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  1. Article ; Online: Fluctuating hepatitis B viremia: Full of sound and fury, signifying nothing?

    Nguyen, Henry H / Lee, Samuel S

    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

    2022  Volume 28, Issue 5, Page(s) 319–321

    MeSH term(s) DNA, Viral ; Hepatitis B/epidemiology ; Hepatitis B virus/genetics ; Humans ; Viremia/epidemiology
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2022-08-09
    Publishing country India
    Document type Editorial ; Comment
    ZDB-ID 2299174-8
    ISSN 1998-4049 ; 1319-3767
    ISSN (online) 1998-4049
    ISSN 1319-3767
    DOI 10.4103/sjg.sjg_307_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Charge Transfer-Promoted Excited State of a Heavy-Atom-Free Photosensitizer for Efficient Application of Mitochondria-Targeted Fluorescence Imaging and Hypoxia Photodynamic Therapy.

    Pham, Thanh Chung / Cho, Moonyeon / Nguyen, Van-Nghia / Nguyen, Van Kieu Thuy / Kim, Gyoungmi / Lee, Seongman / Dehaen, Wim / Yoon, Juyoung / Lee, Songyi

    ACS applied materials & interfaces

    2024  Volume 16, Issue 17, Page(s) 21699–21708

    Abstract: Conventional photosensitizers (PSs) used in photodynamic therapy (PDT) have shown preliminary success; however, they are often associated with several limitations including potential dark toxicity in healthy tissues, limited efficacy under acidic and ... ...

    Abstract Conventional photosensitizers (PSs) used in photodynamic therapy (PDT) have shown preliminary success; however, they are often associated with several limitations including potential dark toxicity in healthy tissues, limited efficacy under acidic and hypoxic conditions, suboptimal fluorescence imaging capabilities, and nonspecific targeting during treatment. In response to these challenges, we developed a heavy-atom-free PS, denoted as
    MeSH term(s) Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Photochemotherapy ; Humans ; Mitochondria/metabolism ; Mitochondria/drug effects ; Optical Imaging ; Reactive Oxygen Species/metabolism ; Boron Compounds/chemistry ; Boron Compounds/pharmacology ; Carbazoles/chemistry ; Carbazoles/pharmacology ; HeLa Cells ; Thiophenes/chemistry ; Thiophenes/pharmacology ; Cell Line, Tumor
    Chemical Substances Photosensitizing Agents ; Reactive Oxygen Species ; Boron Compounds ; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Carbazoles ; Thiophenes
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c03123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrence of Anterior Vaginal Prolapse After Robotic Sacrocolpopexy: Does Cervical Preservation Affect Outcome?

    Eckhardt, Sarah E / Lee, Janet S / Nguyen, John N

    Urogynecology (Philadelphia, Pa.)

    2023  Volume 29, Issue 2, Page(s) 151–159

    Abstract: Importance: Anterior vaginal prolapse (AVP) is the most common site of recurrence after sacrocolpopexy (SCP). Supracervical hysterectomy helps to prevent mesh exposure, but it is unclear if cervical preservation (CP) affects adequate reduction of AVP.!## ...

    Abstract Importance: Anterior vaginal prolapse (AVP) is the most common site of recurrence after sacrocolpopexy (SCP). Supracervical hysterectomy helps to prevent mesh exposure, but it is unclear if cervical preservation (CP) affects adequate reduction of AVP.
    Objective: Our primary objective was to determine the difference in AVP recurrence rates in patients who have undergone SCP with or without CP. Secondary outcomes were composite failure and complications rates.
    Study design: This was a retrospective cohort analysis of women who underwent robotic SCP between 2012 and 2019 at Kaiser Permanente Southern California. The first cohort included women with CP (prior or concomitant supracervical hysterectomy). The second included women without CP (prior or concomitant total hysterectomy). Primary outcome was defined as recurrent AVP beyond the hymen. Patients without 12-month follow-up were included in demographic and surgical data analysis only.
    Results: The charts of 373 patients with CP and 175 without CP were reviewed. Women with CP were more likely to undergo concomitant anterior repair at the time of SCP (14% vs 6%, P < 0.01); however, rates of AVP recurrence were not significantly different between groups (5% vs 3%, P = 0.26). Median follow-up time was 26 months (interquartile range, 14-38 months). Composite failure was similar between groups (17% vs 11%, P = 0.12). Women with CP were more likely to experience asymptomatic apical failure (6% vs 1%, P = 0.03).
    Conclusions: Cervical preservation at the time of SCP is associated with an increased need for concomitant anterior repair but is not associated with higher rates of AVP recurrence or composite failure.
    MeSH term(s) Humans ; Female ; Uterine Prolapse/surgery ; Retrospective Studies ; Robotic Surgical Procedures/adverse effects ; Hysterectomy/adverse effects ; Cohort Studies
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article
    ISSN 2771-1897
    ISSN (online) 2771-1897
    DOI 10.1097/SPV.0000000000001260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inflammatory Markers and Fatigue in Individuals With Moderate to Severe Chronic Obstructive Pulmonary Disease.

