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Article ; Online: Detection of Immunoglobulin M and Immunoglobulin G Antibodies Against Orientia tsutsugamushi for Scrub Typhus Diagnosis and Serosurvey in Endemic Regions.

Gupte, Mohan D / Gupte, Manish / Kamble, Suchit / Mane, Arati / Sane, Suvarna / Bondre, Vijay / Deshpande, Jagadish / Gadkari, Deepak / Murhekar, Manoj V

Indian pediatrics

2020 Volume 57, Issue 12, Page(s) 1131–1134

Abstract: Objective: To estimate the regional cutoff of optical density (OD) values for immuno-globulin M ... diagnosis of scrub typhus and immunoglobulin G (IgG) antibodies in serum for sero-epidemiology in Gorakhpur ...

Abstract	Objective: To estimate the regional cutoff of optical density (OD) values for immuno-globulin M (IgM) antibodies against Orientia tsutsugamushi in serum and cerebrospinal fluid (CSF) for clinical diagnosis of scrub typhus and immunoglobulin G (IgG) antibodies in serum for sero-epidemiology in Gorakhpur, Uttar Pradesh, India. Methods: We used data from a serological investigation of acute encephalitis syndrome patients (n=407) during the 2016 outbreak in Gorakhpur, India to determine the cutoff for OD values for IgM antibodies, and from community-based serosurveys (n=1991) to estimate the cutoff for OD values for IgG antibodies. Results: We determined regionally relevant cutoff for OD values of 0.76 for IgM antibodies in serum and 0.22 in cerebrospinal fluid for scrub typhus diagnosis. For serosurveys, IgG antibody cutoff was 1.5. Conclusion: We have proposed locally relevant cutoffs for scrub typhus endemic regions, which may be useful for correctly classifying infected population.
MeSH term(s)	Antibodies, Bacterial ; Humans ; Immunoglobulin G ; Immunoglobulin M ; Orientia ; Orientia tsutsugamushi ; Scrub Typhus/diagnosis ; Scrub Typhus/epidemiology
Chemical Substances	Antibodies, Bacterial ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2020-09-07
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Zs.A 859: Show issues

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Article ; Online: A novel method of estimating atmospheric boundary layer height using a 205 MHz VHF radar.

Angel, Anita Christy / Manoj, M G

The Science of the total environment

2023 Volume 907, Page(s) 168109

Abstract: The present study proposes a novel methodology for the estimation of atmospheric boundary layer height (ABLH) using data from a 205 MHz VHF (very high frequency) radar installed at the Advanced Centre for Atmospheric Radar Research, Cochin University of ... ...

Abstract	The present study proposes a novel methodology for the estimation of atmospheric boundary layer height (ABLH) using data from a 205 MHz VHF (very high frequency) radar installed at the Advanced Centre for Atmospheric Radar Research, Cochin University of Science and Technology, India. Using a year-long dedicated experimental campaign involving collocated, concurrent radar and radiosonde operations in 2021, clear-sky days were identified for the analysis in order to avoid any further ambiguity in the results. The reference ABLH is derived from the mixing ratio and its gradient profiles from the radiosonde data. A new method has been devised to estimate the boundary layer height using the dataset from radar by combining three parameters, viz., signal-to-noise ratio, wind speed and wind direction. The ABLH is identified as that height at which the sum of the normalized standard deviations of three parameters peaks and subsequently decreases abruptly and substantially above it. This method has been verified against the ABLH estimated from four other variables from the radiosonde data, and a strong correlation (r = 0.91 at 99 % confidence level) between the ABLH derived from both methods has been obtained. This study extends ample opportunity to explore the high temporal variability such as the diurnal cycle of ABLH from the radar, unlike sparsely available radiosonde measurements.
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.168109
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Zs.A 949: Show issues

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Article ; Online: Infrared thermal images using PCSAN-Net-DBOA: An approach of breast cancer classification.

