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Article: Gastric Insufflation with High Flow Nasal Oxygen Therapy in Adult Patients Admitted to Intensive Care Unit: An Observational Study.

Ramachandran, Anjana / Bhatia, Pradeep / Mohammed, Sadik / Kamal, Manoj / Chhabra, Swati / Paliwal, Bharat

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2024 Volume 28, Issue 4, Page(s) 393–398

Abstract: ... and higher flows result in more distension.: How to cite this article: Ramachandran A, Bhatia P ...

Abstract	Background: With the provision of a small positive end-expiratory pressure (PEEP) effect, high-flow nasal oxygen (HFNO) therapy carries a risk of stomach distension. The present study was conducted to find out the air leak in the gastric antrum leading to gastric distension in adult patients with acute respiratory failure receiving HFNO therapy. Materials and methods: Adult patients with early hypoxemic respiratory failure requiring HFNO therapy were enrolled in this trial. Before initiation of HFNO therapy, baseline gastric volume (GV) and the average number of peristaltic contractions over one minute were measured using ultrasound. Once the patient was stabilized on HFNO therapy, a 2nd, 3rd, and 4th ultrasound scans were acquired at 10, 20, and 30 minutes respectively. Vitals and blood gas values were recorded at the baseline and after 30 min of initiation of HFNO therapy. Patient comfort, duration of HFNO therapy, and outcome were also recorded. Results: The GV at 10, 20, and 30 minutes were significantly larger ( Conclusion: In adult patients with hypoxemic respiratory failure, the use of HFNO therapy produces gas leaks into the stomach leading to increased gastric volume. The gastric distension increases the peristaltic contraction and higher flows result in more distension. How to cite this article: Ramachandran A, Bhatia P, Mohammed S, Kamal M, Chhabra S, Paliwal B. Gastric Insufflation with High Flow Nasal Oxygen Therapy in Adult Patients Admitted to Intensive Care Unit: An Observational Study. Indian J Crit Care Med 2024;28(4):393-398.
Language	English
Publishing date	2024-03-31
Publishing country	India
Document type	Journal Article
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24691
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Antiseptic Chitosan-Poly(hexamethylene) Biguanide Hydrogel for the Treatment of Infectious Wounds.

Antony, Irine Rose / Pradeep, Aathira / Pillai, Anoop Vasudevan / Menon, Riju Ramachandran / Kumar, Vasudevan Anil / Jayakumar, Rangasamy

Journal of functional biomaterials

2023 Volume 14, Issue 10

Abstract: Topical wound infections create the ideal conditions for microbial colonization and growth in terms of moisture, temperature, and nutrients. When they are not protected, numerous types of bacteria from the internal microbiota and the external environment ...

Abstract	Topical wound infections create the ideal conditions for microbial colonization and growth in terms of moisture, temperature, and nutrients. When they are not protected, numerous types of bacteria from the internal microbiota and the external environment may colonize them, creating a polymicrobial population. Treatment of these wounds often necessitates the use of antibiotics that may have systemic harmful effects. Unlike antibiotics, topical antiseptics exhibit a wider range of activity and reduced systemic toxicity and resistance. In order to address this issue, we developed an antiseptic Chitosan-Poly (hexamethylene) Biguanide (CS-PHMB) hydrogel. The prepared hydrogel was characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). SEM images showed the smooth morphology and characteristic FTIR peaks of PHMB and confirmed the incorporation of the antiseptic into the chitosan (CS) hydrogel. A Water Vapor Permeation Rate study confirms the moisture retention ability of the CS-PHMB hydrogel. Rheological studies proved the gel strength and temperature stability. The prepared hydrogel inhibited the growth of
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14100528
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Article: Successful Pregnancy Outcomes After Laparoscopic Management of Pheochromocytoma.

Prakash, Pradeep / Kulshrestha, Vidushi / Ramachandran, Rashmi / Kumar, Rajeev

Journal of endourology case reports

2020 Volume 6, Issue 3, Page(s) 170–173

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2020-09-17
Publishing country	United States
Document type	Journal Article
ISSN	2379-9889
ISSN	2379-9889
DOI	10.1089/cren.2019.0139
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Article ; Online: Response.

Ramachandran, Pradeep / Swamy, Lakshmana / Kaul, Viren / Agrawal, Abhinav

Chest

2020 Volume 158, Issue 5, Page(s) 2236–2237

MeSH term(s)	COVID-19 ; Humans ; Intensive Care Units ; Pandemics ; Resource Allocation ; SARS-CoV-2 ; Ventilators, Mechanical
Keywords	covid19
Language	English
Publishing date	2020-10-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.06.037
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Article ; Online: Development of loop-mediated isothermal amplification for detection of Mycoplasma ovipneumoniae in goats, Capra hircus.

