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  1. Article: [Progress in the Genetic Detection of Thalassemia Based on Third-Generation Gene Sequencing --Review].

    Chen, Yan-Jun / Xu, Zhi-Hong

    Zhongguo shi yan xue ye xue za zhi

    2024  Volume 32, Issue 2, Page(s) 634–638

    Abstract: Thalassemia is most widely distributed single gene autosome recessive genetic disease in the world, whose clinical manifestation was changed from asymptomatic anemia to severe anemia requiring continous blood transfusion to maintain life, thus resulting ... ...

    Abstract Thalassemia is most widely distributed single gene autosome recessive genetic disease in the world, whose clinical manifestation was changed from asymptomatic anemia to severe anemia requiring continous blood transfusion to maintain life, thus resulting in a serious economic burden to society and families. Therefore, it is necessary to carry out the corresponding prentatal screening and diagnosis. Most of the conventional detection methods can only detect the common thalassemia genotype, it can easy to cause misdiagnosis or missed diagnosis for those rate genetic variantions. The third-generation sequecing (TGS) has been applied to the detection of thalassemia genes, which is more accurate, reliable and superior to the converntional detection methods. This article reviews the latest research progress of the TGS technology in genetic testing of thalassemia.
    MeSH term(s) Humans ; Thalassemia/genetics ; Thalassemia/diagnosis ; Genetic Testing ; Genotype ; Sequence Analysis, DNA ; High-Throughput Nucleotide Sequencing ; Mutation
    Language Chinese
    Publishing date 2024-04-25
    Publishing country China
    Document type Journal Article ; Review ; English Abstract
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2024.02.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6603: Show issues Location:
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  2. Article: Modification of Peripheral Blood Flow and Angiogenesis by CO

    Elimban, Vijayan / Xu, Yan-Jun / Bhullar, Sukhwinder K / Dhalla, Naranjan S

    Biomedicines

    2023  Volume 11, Issue 12

    Abstract: Previously, it was shown that both blood flow and angiogenesis in the ischemic hind limb of diabetic rats were increased upon ... ...

    Abstract Previously, it was shown that both blood flow and angiogenesis in the ischemic hind limb of diabetic rats were increased upon CO
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123250
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  3. Article ; Online: Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants.

    Li, Qing / Deng, Xiaoyan / Xu, Yan-Jun / Dong, Lin

    Journal of medicinal chemistry

    2023  Volume 66, Issue 17, Page(s) 11593–11631

    Abstract: Considerable effort has been made to achieve less frequent dosing in the development of DPP-4 inhibitors. Enthusiasm for long-acting DPP-4 inhibitors is based on the promise that such agents with less frequent dosing regimens are associated with improved ...

    Abstract Considerable effort has been made to achieve less frequent dosing in the development of DPP-4 inhibitors. Enthusiasm for long-acting DPP-4 inhibitors is based on the promise that such agents with less frequent dosing regimens are associated with improved patient adherence, but the rational design of long-acting DPP-4 inhibitors remains a major challenge. In this Perspective, the development of long-acting DPP-4 inhibitors is comprehensively summarized to highlight the evolution of initial lead compounds on the path toward developing long-acting DPP-4 inhibitors over nearly three decades. The determinants for long duration of action are then examined, including the nature of the target, potency, binding kinetics, crystal structures, selectivity, and preclinical and clinical pharmacokinetic and pharmacodynamic profiles. More importantly, several possible approaches for the rational design of long-acting drugs are discussed. We hope that this information will facilitate the design and development of safer and more effective long-acting DPP-4 inhibitors and other oral drugs.
    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Kinetics ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The therapeutic effect of granulocyte colony stimulating factor (G-CSF) on potential biochemical pregnancy in patients with unexplained repeated transplantation failure (RIF): a case series and literature review.

