2018-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000010326
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Article ; Online: Translational oncology toward benefiting cancer patients: the Sun Yat-sen University Cancer Center experience.

Guerin, Mathilde / Qian, Chaonan / Zhong, Qian / Cui, Qian / Guo, Yunmiao / Bei, Jinxin / Shao, Jianyong / Zhu, Xiaofeng / Huang, Wenlin / Wu, Jiangxue / Liu, Ranyi / Liu, Qiang / Wang, Jing / Jia, Weihua / Zheng, Xiaohui / Zeng, Yixin

Science China. Life sciences

2016 Volume 59, Issue 10, Page(s) 1057–1062

MeSH term(s)	Animals ; China ; Disease Models, Animal ; Genetic Predisposition to Disease/genetics ; Humans ; Medical Oncology/methods ; Medical Oncology/trends ; Molecular Biology/methods ; Molecular Biology/trends ; Molecular Targeted Therapy/methods ; Molecular Targeted Therapy/trends ; Neoplasms/genetics ; Neoplasms/prevention & control ; Neoplasms/therapy ; Tissue Banks/standards ; Tissue Banks/trends ; Translational Medical Research/methods ; Translational Medical Research/trends ; Universities
Language	English
Publishing date	2016-10
Publishing country	China
Document type	Journal Article
ISSN	1869-1889
ISSN (online)	1869-1889
DOI	10.1007/s11427-012-4398-4
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Article ; Online: Establishment of an Adjusted Prognosis Analysis Model for Initially Diagnosed Non-Small-Cell Lung Cancer With Brain Metastases From Sun Yat-Sen University Cancer Center.

Dinglin, Xiao-Xiao / Ma, Shu-Xiang / Wang, Fang / Li, De-Lan / Liang, Jian-Zhong / Chen, Xin-Ru / Liu, Qing / Zeng, Yin-Duo / Chen, Li-Kun

Clinical lung cancer

2017 Volume 18, Issue 3, Page(s) e179–e186

Abstract: ... from NSCLC at Sun Yat-Sen University Cancer Center from 1994 to 2015. The prognostic factors analyzed ...

Abstract	Background: The current published prognosis models for brain metastases (BMs) from cancer have not addressed the issue of either newly diagnosed non-small-cell lung cancer (NSCLC) with BMs or the lung cancer genotype. We sought to build an adjusted prognosis analysis (APA) model, a new prognosis model specifically for NSCLC patients with BMs at the initial diagnosis using adjusted prognosis analysis (APA). Patients and methods: The model was derived using data from 1158 consecutive patients, with 837 in the derivation cohort and 321 in the validation cohort. The patients had initially received a diagnosis of BMs from NSCLC at Sun Yat-Sen University Cancer Center from 1994 to 2015. The prognostic factors analyzed included patient characteristics, disease characteristics, and treatments. The APA model was built according to the numerical score derived from the hazard ratio of each independent prognostic variable. The predictive accuracy of the APA model was determined using a concordance index and was compared with current prognosis models. The results were validated using bootstrap resampling and a validation cohort. Results: We established 2 prognostic models (APA 1 and 2) for the whole group of patients and for those with known epidermal growth factor receptor (EGFR) genotype, respectively. Six factors were independently associated with survival time: Karnofsky performance status, age, smoking history (replaced by EGFR mutation in APA 2), local treatment of intracranial metastases, EGFR-tyrosine kinase inhibitor treatment, and chemotherapy. Patients in the derivation cohort were stratified into low- (score, 0-2), moderate- (score, 3-5), and high-risk (score 6-7) groups according to the median survival time (16.6, 10.3, and 5.2 months, respectively; P < .001). The results were further confirmed in the validation cohort. Conclusion: Compared with recursive partition analysis and graded prognostic assessment, APA seems to be more suitable for initially diagnosed NSCLC with BMs.
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145146-1
ISSN	1938-0690 ; 1525-7304
ISSN (online)	1938-0690
ISSN	1525-7304
DOI	10.1016/j.cllc.2016.12.016
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Article ; Online: On the properties of Se⋯N interaction: the analysis of substituent effects by energy decomposition and orbital interaction.

