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  1. Article ; Online: Idiopathic Hypereosinophilia in an Elderly Male with Contraindications to Glucocorticoids and Good Response to Omalizumab.

    Zhou, Ting / Nie, Xiaoqi / Pan, Ronghua / Deng, Yunhua

    Indian journal of dermatology

    2023  Volume 67, Issue 6, Page(s) 836

    Language English
    Publishing date 2023-03-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_489_21
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 817: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Demethylzeylasteral protects against renal interstitial fibrosis by attenuating mitochondrial complex I-mediated oxidative stress.

    Shen, Pan / Deng, Xuan / Li, Tingting / Chen, Xiaoqi / Wu, Xiaoyan

    Journal of ethnopharmacology

    2024  Volume 327, Page(s) 117986

    Abstract: Ethnopharmacological relevance: Renal interstitial fibrosis (RIF) is a main pathological process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of Tripterygium wilfordii Hook. f., has anti-renal fibrosis effects. However, ... ...

    Abstract Ethnopharmacological relevance: Renal interstitial fibrosis (RIF) is a main pathological process in chronic kidney disease (CKD). Demethylzeylasteral (DML), a major component of Tripterygium wilfordii Hook. f., has anti-renal fibrosis effects. However, its mechanism of action remains incompletely understood.
    Aim of the study: The present study was designed to comprehensively examine the effects of DML on RIF and the underlying mechanisms.
    Materials and methods: Pathological experiments were performed to determine the therapeutic effect of DML on a mouse model of UUO-induced RIF. To determine the novel mechanisms underlying the therapeutic effects of DML against RIF, a comprehensive transcriptomics analysis was performed on renal tissues, which was further verified by a series of experiments.
    Results: Pathological and immunohistochemical staining showed that DML inhibited UUO-induced renal damage and reduced the expression of fibrosis-related proteins in mice. Transcriptomic analysis revealed that the partial subunits of mitochondrial complex (MC) I and II may be targets by which DML protects against RIF. Furthermore, DML treatment reduced mitochondrial reactive oxygen species (ROS) levels, consequently promoting ATP production and mitigating oxidative stress-induced injury in mice and cells. Notably, this protective effect was attributed to the inhibition of MC I activity, suggesting a crucial role for this specific complex in mediating the therapeutic effects of DML against RIF.
    Conclusions: This study provides compelling evidence that DML may be used to treat RIF by effectively suppressing mitochondrial oxidative stress injury mediated by MC I. These findings offer valuable insights into the pharmacological mechanisms of DML and its potential clinical application for patients with CKD.
    MeSH term(s) Humans ; Mice ; Animals ; Kidney Diseases/drug therapy ; Kidney Diseases/prevention & control ; Kidney Diseases/metabolism ; Kidney ; Renal Insufficiency, Chronic/metabolism ; Oxidative Stress ; Fibrosis ; Ureteral Obstruction/metabolism ; Triterpenes
    Chemical Substances demethylzeylasteral ; Triterpenes
    Language English
    Publishing date 2024-03-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.117986
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Asymmetric surfaces endow Janus bismuth oxyhalides with enhanced electronic and catalytic properties for the hydrogen evolution reaction.

    Pan, Haixi / Feng, Liping / Liu, Pengfei / Zheng, Xiaoqi / Zhang, Xiaodong

    Journal of colloid and interface science

    2022  Volume 617, Page(s) 204–213

    Abstract: The electronic and catalytic properties of Janus bismuth oxyhalide ( ... ...

    Abstract The electronic and catalytic properties of Janus bismuth oxyhalide (Bi
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.03.009
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  4. Article ; Online: Correction to: Performance comparison of four types of target enrichment baits for exome DNA sequencing.

    Zhou, Juan / Zhang, Mancang / Li, Xiaoqi / Wang, Zhuo / Pan, Dun / Shi, Yongyong

    Hereditas

    2023  Volume 160, Issue 1, Page(s) 35

    Language English
    Publishing date 2023-09-06
    Publishing country England
    Document type Published Erratum
    ZDB-ID 214294-6
    ISSN 1601-5223 ; 0018-0661
    ISSN (online) 1601-5223
    ISSN 0018-0661
    DOI 10.1186/s41065-023-00296-7
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    Ub I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article ; Online: Synthesis and Properties of Cobalt/Nickel-Iron-Antimony(III, V)-Oxo Tartrate Cluster-Based Compounds.