    Wu, Wei / Xu, Gu-Feng / Hu, Yan-Jun

    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

    2022  Volume 38, Issue 5, Page(s) 443–447

    Abstract: Background: Biochemical pregnancy is a type of embryo transfer failure, patients with unexplained repeated implantation failure (RIF) also have higher biochemical pregnancy rate. Our study intends to evaluate the effect of granulocyte colony-stimulating ...

    Abstract Background: Biochemical pregnancy is a type of embryo transfer failure, patients with unexplained repeated implantation failure (RIF) also have higher biochemical pregnancy rate. Our study intends to evaluate the effect of granulocyte colony-stimulating factor (G-CSF) in patients with unexplained RIF with low hCG levels in early pregnancy.
    Methods: Unexplained RIF patients with low hCG levels after embryo transfer were allocated. G-CSF were administrated from the ninth days after embryo transfer. Clinical pregnancy, miscarriage and live birth rates were evaluated.
    Results: The clinical pregnancy and live birth rates were 52.5% and 30%.
    Conclusion: G-CSF is an effective treatment for potential biochemical pregnancy in unexplained RIF patients.
    MeSH term(s) Birth Rate ; Embryo Implantation ; Embryo Transfer ; Female ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Humans ; Pregnancy ; Pregnancy Rate
    Chemical Substances Granulocyte Colony-Stimulating Factor (143011-72-7)
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639237-4
    ISSN 1473-0766 ; 0951-3590
    ISSN (online) 1473-0766
    ISSN 0951-3590
    DOI 10.1080/09513590.2022.2036716
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    Zs.MO 608: Show issues

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  5. Article ; Online: Pd(II)-Catalyzed β-C(sp

    Ding, Xing-Xing / Ren, Bo-Quan / Li, Bing-Tong / Pang, Zhao-Jiong / Xu, Yan-Jun / Dong, Lin

    The Journal of organic chemistry

    2024  Volume 89, Issue 5, Page(s) 3390–3402

    Abstract: The introduction of alkyne moieties into peptides remains in demand as it represents a promising approach for further structural diversification of peptides. Herein, we describe the Pd(II)-catalyzed C( ... ...

    Abstract The introduction of alkyne moieties into peptides remains in demand as it represents a promising approach for further structural diversification of peptides. Herein, we describe the Pd(II)-catalyzed C(sp
    MeSH term(s) Alanine ; Alkynes ; Glycopeptides ; Catalysis
    Chemical Substances Alanine (OF5P57N2ZX) ; Alkynes ; Glycopeptides
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02823
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    Zs.A 4473: Show issues Location:
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  6. Article ; Online: Lathyrane and premyrsinane Euphorbia diterpenes against Alzheimer's disease: Bioinspired synthesis, anti-cholinesterase and neuroprotection bioactivity.

    Sun, Lian / Wang, Xin-Ming / Tang, Qianhui / Xiao, Yao / Xu, Jin-Bu / Zhang, Tong-Tong / Liu, Yan-Jun / Li, Xiaohuan / Gao, Feng

    Bioorganic chemistry

    2024  Volume 147, Page(s) 107377

    Abstract: The first systematic acylated diversification of naturally scarce premyrsinane diterpenes, together with their biosynthetic precursors lathyrane diterpene were carried out. Two new series of premyrsinane derivates (1a-32a) and lathyrane derivates (1-32) ... ...

    Abstract The first systematic acylated diversification of naturally scarce premyrsinane diterpenes, together with their biosynthetic precursors lathyrane diterpene were carried out. Two new series of premyrsinane derivates (1a-32a) and lathyrane derivates (1-32) were synthesized from the naturally abundant lathyrane diterpene Euphorbia factor L
    Language English
    Publishing date 2024-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107377
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    Zs.A 4207: Show issues Location:
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  7. Article ; Online: A Review of Filtration Performance of Protective Masks.

    Wang, Ao-Bing / Zhang, Xin / Gao, Li-Jun / Zhang, Tao / Xu, Hui-Juan / Bi, Yan-Jun

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Masks are essential and effective small protective devices used to protect the general public against infections such as COVID-19. However, available systematic reviews and summaries on the filtration performance of masks are lacking. Therefore, in order ...

