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  1. Article ; Online: Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond.

    Hasanagic, Senad / Serdarevic, Fadila

    The European respiratory journal

    2020  Volume 56, Issue 2

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Memantine ; Nicotine ; Pandemics ; Pneumonia, Viral ; Receptors, Nicotinic ; SARS-CoV-2
    Chemical Substances Receptors, Nicotinic ; Nicotine (6M3C89ZY6R) ; Memantine (W8O17SJF3T)
    Keywords covid19
    Language English
    Publishing date 2020-08-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01610-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors (nAChR) and beyond

    Hasanagic, Senad / Serdarevic, Fadila

    Eur. respir. j

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32554535
    Database COVID19

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  3. Article: Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond

    Hasanagic, Senad / Serdarevic, Fadila

    Eur. respir. j

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #881076
    Database COVID19

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  4. Article ; Online: Potential role of memantine in the prevention and treatment of COVID-19

    Hasanagic, S. (Senad) / Serdarevic, F. (Fadila)

    The European Respiratory Journal

    its antagonism of nicotinic acetylcholine receptors (nAChR) and beyond

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country nl
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Biostimulants’ influence on tomato fruit characteristics at conventional and low-input NPK regime

    Klokić, Izudin / Koleška, Ivana / Hasanagić, Dino / Murtić, Senad / Bosančić, Borut / Todorović, Vida

    Acta agriculturæ Scandinavica. 2020 Apr. 2, v. 70, no. 3

    2020  

    Abstract: Plant biostimulants are commercial products based on different chemical substances used to enhance plant growth and productivity. The effects of biostimulants, Megafol and Viva, with different dominant compositions (amino acids and humic acids) on two ... ...

    Abstract Plant biostimulants are commercial products based on different chemical substances used to enhance plant growth and productivity. The effects of biostimulants, Megafol and Viva, with different dominant compositions (amino acids and humic acids) on two tomato cultivars (cv. Gravitet F1 and cv. Minaret F1) exposed to conventional and low-input macronutrient nutrition were investigated. Application of both biostimulants positively affected yield at conventional nutrition. In low-input nutrition variant, biostimulant application prevented yield loss only in cv. Minaret F1. Inter-cultivar differences were noticed in fruit characteristics (total phenol content, total flavonoids content and total antioxidative capacity) where application of biostimulants leads to opposite results in the examined cultivars. We considered the possibility of biostimulant usage as an effective nutritional addition for overcoming the problem of excessive fertilisation.
    Keywords amino acids ; antioxidant activity ; flavonoids ; fruit characteristics ; humic acids ; nutrition ; phenols ; plant growth ; tomatoes
    Language English
    Dates of publication 2020-0402
    Size p. 233-240.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 32458-9
    ISSN 1651-1913 ; 0906-4710
    ISSN (online) 1651-1913
    ISSN 0906-4710
    DOI 10.1080/09064710.2019.1711156
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 5695: Show issues

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  6. Article ; Online: Biostimulant prevents yield loss and reduces oxidative damage in tomato plants grown on reduced NPK nutrition

    Ivana Koleška / Dino Hasanagić / Vida Todorović / Senad Murtić / Izudin Klokić / Nada Parađiković / Biljana Kukavica

    Journal of Plant Interactions, Vol 12, Iss 1, Pp 209-

    2017  Volume 218

    Abstract: Plant biostimulants are substances which have the capacity to modify physiological processes in plants in a way that provides potential benefits to growth, development or stress response. Effects of biostimulant application on two tomato hybrids ( ... ...

    Abstract Plant biostimulants are substances which have the capacity to modify physiological processes in plants in a way that provides potential benefits to growth, development or stress response. Effects of biostimulant application on two tomato hybrids (Ombeline F1 and Bostina F1) submitted to reduced nitrogen, phosphorus and potassium (NPK) nutrition aiming at prevention of oxidative stress generation as well as yield and fruit quality loss were investigated in this study. According to obtained results, foliar applied Viva® biostimulant decreased superoxide dismutase (SOD, EC 1.15.1.1) and peroxidase (POD, EC 1.11.1.7) activity in tomato leaves even when recommended NPK nutrition was reduced at 40%. Fruit quality parameters (total soluble solids, total acidity, ascorbic acid and lycopene content) and yield were also maintained in reduced macronutrient fertilization when biostimulant was added. Combination of biostimulant with reduced NPK fertilizer enabled stability of cell homeostasis in tomato plants and their better adaptation to stress conditions. The possibility of biostimulant being used as environmental friendly tool in the reduction of mineral fertilizers without negative consequences regarding yield and fruit quality was discussed.
    Keywords Biostimulant ; tomato ; reduced nutrition ; oxidative stress ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Biostimulant prevents yield loss and reduces oxidative damage in tomato plants grown on reduced NPK nutrition