Zhou, Fangfang / Liu, Ruirui / Tang, Jia / Li, Ping / Cui, Yahui / Zhang, Houyu

Journal of molecular modeling

2016 Volume 22, Issue 1, Page(s) 29

Abstract: The nature and strength of intermolecular Se⋯N interaction between selenium-containing compounds ... pVDZ level. The Se⋯N interaction is found to be dependent on the substituent groups, which greatly ... reveals the nature of closed-shell interaction in these X-Se⋯N contacts. The Se⋯N interaction ...

Abstract	The nature and strength of intermolecular Se⋯N interaction between selenium-containing compounds HSeX (X = CH3, NH2, CF3, OCH3, CN, OH, NO2, Cl, F), and NH3 have been investigated at the MP2/aug-cc-pVDZ level. The Se⋯N interaction is found to be dependent on the substituent groups, which greatly affect the positive electrostatic potential of Se atoms and the accepting electron ability of X-Se σ(∗) antibonding orbital. Energy decomposition of the Se ⋯N interaction reveals that electrostatic and induction forces are comparable in the weak-bonded complexes and induction becomes more significant in the complexes with strong electron-withdrawing substituents. Natural bond orbital (NBO) analysis indicates that the primary source of the induction is the electron transfer from the N lone pair to the X-Se σ(∗) antibonding orbital. The geometry of the complex and the interaction directionality of NH3 to X-Se bond can be regarded as a consequence of the exchange-repulsion. The topological analysis on the electron density reveals the nature of closed-shell interaction in these X-Se⋯N contacts. The Se⋯N interaction in the complexes with the strong electron-withdrawing substituent has a partly covalent character.
Language	English
Publishing date	2016-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1284729-x
ISSN	0948-5023 ; 1610-2940
ISSN (online)	0948-5023
ISSN	1610-2940
DOI	10.1007/s00894-015-2901-0
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Article ; Online: Differences in Staphylococcus aureus nasal carriage and molecular characteristics among community residents and healthcare workers at Sun Yat-Sen University, Guangzhou, Southern China.

Chen, Baiji / Dai, Xinlu / He, Bo / Pan, Kunyi / Li, Hongyu / Liu, Xiaoqiang / Bao, Yunwen / Lao, Weisi / Wu, Xiquan / Yao, Yandan / Huang, Songyin

BMC infectious diseases

2015 Volume 15, Page(s) 303

Abstract: ... of nasal colonization by S. aureus in community residents (CR) and healthcare workers (HW) at Sun Yat-Sen ... Yat-Sen University, Guangzhou. Differences in epidemiological and molecular characteristics of S ...

