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Article: The pharmacological evidence of the chang-yan-ning formula in the treatment of colitis.

Yu, Wei / Zhang, Yijia / Kang, Cai / Zheng, Yang / Liu, Xincheng / Liang, Zhenghao / Yan, Jing

2022 Volume 13, Page(s) 1029088

Abstract: ... susceptibility, dietary intakes, environment, and microbiota. In China, the Chang-Yan-Ning (CYN) formula has been ...

Abstract	Ulcerative colitis (UC) is a subtype of inflammatory bowel disease (IBD) and occurs mainly in the colon. The etiology of UC is rather complex and involves various pathological factors, including genetic susceptibility, dietary intakes, environment, and microbiota. In China, the Chang-Yan-Ning (CYN) formula has been utilized in the clinic to treat gastrointestinal disorders, but its pharmacological evidence remains elusive. The investigation was designed to explore the molecular and cellular mechanisms of CYN. Liquid Chromatography with tandem mass spectrometry (LC/MS) was performed to identify the key components in the formula; Network pharmacology analysis was executed to predict the potential targets of CYN; An experimental murine colitis model was established by utilizing 2% dextran sodium sulfate (DSS), and CYN was administered for 14 days. The pharmacological mechanism of the CYN formula was corroborated by
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.1029088
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Article ; Online: Protective effects of Re-yan-ning mixture on

Han, Lizhu / Kou, Jing / Hu, Kunxia / Wang, Yunlan / Tang, Zhishu / Wu, Zhisheng / Song, Xiao

Pharmaceutical biology

2021 Volume 59, Issue 1, Page(s) 209–221

Abstract: Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Context: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective: To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods: Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Results: The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Discussion and conclusions: The present study demonstrated the protective effects of RYNM on
MeSH term(s)	Animals ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Inflammation/drug therapy ; Inflammation/microbiology ; Male ; NF-kappa B/metabolism ; Pneumonia, Pneumococcal/microbiology ; Pneumonia, Pneumococcal/prevention & control ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Streptococcus pneumoniae/drug effects ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2021-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1872653
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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.

Yu, Borui / Zhou, Mengqi / Dong, Zhaocheng / Zheng, Huijuan / Zhao, Yuxue / Zhou, Jingwei / Zhang, Chao / Wei, Fudong / Yu, Guoyong / Liu, Wei Jing / Liu, Hongfang / Wang, Yaoxian

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1222–1233

Abstract: Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan ...

Abstract	Context: Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown. Objective: To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments. Materials and methods: Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. Results: Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells. Discussion and conclusion: M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
MeSH term(s)	Rats ; Male ; Humans ; Animals ; Diabetic Nephropathies/metabolism ; Network Pharmacology ; Rats, Sprague-Dawley ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glycation End Products, Advanced/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Glycation End Products, Advanced
Language	English
Publishing date	2023-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2241521
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Article ; Online: Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy

Borui Yu / Mengqi Zhou / Zhaocheng Dong / Huijuan Zheng / Yuxue Zhao / Jingwei Zhou / Chao Zhang / Fudong Wei / Guoyong Yu / Wei Jing Liu / Hongfang Liu / Yaoxian Wang

Pharmaceutical Biology, Vol 61, Iss 1, Pp 1222-

2023 Volume 1233

Abstract: ... Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating ...

Abstract	AbstractContext Diabetic nephropathy (DN) is the main cause of end-stage renal disease. Modified Shen-Yan-Fang-Shuai formula (M-SYFSF) has excellent clinical efficacy in treating diabetic kidney disease. However, the potential mechanism of M-SYFSF remains unknown.Objective To investigate the mechanism of M-SYFSF against DN by network pharmacological analysis and biological experiments.Materials and methods Utilizing a web-based pharmacology database, the potential mechanisms of M-SYFSF against DN were identified. In vivo experiments, male SD rats were injected with streptozotocin (50 mg/kg) and got uninephrectomy to construct a model of DN. M-SYFSF (11.34 g/kg/d) was gavaged once per day for 12 weeks after model establishment. In vitro experiments, human proximal tubular cells (HK-2) were performed with advanced glycation end-products (AGEs) (100 μg/mL), then intervened with M-SYFSF freeze-dried powder. Pathological staining, WB, IHC, ELISA were conducted to explore the mechanism of M-SYFSF against DN.Results Network pharmacological analysis showed that MAPK pathway was the potential pathway. Results showed that compared with the Model group, M-SYFSF significantly reduced 24h urine albumin, UACR, and serum creatinine levels (54.90 ± 26.67 vs. 111.78 ± 4.28, 8.87 ± 1.69 vs. 53.94 ± 16.01, 11.56 ± 1.70 vs. 118.70 ± 49.57, respectively), and improved renal pathological changes. Furthermore, the intervention of M-SYFSF reduced the expression of pro-inflammatory cytokines and inhibited the activation of MAPK pathway in AGEs-treated HK-2 cells.Discussion and conclusion M-SYFSF is likely to reduce inflammation in DN by inhibiting the MAPK pathway. It provides a theoretical basis for the clinical application of M-SYFSF in the treatment of DN.
Keywords	Traditional Chinese medicine formula ; protein-protein interaction network ; MAPK signaling pathway ; inflammation ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Modulation of the Gut Microbiota by Shen-Yan-Fang-Shuai Formula Improves Obesity Induced by High-Fat Diets.