Vijayarajan, S M / Manoj Kumar, D / Sudha, G / Reddy, A Basi

Microscopy research and technique

2024

Abstract: This manuscript proposes thermal images using PCSAN-Net-DBOA Initially, the input images are engaged from the database for mastology research with infrared image (DMR-IR) dataset for breast cancer classification. The adaptive distorted Gaussian matched- ... ...

Abstract	This manuscript proposes thermal images using PCSAN-Net-DBOA Initially, the input images are engaged from the database for mastology research with infrared image (DMR-IR) dataset for breast cancer classification. The adaptive distorted Gaussian matched-filter (ADGMF) was used in removing noise and increasing the quality of infrared thermal images. Next, these preprocessed images are given into one-dimensional quantum integer wavelet S-transform (OQIWST) for extracting Grayscale statistic features like standard deviation, mean, variance, entropy, kurtosis, and skewness. The extracted features are given into the pyramidal convolution shuffle attention neural network (PCSANN) for categorization. In general, PCSANN does not show any adaption optimization techniques to determine the optimal parameter to offer precise breast cancer categorization. This research proposes the dung beetle optimization algorithm (DBOA) to optimize the PCSANN classifier that accurately diagnoses breast cancer. The BCD-PCSANN-DBO method is implemented using Python. To classify breast cancer, performance metrics including accuracy, precision, recall, F1 score, error rate, RoC, and computational time are considered. Performance of the BCD-PCSANN-DBO approach attains 29.87%, 28.95%, and 27.92% lower computation time and 13.29%, 14.35%, and 20.54% greater RoC compared with existing methods like breast cancer diagnosis utilizing thermal infrared imaging and machine learning approaches(BCD-CNN), breast cancer classification from thermal images utilizing Grunwald-Letnikov assisted dragonfly algorithm-based deep feature selection (BCD-VGG16) and Breast cancer detection in thermograms using deep selection based on genetic algorithm and Gray Wolf Optimizer (BCD-SqueezeNet), respectively. RESEARCH HIGHLIGHTS: The input images are engaged from the breast cancer dataset for breast cancer classification. The ADQMF was used in removing noise and increasing the quality of infrared thermal images. The extracted features are given into the PCSANN for categorization. DBOA is proposed to optimize PCSANN classifier that classifies breast cancer precisely. The proposed BCD-PCSANN-DBO method is implemented using Python.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099714-3
ISSN	1097-0029 ; 1059-910X
ISSN (online)	1097-0029
ISSN	1059-910X
DOI	10.1002/jemt.24550
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Zs.A 2251: Show issues

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Article ; Online: Ultrasensitive detection of Ag+ and Ce3+ ions using highly fluorescent carboxyl-functionalized carbon nitride nanoparticles.

Chaulagain, Narendra / Garcia, John / Manoj, Aparna / Shankar, Karthik

Nanotechnology

2024

Abstract: The fluorescence quenching of carboxyl-rich g-C3N4 nanoparticles was found to be selective to Ag+ ... polycondensation reaction was used to produce g-C3N4 nanoparticles with distinct green fluorescence and high water ... Stokes shift. Among different metal ion species, the carboxyl-rich g-C3N4 nanoparticles were selective ...

Abstract	The fluorescence quenching of carboxyl-rich g-C3N4 nanoparticles was found to be selective to Ag+ and Ce3+ with a limit of detection as low as 30 pM for Ag+ ions. A solid-state thermal polycondensation reaction was used to produce g-C3N4 nanoparticles with distinct green fluorescence and high water solubility. Dynamic light scattering indicated an average nanoparticle size of 95 nm. The photoluminescence absorption and emission maxima were centered at 405 nm and 540 nm respectively which resulted in a large Stokes shift. Among different metal ion species, the carboxyl-rich g-C3N4 nanoparticles were selective to Ag+ and Ce3+ ions, as indicated by strong fluorescence quenching. The PL sensing of mixtures of Ag+/Ce3+ and Ce3+ followed static Stern-Volmer kinetics with the Stern-Volmer constants determined to be 74.18 ×10^3 M-1 and 27.2 ×10^3 M-1 respectively. The PL sensing of Ag+ followed modified Stern-Volmer kinetics. Sensing was also demonstrated using commercial filter paper functionalized with g-C3N4 nanoparticles, enabling practical on-site applications. .
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ad3d66
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Article: Role of

