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Article ; Online: The Role of Aryl Hydrocarbon Receptor in the Pathogenesis and Treatment of Psoriasis.

Lin, Xiran / Meng, Xianmin / Lin, Jingrong

Journal of cutaneous medicine and surgery

2024 , Page(s) 12034754241239050

Abstract: The pathogenesis of psoriasis is complex. Aryl hydrocarbon receptor (AhR) is a transcription factor that can be bound and activated by structurally diverse ligands and plays an important role in a range of biological processes and in the pathogenesis of ... ...

Abstract	The pathogenesis of psoriasis is complex. Aryl hydrocarbon receptor (AhR) is a transcription factor that can be bound and activated by structurally diverse ligands and plays an important role in a range of biological processes and in the pathogenesis of different diseases. Recently, the role of AhR in psoriasis has attracted attention. AhR has toxicological functions and physiological functions. The overexpression and activation of AhR induced by the environmental pollutant and exogenous AhR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can drive the development of psoriasis. This TCDD-mediated toxicological response disrupts the physiological functions of AhR resulting in skin barrier disorders and the release of inflammatory cytokines, 2 of the pivotal factors of psoriasis. In addition, highly upregulated kynureninase in psoriasis decreases endogenous AhR agonists, thereby weakening the physiological functions of AhR. Activating AhR physiological signalling should be useful in the treatment of psoriasis. Studies have demonstrated that physiological activation of AhR can dampen the severity of psoriasis. The oldest and effective treatment for psoriasis coal tar works by activating AhR, and both new anti-psoriasis drugs tapinarof and benvitimod are formulations of AhR agonist, supporting that activation of AhR can be used as a new strategy for the treatment of psoriasis. Preclinical and preliminary clinical studies have revealed the anti-psoriasis effects of a number of AhR agonists, providing potential candidates for the development of new drugs for the treatment of psoriasis.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1361720-5
ISSN	1615-7109 ; 1203-4754
ISSN (online)	1615-7109
ISSN	1203-4754
DOI	10.1177/12034754241239050
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Article ; Online: The possible role of Wnt/β-catenin signalling in vitiligo treatment.

Lin, Xiran / Meng, Xianmin / Lin, Jingrong

Journal of the European Academy of Dermatology and Venereology : JEADV

2023 Volume 37, Issue 11, Page(s) 2208–2221

Abstract: Vitiligo is a common chronic skin disease which has an adverse impact on patients' life. Its pathogenesis is complex, involving autoimmunity and oxidative stress (OS). Autoimmunity leads to the loss of epidermal melanocytes and the formation of the ... ...

Abstract	Vitiligo is a common chronic skin disease which has an adverse impact on patients' life. Its pathogenesis is complex, involving autoimmunity and oxidative stress (OS). Autoimmunity leads to the loss of epidermal melanocytes and the formation of the depigmented patches of the disease. Treatment of vitiligo should control the exaggerated immune response to arrest the progress of active disease, and then promote melanocytes to repigmentation. Wnt/β-catenin signalling pathway has been of recent interest in vitiligo. Wnt/β-catenin signalling pathway is downregulated in vitiligo. Upregulation of Wnt/β-catenin signalling possibly control vitiligo autoimmune response by protecting melanocyte from OS damage, inhibiting CD8
MeSH term(s)	Humans ; Vitiligo/drug therapy ; Vitiligo/metabolism ; beta Catenin/metabolism ; Hypopigmentation/pathology ; Melanocytes/pathology ; Epidermis/metabolism
Chemical Substances	beta Catenin
Language	English
Publishing date	2023-04-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19022
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article ; Online: Genome-Wide Characterization and Haplotypic Variation Analysis of the

Meng, Qiang / Zhang, Renliang / Wang, Yannan / Zhi, Hui / Tang, Sha / Jia, Guanqing / Diao, Xianmin

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: Panicle development and grain production in crop species are essential breeding characteristics affected by the synthesis of auxin, which is influenced by flavin monooxygenase-encoding genes such ... ...

