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  1. Article: [L. E. Golubinin, the Professor of the Moscow University and His Role in History of National Clinic of Beginning of XX Century].

    Borodulin, V I / Pashkov, K A / Poddubnyi, M V / Topolianskii, A V / Shadrin, P V

    Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

    2018  Volume 26, Issue 5, Page(s) 371–376

    Abstract: The article presents the scientific biography of L. E. Golubinin, the prominent therapist, prepared ... of Public Health". For the first time the role L. E. Golubinin played in organization of the scientific school ... level of the personality of L. E. Golubinin is presented. ...

    Abstract The article presents the scientific biography of L. E. Golubinin, the prominent therapist, prepared on the basis of publications' review and rich archive materials, including documents of the Central Historical Archive of Moscow (f.418) and personal archive of V. D. Shervinsky from the Department of History of Medicine of The Federal State Budget Scientific Institution "N. A. Semashko National Research Institute of Public Health". For the first time the role L. E. Golubinin played in organization of the scientific school of Shervinsky-Golubinin asd a largest therapeutic school in the Moscow University is revealed. Also a high moral level of the personality of L. E. Golubinin is presented.
    MeSH term(s) Academies and Institutes/history ; Ambulatory Care Facilities ; History, 20th Century ; Internal Medicine ; Moscow ; Universities
    Language Russian
    Publishing date 2018-11-01
    Publishing country Russia (Federation)
    Document type Historical Article ; Journal Article
    ZDB-ID 1483853-9
    ISSN 0869-866X
    ISSN 0869-866X
    DOI 10.32687/0869-866X-2018-26-5-371-376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Stanovlenie sovetskoi stomatologii: 1918—1921 gody.

    Yanushevich, O O / Pashkov, K A / Maksimov, E S

    Stomatologiia

    2023  Volume 102, Issue 2, Page(s) 70–76

    Abstract: The main task of the Dentistry subsection of the People's Commissariat for Health, established in August 1918, was the creation of qualified, free, scheduled dental care in the country, accessible to the general population. Dentistry reform had to be ... ...

    Title translation Formation of Soviet dentistry: 1918-1921.
    Abstract The main task of the Dentistry subsection of the People's Commissariat for Health, established in August 1918, was the creation of qualified, free, scheduled dental care in the country, accessible to the general population. Dentistry reform had to be carried out under the conditions of post-revolutionary devastation, famine and the Civil War, in the absence of sufficient funding, appropriate material base, with a significant shortage of dentists and their negative attitude towards the changes taking place. The problem of lack of equipment, materials and medicines was solved by nationalization of private dental offices, and the dentists who were left without equipment were forced to perform labor, and not all of them were able to survive those difficult years. Nevertheless, in the RSFSR a network of state outpatient dental clinics was created, which after the country's transition to the New Economic Policy began to rapidly erode - a sustainable system of free public dentistry was to be created at another time and under different economic conditions.
    MeSH term(s) Humans ; Dentistry ; Dentists
    Language Russian
    Publishing date 2023-05-04
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 421717-2
    ISSN 0039-1735
    ISSN 0039-1735
    DOI 10.17116/stomat202310202170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Utilizing the amide proton transfer technique to characterize diffuse gliomas based on the WHO 2021 classification of CNS tumors.

    Filimonova, Elena / Pashkov, Anton / Borisov, Norayr / Kalinovsky, Anton / Rzaev, Jamil

    The neuroradiology journal

    2024  , Page(s) 19714009241242658

    Abstract: Purpose: Diffuse gliomas present a significant challenge for healthcare systems globally. While brain MRI plays a vital role in diagnosis, prognosis, and treatment monitoring, accurately characterizing gliomas using conventional MRI techniques alone is ... ...

    Abstract Purpose: Diffuse gliomas present a significant challenge for healthcare systems globally. While brain MRI plays a vital role in diagnosis, prognosis, and treatment monitoring, accurately characterizing gliomas using conventional MRI techniques alone is challenging. In this study, we explored the potential of utilizing the amide proton transfer (APT) technique to predict tumor grade and type based on the WHO 2021 Classification of CNS Tumors.
    Methods: Forty-two adult patients with histopathologically confirmed brain gliomas were included in the study. They underwent 3T MRI imaging, which involved APT sequence. Multinomial and binary logistic regression models were employed to classify patients into clinically relevant groups based on MRI findings and demographic variables.
    Results: We found that the best model for tumor grade classification included patient age along with APT values. The highest sensitivity (88%) was observed for Grade 4 tumors, while Grade 3 tumors showed the highest specificity (79%). For tumor type classification, our model incorporated four predictors: APT values, patient's age, necrosis, and the presence of hemorrhage. The glioblastoma group had the highest sensitivity and specificity (87%), whereas balanced accuracy was the lowest for astrocytomas (0.73).
    Conclusion: The APT technique shows great potential for noninvasive evaluation of diffuse gliomas. The changes in the classification of gliomas as per the WHO 2021 version of the CNS Tumor Classification did not affect its usefulness in predicting tumor grade or type.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/19714009241242658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [On the formation of Soviet haematology as an independent scientific clinical discipline and medical profession].

