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  1. Book ; Online ; E-Book: Oxidative stress

    Sies, Helmut

    eustress and distress

    2020  

    Author's details edited by Helmut Sies
    Keywords Oxidative stress
    Subject code 571.9453
    Language English
    Size 1 Online-Ressource (xxxi, 844 Seiten), Illustrationen
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020372244
    ISBN 978-0-12-819696-0 ; 9780128186060 ; 0-12-819696-3 ; 0128186062
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Oxidative eustress: the physiological role of oxidants.

    Sies, Helmut

    Science China. Life sciences

    2023  Volume 66, Issue 8, Page(s) 1947–1948

    MeSH term(s) Oxidants ; Oxidation-Reduction ; Antioxidants/metabolism ; Oxidative Stress
    Chemical Substances Oxidants ; Antioxidants
    Language English
    Publishing date 2023-04-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2546732-3
    ISSN 1869-1889 ; 1674-7305
    ISSN (online) 1869-1889
    ISSN 1674-7305
    DOI 10.1007/s11427-023-2336-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Was H

    Koppenol, Willem H / Sies, Helmut

    Redox biology

    2024  Volume 71, Page(s) 103110

    Abstract: We obviously agree with Wu et al. that ... ...

    Abstract We obviously agree with Wu et al. that H
    MeSH term(s) Hydrogen Peroxide ; Oxygen ; Photosynthesis ; Hydroxyl Radical ; Oxidation-Reduction
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065) ; Hydroxyl Radical (3352-57-6)
    Language English
    Publishing date 2024-03-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Oxidative eustress: On constant alert for redox homeostasis.

    Sies, Helmut

    Redox biology

    2021  Volume 41, Page(s) 101867

    Abstract: In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a ... ...

    Abstract In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a physiological range that has been called the 'Homeodynamic Space', the 'Goldilocks Zone' or the 'Golden Mean'. Spatiotemporal control of redox signaling is achieved by compartmentalized generation and removal of oxidants. The cellular landscape of H
    MeSH term(s) Homeostasis ; Hydrogen Peroxide ; Oxidants ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances Oxidants ; Hydrogen Peroxide (BBX060AN9V)
    Language English
    Publishing date 2021-01-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2021.101867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Oxygen biology and hypoxia

    Sies, Helmut

    (Methods in enzymology ; 435)

    2007  

    Author's details ed. by Helmut Sies
    Series title Methods in enzymology ; 435
    Collection
    Language English
    Size XLVIII, 543, [18] S. : Ill., graph. Darst.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015381637
    ISBN 978-0-12-373970-4 ; 0-12-373970-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 222 -435- verfügbar in Königswinter Königswinter

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  6. Article ; Online: The Warburg effect - Discovered 100 years ago.

    Sies, Helmut / Koppenol, Willem H

    Free radical biology & medicine

    2023  Volume 204, Page(s) 325

    MeSH term(s) Humans ; Energy Metabolism ; Glycolysis ; Neoplasms
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Letter
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2023.05.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Findings in redox biology: From H

    Sies, Helmut

    The Journal of biological chemistry

    2020  Volume 295, Issue 39, Page(s) 13458–13473

    Abstract: My interest in biological chemistry proceeded from ... ...

    Abstract My interest in biological chemistry proceeded from enzymology
    MeSH term(s) Glutathione/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Oxidation-Reduction ; Oxidative Stress
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Journal Article ; Portrait
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.X120.015651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Was hydrogen peroxide present before the arrival of oxygenic photosynthesis? The important role of iron(II) in the Archean ocean

    Willem H. Koppenol / Helmut Sies

    Redox Biology, Vol 69, Iss , Pp 103012- (2024)

    2024  

    Abstract: We address the chemical/biological history of H2O2 back at the times of the Archean eon (2.5–3.9 billion years ago (Gya)). During the Archean eon the pO2 was million-fold lower than the present pO2, starting to increase gradually from 2.3 until 0.6 Gya, ... ...

    Abstract We address the chemical/biological history of H2O2 back at the times of the Archean eon (2.5–3.9 billion years ago (Gya)). During the Archean eon the pO2 was million-fold lower than the present pO2, starting to increase gradually from 2.3 until 0.6 Gya, when it reached ca. 0.2 bar. The observation that some anaerobic organisms can defend themselves against O2 has led to the view that early organisms could do the same before oxygenic photosynthesis had developed at about 3 Gya. This would require the anaerobic generation of H2O2, and here we examine the various mechanisms which were suggested in the literature for this. Given the concentration of Fe2+ at 20–200 μM in the Archean ocean, the estimated half-life of H2O2 is ca. 0.7 s. The oceanic H2O2 concentration was practically zero. We conclude that early organisms were not exposed to H2O2 before the arrival of oxygenic photosynthesis.
    Keywords Archean ; Hydrogen peroxide ; Radiation ; oxidation‐reduction (redox) ; Fenton reaction ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Oxidative Stress: Concept and Some Practical Aspects.

    Sies, Helmut

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 9

    Abstract: Oxidative stress is defined as "an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage". This Commentary presents basic features of this global concept which ...

    Abstract Oxidative stress is defined as "an imbalance between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control and/or molecular damage". This Commentary presents basic features of this global concept which has attracted interest in biology and medicine. The term "antioxidants" in cellular defense against oxidants predominantly includes antioxidant enzymes with their substrates and coenzymes. Exogenous low-molecular-mass compounds also have a role, but this is more limited. Multiple biomarkers of damage due to oxidative stress have been identified for different molecular classes (protein, lipid, carbohydrate, and DNA), and the current state of practical aspects in health and disease is delineated.
    Language English
    Publishing date 2020-09-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9090852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Oxidative eustress

    Helmut Sies

    Redox Biology, Vol 41, Iss , Pp 101867- (2021)

    On constant alert for redox homeostasis

    2021  

    Abstract: In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a ... ...

    Abstract In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a physiological range that has been called the ‘Homeodynamic Space’, the ‘Goldilocks Zone’ or the ‘Golden Mean’. Spatiotemporal control of redox signaling is achieved by compartmentalized generation and removal of oxidants. The cellular landscape of H2O2, the major redox signaling molecule, is characterized by orders-of-magnitude concentration differences between organelles. This concentration pattern is mirrored by the pattern of oxidatively modified proteins, exemplified by S-glutathionylated proteins. The review presents the conceptual background for short-term (non-transcriptional) and longer-term (transcriptional/translational) homeostatic mechanisms of stress and stress responses. The redox set point is a variable moving target value, modulated by circadian rhythm and by external influence, summarily denoted as exposome, which includes nutrition and lifestyle factors. Emerging fields of cell-specific and tissue-specific redox regulation in physiological settings are briefly presented, including new insight into the role of oxidative eustress in embryonal development and lifespan, skeletal muscle and exercise, sleep-wake rhythm, and the function of the nervous system with aspects leading to psychobiology.
    Keywords Redox biology ; Steady-state ; Homeodynamics ; Redox landscape ; Hydrogen peroxide ; Oxidative stress ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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