LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 298

Search options

  1. Book ; Online ; E-Book: The code stroke handbook

    Micieli, Andrew / Joundi, Raed / Khosravani, Houman / Hopyan, Julia / Gladstone, David J.

    approach to the acute stroke patient

    2020  

    Author's details Andrew Micieli, Raed Joundi, Houman Khosravani, Julia Hopyan, David J. Gladstone
    Language English
    Size 1 Online-Ressource (xi, 226 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020487744
    ISBN 978-0-12-820523-5 ; 0128205229 ; 9780128205228 ; 0-12-820523-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Kategorien

  2. Article ; Online: Education case report: CAMPEP Medical Physics PhD education program within Engineering.

    Pogue, Brian W / Gladstone, David J / Zhang, Rongxiao

    Journal of applied clinical medical physics

    2023  Volume 24, Issue 6, Page(s) e14037

    Abstract: Medical physics doctoral programs have large variations in organization, administration and financing. Blending a medical physics stream into an engineering graduate program has advantages of pre-existing financial and educational infrastructures. A case ...

    Abstract Medical physics doctoral programs have large variations in organization, administration and financing. Blending a medical physics stream into an engineering graduate program has advantages of pre-existing financial and educational infrastructures. A case study of the accredited program at Dartmouth was carried out, analyzing operational, financial, educational and outcome features. The support structures provided by each institutional partner were outlined, including engineering school, graduate school, and radiation oncology. The initiatives undertaken by founding faculty were reviewed, along with allocated resources, financial model, and peripheral entrepreneurship activities, each with quantitative outcome metrics. Currently 14 PhD students are enrolled, supported by 22 faculty across both engineering and clinical departments. The total peer-reviewed publications are ≈75/year, while the conventional medical physics fraction of this is about 14/year. Following program formation, a significant rise was seen in jointly published papers between engineering and medical physics faculty, up from 5.6 to 13.3 papers/year, with students publishing an average of 11.3/person with 5.7/person as first author. Student support was predominantly via federal grants, with a stable $5.5million/year, using about $610K/year supporting student stipends and tuition. First year funding, recruiting and staff support were via engineering school. Faculty teaching effort was supported by agreement with each home department, and student services were provided by engineering and graduate schools. Student outcomes were exceptional, with high numbers of presentations, awards, and residency placements at research universities. The lack of financial and student support in medical physics can be mitigated by this hybrid design of blending medical physics doctoral students into an engineering graduate program, providing complementary strengths. Future growth in medical physics programs might consider following this pathway, strengthening research collaborations for clinical physics and engineering faculty, as long as there is vested commitment to teach by the faculty and department leadership.
    MeSH term(s) Humans ; Faculty ; Internship and Residency ; Students, Medical ; Physics
    Language English
    Publishing date 2023-05-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2010347-5
    ISSN 1526-9914 ; 1526-9914
    ISSN (online) 1526-9914
    ISSN 1526-9914
    DOI 10.1002/acm2.14037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Imaging and characterization of optical emission from

    Vasyltsiv, Roman / Rahman, Mahbubur / Harms, Joseph / Clark, Megan / Gladstone, David J / Pogue, Brian W / Zhang, Rongxiao / Bruza, Petr

    Physics in medicine and biology

    2024  Volume 69, Issue 7

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Animals ; Swine ; Proton Therapy/methods ; Protons ; Retrospective Studies ; Diagnostic Imaging ; Phantoms, Imaging
    Chemical Substances Protons
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad2ee6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Mean dose rate in ultra-high dose rate electron irradiation is a significant predictor for O

    Sunnerberg, Jacob P / Zhang, Rongxiao / Gladstone, David J / Swartz, Harold M / Gui, Jiang / Pogue, Brian W

    Physics in medicine and biology

    2023  Volume 68, Issue 16

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Reactive Oxygen Species ; Electrons ; Hydrogen Peroxide ; Oxygen ; Heart Rate ; Radiotherapy Dosage
    Chemical Substances Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ace877
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments.

    Decker, Savannah M / Bruza, Petr / Zhang, Rongxiao / Williams, Benjamin B / Jarvis, Lesley A / Pogue, Brian W / Gladstone, David J

    Medical physics

    2024  

    Abstract: Background: While careful planning and pre-treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way to attain the true delivered ... ...