    Borodulin, V I / Banzelyuk, E N / Pashkov, K A / Topolyanskiy, A V

    Terapevticheskii arkhiv

    2023  Volume 95, Issue 7, Page(s) 597–601

    Abstract: On the basis of a critical analysis of sources and the use of comparative historical research method, the authors reveal the fundamental role of Academician of the USSR Academy of Sciences I.A. Kassirsky in the formation of haematology as an independent ... ...

    Abstract On the basis of a critical analysis of sources and the use of comparative historical research method, the authors reveal the fundamental role of Academician of the USSR Academy of Sciences I.A. Kassirsky in the formation of haematology as an independent clinical discipline in the USSR and put forward the thesis of the decisive importance in this process of the unified haematological school of A.N. Kryukov - I.A. Kassirsky.
    MeSH term(s) Humans ; Hematology ; Academies and Institutes
    Language Russian
    Publishing date 2023-09-29
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 40718-5
    ISSN 2309-5342 ; 0040-3660
    ISSN (online) 2309-5342
    ISSN 0040-3660
    DOI 10.26442/00403660.2023.07.202283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: White and Gray Matter Perfusion in Children with Moyamoya Angiopathy after Revascularization Surgery.

    Filimonova, Elena / Martirosyan, Azniv / Ovsiannikov, Konstantin / Pashkov, Anton / Rzaev, Jamil

    Pediatric neurosurgery

    2023  Volume 58, Issue 4, Page(s) 197–205

    Abstract: Introduction: Surgical revascularization is very effective in patients with moyamoya angiopathy (MMA) and leads to improvements in cortical perfusion parameters. However, changes in white matter hemodynamics are still underestimated. To date, only a few ...

    Abstract Introduction: Surgical revascularization is very effective in patients with moyamoya angiopathy (MMA) and leads to improvements in cortical perfusion parameters. However, changes in white matter hemodynamics are still underestimated. To date, only a few studies have examined brain perfusion changes within deep white matter after bypass surgery in patients with MMA.
    Methods: Ten children with MMA were evaluated using the CT perfusion technique before and after revascularization surgery. Brain perfusion parameters within gray and white matter were compared before and after surgery. The correlations between the perfusion parameters before surgery and the Suzuki stage, as well as between the perfusion parameters and the cognitive scores, were also evaluated.
    Results: Brain perfusion parameters improved significantly in both gray matter (predominantly due to cerebral blood flow within the anterior circulation, p < 0.01) and white matter (predominantly due to cerebral blood volume within the semiovale centrum, p < 0.001). We revealed that the pattern of improvement in perfusion in white matter differed from the pattern of improvement in perfusion in gray matter. Significant correlations were revealed between the Suzuki stage before surgery and the perfusion parameters within the posterior cerebral artery circulation (adjusted p < 0.05). There were also significant correlations between cognitive scores and brain perfusion parameters in gray matter and white matter (adjusted p < 0.05).
    Conclusions: The perfusion parameters of gray matter and white matter in the brain improve differently after bypass surgery in patients with MMA. Different hemodynamics within these compartments could explain this.
    MeSH term(s) Humans ; Child ; Gray Matter/diagnostic imaging ; Moyamoya Disease/diagnostic imaging ; Moyamoya Disease/surgery ; Brain/diagnostic imaging ; Brain/surgery ; White Matter/diagnostic imaging ; Perfusion ; Cerebrovascular Circulation/physiology
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1091757-3
    ISSN 1423-0305 ; 1016-2291
    ISSN (online) 1423-0305
    ISSN 1016-2291
    DOI 10.1159/000531719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [The prospects for the use of drugs based on the phenomenon of RNA interference against HIV infection].

    Pashkov, E A / Pak, A V / Pashkov, E P / Bykov, A S / Budanova, E V / Poddubikov, A V / Svitich, O A / Zverev, V V

    Voprosy virusologii

    2022  Volume 67, Issue 4, Page(s) 278–289

    Abstract: The human immunodeficiency virus (HIV) is currently one of the most pressing global health problems. Since its discovery in 1978, HIV has claimed the lives of more than 35 million people, and the number of people infected today reaches 37 million. In the ...