Borang, Miti / Ramachandran Latha, Rathish / Mampilli, Pradeep / Melepat, Deepa Padinjare / Kaithathara, Vijayakumar

Journal of microbiological methods

2023 Volume 217-218, Page(s) 106885

Abstract: Mycoplasma ovipneumoniae is an important pathogen that causes respiratory disease in goats and sheep, leading to significant economic losses in the livestock industry. A quick and robust diagnostic test will aid in early diagnosis and treatment of the ... ...

Abstract	Mycoplasma ovipneumoniae is an important pathogen that causes respiratory disease in goats and sheep, leading to significant economic losses in the livestock industry. A quick and robust diagnostic test will aid in early diagnosis and treatment of the disease. Loop-mediated isothermal amplification (LAMP) offers several advantages over traditional PCR, including faster amplification, simpler operation, and lower equipment requirements, making it a promising tool for use in basic livestock units where resources and infrastructure may be limited. The present study reports on developing a LAMP assay to rapidly detect M. ovipneumoniae in goats (Capra hircus) targeting the 16S rRNA gene. LAMP was optimized to perform at 60 °C for 75 min. The result was visualized by a change in colour from deep pink to orange and further confirmed by gel electrophoresis, which gave a typical ladder-like pattern. The detection limit of the assay was as low as 0.04 ng/μl, indicating the high sensitivity of the assay. The test failed to amplify DNA isolated from healthy goat blood, Mycoplasma arginini DNA, and Staphylococcus aureus DNA. The sensitivity, specificity, and accuracy of the assay were 97.73% and 94.83%, and 96.08%, respectively. The study concludes that the developed loop-mediated isothermal amplification assay is a practical and reliable tool for field-level diagnosis of M. ovipneumoniae infections in goats, with high sensitivity and specificity under resource-limited conditions.
MeSH term(s)	Animals ; Sheep ; Goats ; Mycoplasma ovipneumoniae/genetics ; RNA, Ribosomal, 16S/genetics ; Nucleic Acid Amplification Techniques/methods ; DNA ; Sensitivity and Specificity ; Molecular Diagnostic Techniques
Chemical Substances	RNA, Ribosomal, 16S ; DNA (9007-49-2)
Language	English
Publishing date	2023-12-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604916-3
ISSN	1872-8359 ; 0167-7012
ISSN (online)	1872-8359
ISSN	0167-7012
DOI	10.1016/j.mimet.2023.106885
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Article ; Online: A National Strategy for Ventilator and ICU Resource Allocation During the Coronavirus Disease 2019 Pandemic.

Ramachandran, Pradeep / Swamy, Lakshmana / Kaul, Viren / Agrawal, Abhinav

Chest

2020 Volume 158, Issue 3, Page(s) 887–889

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Guidelines as Topic ; Humans ; Intensive Care Units/supply & distribution ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Resource Allocation/methods ; SARS-CoV-2 ; Ventilators, Mechanical/supply & distribution
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publishing country	United States
Document type	Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.04.050
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Article: Tunable Optimal Dual Band Metamaterial Absorber for High Sensitivity THz Refractive Index Sensing.

Karthikeyan, Madurakavi / Jayabala, Pradeep / Ramachandran, Sitharthan / Dhanabalan, Shanmuga Sundar / Sivanesan, Thamizharasan / Ponnusamy, Manimaran

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 15

Abstract: We present a simple dual band absorber design and investigate it in the terahertz (THz) region. The proposed absorber works in dual operating bands at 5.1 THz and 11.7 THz. By adjusting the graphene chemical potential, the proposed absorber has the ... ...

Abstract	We present a simple dual band absorber design and investigate it in the terahertz (THz) region. The proposed absorber works in dual operating bands at 5.1 THz and 11.7 THz. By adjusting the graphene chemical potential, the proposed absorber has the controllability of the resonance frequency to have perfect absorption at various frequencies. The graphene surface plasmon resonance results in sharp and narrow resonance absorption peaks. For incident angles up to 8°, the structure possesses near-unity absorption. The proposed sensor absorber's functionality is evaluated using sensing medium with various refractive indices. The proposed sensor is simulated for glucose detection and a maximum sensitivity of 4.72 THz/RIU is observed. It has a maximum figure of merit (FOM) and Quality factor (Q) value of 14 and 32.49, respectively. The proposed optimal absorber can be used to identify malaria virus and cancer cells in blood. Hence, the proposed plasmonic sensor is a serious contender for biomedical uses in the diagnosis of bacterial infections, cancer, malaria, and other diseases.
Language	English
Publishing date	2022-08-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12152693
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Article: Colistimethate sodium-chitosan hydrogel for treating Gram-negative bacterial wound infections

Pradeep, Aathira / Ashok, Nivethitha / Priya, V. / Pillai, Anoop V. / Menon, Riju Ramachandran / Kumar, V. Anil / Jayakumar, R.