Abstract	Panicle development and grain production in crop species are essential breeding characteristics affected by the synthesis of auxin, which is influenced by flavin monooxygenase-encoding genes such as
MeSH term(s)	Haplotypes ; Setaria Plant/genetics ; Setaria Plant/metabolism ; Phylogeny ; Plant Breeding ; Chromosome Mapping ; Gene Expression Regulation, Plant ; Plant Proteins/metabolism
Chemical Substances	Plant Proteins
Language	English
Publishing date	2023-10-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115637
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Article ; Online: Peroxisome proliferator-activator receptor γ and psoriasis, molecular and cellular biochemistry.

Lin, Xiran / Meng, Xianmin / Song, Zhiqi / Lin, Jingrong

Molecular and cellular biochemistry

2022 Volume 477, Issue 7, Page(s) 1905–1920

Abstract: The pathophysiology of psoriasis is complex and has not been completely elucidated. Better understanding of the pathogenesis may contribute to further improvement of our therapeutic strategies controlling psoriasis. Emerging evidence points to a ... ...

Abstract	The pathophysiology of psoriasis is complex and has not been completely elucidated. Better understanding of the pathogenesis may contribute to further improvement of our therapeutic strategies controlling psoriasis. Emerging evidence points to a causative relationship between altered activity of peroxisome proliferator-activated receptor γ (PPARγ) and psoriasis. The present review focuses on deeper understanding of the possible role of PPARγ in the pathogenesis of psoriasis and the potential of PPARγ agonist to improve the treatment of psoriasis. PPARγ is decreased in psoriasis. PPARγ possibly has effects on the multiple aspects of the pathogenesis of psoriasis, including abnormal lipid metabolism, insulin resistance, immune cells, pro-inflammatory cytokines, keratinocytes, angiogenesis, oxidative stress, microRNAs and nuclear factor kappa B. As defective activation of PPARγ is involved in psoriasis development, PPARγ agonists may be promising agents for treatment of psoriasis. Pioglitazone appears an effective and safe option in the treatment of patients with psoriasis, but there are still concerns about its potential side effects. Research effort has recently been undertaken to explore the PPARγ-activating potential of natural products. Among them some have been studied clinically or preclinically for treatment of psoriasis with promising results.
MeSH term(s)	Humans ; Hypoglycemic Agents ; PPAR gamma/metabolism ; Pioglitazone ; Psoriasis/drug therapy ; Psoriasis/metabolism
Chemical Substances	Hypoglycemic Agents ; PPAR gamma ; Pioglitazone (X4OV71U42S)
Language	English
Publishing date	2022-03-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04417-0
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Zs.A 892: Show issues

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Article: The roles of microRNAs in horticultural plant disease resistance.

Zhang, Aiai / Zhang, Shunshun / Wang, Feng / Meng, Xianmin / Ma, Yue / Guan, Jiantao / Zhang, Feng

Frontiers in genetics

2023 Volume 14, Page(s) 1137471

Abstract: The development of the horticultural industry is largely limited by disease and excessive pesticide application. MicroRNAs constitute a major portion of the transcriptomes of eukaryotes. Various microRNAs have been recognized as important regulators of ... ...

Abstract	The development of the horticultural industry is largely limited by disease and excessive pesticide application. MicroRNAs constitute a major portion of the transcriptomes of eukaryotes. Various microRNAs have been recognized as important regulators of the expression of genes involved in essential biological processes throughout the whole life cycle of plants. Recently, small RNA sequencing has been applied to study gene regulation in horticultural plants. In this review, we summarize the current understanding of the biogenesis and contributions of microRNAs in horticultural plant disease resistance. These microRNAs may potentially be used as genetic resources for improving disease resistance and for molecular breeding. The challenges in understanding horticultural plant microRNA biology and the possibilities to make better use of these horticultural plant gene resources in the future are discussed in this review.
Language	English
Publishing date	2023-02-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1137471
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Article ; Online: Genome-Wide Characterization and Haplotypic Variation Analysis of the YUC Gene Family in Foxtail Millet ( Setaria italica )