    Wen, Weiyang / Wang, Yanqi / Pan, Tianyu / Hu, Qianqian / Xiao, Huiping / Wang, Nannan / Li, Xiaoqi / Li, Xinxiong / Hu, Bing / Huang, Xiaoying

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 3

    Abstract: Two types of isostructural iron-cobalt/nickel-antimony-oxo tartrate cluster-based compounds, namely ( ... ...

    Abstract Two types of isostructural iron-cobalt/nickel-antimony-oxo tartrate cluster-based compounds, namely (H
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29030591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  6. Article ; Online: moreThanANOVA: A user-friendly Shiny/R application for exploring and comparing data with interactive visualization.

    Jiang, Wanyanhan / Chen, Han / Yang, Lian / Pan, Xiaoqi

    PloS one

    2022  Volume 17, Issue 7, Page(s) e0271185

    Abstract: In the case of comparing means of various groups, data exploration and comparison for affecting factors or relative indices would be involved. This process is not only complex requiring extensive statistical knowledge and methods, but also challenging ... ...

    Abstract In the case of comparing means of various groups, data exploration and comparison for affecting factors or relative indices would be involved. This process is not only complex requiring extensive statistical knowledge and methods, but also challenging for the complex installation of existing tools for users who lack of statistical knowledge and coding experience. Like, the normal distribution and equal variance are crucial premises of parametric statistical analysis. But some studies reported that associated data from various industries violated the normal distribution and equal variance, parametric analysis still involved leading to invalid results. This is owing to that the normal distribution tests and homogeneity of variance test for different variables are time-cost and error-prone, posing an urgent need for an automatic and user-friendly analysis application, not only integrating normal distribution tests and homogeneity of variance test, but also associated the following statistical analysis. To address this, we developed a Shiny/R application, moreThanANOVA, which is an interactive, user-friendly, open-source and cloud-based visualization application to achieve automatic distribution tests, and correlative significance tests, then customize post-hoc analysis based on the considerations to the trade-off of Type I and Type II errors (deployed at https://hanchen.shinyapps.io/moreThanANOVA/). moreThanANOVA enables novice users to perform their complex statistical analyses quickly and credibly with interactive visualization and download publication-ready graphs for further analysis.
    MeSH term(s) Normal Distribution ; Software
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271185
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  7. Article ; Online: Photoactive rhodamine-based photosensitizer eliminates Staphylococcus aureus via superoxide radical photosensitization.

    Zhang, Zhishang / Dao, Anyi / Yang, Xiaoqi / Pan, Li / Li, Wenqing / Lin, Yicao / Zhang, Xin / Huang, Huaiyi

    Bioorganic chemistry

    2024  Volume 144, Page(s) 107067

    Abstract: Due to the antibiotics abuse, bacterial infection has become one of the leading causes of human death worldwide. Novel selective antimicrobial agents are urgently needed, with the hope of maintaining the balance of the microbial environment. Photo- ... ...

    Abstract Due to the antibiotics abuse, bacterial infection has become one of the leading causes of human death worldwide. Novel selective antimicrobial agents are urgently needed, with the hope of maintaining the balance of the microbial environment. Photo-activated chemotherapeutics have shown great potential to eliminate bacteria with appealing spatiotemporal selectivity. In this work, we reported the structural modification to enhance the triplet excited state property of Rhodamine B, synthesizing a rhodamine-based photosensitizer RBPy. Upon light activation, RBPy exhibited much stronger photosensitization ability than the parent compound Rhodamine B both in solution and in bacteria. Importantly, RBPy can selectively inactivate Staphylococcus aureus and inhibit biofilm formation with high biocompatibility. This work provides a new strategy to develop rhodamine-based photoactive chemotherapeutics for antimicrobial photodynamic therapy.
    MeSH term(s) Humans ; Photosensitizing Agents/pharmacology ; Superoxides ; Staphylococcus aureus ; Photochemotherapy ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Staphylococcal Infections/drug therapy ; Rhodamines/pharmacology
    Chemical Substances Photosensitizing Agents ; Superoxides (11062-77-4) ; Anti-Bacterial Agents ; Rhodamines
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.107067
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: ASPP2