    Abstract Masks are essential and effective small protective devices used to protect the general public against infections such as COVID-19. However, available systematic reviews and summaries on the filtration performance of masks are lacking. Therefore, in order to investigate the filtration performance of masks, filtration mechanisms, mask characteristics, and the relationships between influencing factors and protective performance were first analyzed through mask evaluations. The summary of filtration mechanisms and mask characteristics provides readers with a clear and easy-to-understand theoretical cognition. Then, a detailed analysis of influencing factors and the relationships between the influencing factors and filtration performance is presented in. The influence of the aerosol size and type on filtration performance is nonlinear and nonconstant, and filtration efficiency decreases with an increase in the gas flow rate; moreover, fitness plays a decisive role in the protective effects of masks. It is recommended that the public should wear surgical masks to prevent COVID-19 infection in low-risk and non-densely populated areas. Future research should focus on fitness tests, and the formulation of standards should also be accelerated. This paper provides a systematic review that will be helpful for the design of masks and public health in the future.
    MeSH term(s) Humans ; COVID-19/prevention & control ; Masks ; SARS-CoV-2 ; Respiratory Aerosols and Droplets ; Filtration ; Respiratory Protective Devices ; Personal Protective Equipment
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20032346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Pathophysiology, treatment and rehabilitation of atherosclerosis-related diseases in geriatric population.

    Xu, Yan / Zeng, Xianwei / Tu, Wen-Jun

    Frontiers in medicine

    2024  Volume 11, Page(s) 1358769

    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1358769
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  9. Article ; Online: Characterization of the Complete Chloroplast Genome of

    Cheng, Xiao-Juan / Xu, Yan-Ling / Bush, Catherine M / Lin, Yan-Jun / Du, Xin-Yu / Lu, Lu

    F1000Research

    2023  Volume 11, Page(s) 1358

    Abstract: Gaultheria ... ...

    Abstract Gaultheria nummularioides
    MeSH term(s) Gaultheria ; Ericaceae ; Genome, Chloroplast/genetics ; Phylogeny ; Arthritis, Rheumatoid
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.127937.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Effect of individualized weight management intervention on excessive gestational weight gain and perinatal outcomes: a randomized controlled trial.

    Xu, Mei-Yan / Guo, Yan-Jun / Zhang, Li-Juan / Lu, Qing-Bin

    PeerJ

    2022  Volume 10, Page(s) e13067

    Abstract: It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight ... ...

    Abstract It is unclear whether weight management is still effective for pregnant women with excessive weight gain in the second or third trimester in China. This study adopted individualized weight management intervention for pregnant women with abnormal weight gain in the second or third trimester, to analyze the effect of intervention by observing the gestational weight gain and perinatal outcomes. This randomized controlled trial was performed at Aerospace Center Hospital. The obstetrician determined whether the pregnant women gained too much weight in the second or third trimester according to the Institute of Medicine guidelines, and randomly divided the pregnant women who gained too much weight in the second or third trimester into the intervention group or the control group according to the inclusion and exclusion criteria. The pregnant women in the intervention group and in the control group all received routine prenatal examination and diet nutrition education by the doctors in the Department of Obstetrics and Gynecology. The intervention group underwent individualized weight management, including individualized diet, exercise, psychological assessment, cognitive intervention and continuous communication, the whole process is tracked and managed by professional nutritionists. The obstetrician collected the prenatal examination data and pregnancy outcome data of all enrolled pregnant women. The primary outcome measure was weight gain during pregnancy. A generalized linear model and a logistic regression model were used to compare the outcomes between the two groups. In total, 348 pregnant women participated in this study with 203 in the intervention group and 145 in the control group. The whole gestational weight gain in the intervention group (15.8 ± 5.4 Kg) was lower than that in the control group (17.5 ± 3.6 Kg; adjusted
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Clinical Trial
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.13067
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