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Article ; Online: A stamped aluminium gas chromatographic column disk employing directly grown anodic aluminium oxide stationary phase for the separation of aromatic and chlorinated compounds.

Fan, Chih-Chieh / Wang, Chih-Chia / Lu, Chia-Jung

2024 Volume 149, Issue 2, Page(s) 482–489

Abstract: In this study, mesoporous anodic aluminium oxide (AAO) with moderate polarity was used as a GC stationary phase to demonstrate the applicability to various compound species. The fluidic channel measured 6 meters in length and had a cross-section area of ... ...

Abstract	In this study, mesoporous anodic aluminium oxide (AAO) with moderate polarity was used as a GC stationary phase to demonstrate the applicability to various compound species. The fluidic channel measured 6 meters in length and had a cross-section area of 0.127 mm
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d3an01301d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Hsiao hsiao chung chih chia

Lü, Sha / Liu, Pin / Ma, Han-yen / Chʻen, Shou-chiang

(Kʻo wai hsin tien ti tsʻung shu)

1993

Title translation	Little planter.
Author's details	Ma Han-yen, Chʻen Shou-chiang chu pien ; Lü Sha, Liu Pin pien chu
Series title	Kʻo wai hsin tien ti tsʻung shu
Keywords	Horticulture/Juvenile literature.
Language	Chinese
Size	2, 4, 99 p. :, ill. ;, 18 x 11 cm.
Edition	Ti 1 pan.
Publisher	Kuang-hsi chiao yü chʻu pan she ; Kuang-hsi hsin hua shu tien fa hsing
Publishing place	Kuang-hsi
Document type	Book
ISBN	7543518120 ; 9787543518124
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Correction to: A novel curriculum for the same-sex marriage act and patient right to autonomy act (SMPRA) module based on two new laws in Taiwan: a mixed-methods study.

Shiao, Yi-Chih / Lu, Zxy-Yann Jane / Fu, Chung-Pei / Lin, Jing-Yi / Chang, Yaw-Wen / Chen, Wan-Ting / Wang, Chih-Chia

BMC medical education

2023 Volume 23, Issue 1, Page(s) 378

Language	English
Publishing date	2023-05-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04360-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrogen-bonded cytosine-endowed supramolecular polymeric nanogels: Highly efficient cancer cell targeting and enhanced therapeutic efficacy.

Fan, Wen-Lu / Huang, Shan-You / Yang, Xiu-Jing / Bintang Ilhami, Fasih / Chen, Jem-Kun / Cheng, Chih-Chia

Journal of colloid and interface science

2024 Volume 665, Page(s) 329–344

Abstract: We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy- ... ...

Abstract	We demonstrate that cytosine moieties within physically cross-linked supramolecular polymers not only manipulate drug delivery and release, but also confer specific targeting of cancer cells to effectively enhance the safety and efficacy of chemotherapy-and thus hold significant potential as a new perspective for development of drug delivery systems. Herein, we successfully developed physically cross-linked supramolecular polymers (PECH-PEG-Cy) comprised of hydrogen-bonding cytosine pendant groups, hydrophilic poly(ethylene glycol) side chains, and a hydrophobic poly(epichlorohydrin) main chain. The polymers spontaneously self-assemble into a reversibly hydrogen-bonded network structure induced by cytosine and directly form spherical nanogels in aqueous solution. Nanogels with a high hydrogen-bond network density (i.e., a higher content of cytosine moieties) exhibit outstanding long-term structural stability in cell culture substrates containing serum, whereas nanogels with a relatively low hydrogen-bond network density cannot preserve their structural integrity. The nanogels also exhibit numerous unique physicochemical characteristics in aqueous solution, such as a desirable spherical size, high biocompatibility with normal and cancer cells, excellent drug encapsulation capacity, and controlled pH-responsive drug release properties. More importantly, in vitro experiments conclusively indicate the drug-loaded PECH-PEG-Cy nanogels can selectively induce cancer cell-specific apoptosis and cell death via cytosine receptor-mediated endocytosis, without significantly harming normal cells. In contrast, control drug-loaded PECH-PEG nanogels, which lack cytosine moieties in their structure, can only induce cell death in cancer cells through non-specific pathways, which significantly inhibits the induction of apoptosis. This work clearly demonstrates that the cytosine moieties in PECH-PEG-Cy nanogels confer selective affinity for the surface of cancer cells, which enhances their targeted cellular uptake, cytotoxicity, and subsequent induction of programmed cell death in cancer cells.
MeSH term(s)	Nanogels ; Polymers/chemistry ; Drug Delivery Systems ; Polyethylene Glycols/chemistry ; Apoptosis ; Drug Carriers/chemistry ; Doxorubicin/pharmacology ; Neoplasms/drug therapy
Chemical Substances	Nanogels ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A) ; Drug Carriers ; Doxorubicin (80168379AG)
Language	English
Publishing date	2024-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.03.154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel curriculum for the Same-Sex Marriage Act and Patient Right to Autonomy Act (SMPRA) module based on two new laws in Taiwan: a mixed-methods study.

