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Article ; Online: Automated Computer Vision-Enabled Manufacturing of Nanowire Devices.

Potočnik, Teja / Christopher, Peter J / Mouthaan, Ralf / Albrow-Owen, Tom / Burton, Oliver J / Jagadish, Chennupati / Tan, Hark Hoe / Wilkinson, Timothy D / Hofmann, Stephan / Joyce, Hannah J / Alexander-Webber, Jack A

ACS nano

2022 Volume 16, Issue 11, Page(s) 18009–18017

Abstract: We present a high-throughput method for identifying and characterizing individual nanowires and for automatically designing electrode patterns with high alignment accuracy. Central to our method is an optimized machine-readable, lithographically ... ...

Abstract	We present a high-throughput method for identifying and characterizing individual nanowires and for automatically designing electrode patterns with high alignment accuracy. Central to our method is an optimized machine-readable, lithographically processable, and multi-scale fiducial marker system─dubbed LithoTag─which provides nanostructure position determination at the nanometer scale. A grid of uniquely defined LithoTag markers patterned across a substrate enables image alignment and mapping in 100% of a set of >9000 scanning electron microscopy (SEM) images (>7 gigapixels). Combining this automated SEM imaging with a computer vision algorithm yields location and property data for individual nanowires. Starting with a random arrangement of individual InAs nanowires with diameters of 30 ± 5 nm on a single chip, we automatically design and fabricate >200 single-nanowire devices. For >75% of devices, the positioning accuracy of the fabricated electrodes is within 2 pixels of the original microscopy image resolution. The presented LithoTag method enables automation of nanodevice processing and is agnostic to microscopy modality and nanostructure type. Such high-throughput experimental methodology coupled with data-extensive science can help overcome the characterization bottleneck and improve the yield of nanodevice fabrication, driving the development and applications of nanostructured materials.
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c08187
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Article: Synthesis of the cyclopentane core of pepluanin A

Shepherd, Erin D / Burton, Jonathan W / Hallside, Michal S / Hutchings, Martin / Sutro, Jack L / Thompson, Amber

Tetrahedron. 2020 Mar. 13, v. 76, no. 11

2020

Abstract: The jatrophane class of natural products exhibit a wide range of biological activities with certain members of this family of complex sesquiterpenes being P-glycoprotein inhibitors. Considerable attention has been paid to the synthesis of biologically ... ...

Abstract	The jatrophane class of natural products exhibit a wide range of biological activities with certain members of this family of complex sesquiterpenes being P-glycoprotein inhibitors. Considerable attention has been paid to the synthesis of biologically active jatrophanes although very few have succumbed to total synthesis. Herein we report a synthesis of the cyclopentane core of pepluanin A, a potent P-glycoprotein inhibitor, that features an iodocarbocyclization and an invertive acetal formation as key steps.
Keywords	bioactive properties ; chemical reactions ; chemical structure ; P-glycoproteins ; sesquiterpenoids
Language	English
Dates of publication	2020-0313
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204285-x
ISSN	1464-5416 ; 0040-4020 ; 0563-2064
ISSN (online)	1464-5416
ISSN	0040-4020 ; 0563-2064
DOI	10.1016/j.tet.2020.130981
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Article: Clinical characteristics and treatment patterns of patients with venous thromboembolism (VTE) transitioning from hospital to post-discharge settings.

Burton, Tanya / Hlavacek, Patrick / Guo, Jennifer D / Rosenblatt, Lisa / Mardekian, Jack / Ferri, Mauricio / Russ, Cristina / Kline, Jeffrey A

Hospital practice (1995)

2020 Volume 48, Issue 4, Page(s) 196–205

Abstract: Objective: This study examined anticoagulant use during and after a hospital encounter for venous thromboembolism (VTE), a transition of care largely uncharacterized in the literature.: Methods: Adults with a VTE diagnosis code during a hospital ... ...