    Abstract The human immunodeficiency virus (HIV) is currently one of the most pressing global health problems. Since its discovery in 1978, HIV has claimed the lives of more than 35 million people, and the number of people infected today reaches 37 million. In the absence of highly active antiretroviral therapy (HAART), HIV infection is characterized by a steady decrease in the number of CD4+ T-lymphocytes, but its manifestations can affect the central nervous, cardiovascular, digestive, endocrine and genitourinary systems. At the same time, complications induced by representatives of pathogenic and opportunistic microflora, which can lead to the development of bacterial, fungal and viral concomitant infections, are of particular danger. It should be borne in mind that an important problem is the emergence of viruses resistant to standard therapy, as well as the toxicity of the drugs themselves for the body. In the context of this review, of particular interest is the assessment of the prospects for the creation and clinical use of drugs based on small interfering RNAs aimed at suppressing the reproduction of HIV, taking into account the experience of similar studies conducted earlier. RNA interference is a cascade of regulatory reactions in eukaryotic cells, which results in the degradation of foreign messenger RNA. The development of drugs based on the mechanism of RNA interference will overcome the problem of viral resistance. Along with this, this technology makes it possible to quickly respond to outbreaks of new viral diseases.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; CD4-Positive T-Lymphocytes ; HIV Infections/drug therapy ; Humans ; RNA Interference ; RNA, Small Interfering ; Virus Diseases
    Chemical Substances RNA, Small Interfering
    Language Russian
    Publishing date 2022-09-11
    Publishing country Russia (Federation)
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 201241-8
    ISSN 2411-2097 ; 0507-4088
    ISSN (online) 2411-2097
    ISSN 0507-4088
    DOI 10.36233/0507-4088-124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: [Influence of siRNA complexes on the reproduction of influenza A virus (Orthomyxoviridae:

    Pashkov, E A / Momot, V Y / Pak, A V / Samoilikov, R V / Pashkov, G A / Usatova, G N / Kravtsova, E O / Poddubikov, A V / Nagieva, F G / Sidorov, A V / Pashkov, E P / Svitich, O A / Zverev, V V

    Voprosy virusologii

    2023  Volume 68, Issue 2, Page(s) 95–104

    Abstract: Introduction: Influenza is one of the most pressing global health problems. Despite the wide range of available anti-influenza drugs, the viral drug resistance is an increasing concern and requires the search for new approaches to overcome it. A ... ...

    Abstract Introduction: Influenza is one of the most pressing global health problems. Despite the wide range of available anti-influenza drugs, the viral drug resistance is an increasing concern and requires the search for new approaches to overcome it. A promising solution is the development of drugs with action that is based on the inhibition of the activity of cellular genes through RNA interference.
    Aim: Evaluation in vivo of the preventive potential of miRNAs directed to the cellular genes FLT4, Nup98 and Nup205 against influenza infection.
    Materials and methods: The A/California/7/09 strain of influenza virus (H1N1) and BALB/c mice were used in the study. The administration of siRNA and experimental infection of animals were performed intranasally. The results of the experiment were analyzed using molecular genetic and virological methods.
    Results: The use of siRNA complexes Nup98.1 and Nup205.1 led to a significant decrease in viral reproduction and concentration of viral RNA on the 3rd day after infection. When two siRNA complexes (Nup98.1 and Nup205.1) were administered simultaneously, a significant decrease in viral titer and concentration of viral RNA was also noted compared with the control groups.
    Conclusions: The use of siRNAs in vivo can lead to an antiviral effect when the activity of single or several cellular genes is suppressed. The results indicate that the use of siRNAs targeting the cellular genes whose expression products are involved in viral reproduction is one of the promising methods for the prevention and treatment of not only influenza, but also other respiratory infections.
    MeSH term(s) Animals ; Mice ; Humans ; Influenza A virus ; RNA, Small Interfering/genetics ; RNA, Small Interfering/pharmacology ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/metabolism ; Cell Line ; Influenza, Human ; Antiviral Agents/pharmacology ; RNA, Viral ; Reproduction ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/prevention & control ; Virus Replication
    Chemical Substances RNA, Small Interfering ; Antiviral Agents ; RNA, Viral
    Language Russian
    Publishing date 2023-05-18
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 201241-8
    ISSN 2411-2097 ; 0507-4088
    ISSN (online) 2411-2097
    ISSN 0507-4088
    DOI 10.36233/0507-4088-159
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  8. Article: [The temptation of Russian Pharma. Report I: The design of program of additional medicinal support of particular categories of citizen].

