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Article ; Online: Fluorescence spectroscopy reveals accompanying occurrence of ammonium with fulvic acid-like organic matter in a fluvio-lacustrine aquifer of Jianhan Plain.

Huang, Shuangbing / Wang, Yanxin / Ma, Teng / Wang, Yanyan / Zhao, Long

Environmental science and pollution research international

2016 Volume 23, Issue 9, Page(s) 8508–8517

Abstract: This study is the first to investigate the simultaneous presence of NH4 (+) and fluorescent organic matter components (FOCs) from a fluvio-lacustrine aquifer in Central Jianghan Plain. Sediment, groundwater, and surface water samples were collected for ... ...

Abstract	This study is the first to investigate the simultaneous presence of NH4 (+) and fluorescent organic matter components (FOCs) from a fluvio-lacustrine aquifer in Central Jianghan Plain. Sediment, groundwater, and surface water samples were collected for the sediment organic matter extraction, 3D fluorescence spectroscopy characterization, and/or hydrochemical analysis. NH4 (+) and dissolved organic carbon was ubiquitous in the groundwater. The fluorescence spectroscopy revealed good relationships between NH4 (+) and fulvic acid-like components (FALCs) in the groundwater and sediment-extracted organic matter (SEOM) solutions. NH4 (+) also exhibited significant positive correlation with protein-like component (PLC) (p < 0.001), with the stronger in the SEOM solutions than that in groundwater. Comparisons of spectroscopic indices [e.g., humification index (HIX), biological index (BIX), spectra slope (S275-295), and specific UV absorbance (SUVA254)] between the groundwater and SEOM solutions revealed more labile properties of SEOM. This result indicates that the decreasing NH4 (+)-FOCs correlations of groundwater relative to sediments may be attributed to microbial degradation. Factor analysis identifies important factors that cause NH4 (+) occurrence in the groundwater. The accompanying increase of FALC (C1) and NH4-N with the mole concentration of the normalized HCO3 (-)/(Ca(2+)+Mg(2+)) and [H(+)] suggests that couple effects of various biodegradations simultaneously occur in the aquifer, promoting the occurrence of NH4-DOMs.
MeSH term(s)	Ammonium Compounds/analysis ; Benzopyrans/analysis ; China ; Environmental Monitoring ; Groundwater/chemistry ; Spectrometry, Fluorescence ; Water Pollutants, Chemical/analysis
Chemical Substances	Ammonium Compounds ; Benzopyrans ; Water Pollutants, Chemical ; fulvic acid (XII14C5FXV)
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-016-6092-8
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Article: Fluorescence spectroscopy reveals accompanying occurrence of ammonium with fulvic acid-like organic matter in a fluvio-lacustrine aquifer of Jianhan Plain

Huang, Shuangbing / Yanxin Wang / Teng Ma / Yanyan Wang / Long Zhao

Environmental science and pollution research international. 2016 May, v. 23, no. 9

2016

Abstract: This study is the first to investigate the simultaneous presence of NHâ âº and fluorescent organic matter components (FOCs) from a fluvio-lacustrine aquifer in Central Jianghan Plain. Sediment, groundwater, and surface water samples were collected for ...

Abstract	This study is the first to investigate the simultaneous presence of NHâ âº and fluorescent organic matter components (FOCs) from a fluvio-lacustrine aquifer in Central Jianghan Plain. Sediment, groundwater, and surface water samples were collected for the sediment organic matter extraction, 3D fluorescence spectroscopy characterization, and/or hydrochemical analysis. NHâ âº and dissolved organic carbon was ubiquitous in the groundwater. The fluorescence spectroscopy revealed good relationships between NHâ âº and fulvic acid-like components (FALCs) in the groundwater and sediment-extracted organic matter (SEOM) solutions. NHâ âº also exhibited significant positive correlation with protein-like component (PLC) (pâ<â0.001), with the stronger in the SEOM solutions than that in groundwater. Comparisons of spectroscopic indices [e.g., humification index (HIX), biological index (BIX), spectra slope (Sâââââââ), and specific UV absorbance (SUVAâââ)] between the groundwater and SEOM solutions revealed more labile properties of SEOM. This result indicates that the decreasing NHâ âºâFOCs correlations of groundwater relative to sediments may be attributed to microbial degradation. Factor analysis identifies important factors that cause NHâ âº occurrence in the groundwater. The accompanying increase of FALC (C1) and NH4âN with the mole concentration of the normalized HCOâ â»/(CaÂ²âº+MgÂ²âº) and [Hâº] suggests that couple effects of various biodegradations simultaneously occur in the aquifer, promoting the occurrence of NHââDOMs.
Keywords	absorbance ; ammonium compounds ; ammonium nitrogen ; aquifers ; bicarbonates ; dissolved organic carbon ; factor analysis ; fluorescence ; fluorescence emission spectroscopy ; groundwater ; humification ; protons ; sediments ; surface water
Language	English
Dates of publication	2016-05
Size	p. 8508-8517.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-016-6092-8
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Article ; Online: Hydrophobic gating in bundle-crossing ion channels

Jian Huang / Jianhan Chen

Communications Biology, Vol 6, Iss 1, Pp 1-

a case study of TRPV4

2023 Volume 9

Abstract: Abstract Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free ... ...