Abstract	Objective: This study examined anticoagulant use during and after a hospital encounter for venous thromboembolism (VTE), a transition of care largely uncharacterized in the literature. Methods: Adults with a VTE diagnosis code during a hospital encounter (emergency department [ED], observation area [OBS], or inpatient hospital [IP]) from January 2012 to August 2017 were identified in an electronic health records database. The first such hospital encounter was defined as the index VTE encounter. Patients were linked to a claims database and required to be continuously enrolled for six months before the index admission date through six months after the index discharge date. Anticoagulants administered during the index VTE encounter and filled on or within 30 days of discharge were summarized descriptively overall, and by the type of index VTE encounter (IP, No IP) and anticoagulants administered during the index VTE encounter. Results: Among 2,968 eligible patients, mean (SD) age was 64 (16) years, 51% were female, 67% had an IP index VTE encounter, and 77% received anticoagulation therapy during the index VTE encounter. In total, 60% filled a prescription order for anticoagulant within 30 days post-discharge. Of those who received a direct oral anticoagulant (DOAC), warfarin, or parenteral anticoagulant only during the index VTE encounter, 74%, 69%, and 34%, respectively, filled a prescription for the same anticoagulant post-discharge. Patients treated with a DOAC or warfarin during an ED or OBS VTE encounter without a subsequent inpatient hospitalization were more likely to remain on the same anticoagulation therapy post-discharge than those with an inpatient hospitalization (81% vs 69% for DOAC and 75% vs 68% for warfarin). Conclusions: Many patients treated with anticoagulation therapy during a VTE hospital encounter did not fill a prescription for an anticoagulant within 30 days post-discharge, highlighting an opportunity for improved management of care transitions in this patient population.
MeSH term(s)	Aged ; Aged, 80 and over ; Anticoagulants/administration & dosage ; Anticoagulants/classification ; Continuity of Patient Care/statistics & numerical data ; Drug Administration Routes ; Female ; Guideline Adherence ; Humans ; Insurance Claim Review ; Male ; Middle Aged ; Patient Discharge/statistics & numerical data ; Practice Guidelines as Topic ; Retrospective Studies ; Venous Thromboembolism/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2020-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2570453-9
ISSN	2377-1003 ; 2154-8331 ; 8750-2836
ISSN (online)	2377-1003
ISSN	2154-8331 ; 8750-2836
DOI	10.1080/21548331.2020.1769988
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Article: The MTT assay to evaluate chemosensitivity.

Burton, Jack D

Methods in molecular medicine

2005 Volume 110, Page(s) 69–78

Abstract: The assessment of the degree or rate of cellular proliferation and cell viability is critical to the assessment of the effects of drugs, antibodies, or cytokines on both normal and malignant cell populations. This can be accomplished by either direct or ... ...

Abstract	The assessment of the degree or rate of cellular proliferation and cell viability is critical to the assessment of the effects of drugs, antibodies, or cytokines on both normal and malignant cell populations. This can be accomplished by either direct or indirect counting methods. Direct counting by manual or automated methods, using a hemacytometer or particle counter, respectively, allows for serial cell counting at multiple time points, but these are low-throughput approaches. High-throughput and robust alternatives to direct counting utilize either radiotracers (e.g., 3H-thymidine) or dye compounds, which can be adapted to multiwell culture plate formats. This chapter focuses on the use of tetrazolium-type indicator dyes, of which the compound 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) has been the most widely utilized. Newer tetrazolium dyes that yield water-soluble products and offer added flexibility, increases in sensitivity, and fewer steps, which are offset by increased costs, are also covered.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Cell Count ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Coloring Agents ; Drug Evaluation, Preclinical/methods ; Humans ; Immunologic Factors/pharmacology ; Tetrazolium Salts ; Thiazoles
Chemical Substances	Antineoplastic Agents ; Coloring Agents ; Immunologic Factors ; Tetrazolium Salts ; Thiazoles ; thiazolyl blue (EUY85H477I)
Language	English
Publishing date	2005
Publishing country	United States
Document type	Journal Article
ISSN	1543-1894
ISSN	1543-1894
DOI	10.1385/1-59259-869-2:069
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Article ; Online: New agents and approaches to the treatment of B-cell non-Hodgkin lymphoma.

Burton, Jack D / Goldenberg, David M

Expert opinion on emerging drugs

2010 Volume 15, Issue 4, Page(s) 569–583

Abstract: Importance of the field: B-cell non-Hodgkin lymphoma (NHL) is a significant public health problem as the most common hematologic malignancy in many areas of the world. Current treatments are generally effective, but only a minority of this large group ... ...

Abstract	Importance of the field: B-cell non-Hodgkin lymphoma (NHL) is a significant public health problem as the most common hematologic malignancy in many areas of the world. Current treatments are generally effective, but only a minority of this large group of patients can be cured. Areas covered in this review: Progress in clinical development of novel, targeted agents and newer cytotoxic agents has led to improved, more durable responses in all major subtypes of NHL. This article covers novel therapeutic agents, which are investigational or registered recently for NHL and/or other cancers. Subtypes of B-cell NHL are addressed separately including relevant papers over the past 20 years. What the reader will gain: This review provides a better understanding of studies that have formed the basis for current treatment approaches for B-cell NHL. Also, areas of unmet need are covered. Novel agents are described along with their mechanisms of action, as well as how they might advance the treatment of B-cell NHL. Take home message: This review highlights advancements and the current state of knowledge by presenting clinical trial results as well as preclinical data and advances in prognostic and predictive factors that will pave the way to further progress in NHL.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Clinical Trials as Topic ; Drug Delivery Systems ; Drug Design ; Drug Evaluation, Preclinical ; Humans ; Lymphoma, B-Cell/drug therapy ; Lymphoma, B-Cell/pathology ; Prognosis ; Treatment Outcome
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2061369-6
ISSN	1744-7623 ; 1472-8214
ISSN (online)	1744-7623
ISSN	1472-8214
DOI	10.1517/14728214.2010.514263
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Article ; Online: High-Throughput Electrical Characterization of Nanomaterials from Room to Cryogenic Temperatures.