International journal of biological macromolecules. 2022 June 14,

2022

Abstract: The drug resistance is higher among Gram-negative bacteria and demands the usage of strong antibiotics which can in turn result in systemic toxicity. In the treatment of the chronic wounds harboring pathogenic Gram-negative bacteria, the demand for an ... ...

Abstract	The drug resistance is higher among Gram-negative bacteria and demands the usage of strong antibiotics which can in turn result in systemic toxicity. In the treatment of the chronic wounds harboring pathogenic Gram-negative bacteria, the demand for an antimicrobial product that can be topically administered has been on the rise. In an effort to address the above issue, we have developed Colistimethate sodium (a high-end antibiotic) loaded chitosan hydrogel and characterized. The prepared hydrogel is very stable and observed to be bio- and hemo-compatible in nature. The antibacterial activity of the prepared hydrogel was studied against both ATCC (American Type Culture Collection) strains and clinical isolates of Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae. The CMS incorporated hydrogel is also capable of inhibiting the biofilm formation. The developed hydrogel can be potentially being used for the treatment of Gram-negative bacterial infected wounds.
Keywords	Escherichia coli ; Gram-negative bacteria ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; antibacterial properties ; antibiotics ; biofilm ; chitosan ; drug resistance ; hydrogels ; sodium ; toxicity
Language	English
Dates of publication	2022-0614
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.113
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Powerless in the ICU: Perspectives from ICUs in the Face of Coronavirus Disease 2019.

Ramachandran, Pradeep / Swamy, Lakshmana / Kaul, Viren / Agrawal, Abhinav / Narasimhan, Mangala

Chest

2020 Volume 158, Issue 3, Page(s) 881–883

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Disease Transmission, Infectious/prevention & control ; Humans ; Intensive Care Units/standards ; Pandemics ; Personal Protective Equipment/supply & distribution ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-23
Publishing country	United States
Document type	Editorial
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.05.538
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Article: Impact of Pelvic Bone Anatomy on Inguinal Hernia and the Role of Radiological Pelvimetry.

Rajeev, Akash / Vinod, Ashwin / John, George M / Jacob, Pradeep / Ramachandran, Riju / Marwaha, Vishal

Cureus

2022 Volume 14, Issue 1, Page(s) e21269

Abstract: Introduction One of the most prevalent disorders treated by general surgeons is inguinal hernias. Many of the etiological factors that lead to hernia development are unknown. This study looked at the role of pelvic bone anatomy in the development of ... ...

Abstract	Introduction One of the most prevalent disorders treated by general surgeons is inguinal hernias. Many of the etiological factors that lead to hernia development are unknown. This study looked at the role of pelvic bone anatomy in the development of inguinal hernia. The pubic tubercle's location (as measured by the Radoievitch angle) and its relationship to the formation of inguinal hernia, as well as its function in the pathophysiology of various forms of inguinal hernia, were investigated. Materials and methods From October 2019 to June 2021, a prospective case-control study with 70 individuals over the age of 18 years in each arm was conducted in the Department of General Surgery at our tertiary care institution. Plain digital X-ray radiography of the pelvis, including bilateral hips, was taken in the anteroposterior (AP) view with the patient in the supine position, and the Radoievitch angle and Ami line were measured using suitable measuring instruments. The required information for patients in both groups was tallied and examined in a data sheet. Results Between the case and control groups, there was a statistically significant difference in the mean Radoievitch angles and the mean length of the Ami line (42.46 +/-2.442 degrees vs 40.91 +/-2.547 degrees; p<0.05); (8.54+/-1.059 cm vs 7.27+/-1.034 cm; p<0.05). There was a statistically significant increase in the Radoievitch angle of patients with bilateral hernias compared to unilateral hernias (p-value <0.01), as well as indirect hernias compared to other forms of hernias (p-value <0.05). Conclusion The probability of having an inguinal hernia was higher when the Fruchaud region was increased, as indicated by a larger Radoievitch angle or a longer Ami line. A low-lying pubic tubercle increased the likelihood of bilateral and indirect inguinal hernias. Pelvimetry is an easy test that should be considered on a routine basis and can be applied accurately in all patients. Surgeons can employ pelvimetry to identify patients who are more likely to benefit from non-mesh repairs.
Language	English
Publishing date	2022-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.21269
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