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  1. Article ; Online: Sedation during EUS-guided portal pressure gradient measurement: the elephant in the room.

    Benmassaoud, Amine / Chen, Yen-I

    Gastrointestinal endoscopy

    2022  Volume 96, Issue 4, Page(s) 690–691

    MeSH term(s) Endosonography ; Humans ; Hypertension, Portal ; Portal Pressure
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 391583-9
    ISSN 1097-6779 ; 0016-5107
    ISSN (online) 1097-6779
    ISSN 0016-5107
    DOI 10.1016/j.gie.2022.04.1345
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  2. Article ; Online: Response to Anand and Sharma.

    Benmassaoud, Amine / Tsochatzis, Emmanuel

    The American journal of gastroenterology

    2021  Volume 116, Issue 5, Page(s) 1094–1095

    MeSH term(s) Ascites ; Humans ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic ; Sarcopenia
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001108
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  3. Article ; Online: Response to Debnath and Rathi.

    Benmassaoud, Amine / Tsochatzis, Emmanuel

    The American journal of gastroenterology

    2021  Volume 116, Issue 6, Page(s) 1358–1359

    MeSH term(s) Ascites ; Humans ; Liver Cirrhosis ; Portasystemic Shunt, Transjugular Intrahepatic ; Sarcopenia
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001150
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  4. Article ; Online: Challenging anticoagulation cases: Acute extensive portal vein thrombosis in a patient without cirrhosis - Evidence-based management of a rare clinical entity.

    Benmassaoud, Amine / Rodger, Marc

    Thrombosis research

    2021  Volume 206, Page(s) 133–136

    Abstract: Acute non-cirrhotic and non-malignant portal vein thrombosis (aPVT) is a rare and heterogenous condition. Current guidelines recommend early initiation of therapeutic anticoagulation to prevent extension of thrombosis, and favor recanalization. Although ... ...

    Abstract Acute non-cirrhotic and non-malignant portal vein thrombosis (aPVT) is a rare and heterogenous condition. Current guidelines recommend early initiation of therapeutic anticoagulation to prevent extension of thrombosis, and favor recanalization. Although not formally defined, a poor outcome in the acute setting would include thrombosis extension with progression to intestinal infarction. Patients are also at risk of negative long-term outcomes related to complications of portal hypertension, such as variceal bleeding, ascites, and portal cholangiopathy. Identifying patients at risk of these events despite early initiation of anticoagulation remains challenging. Trials comparing treatment strategies in those failing standard therapy with meaningful radiological and clinical endpoints, whether in the short or long term, are desperately needed. The objective of this review will be to discuss a real-life clinical case and propose a treatment approach for aPVT based on the available evidence. We will mainly focus on management strategies including anticoagulation, prognostic factors, and options beyond anticoagulation, such as thrombolysis, thrombectomy, and transjugular intrahepatic portosystemic shunts. This review will not cover tumor portal vein thrombosis or thrombosis associated with cirrhosis.
    MeSH term(s) Anticoagulants/therapeutic use ; Esophageal and Gastric Varices ; Gastrointestinal Hemorrhage ; Humans ; Liver Cirrhosis/complications ; Liver Cirrhosis/pathology ; Portal Vein/pathology ; Thrombosis/pathology ; Treatment Outcome
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2021.08.013
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  5. Article: Vedolizumab-Associated Hypereosinophilia and Hepatoxicity.

    De Marco, Davide / Bessissow, Talat / Marcus, Victoria / Benmassaoud, Amine

    ACG case reports journal

    2022  Volume 9, Issue 11, Page(s) e00905

    Abstract: Vedolizumab, which is approved for the treatment of ulcerative colitis, has been associated with drug-induced liver injury because of an unclear mechanism. We describe the case of a 29-year-old man who presented with abnormal liver enzymes and peripheral ...

    Abstract Vedolizumab, which is approved for the treatment of ulcerative colitis, has been associated with drug-induced liver injury because of an unclear mechanism. We describe the case of a 29-year-old man who presented with abnormal liver enzymes and peripheral hypereosinophilia after vedolizumab initiation. A complete workup for causes of hepatitis and hypereosinophilia was negative, and liver biopsy showed signs compatible with drug-induced liver injury. After the withdrawal of vedolizumab, the patient's eosinophil count and liver enzymes normalized. As vedolizumab becomes more prominent, it is important to understand the potential side-effect profile of vedolizumab.
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2814825-3
    ISSN 2326-3253
    ISSN 2326-3253
    DOI 10.14309/crj.0000000000000905
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  6. Article ; Online: Prehabilitation in patients awaiting liver transplantation.

