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Article ; Online: Res Medica, April 1967, Special Issue – Lauder Brunton Centenary Symposium on Angina Pectoris

Dr. M. H. Kaufman / Dr. R. B. L. Ewart / R. D. Hunter / Miss Alison Leach / Dr. W. F. M. Fulton / Dr. J. Russell Rees / Professor Melville Arnott / Dr. Richard Gorlin / Peter Bent / Ottar Muller / Professor J. N. Morris / Dr. M. F. Oliver / Sir John Michael / G.C. Friesinger / C. F. Borchgrevink / Dr. D. G. Julian

Res Medica (2014)

2014

Abstract: Welcome Historical Session Opening Address Lauder Brunton History of Angina Pathophysiological Session The Pathology of Angina Experimental Studies on the Myocardial Collateral Circulation First Discussion Coronary Blood Flow and Myocardial Metabolism in ...

Abstract	Welcome Historical Session Opening Address Lauder Brunton History of Angina Pathophysiological Session The Pathology of Angina Experimental Studies on the Myocardial Collateral Circulation First Discussion Coronary Blood Flow and Myocardial Metabolism in Angina Pectoris Cardiac Function in Patients with Angina Second Discussion Therapeutic Session The Modern Epidemic Is Angina Preventable? Third Discussion Chest Pain, Exercise Electrocardiography and Coronary Arteriography (Correlative Studies in Angina Pectoris Prognosis of Angina Pectoris Panel Discussion Summing Up
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2014-07-01T00:00:00Z
Publisher	Royal Medical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Potential protective effects of breast milk and amniotic fluid against novel coronavirus SARS-CoV-2 through decoy receptors.

Rees, April / Turner, Steve / Thornton, Catherine A

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2021 Volume 33, Issue 1, Page(s) e13672

MeSH term(s)	Amniotic Fluid ; Breast Feeding ; COVID-19 ; Female ; Humans ; Milk, Human ; SARS-CoV-2
Language	English
Publishing date	2021-10-11
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.13672
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Article: Assessing truck driver exposure at the World Trade Center disaster site: personal and area monitoring for particulate matter and volatile organic compounds during October 2001 and April 2002.

Geyh, Alison S / Chillrud, Steven / Williams, D'Ann L / Herbstman, Julie / Symons, J Morel / Rees, Katherine / Ross, James / Kim, Sung Roul / Lim, Ho-Jin / Turpin, Barbara / Breysse, Patrick

Journal of occupational and environmental hygiene

2005 Volume 2, Issue 3, Page(s) 179–193

Abstract: ... and April 2002. In cooperation with a local labor union, 54 drivers (October) and 15 drivers (April ... during April. During both months, monitoring was also conducted at one location in the middle ... from 23% to 100% suggesting significant fire activity during some of the sampled shifts. During April ...

Abstract	The destruction of the World Trade Center (WTC) in New York City on September 11, 2001, created a 16-acre debris field composed of pulverized and burning material significantly impacting air quality. Site cleanup began almost immediately. Cleanup workers were potentially exposed to airborne contaminants, including particulate matter, volatile organic compounds, and asbestos, at elevated concentrations. This article presents the results of the exposure assessment of one important group of WTC workers, truck drivers, as well as area monitoring that was conducted directly on site during October 2001 and April 2002. In cooperation with a local labor union, 54 drivers (October) and 15 drivers (April) were recruited on site to wear two monitors during their 12-hour work shifts. In addition, drivers were administered a questionnaire asking for information ranging from "first day at the site" to respirator use. Area monitoring was conducted at four perimeter locations during October and three perimeter locations during April. During both months, monitoring was also conducted at one location in the middle of the rubble. Contaminants monitored for included total dust (TD), PM10, PM2.5, and volatile organic compounds. Particle samples were analyzed for mass, as well as elemental and organic carbon content. During October, the median personal exposure to TD was 346 microg/m3. The maximum area concentration, 1742 microg/m3, was found in middle of the debris. The maximum TD concentration found at the perimeter was 392 microg/m3 implying a strong concentration gradient from the middle of debris outward. PM2.5/PM10 ratios ranged from 23% to 100% suggesting significant fire activity during some of the sampled shifts. During April, the median personal exposure to TD was 144 microg/m3, and the highest area concentration, 195 microg/m3, was found at the perimeter. During both months, volatile organic compounds concentrations were low.
MeSH term(s)	Air Pollutants/analysis ; Aircraft ; Asbestos/analysis ; Automobile Driving ; Construction Materials ; Dust ; Environmental Monitoring ; Humans ; Hygiene ; Motor Vehicles ; New York City ; Occupational Exposure ; Organic Chemicals/analysis ; Particle Size ; Seasons ; September 11 Terrorist Attacks ; Volatilization
Chemical Substances	Air Pollutants ; Dust ; Organic Chemicals ; Asbestos (1332-21-4)
Language	English
Publishing date	2005-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2131820-7
ISSN	1545-9624
ISSN	1545-9624
DOI	10.1080/15459620590923154
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Article: Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?