Qiang Meng / Renliang Zhang / Yannan Wang / Hui Zhi / Sha Tang / Guanqing Jia / Xianmin Diao

International Journal of Molecular Sciences, Vol 24, Iss 21, p

2023 Volume 15637

Abstract	Panicle development and grain production in crop species are essential breeding characteristics affected by the synthesis of auxin, which is influenced by flavin monooxygenase-encoding genes such as YUC ( YUCCA ) family members. In this trial, fourteen YUCs were identified and named uniformly in foxtail millet, an ancient crop species cultivated across the world. The phylogenetic analysis revealed that the SiYUCs were clustered into four subgroups; protein motif and gene structure analyses suggested that the closely clustered SiYUC genes were relatively conserved within each subgroup; while genome mapping analysis indicated that the SiYUC genes were unevenly distributed on foxtail millet chromosomes and colinear with other grass species. Transcription analysis revealed that the SiYUC genes differed greatly in expression pattern in different tissues and contained hormonal/light/stress-responding cis -elements. The haplotype characterization of SiYUC genes indicated many superior haplotypes of SiYUCs correlated with higher panicle and grain weight could be favorably selected by breeding. These results will be useful for the further study of the functional characteristics of SiYUC genes, particularly with regard to the marker-assisted pyramiding of beneficial haplotypes in foxtail millet breeding programs.
Keywords	YUC genes ; auxin ; gene expression ; haplotype analysis ; foxtail millet ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Deep Learning-Based Image Segmentation of Cone-Beam Computed Tomography Images for Oral Lesion Detection.

Wang, Xueling / Meng, Xianmin / Yan, Shu

Journal of healthcare engineering

2021 Volume 2021, Page(s) 4603475

Abstract: This paper aimed to study the adoption of deep learning (DL) algorithm of oral lesions for segmentation of cone-beam computed tomography (CBCT) images. 90 patients with oral lesions were taken as research subjects, and they were grouped into blank, ... ...

Abstract	This paper aimed to study the adoption of deep learning (DL) algorithm of oral lesions for segmentation of cone-beam computed tomography (CBCT) images. 90 patients with oral lesions were taken as research subjects, and they were grouped into blank, control, and experimental groups, whose images were treated by the manual segmentation method, threshold segmentation algorithm, and full convolutional neural network (FCNN) DL algorithm, respectively. Then, effects of different methods on oral lesion CBCT image recognition and segmentation were analyzed. The results showed that there was no substantial difference in the number of patients with different types of oral lesions among three groups (
MeSH term(s)	Algorithms ; Cone-Beam Computed Tomography ; Deep Learning ; Humans ; Image Processing, Computer-Assisted ; Neural Networks, Computer ; Research Subjects
Language	English
Publishing date	2021-09-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2021/4603475
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Article ; Online: Deep Learning-Based Image Segmentation of Cone-Beam Computed Tomography Images for Oral Lesion Detection

Xueling Wang / Xianmin Meng / Shu Yan

Journal of Healthcare Engineering, Vol

2021 Volume 2021

Abstract	This paper aimed to study the adoption of deep learning (DL) algorithm of oral lesions for segmentation of cone-beam computed tomography (CBCT) images. 90 patients with oral lesions were taken as research subjects, and they were grouped into blank, control, and experimental groups, whose images were treated by the manual segmentation method, threshold segmentation algorithm, and full convolutional neural network (FCNN) DL algorithm, respectively. Then, effects of different methods on oral lesion CBCT image recognition and segmentation were analyzed. The results showed that there was no substantial difference in the number of patients with different types of oral lesions among three groups (P>0.05). The accuracy of lesion segmentation in the experimental group was as high as 98.3%, while those of the blank group and control group were 78.4% and 62.1%, respectively. The accuracy of segmentation of CBCT images in the blank group and control group was considerably inferior to the experimental group (P<0.05). The segmentation effect on the lesion and the lesion model in the experimental group and control group was evidently superior to the blank group (P<0.05). In short, the image segmentation accuracy of the FCNN DL method was better than the traditional manual segmentation and threshold segmentation algorithms. Applying the DL segmentation algorithm to CBCT images of oral lesions can accurately identify and segment the lesions.
Keywords	Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MicroRNA-34a and microRNA-146a target CELF3 and suppress the osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.