    Abstract Background: While careful planning and pre-treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way to attain the true delivered dose. Several countries outside the US require daily IVD for quality assurance. However, elsewhere, the manual labor and time considerations of traditional in vivo dosimeters may be preventing frequent use of IVD in the clinic.
    Purpose: This study expands upon previous research using plastic scintillator discs for optical dosimetry for electron therapy treatments. We present the characterization of scintillator discs for in vivo x-ray dosimetry and describe additional considerations due to geometric complexities.
    Methods: Plastic scintillator discs were coated with reflective white paint on all sides but the front surface. An anti-reflective, matte coating was applied to the transparent face to minimize specular reflection. A time-gated iCMOS camera imaged the discs under various irradiation conditions. In post-processing, background-subtracted images of the scintillators were fit with Gaussian-convolved ellipses to extract several parameters, including integral output, and observation angle.
    Results: Dose linearity and x-ray energy independence were observed, consistent with ideal characteristics for a dosimeter. Dose measurements exhibited less than 5% variation for incident beam angles between 0° and 75° at the anterior surface and 0-60
    Conclusions: Plastic scintillator discs have characteristics that are well-suited for in vivo optical dosimetry for x-ray radiotherapy treatments. Unlike typical point dosimeters, there is no inherent readout time delay, and an optical recording of the measurement is saved after treatment for future reference. While several factors influence the integral output for the same dose, they have been quantified here and may be corrected in post-processing.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.17071
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: A roadmap for research in medical physics via academic medical centers: The DIVERT Model.

    Pogue, Brian W / Zhang, Rongxiao / Gladstone, David J

    Medical physics

    2021  Volume 48, Issue 6, Page(s) 3151–3159

    Abstract: The field of medical physics has struggled with the role of research in recent years, as professional interests have dominated its growth toward clinical service. This article focuses on the subset of medical physics programs within academic medical ... ...

    Abstract The field of medical physics has struggled with the role of research in recent years, as professional interests have dominated its growth toward clinical service. This article focuses on the subset of medical physics programs within academic medical centers and how a refocused academic mission within these centers should drive and support Discovery and Invention with Ventures and Engineering for Research Translation (DIVERT). A roadmap to a DIVERT-based scholarly research program is discussed here around the core building blocks of: (a) creativity in research and team building, (b) improved quality metrics to assess activity, (c) strategic partnerships and spinoff directions that extend capabilities, and (d) future directions driven by faculty-led initiatives. Within academia, it is the unique discoveries and inventions of faculty that lead to their recognition as scholars, and leads to financial support for their research programs and reconition of their intellectual contributions. Innovation must also be coupled to translation to demonstrate outcome successes. These ingredients are critical for research funding, and the two-decade growth in biomedical engineering research funding is an illustration of this, where technology invention has been the goal. This record can be contrasted with flat funding within radiation oncology and radiology, where a growing fraction of research is more procedure-based. However, some centers are leading the change of the definition of medical physics, by the inclusion or assimilation of researchers in fields such as biomedical engineering, machine learning, or data science, thereby widening the scope for new discoveries and inventions. New approaches to the assessment of research quality can help realize this model, revisiting the measures of success and impact. While research partnerships with large industry are productive, newer efforts that foster enterprise startups are changing how institutions see the benefits of the connection between academic innovation and affiliated startup company formation. This innovation-to-enterprise focus can help to cultivate a broader bandwidth of donor-to-investor networks. There are many predictions on future directions in medical physics, yet the actual inventive and discovery steps come from individual research faculty creativity. All success through a DIVERT model requires that faculty-led initiatives span the gap from invention to translation, with support from institutional leadership at all steps in the process. Institutional investment in faculty through endowments or clinical revenues will likely need to increase in the coming years due to the relative decreasing size of grants. Yet, radiology and radiation oncology are both high-revenue, translational fields, with the capacity to synergistically support clinical and research operations through large infrastructures that are mutually beneficial. These roadmap principles can provide a pathway for committed academic medical physics programs in scholarly leadership that will preserve medical physics as an active part of university academics.
    MeSH term(s) Biomedical Research ; Engineering ; Humans ; Inventions ; Physics ; Research Personnel ; Universities
    Language English
    Publishing date 2021-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.14849
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Proton and Electron Ultrahigh-Dose-Rate Isodose Irradiations Produce Differences in Reactive Oxygen Species Yields.

    Thomas, William / Sunnerberg, Jacob / Reed, Matthew / Gladstone, David J / Zhang, Rongxiao / Harms, Joseph / Swartz, Harold M / Pogue, Brian W

    International journal of radiation oncology, biology, physics

    2023  Volume 118, Issue 1, Page(s) 262–267

    MeSH term(s) Humans ; Protons ; Reactive Oxygen Species ; Electrons ; Radiotherapy Dosage ; Proton Therapy
    Chemical Substances Protons ; Reactive Oxygen Species
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.07.042
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Biomarkers for predicting atrial fibrillation: An explorative sub-analysis of the randomised SCREEN-AF trial.

    Schmalstieg-Bahr, Katharina / Gladstone, David J / Hummers, Eva / Suerbaum, Johanna / Healey, Jeff S / Zapf, Antonia / Köster, Denise / Werhahn, Stefanie M / Wachter, Rolf

    The European journal of general practice

    2024  Volume 30, Issue 1, Page(s) 2327367

    Abstract: Background: Atrial fibrillation (AF) is a common treatable risk factor for stroke. Screening for paroxysmal AF in general practice is difficult, but biomarkers might help improve screening strategies.: Objectives: We investigated six blood biomarkers ...