    Koleška, Ivana / Hasanagić, Dino / Klokić, Izudin / Kukavica, Biljana / Murtić, Senad / Parađiković, Nada / Todorović, Vida

    Journal of plant interactions. 2017 Jan. 1, v. 12, no. 1

    2017  

    Abstract: Plant biostimulants are substances which have the capacity to modify physiological processes in plants in a way that provides potential benefits to growth, development or stress response. Effects of biostimulant application on two tomato hybrids ( ... ...

    Abstract Plant biostimulants are substances which have the capacity to modify physiological processes in plants in a way that provides potential benefits to growth, development or stress response. Effects of biostimulant application on two tomato hybrids (Ombeline F1 and Bostina F1) submitted to reduced nitrogen, phosphorus and potassium (NPK) nutrition aiming at prevention of oxidative stress generation as well as yield and fruit quality loss were investigated in this study. According to obtained results, foliar applied Viva® biostimulant decreased superoxide dismutase (SOD, EC 1.15.1.1) and peroxidase (POD, EC 1.11.1.7) activity in tomato leaves even when recommended NPK nutrition was reduced at 40%. Fruit quality parameters (total soluble solids, total acidity, ascorbic acid and lycopene content) and yield were also maintained in reduced macronutrient fertilization when biostimulant was added. Combination of biostimulant with reduced NPK fertilizer enabled stability of cell homeostasis in tomato plants and their better adaptation to stress conditions. The possibility of biostimulant being used as environmental friendly tool in the reduction of mineral fertilizers without negative consequences regarding yield and fruit quality was discussed.
    Keywords acidity ; ascorbic acid ; foliar application ; fruit quality ; homeostasis ; hybrids ; leaves ; lycopene ; mineral fertilizers ; nitrogen ; NPK fertilizers ; nutrition ; oxidative stress ; peroxidase ; phosphorus ; potassium ; stress response ; superoxide dismutase ; tomatoes ; total soluble solids
    Language English
    Dates of publication 2017-0101
    Size p. 209-218.
    Publishing place Taylor & Francis
    Document type Article
    ZDB-ID 2234941-8
    ISSN 1742-9153 ; 1742-9145
    ISSN (online) 1742-9153
    ISSN 1742-9145
    DOI 10.1080/17429145.2017.1319503
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7652: Show issues

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  8. Article ; Online: Antipsychotic drugs

    Siafis, Spyridon / Deste, Giacomo / Ceraso, Anna / Mussoni, Christian / Vita, Antonio / Hasanagic, Senad / Schneider-Thoma, Johannes / Papazisis, Georgios / Davis, John M / Leucht, Stefan

    Psychological medicine

    2019  Volume 50, Issue 15, Page(s) 2622–2633

    Abstract: Background: Comparisons of antipsychotics with placebo can be biased by unblinding due to side effects. Therefore, this meta-analysis compared the efficacy of antipsychotics for acute schizophrenia in trials using barbiturates or benzodiazepines as ... ...

    Abstract Background: Comparisons of antipsychotics with placebo can be biased by unblinding due to side effects. Therefore, this meta-analysis compared the efficacy of antipsychotics for acute schizophrenia in trials using barbiturates or benzodiazepines as active placebos.
    Methods: Randomized controlled trials (RCTs) in acute schizophrenia with at least 3 weeks duration and comparing any antipsychotic with barbiturates or benzodiazepines were eligible. ClinicalTrials.gov, CENTRAL, EMBASE, MEDLINE, PsycINFO, PubMed, WHO-ICTRP as well as previous reviews were searched up to 9 January 2018. Two separate meta-analyses, one for barbiturates and one for benzodiazepines, were conducted using random-effects models. The primary outcome was response to treatment, and mean values of schizophrenia rating scales and dropouts were analyzed as secondary outcomes. This study is registered with PROSPERO (CRD42018086263).
    Results: Seven barbiturate-RCTs (number of participants n = 1736), and two benzodiazepine-RCTs (n = 76) were included in the analysis. The studies were published between 1960 and 1968 and involved mainly chronically ill patients. More patients on antipsychotics in comparison to barbiturates achieved a 'good' response (36.2% v. 16.8%; RR 2.15; 95% CI 1.36-3.41; I2 = 48.9) and 'any' response (57.4% v. 27.8%; RR 2.07; 95% CI 1.35-3.18; I2 = 68.2). In a single small trial (n = 60), there was no difference between antipsychotics and benzodiazepines on 'any' response (74.7% v. 65%; RR 1.15; 95% CI 0.82-1.62).
    Conclusions: Antipsychotic drugs were more efficacious than barbiturates, based on a large sample size. Response ratios were similar to those observed in placebo-controlled trials. The results on benzodiazepines were inconclusive due to the small number of studies and participants.
    MeSH term(s) Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Barbiturates/adverse effects ; Barbiturates/therapeutic use ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Humans ; Randomized Controlled Trials as Topic ; Schizophrenia/drug therapy
    Chemical Substances Antipsychotic Agents ; Barbiturates ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2019-10-18
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 217420-0
    ISSN 1469-8978 ; 0033-2917
    ISSN (online) 1469-8978
    ISSN 0033-2917
    DOI 10.1017/S003329171900285X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1003: Show issues Location:
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  9. Article: The Bcl-2 protein: a prognostic indicator strongly related to ER and PR in breast cancer.

