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  1. Article ; Online: An embarrassment of riches: RORγt

    Stephen-Victor, Emmanuel / Chatila, Talal A

    Immunity

    2022  Volume 55, Issue 11, Page(s) 1978–1980

    Abstract: ... ...

    Abstract RORγt
    MeSH term(s) Nuclear Receptor Subfamily 1, Group F, Member 3 ; Peripheral Tolerance ; Embarrassment ; T-Lymphocytes, Regulatory ; Antigen-Presenting Cells ; Th17 Cells ; Forkhead Transcription Factors ; Immune Tolerance
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 3 ; Forkhead Transcription Factors
    Language English
    Publishing date 2022-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2022.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4227: Show issues Location:
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  2. Article ; Online: Multimerized IgG1 Fc molecule as an anti-inflammatory agent.

    Stephen-Victor, Emmanuel / Bayry, Jagadeesh

    Nature reviews. Rheumatology

    2018  Volume 14, Issue 7, Page(s) 390–392

    MeSH term(s) Anti-Inflammatory Agents ; Autoimmune Diseases ; Complement System Proteins ; Humans ; Immunoglobulin G ; Receptors, IgG
    Chemical Substances Anti-Inflammatory Agents ; Immunoglobulin G ; Receptors, IgG ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2018-06-20
    Publishing country United States
    Document type News ; Comment
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-018-0013-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6338: Show issues Location:
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  3. Article: Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms.

    Das, Mrinmoy / Stephen-Victor, Emmanuel / Bayry, Jagadeesh

    Oncoimmunology

    2020  Volume 9, Issue 1, Page(s) 1773193

    Abstract: Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of regulatory T ... ...

    Abstract Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of regulatory T cells (Treg cells) in this process. We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism.
    MeSH term(s) Basophils/metabolism ; Forkhead Transcription Factors/metabolism ; Humans ; Interleukin-3 ; STAT5 Transcription Factor/metabolism ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Forkhead Transcription Factors ; Interleukin-3 ; STAT5 Transcription Factor
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.1080/2162402X.2020.1773193
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  4. Article ; Online: Dietary and Microbial Determinants in Food Allergy.

    Stephen-Victor, Emmanuel / Crestani, Elena / Chatila, Talal A

    Immunity

    2020  Volume 53, Issue 2, Page(s) 277–289

    Abstract: The steep rise in food allergy (FA) has evoked environmental factors involved in disease pathogenesis, including the gut microbiota, diet, and their metabolites. Early introduction of solid foods synchronizes with the "weaning reaction," a time during ... ...

    Abstract The steep rise in food allergy (FA) has evoked environmental factors involved in disease pathogenesis, including the gut microbiota, diet, and their metabolites. Early introduction of solid foods synchronizes with the "weaning reaction," a time during which the microbiota imprints durable oral tolerance. Recent work has shown that children with FA manifest an early onset dysbiosis with the loss of Clostridiales species, which promotes the differentiation of ROR-γt
    MeSH term(s) Animals ; Clostridiales/isolation & purification ; Desensitization, Immunologic/methods ; Diet ; Dysbiosis/microbiology ; Food Hypersensitivity/immunology ; Gastrointestinal Microbiome/physiology ; Humans ; Immune Tolerance/immunology ; Immunoglobulin E/immunology ; Mice ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2020.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The microbial origins of food allergy.

    Rachid, Rima / Stephen-Victor, Emmanuel / Chatila, Talal A

    The Journal of allergy and clinical immunology

    2020  Volume 147, Issue 3, Page(s) 808–813

    Abstract: Food allergy (FA) is a significant public health issue, propelled by its rapidly increasing prevalence. Its sharp rise into prominence has focused attention on causative environmental factors and their interplay with the immune system in disease ... ...

    Abstract Food allergy (FA) is a significant public health issue, propelled by its rapidly increasing prevalence. Its sharp rise into prominence has focused attention on causative environmental factors and their interplay with the immune system in disease pathogenesis. In that regard, there is now substantial evidence that alterations in the gut microbiome early in life imprint the host gut mucosal immunity and may play a critical role in precipitating FA. These changes may impact key steps in the development of the infant gut microbiome, including its shaping by maternal factors and upon the introduction of solid food (the weaning reaction). These early-life changes may have long-range effects on host immunity that manifest later in time as disease pathology. Experimental studies have shown that resetting the host intestinal immune responses by treatment with either a healthy fecal microbiota transplantation or defined commensal bacterial taxa can prevent or treat FA. The mechanisms by which these interventions suppress FA include restoration of gut immune regulatory checkpoints, notably the retinoic orphan receptor gamma T
    MeSH term(s) Animals ; Dysbiosis/immunology ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Fecal Microbiota Transplantation ; Food Hypersensitivity/immunology ; Food Hypersensitivity/microbiology ; Food Hypersensitivity/therapy ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity, Mucosal ; Immunoglobulin A/metabolism ; Immunoglobulin E/metabolism ; Models, Immunological ; Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Immunoglobulin A ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2020-12-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2020.12.624
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    Uh III Zs.92: Show issues Location:
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  6. Article ; Online: Regulation of oral immune tolerance by the microbiome in food allergy.