    Lee, Jung Eun / Nguyen, Huong Q / Fan, Vincent S

    Nursing research

    2023  Volume 73, Issue 1, Page(s) 54–61

    Abstract: Background: Fatigue, a prevalent complex symptom among patients with chronic obstructive pulmonary disease (COPD), is considered an important clinical indicator of disease severity. However, the underlying mechanisms of COPD-related fatigue are not ... ...

    Abstract Background: Fatigue, a prevalent complex symptom among patients with chronic obstructive pulmonary disease (COPD), is considered an important clinical indicator of disease severity. However, the underlying mechanisms of COPD-related fatigue are not fully understood.
    Objectives: This analysis explored the relationships between peripheral inflammatory markers and COPD-related fatigue in people with moderate to severe COPD.
    Methods: This is a secondary analysis of a longitudinal observational study of individuals with COPD examining the biological causes and functional consequences of depression. The data used in this study were collected at baseline. Systemic inflammation markers included C-reactive protein (CRP) and three pro-inflammatory cytokines consisting of interleukin-6 (IL-6), IL-8, and tumor necrosis factor-α. COPD-related fatigue was self-reported using the Chronic Respiratory Questionnaire. Covariates included age; gender; smoking status; disease severity; symptoms of depression, anxiety, and pain; and social support. Multivariable linear regression analyses were conducted.
    Results: The sample included 300 adults living with COPD; 80% were male, and the average age was 67.6 years. Modest correlations were found between two systemic inflammatory markers (CRP and IL-8) and COPD-related fatigue. CRP was the only inflammatory marker significantly associated with fatigue symptoms after adjusting for covariates in multivariable analyses. Depression, pain, and education level were also significant predictors of COPD-related fatigue.
    Discussion: The findings suggest that altered immune response based on CRP may contribute to COPD-related fatigue. Management of depression and pain may work as an effective treatment strategy for COPD-related fatigue. Further longitudinal studies with a broader range of inflammatory markers and multidimensional measures of fatigue symptoms are warranted.
    MeSH term(s) Adult ; Aged ; Female ; Humans ; Male ; Biomarkers ; C-Reactive Protein/analysis ; Fatigue/etiology ; Interleukin-8 ; Pain ; Pulmonary Disease, Chronic Obstructive/complications ; Observational Studies as Topic
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4) ; Interleukin-8
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80332-7
    ISSN 1538-9847 ; 0029-6562
    ISSN (online) 1538-9847
    ISSN 0029-6562
    DOI 10.1097/NNR.0000000000000695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Telehealth transitional care and 30-day readmission during the COVID-19 pandemic.

    Shen, Ernest / Huang, Cheng-Wei / Huynh, Dan N / Lee, Janet S / Nguyen, Huong Q

    The American journal of managed care

    2024  Volume 30, Issue 1, Page(s) e1–e3

    Abstract: Transitional care management (TCM) services after hospital discharge are critical for continuity of care, and the COVID-19 pandemic accelerated the shift to telehealth modes of delivery. This study examined the shift from face-to-face to telehealth care ... ...

    Abstract Transitional care management (TCM) services after hospital discharge are critical for continuity of care, and the COVID-19 pandemic accelerated the shift to telehealth modes of delivery. This study examined the shift from face-to-face to telehealth care around the start of the pandemic (April-July 2020) compared with the same months in 2019 and 2021 and the corresponding 30-day readmission rates. We compared the rates of face-to-face and telehealth TCM as well as face-to-face and telehealth non-TCM services and observed a dramatic shift to telehealth in 2020 with a slight drop-off in 2021. For TCM services specifically, face-to-face visits made up nearly 90% of visits in 2019, whereas telehealth made up the vast majority in 2020 and 2021 at 97.5% and 84.9%, respectively. Over the same time periods, 30-day readmission rates remained steady at 10% along with no changes in 30-day mortality. Among those who completed TCM visits, 30-day readmission rates remained between 8% and 9% and 30-day mortality remained below 1%. These data indicate that this dramatic systemwide shift from face-to-face to telehealth TCM was not accompanied by concurrent changes in either 30-day readmission or mortality rates. Although the findings may be subject to ecologic bias, the data at hand did not allow for reliable estimation of differences in effects of patient-level service delivery type on readmission risk or mortality due to the extremely low volume of face-to-face visits during the pandemic periods. Future research would be needed to conduct such comparisons.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Patient Readmission ; Pandemics ; Transitional Care ; Telemedicine
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2024.89487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Updates in characteristics and survival rates of cirrhosis in a nationwide cohort of real-world U.S. patients, 2003-2021.

    Tran, Sally / Zou, Biyao / Lee, KeeSeok / Kam, Leslie / Yeo, YeeHui / Henry, Linda / Cheung, Ramsey / Nguyen, Mindie H

    Alimentary pharmacology & therapeutics

    2024  

    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.18024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Using item response theory to develop and refine patient-reported outcome measures.

    Nguyen, Tam H / Lee, Christopher S / Kim, Miyong T

    European journal of cardiovascular nursing

    2022  Volume 21, Issue 5, Page(s) 509–515

    Abstract: There is a long tradition of incorporating patient-reported outcomes (PROs) into nursing research and practice. Classical Test Theory (CTT) has been the traditional approach used to develop and refine PROs. Item response theory (IRT) offers promise for ... ...