    Pashkov, K A / Maksimov, E S / Zhmaka, A G / Paren'kova, O R / Shadrin, P V

    Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny

    2023  Volume 31, Issue 3, Page(s) 473–480

    Abstract: In 1918, the Dentistry subsection of the People's Commissariat of Health Care was organized with purpose of establishing national public free qualified state dental care. The organized institution was headed by P. G. Dauge, the dentist by education and ... ...

    Abstract In 1918, the Dentistry subsection of the People's Commissariat of Health Care was organized with purpose of establishing national public free qualified state dental care. The organized institution was headed by P. G. Dauge, the dentist by education and the associate of Lenin by revolutionary activity. He developed dentistry reform plan as far back as the Revolution. The plan provided for organizing state dental clinics on the basis of requisitioned private dental offices and their former owners left without implements were to be engaged into public service. This process was regulated by the resolutions developed by the Dentistry subsection and adopted by the People's Commissariat of Health ("On the state organization of dental care in the Republic", "On labor service of medical personnel" ) as well as by numerous instructions and circulars. The main problems when organizing state dentistry became missing or inadequate financing, deficiency of equipment, required instruments, materials and medications as well as reluctance of dentists to be deprived of their offices and to change to state service. The organization of national state dental care was impeded by military mobilization of dentists and dental technicians that resulted in more than one third of specialists found themselves in the Red Army. The state outpatient clinics network, organized in conditions of war communism, decreased drastically after transition to the new economic policy in 1921.
    MeSH term(s) Humans ; Delivery of Health Care ; Russia
    Language Russian
    Publishing date 2023-07-10
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1483853-9
    ISSN 0869-866X
    ISSN 0869-866X
    DOI 10.32687/0869-866X-2023-31-3-473-480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative Characterization of the Expression Profiles of Cardiac Kv7.1 Channels Containing Two Rare Genetic Variants.

    Pashkov, Alexander / Karlova, Maria / Moisenovich, Anastasia / Abramochkin, Denis / Zaklyazminskaya, Elena / Sokolova, Olga

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1118–1119

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.573
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  10. Article ; Online: Diffusion tensor imaging reveals distributed white matter abnormalities in primary trigeminal neuralgia: Tract-based spatial statistics study.

    Filimonova, Elena / Pashkov, Anton / Moysak, Galina / Martirosyan, Azniv / Zaitsev, Boris / Rzaev, Jamil

    Clinical neurology and neurosurgery

    2023  Volume 236, Page(s) 108080

    Abstract: Background: Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not limited to the trigeminal system. Despite the significant advances in uncovering underlying mechanisms, there is a paucity of comprehensive and ...

    Abstract Background: Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not limited to the trigeminal system. Despite the significant advances in uncovering underlying mechanisms, there is a paucity of comprehensive and consistent data regarding the role of white matter throughout the entire brain in PTN.
    Methods: We performed a prospective case-control study. Sixty patients with PTN and 28 age- and sex-matched healthy controls were evaluated using diffusion tensor imaging (DTI). A tract-based spatial statistical approach was performed to investigate white matter impairment in patients with PTN with several metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Additionally, ROI-based analysis was performed for each white matter tract to compare FA values between groups with correction for patient age and sex. Correlations between DTI data and nerve root compression severity, as well as pain severity, were also evaluated in patients with PTN.
    Results: Our analysis demonstrated a widespread and symmetrical reduction in FA values among TN patients when compared to the control group (p < 0.05). Specifically, this FA decrease was predominantly observed in regions such as the corona radiata, internal capsule, optic radiation, and thalami, as well as structures within the posterior fossa, notably the cerebellar peduncles. No statistically significant differences were found between patients and the control group during the MD, AD and RD map analyses. ROI-based analysis did not reveal statistically significant changes in FA values in white matter tracts (p > 0.05 in all comparisons, FDR-corrected); however, there were trends towards FA value decreases in the internal capsule (p = 0.08, FDR-corrected) and inferior fronto-occipital fasciculus (p = 0.09, FDR-corrected).
    Conclusions: Our findings indicate the presence of microstructural abnormalities in white matter among individuals with primary trigeminal neuralgia, which may potentially play a role in the development and progression of the condition.
    MeSH term(s) Humans ; Diffusion Tensor Imaging/methods ; Trigeminal Neuralgia/diagnostic imaging ; White Matter/diagnostic imaging ; Case-Control Studies ; Brain/pathology ; Anisotropy
    Language English
    Publishing date 2023-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2023.108080
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