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  1. Article: Editorial: Unravelling human placental (patho-) physiology at the epigenetic and transcriptome level.

    Samara, Athina / Khalil, Asma

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1228803

    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1228803
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Protocol to dissect and dissociate the mouse brainstem for single-cell RNA-seq applications.

    Phillips, Wiktor S / Ramadan, Naify / Samara, Athina / Herlenius, Eric

    STAR protocols

    2024  Volume 5, Issue 1, Page(s) 102908

    Abstract: Processing dissociated cells for transcriptomics is challenging when targeting small brain structures, like brainstem nuclei, where cell yield may be low. Here, we present a protocol for dissecting, dissociating, and cryopreserving mouse brainstem that ... ...

    Abstract Processing dissociated cells for transcriptomics is challenging when targeting small brain structures, like brainstem nuclei, where cell yield may be low. Here, we present a protocol for dissecting, dissociating, and cryopreserving mouse brainstem that allows asynchronous sample collection and downstream processing of cells obtained from brainstem tissue in neonatal mice. Although we demonstrate this protocol with the isolated preBötzinger complex and downstream SmartSeq3 cDNA library preparation, it could be readily adapted for other brainstem areas and library preparation approaches.
    MeSH term(s) Mice ; Animals ; Single-Cell Gene Expression Analysis ; Brain Stem ; Cell Nucleus ; Gene Expression Profiling/methods ; Gene Library
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.102908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pregnant women and measles: we need to be vigilant during outbreaks.

    Khalil, Asma / Samara, Athina / Campbell, Colin / Ladhani, Shamez N

    EClinicalMedicine

    2024  Volume 72, Page(s) 102594

    Abstract: A number of countries including the UK are currently experiencing large outbreaks of measles affecting mainly young children but also adolescents and young adults. Women of childbearing age are a particular group of concern because the 1988 Wakefield ... ...

    Abstract A number of countries including the UK are currently experiencing large outbreaks of measles affecting mainly young children but also adolescents and young adults. Women of childbearing age are a particular group of concern because the 1988 Wakefield Lancet paper, which falsely asserted a connection between the MMR vaccine and autism, was associated with a large and sharp decline in childhood MMR uptake over several years. This has left large cohorts of non-immune adolescents and young adults (born between 1998 and 2004), including young women who are now of childbearing age and remain susceptible to measles as well as rubella. Pregnant mothers are at higher risk of serious complications, such as pneumonia, with adverse pregnancy complications including fetal loss, premature birth, and neonatal death. Measles infection may also result in subacute sclerosing panencephalitis (SSPE), a very rare but very severe and invariably fatal neurodegenerative complication that typically manifests many years after acute measles infection but can have a short-onset latency with a fulminant course in pregnant women. Here, we summarise the epidemiology of measles infection, factors associated with the current measles outbreaks, as well as the risks and outcomes of measles, including SSPE, in pregnancy. We propose an algorithm for clinical management of measles infection in pregnancy. We also highlight the importance of early liaison with local health protection teams for risk assessment, diagnosis and management of suspected measles in pregnancy and close contacts as well as susceptible pregnant women exposed to a person with measles in the community.
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2024.102594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Do not forget pregnant and post-partum women during group A streptococcal disease outbreaks.

    Khalil, Asma / Samara, Athina / O'Brien, Pat / Ladhani, Shamez N

    The Lancet. Microbe

    2023  Volume 4, Issue 6, Page(s) e382–e383

    MeSH term(s) Pregnancy ; Humans ; Female ; Postpartum Period ; Pregnancy Complications
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00064-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Listeria outbreaks cause maternal and perinatal mortality and morbidity: we must do better.

    Khalil, Asma / Samara, Athina / O'Brien, Pat / Ladhani, Shamez

    The Lancet. Microbe

    2023  Volume 4, Issue 4, Page(s) e206–e207

    MeSH term(s) Female ; Humans ; Pregnancy ; Disease Outbreaks ; Listeria ; Morbidity ; Perinatal Mortality ; Listeriosis/epidemiology ; Infant, Newborn
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00388-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Treatment and prevention of mpox in pregnant people and young children.