    Mao, Jiaren / Tan, Zhongjun / Pan, Xiaoqi / Meng, Feijian

    Experimental and therapeutic medicine

    2021  Volume 21, Issue 4, Page(s) 397

    Abstract: Transcatheter arterial chemoembolization (TACE) induces ischemia-hypoxia and local chemotherapy-induced cytotoxicity which destroys cancerous cells. However, some patients do not respond to TACE. The causes for such a lack of response remain unclear. ... ...

    Abstract Transcatheter arterial chemoembolization (TACE) induces ischemia-hypoxia and local chemotherapy-induced cytotoxicity which destroys cancerous cells. However, some patients do not respond to TACE. The causes for such a lack of response remain unclear. Recent studies have revealed that self-regulation of apoptosis-stimulating p53 protein 2 (
    Language English
    Publishing date 2021-02-24
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.9828
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect of synthesis temperature on the structural morphology of a metal-organic framework and the capacitor performance of derived cobalt-nickel layered double hydroxides.

    Wang, Xiaoliang / Song, Xiaoqi / Gao, Jingsong / Zhang, Yibo / Pan, Kui / Wang, Hongwei / Guo, Lige / Li, Panpan / Huang, Chuanhui / Yang, Shaobin

    Journal of colloid and interface science

    2024  Volume 664, Page(s) 946–959

    Abstract: Three-dimensional interconnected nickel-cobalt layered double hydroxides (NiCo-LDHs) were prepared on nickel foam by ion exchange using a cobalt-based metal-organic framework (Co-MOF) as a template at different temperatures. The effects of the Co-MOF ... ...

    Abstract Three-dimensional interconnected nickel-cobalt layered double hydroxides (NiCo-LDHs) were prepared on nickel foam by ion exchange using a cobalt-based metal-organic framework (Co-MOF) as a template at different temperatures. The effects of the Co-MOF preparation temperature on the growth, mass, morphology, and electrochemical properties of the Co-MOF and derived NiCo-LDH samples were studied. The synthesis temperature from 30 to 50 °C gradually increased the mass of the active material and the thickness of the Co-MOF sheets grown on the nickel foam. The higher the temperature is, the larger the proportion of Co
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.03.105
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: The mechanism and application of computer-assisted full facial skin imaging systems.

    Zhang, Yue / Pan, Ruoxin / Gu, Duoduo / Meng, Xiaoqi / Liu, Tingwei / Xu, Yang

    Skin health and disease

    2023  Volume 4, Issue 2, Page(s) e320

    Abstract: Computer-assisted full facial imaging systems are currently among the most widely used skin analysis instruments in dermatology and medical cosmetology. These systems offer objective quantitative evaluation of facial skin conditions, and as they are non- ... ...

    Abstract Computer-assisted full facial imaging systems are currently among the most widely used skin analysis instruments in dermatology and medical cosmetology. These systems offer objective quantitative evaluation of facial skin conditions, and as they are non-invasive, play an important role in assessing dermatological conditions such as pigmentation, inflammation, vascular diseases, skin texture, the severity of ageing, and therapeutic follow-up. Although computer-assisted full facial imaging systems enable quantitative analysis in the scope of medical treatment and cosmetic evaluation, their results may considerably vary because of the influence of environmental and postural factors for improper operation. Furthermore, manual observation is sometimes necessary for experimental work for more accuracy, and familiarity with the imaging principles and application points is necessary to best apply this technique. This report aims to discuss and interpret these systems' imaging mechanisms and explore the primary issues with their application.
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2690-442X
    ISSN (online) 2690-442X
    DOI 10.1002/ski2.320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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