Abstract	Abstract Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free energy barrier to ion permeation. Intriguingly, many ion channels also contain highly hydrophobic inner pores enclosed by bundle crossing, which can undergo spontaneous dewetting and give rise to a “vapor barrier” to block ion flow even in the absence of physical constriction. Using atomistic simulations, we show that hydrophobic gating and bundle-crossing mechanisms co-exist and complement one and another in the human TRPV4 channel. In particular, a single hydrophilic mutation in the lower pore can increase pore hydration and reduce the ion permeation free energy barrier by about half without affecting the bundle crossing. We believe that hydrophobic gating may play a key role in other bundle-crossing ion channels with hydrophobic inner pores.
Keywords	Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hydrophobic gating in bundle-crossing ion channels: a case study of TRPV4.

Huang, Jian / Chen, Jianhan

Communications biology

2023 Volume 6, Issue 1, Page(s) 1094

Abstract: Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free energy barrier ...

Abstract	Transmembrane ion channels frequently regulate ion permeation by forming bundle crossing of the pore-lining helices when deactivated. The resulting physical constriction is believed to serve as the de facto gate that imposes the major free energy barrier to ion permeation. Intriguingly, many ion channels also contain highly hydrophobic inner pores enclosed by bundle crossing, which can undergo spontaneous dewetting and give rise to a "vapor barrier" to block ion flow even in the absence of physical constriction. Using atomistic simulations, we show that hydrophobic gating and bundle-crossing mechanisms co-exist and complement one and another in the human TRPV4 channel. In particular, a single hydrophilic mutation in the lower pore can increase pore hydration and reduce the ion permeation free energy barrier by about half without affecting the bundle crossing. We believe that hydrophobic gating may play a key role in other bundle-crossing ion channels with hydrophobic inner pores.
MeSH term(s)	Humans ; Ion Channel Gating/physiology ; TRPV Cation Channels/genetics ; Mutation ; Protein Structure, Secondary ; Hydrophobic and Hydrophilic Interactions
Chemical Substances	TRPV Cation Channels ; TRPV4 protein, human
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05471-0
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Article: Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms.

Huang, Jian / Korsunsky, Aron / Yazdani, Mahdieh / Chen, Jianhan

Frontiers in molecular neuroscience

2024 Volume 16, Page(s) 1334370

Abstract: Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases. These proteins are actively pursued as ... ...

Abstract	Transient receptor potential (TRP) channels are a large and diverse family of transmembrane ion channels that are widely expressed, have important physiological roles, and are associated with many human diseases. These proteins are actively pursued as promising drug targets, benefitting greatly from advances in structural and mechanistic studies of TRP channels. At the same time, the complex, polymodal activation and regulation of TRP channels have presented formidable challenges. In this short review, we summarize recent progresses toward understanding the structural basis of TRP channel function, as well as potential ligand binding sites that could be targeted for therapeutics. A particular focus is on the current understanding of the molecular mechanisms of TRP channel activation and regulation, where many fundamental questions remain unanswered. We believe that a deeper understanding of the functional mechanisms of TRP channels will be critical and likely transformative toward developing successful therapeutic strategies targeting these exciting proteins. This endeavor will require concerted efforts from computation, structural biology, medicinal chemistry, electrophysiology, pharmacology, drug safety and clinical studies.
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2452967-9
ISSN	1662-5099
ISSN	1662-5099
DOI	10.3389/fnmol.2023.1334370
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Article ; Online: Thiophene-based porphyrin polymers for Mercury (II) efficient removal in aqueous solution.

Wang, Lizhi / Liu, Junlong / Wang, Jiajia / Zhang, Du / Huang, Jianhan

Journal of colloid and interface science

2023 Volume 653, Issue Pt A, Page(s) 405–412

Abstract: Development of novel sulf-functionalized porous organic polymers (POPs) for Mercury (II) ( ... ...

Abstract	Development of novel sulf-functionalized porous organic polymers (POPs) for Mercury (II) (Hg
Language	English
Publishing date	2023-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.09.089
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Article ; Online: Perfluoroalkyl-Decorated Noble-Metal-Free MOFs for the Highly Efficient One-Pot Four-Component Coupling between Aldehydes, Amines, Alkynes, and Flue Gas CO

Yang, Fan / Wang, Jiajia / Wang, You / Yu, Benling / Cao, Yiwen / Li, Jiawei / Wu, Linlin / Huang, Jianhan / Liu, You-Nian

Angewandte Chemie (International ed. in English)

2024 Volume 63, Issue 6, Page(s) e202318115

Abstract: The non-noble-metal catalysed-multicomponent reactions between flue gas ... ...