    Khalil, Asma / Samara, Athina / O'Brien, Pat / Ladhani, Shamez N

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 4, Page(s) 396–397

    MeSH term(s) Child, Preschool ; Female ; Humans ; Pregnancy ; Mpox (monkeypox)/prevention & control ; Mpox (monkeypox)/therapy
    Language English
    Publishing date 2023-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00054-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Revisiting ameloblastin; addressing the EMT-ECM axis above and beyond oral biology.

    Reseland, Janne E / Heyward, Catherine A / Samara, Athina

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1251540

    Abstract: Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, ... ...

    Abstract Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, and adipose tissue. Using immunofluorescence in a pilot scheme, we identified that AMBN is expressed in different parts of the gastrointestinal (GI) tract. AMBN mRNA and protein detection in several tissues along the length of the GI tract suggests a role for AMBN in the structure and tissue integrity of the extracellular matrix (ECM). Intracellular AMBN expression in subsets of cells indicates a potential alternative role in signaling processes. Of note, our previous functional AMBN promoter analyses had shown that it contains epithelial-mesenchymal transition (EMT) regulatory elements. ΑΜΒΝ is herein presented as a paradigm shift of the possible associations and the spatiotemporal regulation of the ECM regulating the EMT and
    Language English
    Publishing date 2023-11-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1251540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Revisiting ameloblastin; addressing the EMT-ECM axis above and beyond oral biology

    Janne E. Reseland / Catherine A. Heyward / Athina Samara

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, ... ...

    Abstract Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, and adipose tissue. Using immunofluorescence in a pilot scheme, we identified that AMBN is expressed in different parts of the gastrointestinal (GI) tract. AMBN mRNA and protein detection in several tissues along the length of the GI tract suggests a role for AMBN in the structure and tissue integrity of the extracellular matrix (ECM). Intracellular AMBN expression in subsets of cells indicates a potential alternative role in signaling processes. Of note, our previous functional AMBN promoter analyses had shown that it contains epithelial–mesenchymal transition (EMT) regulatory elements. ΑΜΒΝ is herein presented as a paradigm shift of the possible associations and the spatiotemporal regulation of the ECM regulating the EMT and vice versa, using the example of AMBN expression beyond oral biology.
    Keywords ameloblastin ; extracellular matrix ; epithelial–mesenchymal transition ; endothelial–mesenchymal transition–extracellular matrix axis ; gastrointestinal tract ; tonsils ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Central Pancreatectomy: Balancing between the Favorable Functional Results and the Increased Associated Morbidity.

    Symeonidis, Dimitrios / Paraskeva, Ismini / Samara, Athina A / Kissa, Labrini / Valaroutsos, Alexandros / Petsa, Eleana / Tepetes, Konstantinos

    Surgery journal (New York, N.Y.)

    2024  Volume 10, Issue 1, Page(s) e20–e24

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2864275-2
    ISSN 2378-5136 ; 2378-5128
    ISSN (online) 2378-5136
    ISSN 2378-5128
    DOI 10.1055/s-0044-1782655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Is There an Effect of Fetal Mesenchymal Stem Cells in the Mother-Fetus Dyad in COVID-19 Pregnancies and Vertical Transmission?

    Samara, Athina / Herlenius, Eric

    Frontiers in physiology

    2021  Volume 11, Page(s) 624625

    Abstract: Because of the polysystemic nature of coronavirus disease 2019 (COVID-19), during the present pandemic, there have been serious concerns regarding pregnancy, vertical transmission, and intrapartum risk. The majority of pregnant patients with COVID-19 ... ...

    Abstract Because of the polysystemic nature of coronavirus disease 2019 (COVID-19), during the present pandemic, there have been serious concerns regarding pregnancy, vertical transmission, and intrapartum risk. The majority of pregnant patients with COVID-19 infection present with mild or asymptomatic course of the disease. Some cases were hospitalized, and few needed intensive care unit admission, or mechanical ventilation. There have also been scarce case reports where neonates required mechanical ventilation post COVID-19 pregnancies. Without approved therapies other than dexamethasone, advanced mesenchymal cell therapy is one immunomodulatory therapeutic approach that is currently explored and might hold great promise. We suggest that the circulating fetal stem cells might have an immune-protective effect to mothers and contribute to the often mild and even asymptomatic post-COVID-19 pregnancies. Thus, COVID-19 pregnancies come forth as a paradigm to be further and more comprehensively approached, to understand both the mechanism and action of circulating stem cells in immunoprotection and hypoxia in microcirculation.
    Language English
    Publishing date 2021-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.624625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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