    Benmassaoud, Amine / Martel, Myriam / Carli, Franco / Geraci, Olivia / Daskalopoulou, Stella S / Sebastiani, Giada / Bessissow, Amal

    Transplantation reviews (Orlando, Fla.)

    2024  Volume 38, Issue 2, Page(s) 100835

    Abstract: Background: Frailty, malnutrition and sarcopenia lead to a significant increase in morbidity and mortality before and after liver transplantation (LT). Prehabilitation attempts to optimize physical fitness of individuals before major surgeries. To date, ...

    Abstract Background: Frailty, malnutrition and sarcopenia lead to a significant increase in morbidity and mortality before and after liver transplantation (LT). Prehabilitation attempts to optimize physical fitness of individuals before major surgeries. To date, little is known about its impact on patients awaiting LT.
    Aims: The aim of our scoping review was to describe whether prehabilitation in patients awaiting LT is feasible and safe, and whether it leads to a change in clinical parameters before or after transplantation.
    Methods: We performed a systematic review of the literature from 1946 to November 2023 to identify prospective studies and randomized controlled trials of adult LT candidates who participated in an exercise training program.
    Results: Out of 3262 citations initially identified, six studies were included. Studies were heterogeneous in design, patient selection, intervention, duration, and outcomes assessed. All studies were self-described as pilot or feasibility studies and had a sample size ranging from 13 to 33. Two studies were randomized controlled trials. Two study restricted to patients with cirrhosis who were eligible for liver transplantation or on the transplant list. Exercise programs lasted between 6 and 12 weeks. In terms of feasibility, proportion of eligible patients that were recruited was between 54 and 100%. Program completion ranged between 38 and 90%. Interventions appeared safe with 9 (9.2%) adverse events noted. In the intervention group, improvements were generally noted in peak oxygen consumption and workload, 6-min walking distance, and muscle strength. One study suggested a decrease in post-transplant hospital length of stay.
    Conclusions: Overall, it appears that prehabilitation with exercise training is feasible, and safe in patients awaiting LT. Higher quality and larger studies are needed to confirm its impact on pre- and post-transplantation-related outcomes.
    MeSH term(s) Adult ; Humans ; Liver Transplantation ; Preoperative Exercise ; Prospective Studies ; Exercise ; Exercise Therapy ; Quality of Life ; Preoperative Care ; Postoperative Complications/prevention & control
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 639400-0
    ISSN 1557-9816 ; 0955-470X
    ISSN (online) 1557-9816
    ISSN 0955-470X
    DOI 10.1016/j.trre.2024.100835
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  7. Article: Loco-regional treatments on the liver transplant waiting list: unmasking hepatocellular carcinoma (HCC) biology.

    Benmassaoud, Amine / Tsochatzis, Emmanuel A

    Hepatobiliary surgery and nutrition

    2018  Volume 7, Issue 3, Page(s) 199–201

    Language English
    Publishing date 2018-07-03
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn.2018.02.03
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  8. Article ; Online: Canadian Association of Gastroenterology Position Statement on the Impact of Simethicone on Endoscope Reprocessing.

    Benmassaoud, Amine / Parent, Josée

    Journal of the Canadian Association of Gastroenterology

    2018  Volume 1, Issue 1, Page(s) 40–42

    Abstract: A recent study by Ofstead et al. published in the American Journal of Infection Control described the presence of residual simethicone and non-pathogenic bacterial colonization in endoscopes despite adherence to reprocessing procedures(1). These findings ...

    Abstract A recent study by Ofstead et al. published in the American Journal of Infection Control described the presence of residual simethicone and non-pathogenic bacterial colonization in endoscopes despite adherence to reprocessing procedures(1). These findings received significant media attention, in part because they were released following a warning issued by the Food and Drug Administration and the Centre for Disease Control regarding the potential transmission of multi-drug resistant bacteria associated with the use of duodenoscopes(2, 3). In light of the findings described by Ofstead et al., the Canadian Association of Gastroenterology (CAG) would like to update its members on what is currently known.
    Language English
    Publishing date 2018-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2940642-0
    ISSN 2515-2092 ; 2515-2084
    ISSN (online) 2515-2092
    ISSN 2515-2084
    DOI 10.1093/jcag/gwx002
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  9. Article ; Online: Splenomegaly is a marker of advanced chronic liver disease and portal hypertension in HIV infection.