    Bilalović, Nurija / Vranić, Semir / Hasanagić, Senad / Basić, Hiba / Tatarević, Aida / Beslija, Semir / Selak, Ivan

    Bosnian journal of basic medical sciences

    2005  Volume 4, Issue 4, Page(s) 5–12

    Abstract: Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the ... ...

    Abstract Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the expression patterns of Bcl-2, estrogen receptors (ER), progesterone receptors (PR) in 71 primary invasive breast carcinomas and their association with other clinicopathological parameters. Samples from 71 patients with invasive breast cancer with follow-up ranging from 4-103 months (median 57 months) were included in the study. Forty-six patients (66%) obtained a complete response, while 5 (9%) were considered non-responders during the follow up period of 103 months. Eighteen (25%) patients died, 15 (21%) from primary disease and 3 (4%) from other disease. In unvaried analysis, tumor size (<2 cm), lymph node (<4 lymph nodes), hormonal status and Bcl-2 expression are correlated with longer overall (OS) and relapse-free survival (RFS). Patients with 4 or more positive axillary lymph nodes had significantly shorter OS (p=0.01) and RFS (p=0.009). Higher expression of Bcl-2 was associated with longer OS (p=0.02) and RFS (p=0.03), and this result were independent of axillary lymph nodes and tumor size in Cox multivariate analysis.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Rate
    Chemical Substances Proto-Oncogene Proteins c-bcl-2 ; Receptors, Estrogen ; Receptors, Progesterone
    Language English
    Publishing date 2005-01-19
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2240029-1
    ISSN 1512-8601
    ISSN 1512-8601
    DOI 10.17305/bjbms.2004.3352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6314: Show issues Location:
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  10. Article ; Online: The Bcl-2 protein

    Nurija Bilalović / Semir Vranić / Senad Hasanagić / Hiba Basić / Aida Tatarević / Semir Bešlija / Ivan Selak

    Bosnian Journal of Basic Medical Sciences, Vol 4, Iss

    a prognostic indicator strongly related to ER and PR in breast cancer

    2004  Volume 4

    Abstract: Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the ... ...

    Abstract Bcl-2, the protein product of the Bcl-2 gene, is a member of the Bcl-2 family of proteins that play a crucial role in a complex mechanism of apoptosis. It was recently proposed that bcl-2 could inhibit cancer progression. In this study, we evaluated the expression patterns of Bcl-2, estrogen receptors (ER), progesterone receptors (PR) in 71 primary invasive breast carcinomas and their association with other clinicopathological parameters. Samples from 71 patients with invasive breast cancer with follow-up ranging from 4-103 months (median 57 months) were included in the study. Forty-six patients (66%) obtained a complete response, while 5 (9%) were considered non-responders during the follow up period of 103 months. Eighteen (25%) patients died, 15 (21%) from primary disease and 3 (4%) from other disease. In unvaried analysis, tumor size (<2 cm), lymph node (<4 lymph nodes), hormonal status and Bcl-2 expression are correlated with longer overall (OS) and relapse-free survival (RFS). Patients with 4 or more positive axillary lymph nodes had significantly shorter OS (p=0.01) and RFS (p=0.009). Higher expression of Bcl-2 was associated with longer OS (p=0.02) and RFS (p=0.03), and this result were independent of axillary lymph nodes and tumor size in Cox multivariate analysis.
    Keywords Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2004-11-01T00:00:00Z
    Publisher Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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