    Abstract There is a long tradition of incorporating patient-reported outcomes (PROs) into nursing research and practice. Classical Test Theory (CTT) has been the traditional approach used to develop and refine PROs. Item response theory (IRT) offers promise for addressing measurement problems that have been difficult to solve using CTT. This paper presents foundational concepts in IRT to illustrate how it can be used to improve the development and refinement of PRO measures, with emphasis on interpreting key IRT parameters.
    MeSH term(s) Humans ; Patient Reported Outcome Measures ; Psychometrics
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151245-0
    ISSN 1873-1953 ; 1474-5151
    ISSN (online) 1873-1953
    ISSN 1474-5151
    DOI 10.1093/eurjcn/zvac020
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  8. Article ; Online: Oxidative Mechanisms and Cardiovascular Abnormalities of Cirrhosis and Portal Hypertension.

    Liu, Hongqun / Nguyen, Henry H / Hwang, Sang Youn / Lee, Samuel S

    International journal of molecular sciences

    2023  Volume 24, Issue 23

    Abstract: In patients with portal hypertension, there are many complications including cardiovascular abnormalities, hepatorenal syndrome, ascites, variceal bleeding, and hepatic encephalopathy. The underlying mechanisms are not yet completely clarified. It is ... ...

    Abstract In patients with portal hypertension, there are many complications including cardiovascular abnormalities, hepatorenal syndrome, ascites, variceal bleeding, and hepatic encephalopathy. The underlying mechanisms are not yet completely clarified. It is well known that portal hypertension causes mesenteric congestion which produces reactive oxygen species (ROS). ROS has been associated with intestinal mucosal injury, increased intestinal permeability, enhanced gut bacterial overgrowth, and translocation; all these changes result in increased endotoxin and inflammation. Portal hypertension also results in the development of collateral circulation and reduces liver mass resulting in an overall increase in endotoxin/bacteria bypassing detoxication and immune clearance in the liver. Endotoxemia can in turn aggravate oxidative stress and inflammation, leading to a cycle of gut barrier dysfunction → endotoxemia → organ injury. The phenotype of cardiovascular abnormalities includes hyperdynamic circulation and cirrhotic cardiomyopathy. Oxidative stress is often accompanied by inflammation; thus, blocking oxidative stress can minimize the systemic inflammatory response and alleviate the severity of cardiovascular diseases. The present review aims to elucidate the role of oxidative stress in cirrhosis-associated cardiovascular abnormalities and discusses possible therapeutic effects of antioxidants on cardiovascular complications of cirrhosis including hyperdynamic circulation, cirrhotic cardiomyopathy, and hepatorenal syndrome.
    MeSH term(s) Humans ; Esophageal and Gastric Varices/complications ; Hepatorenal Syndrome/complications ; Reactive Oxygen Species/pharmacology ; Endotoxemia/complications ; Gastrointestinal Hemorrhage ; Liver Cirrhosis/therapy ; Hypertension, Portal/complications ; Oxidative Stress ; Inflammation/complications ; Cardiomyopathies/complications ; Cardiovascular Abnormalities/complications ; Endotoxins/pharmacology
    Chemical Substances Reactive Oxygen Species ; Endotoxins
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms242316805
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  9. Article ; Online: Association Between Intensity and Timing of Specialty Palliative Care and Hospice Exposure With Quality of End-of-Life Care.

    Wang, Susan E / Gozansky, Wendolyn S / Steiner, Claudia / Lee, Janet S / Nguyen, AnMarie / Shen, Ernest / Martel, Helene / Mangels, Diana B / Sterett, Andrew T / Zalavadia, Ravi / Hou, Nanjiang / Nguyen, Huong Q

    Journal of palliative medicine

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1427361-5
    ISSN 1557-7740 ; 1096-6218
    ISSN (online) 1557-7740
    ISSN 1096-6218
    DOI 10.1089/jpm.2023.0407
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  10. Article ; Online: Highly Selective and Scalable Molecular Fluoride Sensor for Naked-Eye Detection.

    Ullah, Zakir / Subramanian, Saravanan / Lim, Haeseong / Dogan, Nesibe A / Lee, Joo Sung / Nguyen, Thien S / Yavuz, Cafer T

    ACS applied materials & interfaces

    2024  

    Abstract: Fluoride is widely present in nature, and human exposure to it is generally regarded as inevitable. High levels of fluoride intake induce acute and chronic illnesses. To reduce potential harm to the general public, it is essential to create selective ... ...

    Abstract Fluoride is widely present in nature, and human exposure to it is generally regarded as inevitable. High levels of fluoride intake induce acute and chronic illnesses. To reduce potential harm to the general public, it is essential to create selective fluoride detectors capable of providing a colorimetric response for naked-eye detection without the need for sophisticated equipment. Here, we report a one-pot synthesis of four different diaminomaleonitrile-derived Schiff base sensors. The terephthalaldehyde adduct provided a strong color change visible to the naked eye at a F
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.4c01187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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