Shiao, Yi-Chih / Lu, Zxy-Yann Jane / Fu, Chung-Pei / Lin, Jing-Yi / Chang, Yaw-Wen / Chen, Wan-Ting / Wang, Chih-Chia

BMC medical education

2023 Volume 23, Issue 1, Page(s) 91

Abstract: Background: The establishment of laws has had a tremendous impact on holistic medical care. The Patient Right to Autonomy (PRA) Act and the Same-Sex Marriage Act have been passed in Taiwan, and both have sparked intense societal debate. The Same-Sex ... ...

Abstract	Background: The establishment of laws has had a tremendous impact on holistic medical care. The Patient Right to Autonomy (PRA) Act and the Same-Sex Marriage Act have been passed in Taiwan, and both have sparked intense societal debate. The Same-Sex Marriage Act and PRA Act (SMPRA) teaching module was created for the Gender, Medicine, and Law (GML) course of the medical curriculum. This video trigger-assisted problem-based learning (VTA-PBL) software has integrated content on the aforementioned legislative proclamations. It upends conventional beliefs and fosters reflective practices on sexual rights and the right to representation among medical students. This study examined how the SMPRA module affected the knowledge and attitudes of medical students taking up the GML course. Methods: A simple pre-/post-test design evaluated the outcomes of the PBL module to examine the changes in knowledge and attitudes of medical students toward same-sex marriage rights. In 2019 and 2020, 126 and 49 5th-year medical students took up the GML course, respectively. The GML components included a video scenario representing advanced decision-making and a healthcare agency with a same-sex couple, a PBL discussion, and student feedback presentations. The mechanisms of feedback collection and measuring student knowledge and attitudes toward sexual rights differed between one cohort in 2019 and the other in 2020. Pre- and post-lecture tests were used in the first school year, whereas a post-lecture open-ended questionnaire survey was used in the second school year. Results: In total, 90 and 39 eligible questionnaires were received in the first and second school years, respectively, which corresponded to response rates of 71% and 80%. Students showed a better understanding of and positive enhancement of proficiency in legal and ethical content and relevant clinical practice. Qualitative analysis revealed that students viewed healthcare providers as checkpoints for conflicts of interest; medical ethics as the cornerstone of clinical practice; cultural background as a significant influence on decision-making; and empathetic communication as the cornerstone of relationships between patients, family members, and doctors. Conclusion: The GML course of the SMPRA module fosters reflective practices on ethical and legal sexual rights issues.
MeSH term(s)	Humans ; Marriage ; Taiwan ; Curriculum ; Problem-Based Learning ; Patient Rights ; Students, Medical
Language	English
Publishing date	2023-02-04
Publishing country	England
Document type	Video-Audio Media ; Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04076-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognostic factors for poor outcomes in patients with severe COVID-19 treated with remdesivir plus dexamethasone in Taiwan.

Lai, Yi-Hsuan / Lee, Yi-Chih / Chen, I-Ren / Lin, Shih-Neng / Chang, Yuh-Lih / Lu, Chih-Chia / Wu, Ping-Feng / Lin, Yi-Tsung

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

2023 Volume 56, Issue 6, Page(s) 1207–1213

Abstract: Background: Coronavirus disease-2019 (COVID-19) remains a global public health concern, and remdesivir plus dexamethasone combination therapy is suggested for patients with severe disease. However, the factors associated with poor outcomes in these ... ...