Abstract	Background: The pathogenic potential and commensal nature of Staphylococcus aureus allows for easy transmission both within and outside of the hospital environment, and nasal carriage may be responsible for some serious infections. This study aimed to determine the molecular and epidemiological characteristics of nasal colonization by S. aureus in community residents (CR) and healthcare workers (HW) at Sun Yat-Sen University, Guangzhou, China. Methods: A total of 589 volunteers, both CR (n = 297) and HW (n = 292), were recruited. Each subject completed a questionnaire, and specimens were obtained from the anterior nares for S. aureus screening. Genotypic analysis included pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing, and virulence gene detection. Results: A total of 138 S. aureus isolates were recovered from separate subjects (23.4%, 138/589), with four isolates showing methicillin resistance (0.7%, 4/589). The prevalence of S. aureus carriage was 25.3% (75/297) in CR and 21.6% (63/292) in HW. Methicillin-resistant S. aureus (MRSA) were isolated from one CR (0.3%, 1/297) and three HW (1.0%, 3/292). The most common risk factors for S. aureus carriage in CR were being male, age ≤ 30 years, and nasal cavity cleaning habits. Having a household member in the healthcare profession was associated with increased risk among HW. Sequence type (ST)188 and ST59 were the most prevalent among the 20 observed STs, accounting for 14.6% and 12.2% of all isolates, respectively. The four MRSA isolates presented four different STs, with one isolate carrying a type IVa SCCmec element and the other three isolates containing type III SCCmec. PFGE analysis grouped the 129 isolates into 23 pulsotypes, with profiles A, N, E, L, and O the most prevalent. The Panton-Valentine leucocidin gene (pvl) was identified in two of the 138 isolates, while 57.5% of isolates carried both the Staphylococcus aureus enterotoxin A (sea) and enterotoxin B (seb) genes. Conclusions: These data indicate a low prevalence of nasal MRSA carriage but evidence of molecular heterogeneity among S. aureus isolates from CR and HW at Sun Yat-Sen University, Guangzhou. Differences in epidemiological and molecular characteristics of S. aureus between CR and HW populations may be useful for the understanding and prevention of S. aureus infection.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bacterial Typing Techniques/methods ; Child ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Personnel/statistics & numerical data ; Hospitals, University/statistics & numerical data ; Humans ; Inpatients/statistics & numerical data ; Male ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Middle Aged ; Multilocus Sequence Typing ; Nasal Cavity/microbiology ; Prevalence ; Staphylococcal Infections/epidemiology ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification ; Young Adult
Language	English
Publishing date	2015-07-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-015-1032-7
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Article ; Online: Forty-six cases of nasopharyngeal carcinoma treated with 50 Gy radiotherapy plus hematoporphyrin derivative: 20 years of follow-up and outcomes from the Sun Yat-sen University Cancer Center.

Xu, Bing-Qing / Tu, Zi-Wei / Tao, Ya-Lan / Liu, Zhi-Gang / Li, Xiao-Hui / Yi, Wei / Jiang, Chang-Bing / Xia, Yun-Fei

Chinese journal of cancer

2016 Volume 35, Page(s) 37

Abstract: Background: With the improved overall survival (OS) of nasopharyngeal carcinoma (NPC) patients, the importance of quality of life (QoL) is increasingly being recognized. For some radiosensitive NPC patients, whether low-dose radiotherapy can improve the ...

Abstract	Background: With the improved overall survival (OS) of nasopharyngeal carcinoma (NPC) patients, the importance of quality of life (QoL) is increasingly being recognized. For some radiosensitive NPC patients, whether low-dose radiotherapy can improve the QoL without affecting clinical efficacy is unknown. This study aimed to assess the survival rates and QoL of NPC patients treated with 50 Gy radiotherapy plus hematoporphyrin derivative (HPD). Methods: Forty-six newly diagnosed NPC patients treated with 50 Gy radiotherapy plus HPD between June 1988 and July 1992 were analyzed. All patients were restaged according to the 7th edition of the American Joint Committee on Cancer staging system. The radiotherapy plan was designed on the basis of pretreatment computed tomography. The OS, local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates were estimated using the Kaplan-Meier method. QoL was assessed using the Late Radiation Morbidity Scoring Criteria of the Radiation Therapy Oncology Group. Results: The 5-year OS, LRFS, DMFS, and DFS rates were 74.3%, 72.6%, 82.1%, and 61.2%, respectively. The corresponding 10-year rates were 38.4%, 62.9%, 78.5%, and 49.8%, respectively, and the 20-year rates were 27.7%, 51.4%, 78.5%, and 40.7%, respectively. None of the patients developed severe radiation-related complications, such as radiation-induced temporal lobe necrosis, hearing loss, trismus, and dysphagia. Conclusion: Some NPC patients were sensitive to 50 Gy radiotherapy plus HPD, and this sensitivity was characterized by long-term survival without significant late treatment morbidities.
MeSH term(s)	Adult ; Aged ; Carcinoma ; Female ; Follow-Up Studies ; Hematoporphyrins/therapeutic use ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/radiotherapy ; Quality of Life ; Radiotherapy Dosage ; Survival Analysis ; Treatment Outcome
Chemical Substances	Hematoporphyrins
Language	English
Publishing date	2016-04-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1045160-2
ISSN	1944-446X ; 1000-467X
ISSN (online)	1944-446X
ISSN	1000-467X
DOI	10.1186/s40880-016-0098-y
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