Jenkins, Benjamin J / Rees, April / Jones, Nicholas / Thornton, Catherine A

Immunometabolism

2021 Volume 3, Issue 4, Page(s) e210031

Abstract: Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an ... ...

Abstract	Pregnancy is characterised by metabolic changes that occur to support the growth and development of the fetus over the course of gestation. These metabolic changes can be classified into two distinct phases: an initial anabolic phase to prepare an adequate store of substrates and energy which are then broken down and used during a catabolic phase to meet the energetic demands of the mother, placenta and fetus. Dynamic readjustment of immune homeostasis is also a feature of pregnancy and is likely linked to the changes in energy substrate utilisation at this time. As cellular metabolism is increasingly recognised as a key determinant of immune cell phenotype and function, we consider how changes in maternal metabolism might contribute to T cell plasticity during pregnancy.
Language	English
Publishing date	2021-10-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2754912-4
ISSN	2084-6835
ISSN	2084-6835
DOI	10.20900/immunometab20210031
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Article ; Online: The dynamic inflammatory profile of pregnancy can be monitored using a novel lipid-based mass spectrometry technique.

Rees, April / Edwards-I-Coll, Zoe / Richards, Oliver / Raikes, Molly E / Angelini, Roberto / Thornton, Catherine A

Molecular omics

2023 Volume 19, Issue 4, Page(s) 340–350

Abstract: The lipid environment changes throughout pregnancy both physiologically with emergent insulin resistance and ... ...

Abstract	The lipid environment changes throughout pregnancy both physiologically with emergent insulin resistance and pathologically
MeSH term(s)	Male ; Humans ; Female ; Pregnancy ; Phosphatidylcholines/analysis ; Inflammation ; Spectrometry, Mass, Electrospray Ionization/methods ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods ; Biomarkers ; Lysophosphatidylcholines
Chemical Substances	Phosphatidylcholines ; Biomarkers ; Lysophosphatidylcholines
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2515-4184
ISSN (online)	2515-4184
DOI	10.1039/d2mo00294a
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Article ; Online: Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity.

Rees, April / Richards, Oliver / Chambers, Megan / Jenkins, Benjamin J / Cronin, James G / Thornton, Catherine A

Clinical and experimental immunology

2022 Volume 208, Issue 2, Page(s) 132–146

Abstract: Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. ... ...

