Article ; Online: Potential new treatment strategies for COVID-19: is there a role for bromhexine as add-on therapy?
Internal and emergency medicine
2020 Volume 15, Issue 5, Page(s) 801–812
Abstract: Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of ... ...
| Abstract | Of huge importance now is to provide a fast, cost-effective, safe, and immediately available pharmaceutical solution to curb the rapid global spread of SARS-CoV-2. Recent publications on SARS-CoV-2 have brought attention to the possible benefit of chloroquine in the treatment of patients infected by SARS-CoV-2. Whether chloroquine can treat SARS-CoV-2 alone and also work as a prophylactic is doubtful. An effective prophylactic medication to prevent viral entry has to contain, at least, either a protease inhibitor or a competitive virus ACE2-binding inhibitor. Using bromhexine at a dosage that selectively inhibits TMPRSS2 and, in so doing, inhibits TMPRSS2-specific viral entry is likely to be effective against SARS-CoV-2. We propose the use of bromhexine as a prophylactic and treatment. We encourage the scientific community to assess bromhexine clinically as a prophylactic and curative treatment. If proven to be effective, this would allow a rapid, accessible, and cost-effective application worldwide. |
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| MeSH term(s) | Betacoronavirus ; Bromhexine/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Expectorants/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Serine Endopeptidases/drug effects ; Virus Internalization/drug effects |
| Chemical Substances | Expectorants ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; Bromhexine (Q1J152VB1P) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-26 |
| Publishing country | Italy |
| Document type | Journal Article ; Review |
| ZDB-ID | 2454173-4 |
| ISSN | 1970-9366 ; 1828-0447 |
| ISSN (online) | 1970-9366 |
| ISSN | 1828-0447 |
| DOI | 10.1007/s11739-020-02383-3 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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