Meng, Xianmin / Wang, Wenjie / Wang, Xueling

Journal of dental sciences

2021 Volume 17, Issue 3, Page(s) 1281–1291

Abstract: Background/purpose: During orthodontic tooth movement, mechanical forces induce the osteogenic differentiation of periodontal ligament stem cells (PDLSCs), which contributes to alveolar bone remodeling. MicroRNAs (miRNAs) are involved in regulating ... ...

Abstract	Background/purpose: During orthodontic tooth movement, mechanical forces induce the osteogenic differentiation of periodontal ligament stem cells (PDLSCs), which contributes to alveolar bone remodeling. MicroRNAs (miRNAs) are involved in regulating PDLSC osteogenic differentiation. Therefore, we intended to explore the role of miR-34a and miR-146a in osteogenic differentiation of PDLSCs under cyclic stretch. Materials and methods: Phenotypic identification of PDLSCs was determined by flow cytometry analysis. PDLSCs were incubated with osteogenic differentiation medium for 3 weeks and the osteogenic differentiation capability was detected by Alizarin Red staining. To mimic the orthodontic forces, cyclic mechanical stretch was applied to PDLSCs. Alkaline phosphatase (ALP) activity assay and ALP staining were used for evaluating the ALP activity. The expression of osteogenesis markers in PDLSCs was assessed by western blotting and qRT-PCR. The binding between miR-34a (or miR-146a) and CUGBP Elav-like family member 3 (CELF3) was validated by luciferase reporter assay. Results: Cyclic stretch elevated ALP activity and the expression of osteogenesis markers, osteopontin (OPN), runt-related transcription factor 2 (RUNX2), type I collagen (COL1), ALP, osteocalcin (OCN) and osterix (OSX), in PDLSCs. MiR-146a and miR-34a were downregulated in PDLSCs under cyclic stretch. Either overexpressing miR-146a and miR-34a reduced ALP activity and the expression of osteogenesis markers. CELF3 was a target of both miR-146a and miR-34a. CELF3 silencing attenuated while CELF3 overexpression enhanced ALP activity and the expression of osteogenesis markers. Conclusion: MiR-34a and miR-146a repress cyclic stretch-induced osteogenic differentiation of PDLSCs via regulating the expression of CELF3.
Language	English
Publishing date	2021-12-06
Publishing country	Netherlands
Document type	Journal Article
ISSN	2213-8862
ISSN (online)	2213-8862
DOI	10.1016/j.jds.2021.11.011
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Article ; Online: Identification and haplotype analysis of SiCHLI: a gene for yellow-green seedling as morphological marker to accelerate foxtail millet (Setaria italica) hybrid breeding.

Liang, Hongkai / He, Qiang / Zhang, Hui / Zhi, Hui / Tang, Sha / Wang, Hailong / Meng, Qiang / Jia, Guanqing / Chang, Jinhua / Diao, Xianmin

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

2023 Volume 136, Issue 1, Page(s) 24

Abstract: Key message: We cloned and developed functional markers for the SiCHLI gene, which is responsible for the yellow-green color of leaves in foxtail millet, a frequently used marker trait in the hybrid breeding of foxtail millet by using bulked segregant ... ...

Abstract	Key message: We cloned and developed functional markers for the SiCHLI gene, which is responsible for the yellow-green color of leaves in foxtail millet, a frequently used marker trait in the hybrid breeding of foxtail millet by using bulked segregant analysis sequencing and haplotype analysis on the F
MeSH term(s)	Seedlings ; Setaria Plant/genetics ; Haplotypes ; Chlorophyll A/metabolism ; Plant Breeding
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y)
Language	English
Publishing date	2023-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2170-2
ISSN	1432-2242 ; 0040-5752
ISSN (online)	1432-2242
ISSN	0040-5752
DOI	10.1007/s00122-023-04309-x
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