Abstract	Mandatory maternal metabolic and immunological changes are essential to pregnancy success. Parallel changes in metabolism and immune function make immunometabolism an attractive mechanism to enable dynamic immune adaptation during pregnancy. Immunometabolism is a burgeoning field with the underlying principle being that cellular metabolism underpins immune cell function. With whole body changes to the metabolism of carbohydrates, protein and lipids well recognised to occur in pregnancy and our growing understanding of immunometabolism as a determinant of immunoinflammatory effector responses, it would seem reasonable to expect immune plasticity during pregnancy to be linked to changes in the availability and handling of multiple nutrient energy sources by immune cells. While studies of immunometabolism in pregnancy are only just beginning, the recognised bi-directional interaction between metabolism and immune function in the metabolic disorder obesity might provide some of the earliest insights into the role of immunometabolism in immune plasticity in pregnancy. Characterised by chronic low-grade inflammation including in pregnant women, obesity is associated with numerous adverse outcomes during pregnancy and beyond for both mother and child. Concurrent changes in metabolism and immunoinflammation are consistently described but any causative link is not well established. Here we provide an overview of the metabolic and immunological changes that occur in pregnancy and how these might contribute to healthy versus adverse pregnancy outcomes with special consideration of possible interactions with obesity.
MeSH term(s)	Female ; Humans ; Inflammation ; Obesity ; Pregnancy
Language	English
Publishing date	2022-03-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1093/cei/uxac003
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Article ; Online: Maternal body mass index is associated with an altered immunological profile at 28 weeks of gestation.

Rees, April / Richards, Oliver / Allen-Kormylo, Anastasia / Jones, Nicholas / Thornton, Catherine A

Clinical and experimental immunology

2022 Volume 208, Issue 1, Page(s) 114–128

Abstract: Healthy pregnancy is accompanied by various immunological and metabolic adaptations. Maternal obesity has been implicated in adverse pregnancy outcomes such as miscarriage, preeclampsia, and gestational diabetes mellitus (GDM), while posing a risk to the ...

Abstract	Healthy pregnancy is accompanied by various immunological and metabolic adaptations. Maternal obesity has been implicated in adverse pregnancy outcomes such as miscarriage, preeclampsia, and gestational diabetes mellitus (GDM), while posing a risk to the neonate. There is a lack of knowledge surrounding obesity and the maternal immune system. The objective of this study was to consider if immunological changes in pregnancy are influenced by maternal obesity. Peripheral blood was collected from fasted GDM-negative pregnant women at 26-28 weeks of gestation. Analysis was done using immunoassay, flow cytometry, bioenergetics analysis, and cell culture. The plasma profile was significantly altered with increasing BMI, specifically leptin (r = 0.7635), MCP-1 (r = 0.3024), and IL-6 (r = 0.4985). Circulating leukocyte populations were also affected with changes in the relative abundance of intermediate monocytes (r = -0.2394), CD4:CD8 T-cell ratios (r = 0.2789), and NKT cells (r = -0.2842). Monocytes analysed in more detail revealed elevated CCR2 expression and decreased mitochondrial content with increased BMI. However, LPS-stimulated cytokine production and bioenergetic profile of PBMCs were not affected by maternal BMI. The Th profile skews towards Th17 with increasing BMI; Th2 (r = -0.3202) and Th9 (r = -0.3205) cells were diminished in maternal obesity, and CytoStim™-stimulation exacerbates IL-6 (r = 0.4166), IL-17A (r = 0.2753), IL-17F (r = 0.2973), and IL-22 (r = 0.2257) production with BMI, while decreasing IL-4 (r = -0.2806). Maternal obesity during pregnancy creates an inflammatory microenvironment. Successful pregnancy requires Th2-biased responses yet increasing maternal BMI favours a Th17 response that could be detrimental to pregnancy. Further research should investigate key populations of cells identified here to further understand the immunological challenges that beset pregnant women with obesity.
MeSH term(s)	Infant, Newborn ; Female ; Pregnancy ; Humans ; Body Mass Index ; Obesity, Maternal/complications ; Interleukin-6 ; Diabetes, Gestational ; Obesity
Chemical Substances	Interleukin-6
Language	English
Publishing date	2022-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1093/cei/uxac023
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Article ; Online: Macrophage Plasticity in Reproduction and Environmental Influences on Their Function.

Chambers, Megan / Rees, April / Cronin, James G / Nair, Manju / Jones, Nicholas / Thornton, Catherine A

Frontiers in immunology

2021 Volume 11, Page(s) 607328

Abstract: Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning ... ...