Abstract	Background: Coronavirus disease-2019 (COVID-19) remains a global public health concern, and remdesivir plus dexamethasone combination therapy is suggested for patients with severe disease. However, the factors associated with poor outcomes in these patients remain unclear. We identified the factors associated with poor outcomes in Taiwanese patients with severe COVID-19 treated with remdesivir plus dexamethasone. Methods: Adults with severe COVID-19 (oxygen saturation <94% on room air or requiring supplemental oxygen) treated with remdesivir and dexamethasone were identified between 1 May and 31 July 2021. The main outcomes were 14-day non-recovery, 28-day mortality, and progression to respiratory failure requiring invasive mechanical ventilation or death in initially non-ventilated patients. The prognostic factors associated with poor outcomes were analyzed by multivariate logistic regression and Cox regression. Results: Of the 110 patients treated with remdesivir and dexamethasone, 57 (51.8%) recovered within 14 days and 6 (5.5%) died within 28 days. Of the 89 initially non-ventilated patients, 12 (13.5%) progressed to respiratory failure or death. Charlson Comorbidity Index, SOFA score, and admission to remdesivir treatment interval were associated with 14-day non-recovery. C-reactive protein level was associated with 28-day mortality. Pneumonia Severity Index and admission to remdesivir treatment interval were associated with progression to respiratory failure requiring invasive mechanical ventilation or death in initially non-ventilated patients. Conclusion: High disease severity on admission and delayed initiation of remdesivir therapy were associated with poor outcomes in COVID-19 patients treated with remdesivir and dexamethasone.
MeSH term(s)	Adult ; Humans ; COVID-19 ; SARS-CoV-2 ; Taiwan ; Prognosis ; Antiviral Agents ; COVID-19 Drug Treatment ; Dexamethasone/therapeutic use ; Respiratory Insufficiency/drug therapy
Chemical Substances	remdesivir (3QKI37EEHE) ; Antiviral Agents ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1497590-7
ISSN	1995-9133 ; 1684-1182 ; 0253-2662
ISSN (online)	1995-9133
ISSN	1684-1182 ; 0253-2662
DOI	10.1016/j.jmii.2023.08.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 2083: Show issues

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Article ; Online: Correction to

Yi-Chih Shiao / Zxy-Yann Jane Lu / Chung-Pei Fu / Jing-Yi Lin / Yaw-Wen Chang / Wan-Ting Chen / Chih-Chia Wang

BMC Medical Education, Vol 23, Iss 1, Pp 1-

A novel curriculum for the same-sex marriage act and patient right to autonomy act (SMPRA) module based on two new laws in Taiwan: a mixed-methods study

2023 Volume 1

Keywords	Special aspects of education ; LC8-6691 ; Medicine ; R
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Performance enhancement by particle gradient assembly patterning of electrochemiluminescence immunosensor formed using magnetolithgraphy in determination of human serum albumin.

Liao, Bao-Yu / Cheng, Chih-Chia / Wang, Chih-Feng / Lu, Chien-Hsing / Chen, Jem-Kun

Biosensors & bioelectronics

2021 Volume 183, Page(s) 113240

Abstract: Gradient properties facilitate the correlation of chemical and physical features of particles on the structure and adherent fate. Herein, performance enhancement is explored by particle gradient assembly patterning (PGAP) formed with magnetic field ... ...

Abstract	Gradient properties facilitate the correlation of chemical and physical features of particles on the structure and adherent fate. Herein, performance enhancement is explored by particle gradient assembly patterning (PGAP) formed with magnetic field gradient (MFG) by magnetolithography (ML) in the electrochemiluminescence (ECL) measurement. Magnetic Fe
MeSH term(s)	Biosensing Techniques ; Cadmium Compounds ; Electrochemical Techniques ; Humans ; Immunoassay ; Limit of Detection ; Luminescent Measurements ; Metal Nanoparticles ; Quantum Dots ; Serum Albumin, Human ; Silicon Dioxide ; Tellurium
Chemical Substances	Cadmium Compounds ; Silicon Dioxide (7631-86-9) ; Tellurium (NQA0O090ZJ) ; cadmium telluride (STG188WO13) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113240
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2275: Show issues

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Article ; Online: A chromosome-level genome assembly of the Asian house martin implies potential genes associated with the feathered-foot trait.