    Kablawi, Dana / Alhinai, Alshaima / Wong, Philip / Deschenes, Marc / Sebastiani, Giada / Benmassaoud, Amine

    HIV medicine

    2022  Volume 24, Issue 3, Page(s) 366–371

    Abstract: Objectives: To evaluate the clinical significance of splenomegaly as a marker of underlying liver disease in people with HIV (PWH).: Methods: We included consecutive PWH from a prospective cohort from 2010 to 2020 with available liver stiffness ... ...

    Abstract Objectives: To evaluate the clinical significance of splenomegaly as a marker of underlying liver disease in people with HIV (PWH).
    Methods: We included consecutive PWH from a prospective cohort from 2010 to 2020 with available liver stiffness measurement (LSM) and liver imaging to define splenomegaly (> 13 cm) within 1 year. Cut-offs of LSM > 10 kPa and > 21 kPa were used to identify advanced chronic liver disease (ACLD) and portal hypertension, respectively. Logistic regression multivariable analysis was employed to identify independent predictors of ACLD.
    Results: In all, 331 PWH were included, 76% of them men, with a median (interquartile range) age of 51.3 (45-58) years, all receiving antiretroviral treatment, and 53% were HIV monoinfected. The PWH with splenomegaly exhibited a higher prevalence of ACLD compared with those with normal spleen size, as per LSM (26% vs. 9%; p = 0.009). Portal hypertension diagnosed by LSM was also more prevalent in PWH with splenomegaly than in those without (15% vs. 2%; p < 0.001). Independent predictors of ACLD were viral hepatitis coinfection [adjusted odds ratio (aOR) = 3.15, 95% confidence interval (CI): 1.65-6.0], lower platelets (aOR = 0.99, 95% CI: 0.99-0.99) and splenomegaly (aOR = 2.41, 95% CI: 1.17-4.99). In patients with available oesophagogastroduodenoscopy, splenomegaly was also associated with higher prevalence of oesophageal varices and other endoscopic findings of portal hypertension (38% vs. 17%; p = 0.027).
    Conclusions: Splenomegaly identified on routine imaging may have utility as a marker of ACLD and portal hypertension, prompting further investigations.
    MeSH term(s) Male ; Humans ; Middle Aged ; Liver Cirrhosis/complications ; Splenomegaly/complications ; Splenomegaly/pathology ; HIV Infections/drug therapy ; Prospective Studies ; Liver/diagnostic imaging ; Hypertension, Portal/complications ; Hypertension, Portal/diagnosis ; Hypertension, Portal/pathology ; Elasticity Imaging Techniques/methods
    Language English
    Publishing date 2022-08-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13390
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  10. Article ; Online: Optimizing patients with non-alcoholic fatty liver disease pre-transplant.

    Benmassaoud, Amine / Deschenes, Marc / Chen, Tianyan / Ghali, Peter / Sebastiani, Giada

    Canadian liver journal

    2020  Volume 3, Issue 3, Page(s) 237–250

    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. Non-alcoholic steatohepatitis (NASH), which is the progressive counterpart of the disease, is becoming the leading indication for liver ... ...

    Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. Non-alcoholic steatohepatitis (NASH), which is the progressive counterpart of the disease, is becoming the leading indication for liver transplantation in North America. Owing to the lack of symptoms, NASH is often an incidental diagnosis, resulting in a significant proportion of patients being diagnosed when advanced liver disease has already developed. NAFLD has recently been characterized as the hepatic manifestation of metabolic syndrome. Consequently, it is a multisystem disease that often co-exists with several other conditions, such as obesity, diabetes, cardiovascular diseases, and extra-hepatic malignancy, which have an impact on selection of transplant recipients. The complexity of diagnostic approach, need for multidisciplinary clinical management, and lack of a specific treatment further complicate the picture of this extremely prevalent liver condition. NAFLD patients with advanced liver disease should be considered for early referral to liver transplant clinics for careful metabolic and cardiovascular risk stratification because they have worse survival rates after liver transplantation than other patients with chronic liver disease. Early referral will also facilitate optimization of metabolic comorbidities before proceeding with transplantation. This review provides an overview of strategies to identify patients with advanced NAFLD, with an emphasis on the management of associated comorbidities and optimal timing of pre-transplant evaluation. Other topics that have been shown to affect recipient optimization, such as the role of lifestyle changes and bariatric surgery in the management of obesity, as well as sarcopenia in decompensated NASH-related cirrhosis, are addressed.
    Language English
    Publishing date 2020-08-20
    Publishing country Canada
    Document type Journal Article ; Review
    ISSN 2561-4444
    ISSN (online) 2561-4444
    DOI 10.3138/canlivj-2019-0025
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