Wang, Zhen / Lu, Junfeng / Zhou, Jingwei / Sun, Weiwei / Qiu, Yang / Chen, Weihong / Gao, Yabin / Yang, Ruibing / Ai, Sinan / Liu, Zhongjie / Guo, Yingbo / Liu, Wei Jing / Wang, Yaoxian / Peng, Liang

Frontiers in microbiology

2020 Volume 11, Page(s) 564376

Abstract: ... disrupted intestinal barrier and chronic inflammation. Shen-Yan-Fang-Shuai formula (SYFSF) is a traditional ...

Abstract	Obesity and related metabolic disorders are associated with intestinal microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Shen-Yan-Fang-Shuai formula (SYFSF) is a traditional Chinese herbal formula composed of Astragali Radix, Radix Angelicae Sinensis, Rheum Officinale Baill, and four other herbs. In this study, we identified that SYFSF treatment prevented weight gain, low-grade inflammation and insulin resistance in high-fat diet (HFD)-fed mice. SYFSF also substantially improved gut barrier function, reduced metabolic endotoxemia, as well as systemic inflammation. Sequencing of 16S rRNA genes obtained from fecal samples demonstrated that SYFSF attenuated HFD-induced gut dysbiosis, seen an decreased Firmicutes to Bacteroidetes ratios. Microbial richness and diversity were also higher in the SYFSF-treated HFD group. Furthermore, similar therapeutic effects and changes in gut microbiota profile caused by SYFSF could be replicated by fecal microbiota transfer (FMT). Taken together, our study highlights the efficacy of SYFSF in preventing obesity and related metabolic disorders. Its therapeutic effect is associated with the modulation of gut microbiota, as a prebiotic.
Language	English
Publishing date	2020-12-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.564376
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Article ; Online: Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-

Lv, Jie / Wang, Zhen / Wang, Ying / Sun, Weiwei / Zhou, Jingwei / Wang, Mengdi / Liu, Wei Jing / Wang, Yaoxian

Journal of diabetes research

2017 Volume 2017, Page(s) 4319057

Abstract: ... therapeutic strategies have not yet been established. The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional ...

Abstract	Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease, and satisfactory therapeutic strategies have not yet been established. The Shen-Yan-Fang-Shuai Formula (SYFSF) is a traditional Chinese formula composed of Astragali radix,
MeSH term(s)	Albuminuria/drug therapy ; Albuminuria/metabolism ; Animals ; Cell Line ; Creatinine/blood ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Kidney/drug effects ; Kidney/metabolism ; Male ; Mesangial Cells/drug effects ; Mesangial Cells/metabolism ; NF-kappa B/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Transforming Growth Factor beta1/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2017-06-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2711897-6
ISSN	2314-6753 ; 2314-6753
ISSN (online)	2314-6753
ISSN	2314-6753
DOI	10.1155/2017/4319057
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Article ; Online: Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

Lizhu Han / Jing Kou / Kunxia Hu / Yunlan Wang / Zhishu Tang / Zhisheng Wu / Xiao Song