Mahato, Abhishek / Jain, Anurag / Manoj, M G / Joshi, Richa

World journal of nuclear medicine

2023 Volume 22, Issue 3, Page(s) 244–247

Abstract: Urethral melanomas are a rare subtype of noncutaneous melanomas. The disease has a tendency to have skip lesions and early metastases as compared with cutaneous melanomas. The role of fluorine-18 fluorodeoxyglucose ( ...

Abstract	Urethral melanomas are a rare subtype of noncutaneous melanomas. The disease has a tendency to have skip lesions and early metastases as compared with cutaneous melanomas. The role of fluorine-18 fluorodeoxyglucose (
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0043-1771280
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Zs.A 7137: Show issues

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Article: Screening and validation of novel serum panel of microRNA in stratification of prostate cancer.

Manoj, Anveshika / Ahmad, Mohammad K / Prasad, Gautam / Kumar, Durgesh / Mahdi, Abbas A / Kumar, Manoj

Prostate international

2023 Volume 11, Issue 3, Page(s) 150–158

Abstract: Background: Owing to the heterogeneous nature of prostate cancer (PCa) and errors in the characterization of the disease, researchers have been trying to unveil molecular biomarkers like microRNA (miRNA) as diagnostic markers. The purpose of our study ... ...

Abstract	Background: Owing to the heterogeneous nature of prostate cancer (PCa) and errors in the characterization of the disease, researchers have been trying to unveil molecular biomarkers like microRNA (miRNA) as diagnostic markers. The purpose of our study is to demonstrate the precision of a panel of miRNAs as biomarkers with diagnostic potential for risk stratification. Materials and methods: The present study demonstrates the comparative expression profiles of miRNA-141,-1290,-100, and -335 in both tissue and serum, including Benign Prostate Hyperplasia (BPH) and PCa, with healthy volunteers. Firstly, we demonstrate the expression of all miRNAs in the discovery cohort, including metastasis and benign tissue, and later validate their non-invasive diagnostic potential in BPH and PCa with healthy volunteers. MiRNA was isolated from tissue and serum to be quantified by RT-PCR and analyzed for biomarker potential by receiver operating characteristic (ROC) curve analysis, followed by targetome analysis of each miRNA. Results: Among the non-invasive miRNA assessed, it was seen that miRNA 141 ( Conclusions: To the best of our knowledge, we are going to report for the first time this panel of miRNA that can be used to accurately and efficiently diagnose BPH and PCa patients from healthy males.
Language	English
Publishing date	2023-06-21
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2711928-2
ISSN	2287-903X ; 2287-8882
ISSN (online)	2287-903X
ISSN	2287-8882
DOI	10.1016/j.prnil.2023.06.002
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Article ; Online: Non-Invasive Delivery of Insulin for Breaching Hindrances against Diabetes.

Sarangi, Manoj / Padhi, Sasmita / Rath, Goutam

Critical reviews in therapeutic drug carrier systems

2024 Volume 41, Issue 5, Page(s) 1–64

Abstract: Insulin is recognized as a crucial weapon in managing diabetes. Subcutaneous (s.c.) injections are the traditional approach for insulin administration, which usually have many limitations. Numerous alternative (non-invasive) slants through different ... ...