ACS nano

2020 Volume 14, Issue 11, Page(s) 15293–15305

Abstract: We present multiplexer methodology and hardware for nanoelectronic device characterization. This high-throughput and scalable approach to testing large arrays of nanodevices operates from room temperature to milli-Kelvin temperatures and is universally ... ...

Abstract	We present multiplexer methodology and hardware for nanoelectronic device characterization. This high-throughput and scalable approach to testing large arrays of nanodevices operates from room temperature to milli-Kelvin temperatures and is universally compatible with different materials and integration techniques. We demonstrate the applicability of our approach on two archetypal nanomaterials-graphene and semiconductor nanowires-integrated with a GaAs-based multiplexer using wet or dry transfer methods. A graphene film grown by chemical vapor deposition is transferred and patterned into an array of individual devices, achieving 94% yield. Device performance is evaluated using data fitting methods to obtain electrical transport metrics, showing mobilities comparable to nonmultiplexed devices fabricated on oxide substrates using wet transfer techniques. Separate arrays of indium-arsenide nanowires and micromechanically exfoliated monolayer graphene flakes are transferred using pick-and-place techniques. For the nanowire array mean values for mobility μ
Language	English
Publishing date	2020-10-26
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.0c05622
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Article ; Online: Fast Twist Angle Mapping of Bilayer Graphene Using Spectroscopic Ellipsometric Contrast Microscopy.

Potočnik, Teja / Burton, Oliver / Reutzel, Marcel / Schmitt, David / Bange, Jan Philipp / Mathias, Stefan / Geisenhof, Fabian R / Weitz, R Thomas / Xin, Linyuan / Joyce, Hannah J / Hofmann, Stephan / Alexander-Webber, Jack A

Nano letters

2023 Volume 23, Issue 12, Page(s) 5506–5513

Abstract: Twisted bilayer graphene provides an ideal solid-state model to explore correlated material properties and opportunities for a variety of optoelectronic applications, but reliable, fast characterization of the twist angle remains a challenge. Here we ... ...

Abstract	Twisted bilayer graphene provides an ideal solid-state model to explore correlated material properties and opportunities for a variety of optoelectronic applications, but reliable, fast characterization of the twist angle remains a challenge. Here we introduce spectroscopic ellipsometric contrast microscopy (SECM) as a tool for mapping twist angle disorder in optically resonant twisted bilayer graphene. We optimize the ellipsometric angles to enhance the image contrast based on measured and calculated reflection coefficients of incident light. The optical resonances associated with van Hove singularities correlate well to Raman and angle-resolved photoelectron emission spectroscopy, confirming the accuracy of SECM. The results highlight the advantages of SECM, which proves to be a fast, nondestructive method for characterization of twisted bilayer graphene over large areas, unlocking process, material, and device screening and cross-correlative measurement potential for bilayer and multilayer materials.
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c00619
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Article ; Online: Spiritual Care of Inpatients Focusing on Outcomes and the Role of Chaplaincy Services: A Systematic Review.

Kirchoff, Robert W / Tata, Beba / McHugh, Jack / Kingsley, Thomas / Burton, M Caroline / Manning, Dennis / Lapid, Maria / Chaudhary, Rahul

Journal of religion and health

2021 Volume 60, Issue 2, Page(s) 1406–1422

Abstract: Objective: To identify demographic trends associated with patient utilization and healthcare provider request for spiritual care services and to describe the impact of spiritual care on the quality of life (QoL), spiritual well-being (SWB) and level of ... ...