Abstract	The non-noble-metal catalysed-multicomponent reactions between flue gas CO
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202318115
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Article ; Online: Activation of TMEM16F by inner gate charged mutations and possible lipid/ion permeation mechanisms.

Jia, Zhiguang / Huang, Jian / Chen, Jianhan

Biophysical journal

2022 Volume 121, Issue 18, Page(s) 3445–3457

Abstract: Transmembrane protein 16F (TMEM16F) is a ubiquitously expressed ... ...

Abstract	Transmembrane protein 16F (TMEM16F) is a ubiquitously expressed Ca
MeSH term(s)	Animals ; Anoctamins/chemistry ; Anoctamins/genetics ; Anoctamins/metabolism ; Ion Channels/metabolism ; Lysine ; Mammals/metabolism ; Mutation ; Phospholipid Transfer Proteins/metabolism ; Phospholipids/chemistry
Chemical Substances	Anoctamins ; Ion Channels ; Phospholipid Transfer Proteins ; Phospholipids ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218078-9
ISSN	1542-0086 ; 0006-3495
ISSN (online)	1542-0086
ISSN	0006-3495
DOI	10.1016/j.bpj.2022.08.011
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Article ; Online: Anisole-modified hyper-cross-linked resins for efficient adsorption of aniline from aqueous solution.

Zeng, Xu / Huang, Jianhan

Journal of colloid and interface science

2020 Volume 569, Page(s) 177–183

Abstract: The development of functionalized hyper-cross-linked resins (HCLRs) with high Brunauer-Emmett-Teller (BET) surface area ( ... ...

Abstract	The development of functionalized hyper-cross-linked resins (HCLRs) with high Brunauer-Emmett-Teller (BET) surface area (S
Language	English
Publishing date	2020-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2020.02.082
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Article ; Online: Development and validation of a 23-gene expression signature for molecular subtyping of medulloblastoma in a long-term Chinese cohort.

Wang, Yuyuan / Huang, Jianhan / Yin, Xian / Xu, Qinghua / Sun, Yifeng / Yao, Yu / Xiong, Ji

Acta neurochirurgica

2024 Volume 166, Issue 1, Page(s) 72

Abstract: Purpose: Medulloblastoma is the most common childhood malignant brain tumor and is a leading cause of cancer-related death in children. Recent transcriptional studies have shown that medulloblastomas comprise at least four molecular subgroups, each with ...

Abstract	Purpose: Medulloblastoma is the most common childhood malignant brain tumor and is a leading cause of cancer-related death in children. Recent transcriptional studies have shown that medulloblastomas comprise at least four molecular subgroups, each with distinct demographics, genetics, and clinical outcomes. Medulloblastoma subtyping has become critical for subgroup-specific therapies. The use of gene expression assays to determine the molecular subgroup of clinical specimens is a long-awaited application of molecular biology for this pediatric cancer. Methods: In the current study, we established a medulloblastoma transcriptome database of 460 samples retrieved from three published datasets (GSE21140, GSE37382, and GSE37418). With this database, we identified a 23-gene signature that is significantly associated with the medulloblastoma subgroups and achieved a classification accuracy of 95.2%. Results: The 23-gene signature was further validated in a long-term cohort of 142 Chinese medulloblastoma patients. The 23-gene signature classified 21 patients as WNT (15%), 41 as SHH (29%), 16 as Group 3 (11%), and 64 as Group 4 (45%). For patients of WNT, SHH, Group 3, and Group 4, 5-year overall-survival rate reached 80%, 62%, 27%, and 47%, respectively (p < 0.0001), meanwhile 5-year progression-free survival reached 80%, 52%, 27%, and 45%, respectively (p < 0.0001). Besides, SHH/TP53-mutant tumors were associated with worse prognosis compared with SHH/TP53 wild-type tumors and other subgroups. We demonstrated that subgroup assignments by the 23-gene signature and Northcott's NanoString assay were highly comparable with a concordance rate of 96.4%. Conclusions: In conclusion, we present a novel gene signature that is capable of accurately and reliably assigning FFPE medulloblastoma samples to their molecular subgroup, which may serve as an auxiliary tool for medulloblastoma subtyping in the clinic. Future incorporation of this gene signature into prospective clinical trials is warranted to further evaluate its clinical.
MeSH term(s)	Humans ; Child ; Medulloblastoma/diagnosis ; Medulloblastoma/genetics ; Transcriptome/genetics ; Prospective Studies ; Brain Neoplasms ; Cerebellar Neoplasms/genetics ; China
Language	English
Publishing date	2024-02-08
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-024-05922-5
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