Chan, Yuan-Fu / Lu, Chia-Wei / Kuo, Hao-Chih / Hung, Chih-Ming

G3 (Bethesda, Md.)

2024

Abstract: The presence of feathers is a vital characteristic among birds, yet most modern birds had no feather on their feet. The discoveries of feathers on the hind limbs of basal birds and dinosaurs have sparked an interest in the evolutionary origin and genetic ...

Abstract	The presence of feathers is a vital characteristic among birds, yet most modern birds had no feather on their feet. The discoveries of feathers on the hind limbs of basal birds and dinosaurs have sparked an interest in the evolutionary origin and genetic mechanism of feathered feet. However, the majority of studies investigating the genes associated with this trait focused on domestic populations. Understanding the genetic mechanism underpinned feathered-foot development in wild birds is still in its infancy. Here, we assembled a chromosome-level genome of the Asian house martin (Delichon dasypus) using the long-read HiFi sequencing approach to initiate the search for genes associated with its feathered feet. We employed the whole genome alignment of D. dasypus with other swallow species to identify high-SNP regions and chromosomal inversions in the D. dasypus genome. After filtering out variations unrelated to D. dasypus evolution, we found six genes related to feather development near the high-SNP regions. We also detected three feather development genes in chromosomal inversions between the Asian house martin and the barn swallow genomes. We discussed their association with the WNT, BMP and FGF pathways and their potential roles in feathered-foot development. Future studies are encouraged to utilize the D. dasypus genome to explore the evolutionary process of the feathered-foot trait in avian species. This endeavor will shed light on the evolutionary path of feathers in birds.
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1093/g3journal/jkae077
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel curriculum for the Same-Sex Marriage Act and Patient Right to Autonomy Act (SMPRA) module based on two new laws in Taiwan

Yi-Chih Shiao / Zxy-Yann Jane Lu / Chung-Pei Fu / Jing-Yi Lin / Yaw-Wen Chang / Wan-Ting Chen / Chih-Chia Wang

BMC Medical Education, Vol 23, Iss 1, Pp 1-

a mixed-methods study

2023 Volume 9

Abstract: Abstract Background The establishment of laws has had a tremendous impact on holistic medical care. The Patient Right to Autonomy (PRA) Act and the Same-Sex Marriage Act have been passed in Taiwan, and both have sparked intense societal debate. The Same- ... ...

Abstract	Abstract Background The establishment of laws has had a tremendous impact on holistic medical care. The Patient Right to Autonomy (PRA) Act and the Same-Sex Marriage Act have been passed in Taiwan, and both have sparked intense societal debate. The Same-Sex Marriage Act and PRA Act (SMPRA) teaching module was created for the Gender, Medicine, and Law (GML) course of the medical curriculum. This video trigger-assisted problem-based learning (VTA–PBL) software has integrated content on the aforementioned legislative proclamations. It upends conventional beliefs and fosters reflective practices on sexual rights and the right to representation among medical students. This study examined how the SMPRA module affected the knowledge and attitudes of medical students taking up the GML course. Methods A simple pre-/post-test design evaluated the outcomes of the PBL module to examine the changes in knowledge and attitudes of medical students toward same-sex marriage rights. In 2019 and 2020, 126 and 49 5th-year medical students took up the GML course, respectively. The GML components included a video scenario representing advanced decision-making and a healthcare agency with a same-sex couple, a PBL discussion, and student feedback presentations. The mechanisms of feedback collection and measuring student knowledge and attitudes toward sexual rights differed between one cohort in 2019 and the other in 2020. Pre- and post-lecture tests were used in the first school year, whereas a post-lecture open-ended questionnaire survey was used in the second school year. Results In total, 90 and 39 eligible questionnaires were received in the first and second school years, respectively, which corresponded to response rates of 71% and 80%. Students showed a better understanding of and positive enhancement of proficiency in legal and ethical content and relevant clinical practice. Qualitative analysis revealed that students viewed healthcare providers as checkpoints for conflicts of interest; medical ethics as the cornerstone of ...
Keywords	Gender ; Medicine ; Law ; Sexual rights ; Medical ethics ; Legal ethics ; Special aspects of education ; LC8-6691 ; R
Subject code	170
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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