Pharmaceutical Biology, Vol 59, Iss 1, Pp 209-

2021 Volume 221

Abstract: Context Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Context Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. Objective To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Materials and methods Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Streptococcus pneumonia model to verify the results of network pharmacology enrichment analysis. Forty male SPF Sprague Dawley rats were divided into four groups of 10 rats: control (normal saline), model (normal saline), levofloxacin-intervened and RYNM-intervened groups. IL-10, NOS2, COX-1, IL-6, TNF-α and NF-κB in serum and BALF were detected by ELISA. Western blot detected IL-17, IL-6, TNF-α, COX-2 and Bcl-2. Results The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Streptococcus pneumonia with RYNM. The in vivo experiments indicated that model group has visible inflammation and lesions while RYNM and levofloxacin groups have not. The RYNM exhibited its therapeutic effects on Streptococcus pneumonia mainly via the regulation of cell proliferation and survival through the IL-6/IL-10/IL-17, Bax/Bcl-2, COX-1/COX-2, NF-κB and TNF-α signalling pathways. Discussion and conclusions The present study demonstrated the protective effects of RYNM on Streptococcus pneumonia, providing a potential mechanism for the treatment of bacterial pneumonia with RYNM.
Keywords	traditional chinese medicine ; pneumonia ; signal pathway ; Therapeutics. Pharmacology ; RM1-950
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology

Han, Lizhu / Kou, Jing / Hu, Kunxia / Wang, Yunlan / Tang, Zhishu / Wu, Zhisheng / Song, Xiao

Pharmaceutical Biology. 2021 Jan. 1, v. 59, no. 1 p.207-219

2021

Abstract: Re-yan-ning mixture (RYNM) is a new national drug approved by China's State ...

Abstract	Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. Using the network pharmacology approach, the multiple components, component candidate targets and multiple therapeutic targets of RYNM were screened and functionally enriched. Also, we established a rat Streptococcus pneumonia model to verify the results of network pharmacology enrichment analysis. Forty male SPF Sprague Dawley rats were divided into four groups of 10 rats: control (normal saline), model (normal saline), levofloxacin-intervened and RYNM-intervened groups. IL-10, NOS2, COX-1, IL-6, TNF-α and NF-κB in serum and BALF were detected by ELISA. Western blot detected IL-17, IL-6, TNF-α, COX-2 and Bcl-2. The network pharmacology approach successfully identified 48 bioactive components in RYNM, and 65 potential targets and 138 signal pathways involved in the treatment of Streptococcus pneumonia with RYNM. The in vivo experiments indicated that model group has visible inflammation and lesions while RYNM and levofloxacin groups have not. The RYNM exhibited its therapeutic effects on Streptococcus pneumonia mainly via the regulation of cell proliferation and survival through the IL-6/IL-10/IL-17, Bax/Bcl-2, COX-1/COX-2, NF-κB and TNF-α signalling pathways. The present study demonstrated the protective effects of RYNM on Streptococcus pneumonia, providing a potential mechanism for the treatment of bacterial pneumonia with RYNM.
Keywords	Food and Drug Administration ; Streptococcus ; Western blotting ; bacterial pneumonia ; blood serum ; bronchitis ; cell proliferation ; inflammation ; interleukin-10 ; interleukin-17 ; interleukin-6 ; levofloxacin ; males ; mechanism of action ; models ; pharmacology ; rats ; therapeutics ; China ; Traditional Chinese medicine ; pneumonia ; signal pathway
Language	English
Dates of publication	2021-0101
Size	p. 207-219.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2021.1872653
Database	NAL-Catalogue (AGRICOLA)

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Book: Jin dai Shanghai de fen mian wei sheng yan jiu (1927-1949)

Zhao, Jing

(Shanghai cheng shi she hui bian qian cong shu)

2015

Author's details	Zhao Jing zhu
Series title	Shanghai cheng shi she hui bian qian cong shu
MeSH term(s)	Labor, Obstetric/history ; Maternal Health Services/history ; Health Services Research ; History, 20th Century
Keywords	China
Language	Chinese
Size	8, 2, 312 pages :, illustrations, portraits ;, 23 cm.
Edition	Di 1 ban.
Document type	Book
ISBN	9787532641208 ; 7532641201
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Gong li yi yuan gong yi xing hui gui ji ping jia yan jiu

Jing, Yongfa

2014

Author's details	Jing Yongfa zhu
MeSH term(s)	Hospitals, Public/economics ; Uncompensated Care ; Charities
Keywords	China
Language	Chinese
Size	2, 5, 192 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787516155738 ; 751615573X
Database	Catalogue of the US National Library of Medicine (NLM)

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