Abstract	Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning reproductive success including implantation, placentation and parturition. Macrophages are also present in breast milk and impart immunomodulatory benefits to the infant. For a healthy pregnancy, the maternal immune system must adapt to prevent fetal rejection and support development of the semi-allogenic fetus without compromising host defense. These functions are dependent on macrophage polarization which is governed by the local tissue microenvironmental milieu. Disruption of this microenvironment, possibly by environmental factors of infectious and non-infectious origin, can affect macrophage phenotype and function and is linked to adverse obstetric outcomes, e.g. spontaneous miscarriage and preterm birth. Determining environmental influences on cellular and molecular mechanisms that control macrophage polarization at the maternal-fetal interface and the role of this in pregnancy complications could support approaches to alleviating adverse pregnancy outcomes.
MeSH term(s)	Animals ; Cell Plasticity/drug effects ; Cellular Microenvironment ; Environmental Exposure/adverse effects ; Environmental Pollutants/adverse effects ; Female ; Humans ; Macrophages/drug effects ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Phenotype ; Placenta/drug effects ; Placenta/immunology ; Placenta/metabolism ; Placenta/pathology ; Pregnancy ; Pregnancy Complications/chemically induced ; Pregnancy Complications/immunology ; Pregnancy Complications/metabolism ; Pregnancy Complications/pathology ; Pregnancy Outcome ; Reproduction/drug effects ; Risk Factors ; Signal Transduction ; Uterus/drug effects ; Uterus/immunology ; Uterus/metabolism ; Uterus/pathology
Chemical Substances	Environmental Pollutants
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.607328
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Article ; Online: Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer.

Farook, M Rufaik / Croxford, Zack / Morgan, Steffan / Horlock, Anthony D / Holt, Amy K / Rees, April / Jenkins, Benjamin J / Tse, Carmen / Stanton, Emma / Davies, D Mark / Thornton, Catherine A / Jones, Nicholas / Sheldon, I Martin / Vincent, Emma E / Cronin, James G

Molecular metabolism

2024 Volume 81, Page(s) 101900

Abstract: The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients ... ...

Abstract	The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of cases and reduced MPC1 mRNA expression. To explore the metabolic effect of reduced expression, we demonstrate that depleting MPC1 in HGSOC cell lines drives expression of key proline biosynthetic genes; PYCR1, PYCR2 and PYCR3, and biosynthesis of proline. We show that altered proline metabolism underpins cancer cell proliferation, reactive oxygen species (ROS) production, and type I and type VI collagen formation in ovarian cancer cells. Furthermore, exploring The Cancer Genome Atlas, we discovered the PYCR3 isozyme to be highly expressed in a third of HGSOC patients, which was associated with more aggressive disease and diagnosis at a younger age. Taken together, our study highlights that targeting proline metabolism is a potential therapeutic avenue for the treatment of HGSOC.
MeSH term(s)	Female ; Humans ; Cell Proliferation ; Collagen ; Monocarboxylic Acid Transporters/genetics ; Ovarian Neoplasms/genetics ; Proline
Chemical Substances	Collagen (9007-34-5) ; Monocarboxylic Acid Transporters ; Proline (9DLQ4CIU6V) ; MPC1 protein, human
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2024.101900
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Article: Michael John Ransford Dawkins 5 April 1931-27 June 1965.

Smith, J F / Rees, K R

The Journal of pathology and bacteriology

1967 Volume 93, Issue 1, Page(s) 365–369

MeSH term(s)	Bibliography as Topic ; England ; History of Medicine ; Pathology/history
Language	English
Publishing date	1967-01
Publishing country	England
Document type	Bibliography ; Biography ; Historical Article ; Journal Article
ZDB-ID	3101-x
ISSN	1555-2039 ; 0368-3494
ISSN (online)	1555-2039
ISSN	0368-3494
DOI	10.1002/path.1700930142
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