    Stephen-Victor, Emmanuel / Chatila, Talal A

    Current opinion in immunology

    2019  Volume 60, Page(s) 141–147

    Abstract: The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the ... ...

    Abstract The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by a variety of environmental insults, including among others antibiotic usage and mode of delivery, that act to subvert the immune regulatory response that enforce tolerance to dietary antigens. A key attribute of this dysbiosis is the loss of Clostridial bacterial species that act to promote the formation of food allergen-specific nascent regulatory T cells in the gut. Significantly, different immunoprotective commensal bacteria, including members of the Clostridiales and Bacteroidales orders act to induce the transcription factor RORγt in nascent Treg cells via an upstream MyD88-dependent mechanism to promote tolerance to dietary antigens. Activation of this axis is disrupted by the dysbiosis, and can be restored by treatment with therapeutic microbiota. These findings highlight the potential for novel microbiota-based approaches to the prevention and treatment of the FA epidemic.
    MeSH term(s) Animals ; Disease Susceptibility/immunology ; Dysbiosis/immunology ; Food Hypersensitivity/genetics ; Food Hypersensitivity/immunology ; Food Hypersensitivity/therapy ; Gene-Environment Interaction ; Genetic Predisposition to Disease ; Humans ; Immune Tolerance ; Immunomodulation ; Microbiota/immunology ; Precision Medicine ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Language English
    Publishing date 2019-07-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2019.06.001
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    Zs.A 2773: Show issues Location:
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    Zs.MG 13: Show issues

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  7. Article ; Online: Essential functions of regulatory T cell TGF-β1 revealed by differential gene-targeting approaches.

    Stephen-Victor, Emmanuel / Cui, Ye / Wang, Ziwei / Benamar, Mehdi / Charbonnier, Louis-Marie / Chatila, Talal A

    Immunity

    2021  Volume 54, Issue 3, Page(s) 397–398

    MeSH term(s) Flow Cytometry ; T-Lymphocytes, Regulatory ; Transforming Growth Factor beta/genetics ; Transforming Growth Factor beta1/genetics
    Chemical Substances Transforming Growth Factor beta ; Transforming Growth Factor beta1
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.02.005
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  8. Article ; Online: Potential of regulatory T-cell-based therapies in the management of severe COVID-19.

    Stephen-Victor, Emmanuel / Das, Mrinmoy / Karnam, Anupama / Pitard, Bruno / Gautier, Jean-François / Bayry, Jagadeesh

    The European respiratory journal

    2020  Volume 56, Issue 3

    MeSH term(s) Betacoronavirus ; COVID-19 ; China ; Coronavirus ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; T-Lymphocytes, Regulatory
    Keywords covid19
    Language English
    Publishing date 2020-09-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02182-2020
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  9. Article ; Online: IL-26: An Emerging Proinflammatory Member of the IL-10 Cytokine Family with Multifaceted Actions in Antiviral, Antimicrobial, and Autoimmune Responses.

    Stephen-Victor, Emmanuel / Fickenscher, Helmut / Bayry, Jagadeesh

    PLoS pathogens

    2016  Volume 12, Issue 6, Page(s) e1005624

    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1005624
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  10. Article ; Online: Correction: Saha, C., et al. Differential Effects of

    Saha, Chaitrali / Das, Mrinmoy / Stephen-Victor, Emmanuel / Friboulet, Alain / Bayry, Jagadeesh / Kaveri, Srini V

    Molecules (Basel, Switzerland)

    2019  Volume 24, Issue 20

    Abstract: The authors wish to make the following corrections to this paper [ ... ]. ...

    Abstract The authors wish to make the following corrections to this paper [...].
    Language English
    Publishing date 2019-10-18
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules24203762
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    Zs.MO 81: Show issues

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