    Abstract Background: Atrial fibrillation (AF) is a common treatable risk factor for stroke. Screening for paroxysmal AF in general practice is difficult, but biomarkers might help improve screening strategies.
    Objectives: We investigated six blood biomarkers for predicting paroxysmal AF in general practice.
    Methods: This was a pre-specified sub-study of the SCREEN-AF RCT done in Germany. Between 12/2017-03/2019, we enrolled ambulatory individuals aged 75 years or older with a history of hypertension but without known AF. Participants in the intervention group received active AF screening with a wearable patch, continuous ECG monitoring for 2x2 weeks and usual care in the control group. The primary endpoint was ECG-confirmed AF within six months after randomisation. High-sensitive Troponin I (hsTnI), brain natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-pro BNP), N-terminal pro atrial natriuretic peptide (NT-ANP), mid-regional pro atrial natriuretic peptide (MR-pro ANP) and C-reactive protein (CRP) plasma levels were investigated at randomisation for predicting AF within six months after randomisation.
    Results: Blood samples were available for 291 of 301 (96.7%) participants, including 8 with AF (3%). Five biomarkers showed higher median results in AF-patients: BNP 78 vs. 41 ng/L (
    Conclusion: Natriuretic peptide levels and hsTnI are higher in patients with AF than without and may help select patients for AF screening, but larger trials are needed.
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Atrial Natriuretic Factor ; Biomarkers ; Stroke ; Germany
    Chemical Substances Atrial Natriuretic Factor (85637-73-6) ; Biomarkers
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1281338-2
    ISSN 1751-1402 ; 1381-4788
    ISSN (online) 1751-1402
    ISSN 1381-4788
    DOI 10.1080/13814788.2024.2327367
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Rapid Switching of a C-series Linear Accelerator between Conventional and UHDR Research Mode with Beamline Modifications and Output Stabilization.

    Sloop, Austin / Ashraf, M Ramish / Rahman, Mahbubur / Sunnerberg, Jacob / Dexter, Chad A / Thompson, Lawrence / Gladstone, David J / Pogue, Brian W / Bruza, Petr / Zhang, Rongxiao

    International journal of radiation oncology, biology, physics

    2024  

    Abstract: Purpose: In this study, a decommissioned C-series linear accelerator (linac) was configured to enable rapid and reliable conversion between the production of conventional electron beams and an Ultrahigh-dose-rate (UHDR) electron beamline to the ... ...

    Abstract Purpose: In this study, a decommissioned C-series linear accelerator (linac) was configured to enable rapid and reliable conversion between the production of conventional electron beams and an Ultrahigh-dose-rate (UHDR) electron beamline to the treatment room isocenter for FLASH radiation therapy. Efforts to tune the beam resulted in a consistent, stable UHDR beamline.
    Methods and materials: The linac was configured to allow for efficient switching between conventional and modified electron output modes within two minutes. Additions to the air system allow for retraction of the X-ray target from the beamline when the 10MV photon mode is selected. With the carousel set to an empty port, this grants access to the higher current pristine electron beam normally used to produce clinical photon fields. Monitoring signals related to the automatic frequency control (AFC) system allows for tuning of the waveguide while the machine is in a hold state so a stable beam is produced from the initial pulse. A pulse counting system implemented on a FPGA-based controller platform controls the delivery to a desired number of pulses. Beam profiles were measured with Gafchromic film. Pulse-by-pulse dosimetry was measured using a custom electrometer designed around the Edge
    Results: This method reliably produces a stable UHDR electron beam. Open field measurements of the 16cm (FWHM) gaussian beam saw average dose rates of 432Gy/s at treatment isocenter. Pulse overshoots were limited and ramp up was eliminated. Over the last year, there have been no recorded incidents that resulted in machine downtime due to the UHDR conversions.
    Conclusion: Stable 10MeV UHDR beams were generated to produce an average dose rate of 432Gy/s at the treatment room isocenter. With a reliable pulse-counting beam control system, consistent doses can be delivered for FLASH experiments with the ability to accommodate a wide range of field sizes, source-to-surface distances, and other experimental apparatus that may be relevant for future clinical translation.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.01.215
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Left Atrial Enlargement Could Be Detected on Extended Computed Tomography Angiography Within Initial Stroke Assessment-Reply.

    Healey, Jeff S / Gladstone, David J / Hart, Robert G

    JAMA neurology

    2019  Volume 77, Issue 1, Page(s) 134–135

    MeSH term(s) Aspirin ; Atrial Fibrillation/diagnostic imaging ; Computed Tomography Angiography ; Humans ; Rivaroxaban ; Stroke/diagnostic imaging
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2019-11-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2019.3794
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top