Abstract	Insulin is recognized as a crucial weapon in managing diabetes. Subcutaneous (s.c.) injections are the traditional approach for insulin administration, which usually have many limitations. Numerous alternative (non-invasive) slants through different routes have been explored by the researchers for making needle-free delivery of insulin for attaining its augmented absorption as well as bioavailability. The current review delineating numerous pros and cons of several novel approaches of non-invasive insulin delivery by overcoming many of their hurdles. Primary information on the topic was gathered by searching scholarly articles from PubMed added with extraction of data from auxiliary manuscripts. Many approaches (discussed in the article) are meant for the delivery of a safe, effective, stable, and patient friendly administration of insulin via buccal, oral, inhalational, transdermal, intranasal, ocular, vaginal and rectal routes. Few of them have proven their clinical efficacy for maintaining the glycemic levels, whereas others are under the investigational pipe line. The developed products are comprising of many advanced micro/nano composite technologies and few of them might be entering into the market in near future, thereby garnishing the hopes of millions of diabetics who are under the network of s.c. insulin injections.
MeSH term(s)	Female ; Humans ; Insulin ; Insulin, Regular, Human ; Diabetes Mellitus/drug therapy ; Administration, Rectal ; Biological Availability
Chemical Substances	Insulin ; Insulin, Regular, Human
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2012632-3
ISSN	2162-660X ; 0743-4863
ISSN (online)	2162-660X
ISSN	0743-4863
DOI	10.1615/CritRevTherDrugCarrierSyst.2023048197
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Zs.A 2124: Show issues

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Article ; Online: Investigation on trommeled legacy waste from full-scale mining of old dumpsites: Suitable for valorization or scientific disposal?

Parida, Debaprakash / Ramana, G V / Datta, Manoj

Journal of environmental management

2024 Volume 356, Page(s) 120580

Abstract: The burgeoning interest in resource recovery from old dumpsites has significantly propelled the adoption of Landfill Mining (LFM) in recent years. This study is centred around evaluating the quality of materials recovered from the full-scale LFM ... ...

Abstract	The burgeoning interest in resource recovery from old dumpsites has significantly propelled the adoption of Landfill Mining (LFM) in recent years. This study is centred around evaluating the quality of materials recovered from the full-scale LFM activities at two major dumpsites in India, focusing on the valorization potential of the segregated legacy waste. A detailed analysis was conducted on the segregated waste fractions based on particle size (-30 mm, 30 to 6 mm, and -6 mm, as sourced from the sites), employing both batch and column leaching methods across a range of liquid-to-solid (L/S) ratios (0.1-10.0 L/kg). The findings reveal a pronounced concentration of contaminants within the -6 mm fraction compared to the 30 to 6 mm and -30 mm fractions. Column leaching tests revealed a reduction in contaminant concentration, correlating with incremental changes in L/S ratio. Notably, this trend remained consistent across varying particle sizes and specific type of contaminants assessed. Notably, color intensity of leachate reduced significantly from 720 to 1640 Platinum Cobalt Units (PCU) at an L/S ratio of 0.1 L/kg to a minimal 94-225 PCU at an L/S of 10 L/kg. Dissolved salts emerged as a primary concern, marking them as significant contaminants in both leaching methods. The analysis confirmed that the segregated fractions comply with the USEPA Waste Acceptance Criteria (WAC), permitting their disposal in non-hazardous waste landfills. However, the elevated presence of dissolved salts, exceeding reuse limits by 5-35 times, limits their open or unrestricted reuse. Despite this, isolated reuse aligns with regulations from the Netherlands and Germany, suggesting viable pathways for compliant utilization. Geotechnical assessments indicate the potential for repurposing the -30 mm fraction as alternative earthfill and construction material. While heavy metal leaching does not pose significant concerns, the prevalent unscientific disposal practices near urban settlements highlight potential human health risks. This investigation enriches the understanding of the physicochemical properties, leaching behaviour, and reuse potential of segregated legacy waste, offering crucial insights for civic authorities in determining appropriate reuse and disposal strategies for such materials.
MeSH term(s)	Humans ; Refuse Disposal/methods ; Salts ; Waste Disposal Facilities ; Metals, Heavy/analysis ; Cobalt/analysis ; Solid Waste/analysis
Chemical Substances	Salts ; Metals, Heavy ; Cobalt (3G0H8C9362) ; Solid Waste
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120580
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Z 7556: Show issues

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Article ; Online: Characterization of MSW incineration bottom ash for use as structural fill in reinforced soil structures: Geoenvironmental, geotechnical and economical assessment.