Abstract	Objective: To identify demographic trends associated with patient utilization and healthcare provider request for spiritual care services and to describe the impact of spiritual care on the quality of life (QoL), spiritual well-being (SWB) and level of satisfaction (SAT) of hospitalized patients. Patients and methods: A systematic search of Ovid MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, was combined with review of relevant bibliographies. A total of 464 titles and abstracts were reviewed. Data were independently extracted by reviewers according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data on the effects of spiritual interventions on QoL, SWB and SAT were extracted, along with demographic data reflecting chaplain services. The results of the studies are presented narratively and in a qualitative manner. Results: Observational or experimental studies investigating chaplain utilization demographics (n = 12), patient satisfaction (n = 9) and QoL/SWB (n = 3) were included. Perceived severity of illness, average length of stay and older age were consistently found to be predictors of higher need for spiritual care. Receipt of spiritual care was correlated with increased patient and family satisfaction, independent of clinical outcome. Chaplain interventions were associated with improvement in perceived QoL and SWB. In spite of this, healthcare workers rarely attempt to explore the patient's or family's need for spiritual care, with the majority of chaplaincy consults occurring in the final day of the patient's life, potentially leading to a failure to meet the spiritual needs of non-terminal patients who have spiritual trauma related to their resolving illnesses. Conclusion: Attention to the spiritual needs of hospitalized patients is an essential yet often overlooked aspect of patient care. Chaplains serve as spiritual care specialists whose services can enhance the hospital experience, improve patient satisfaction and help to bridge potential gaps between the patient and medical providers.
MeSH term(s)	Aged ; Clergy ; Humans ; Inpatients ; Patient Satisfaction ; Quality of Life ; Spirituality
Language	English
Publishing date	2021-02-11
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	2017250-3
ISSN	1573-6571 ; 0022-4197
ISSN (online)	1573-6571
ISSN	0022-4197
DOI	10.1007/s10943-021-01191-z
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Article ; Online: Correction to: Spiritual Care of Inpatients Focusing on Outcomes and the Role of Chaplaincy Services: A Systematic Review.

Kirchoff, Robert W / Tata, Beba / McHugh, Jack / Kingsley, Thomas / Burton, M Caroline / Manning, Dennis / Lapid, Maria / Chaudhary, Rahul

Journal of religion and health

2021 Volume 60, Issue 3, Page(s) 2190

Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2017250-3
ISSN	1573-6571 ; 0022-4197
ISSN (online)	1573-6571
ISSN	0022-4197
DOI	10.1007/s10943-021-01250-5
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Article ; Online: Combining the quantitative faecal immunochemical test and full blood count reliably rules out colorectal cancer in a symptomatic patient referral pathway.

Johnstone, Mark S / Burton, Paul / Kourounis, Georgios / Winter, Jack / Crighton, Emilia / Mansouri, David / Witherspoon, Paul / Smith, Karen / McSorley, Stephen T

International journal of colorectal disease

2021 Volume 37, Issue 2, Page(s) 457–466

Abstract: Purpose: Faecal Immunochemical Test (FIT) has proven utility for Colorectal Cancer (CRC) detection in symptomatic patients. Most studies have examined FIT in symptomatic patients subsequently referred from primary care. We investigated associations ... ...

Abstract	Purpose: Faecal Immunochemical Test (FIT) has proven utility for Colorectal Cancer (CRC) detection in symptomatic patients. Most studies have examined FIT in symptomatic patients subsequently referred from primary care. We investigated associations between CRC and FIT in both referred and non-referred symptomatic patients. Methods: A retrospective, observational study of all patients with a FIT submitted Aug 2018 to Jan 2019 in NHS GG&C was performed. Referral to colorectal/gastroenterology and decision to perform colonoscopy were recorded. FIT results were grouped as f-Hb < 10/10-149/150-399/ ≥ 400 μg/g. The MCN cancer registry identified new cases of CRC. Covariables were compared using the χ Results: A total of 4968 patients were included. Raised FIT correlated with decision to refer (p < 0.001) and scope (p < 0.001). With 23-month median follow-up, 61 patients were diagnosed with CRC. These patients were older (median 69 vs 59 years, cancer and no cancer respectively, p = 0.001), more likely to be male (55.7% vs 42.1%, p = 0.033), and to report rectal bleeding (51.7% vs 36.1%, p = 0.013). FIT (< 10 µg/g 8.2% vs 76.7% and ≥ 400 µg/g 55.7% vs 3.8%, p < 0.001) and anaemia (45.9% vs 19.7%, p < 0.001) were associated with CRC. On multivariate analysis, age (p = 0.023), male sex (p = 0.04), FIT (≥ 400 OR 54.256 (95% CI:20.683-142.325; p < 0.001)), and anaemia (OR 1.956 (1.071-3.574; p = 0.029)) independently predicted CRC. One patient (0.04%) with a negative FIT and normal haemoglobin had CRC. Conclusion: GP referral and secondary care investigation patterns were influenced by FIT. The combination of normal Hb and f-Hb excluded CRC in 99.96% of cases, providing excellent reassurance to those prioritising access to endoscopy services.
MeSH term(s)	Colonoscopy ; Colorectal Neoplasms/diagnosis ; Early Detection of Cancer ; Feces/chemistry ; Female ; Hemoglobins/analysis ; Humans ; Male ; Occult Blood ; Referral and Consultation ; Retrospective Studies ; Sensitivity and Specificity
Chemical Substances	Hemoglobins
Language	English
Publishing date	2021-12-21
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-021-04079-2
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