Bansal, Deepesh / Ramana, G V / Datta, Manoj / Gupta, Garima

Waste management (New York, N.Y.)

2023 Volume 168, Page(s) 344–353

Abstract: ... The economic viability of using IBA instead of locally available river sand for a 12 m high MSE wall is also established ...

Abstract	The study presents the geoenvironmental and geotechnical characterization of MSW incineration bottom ash (IBA) and examines its reuse as structural fill in reinforced soil structures (RSS).The suitability of reuse has been assessed with regard to international regulatory standards. The prime focus of the work remains on evaluating the pullout response of geosynthetic reinforcements through IBA fill to determine the interaction coefficient, which has never been addressed in the literature. The economic viability of using IBA instead of locally available river sand for a 12 m high MSE wall is also established. The column leaching test results confirm that IBA can be utilized in RSS with suitable design measures. The geotechnical investigation shows that IBA is a well-graded, non-plastic lightweight material with adequate drainage and high shear strength. The pullout test results demonstrate that the interaction coefficient of polymeric strips and geogrid in IBA (0.73-1.53 and 0.79-1.91, respectively) is comparable or higher to materials conventionally used as structural fill in RSS, indicating adequate bondage between IBA and geosynthetic reinforcement. Further, it is estimated that using IBA as a substitute for available river sand in the vicinity can potentially reduce the overall RSS project cost by 15-20%, even if IBA has to be transported 50 km away from the project site.
MeSH term(s)	Incineration ; Coal Ash/chemistry ; Soil ; Sand ; Shear Strength ; Solid Waste/analysis
Chemical Substances	Coal Ash ; Soil ; Sand ; Solid Waste
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2023.06.024
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Article: Role of 18F-FDG PET-CT in Urethral Malignant Melanoma and Analysis of the UK Guidelines on Ano-uro-genital Melanomas

Mahato, Abhishek / Jain, Anurag / Manoj, M.G. / Joshi, Richa

World Journal of Nuclear Medicine

2023 Volume 22, Issue 03, Page(s) 244–247

Abstract	Urethral melanomas are a rare subtype of noncutaneous melanomas. The disease has a tendency to have skip lesions and early metastases as compared with cutaneous melanomas. The role of fluorine-18 fluorodeoxyglucose ( 18 F-FDG) positron emission tomography computed tomography (PET-CT) is well established in cases of cutaneous melanomas and is recommended by the National Comprehensive Cancer Network (NCCN) for stage IIB to IV cancer. There are no established guidelines on the management of noncutaneous melanomas; however, a recently published United Kingdom national guideline aims to streamline the management of ano-uro-genital melanomas. The guideline describes a very limited role in the use of 18 F-FDG PET-CT in this case scenario. The tendency to skip lesions, early metastases, involvement of brain parenchyma, and finally the usage of anti-PD-1 medications are key areas where 18 F-FDG PET-CT has shown superiority over CT scan. With this case report, we aim to highlight the strength of 18 F-FDG PET-CT in the management of urethral melanomas, which can be extrapolated to other ano-uro-genital melanomas.
Keywords	ano-uro-genital melanoma ; FDG PET-CT ; mucosal melanoma ; UK guidelines ; urethral melanoma
Language	English
Publishing date	2023-09-01
Publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2911903-0
ISSN	1607-3312 ; 1450-1147
ISSN (online)	1607-3312
ISSN	1450-1147
DOI	10.1055/s-0043-1771280
Database	Thieme publisher's database

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