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  1. Book: Neurobiology of addiction

    Swann, Alan C. / Moeller, F. Gerard / Lijffijt, Marijn

    2016  

    Author's details edited by Alan C. Swann, MD; F. Gerard Moeller, MD; Marijn Lijffijt, PHD
    Keywords Substance-Related Disorders / physiopathology ; Behavior, Addictive / physiopathology ; Brain / drug effects ; Neurobiology
    Language English
    Size xiii, 359 Seiten, Illustrationen, Diagramme
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT019118205
    ISBN 978-0-19-936789-4 ; 0-19-936789-2
    Database Catalogue ZB MED Medicine, Health

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    2016 A 2244 available for loan (reading room) Lesesaal EG

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  2. Book ; Conference proceedings: Special needs of women with bipolar disorder

    Swann, Alan C.

    CME certified symposium monograph

    (CNS spectrums ; 9,8, Suppl. Aug.)

    2004  

    Author's details presenter Alan C. Swann
    Series title CNS spectrums ; 9,8, Suppl. Aug.
    Collection
    Language English
    Size 11 S. : graph. Darst.
    Publisher MBL Communications
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT014285707
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Mixed features: evolution of the concept, past and current definitions, and future prospects.

    Swann, Alan C

    CNS spectrums

    2017  Volume 22, Issue 2, Page(s) 161–169

    Abstract: Mixed states address the relationships between episodes and the course of an illness, presenting significant clinical challenges. Recurrent affective disorders were described thousands of years ago as dimensional disturbances of the basic elements of ... ...

    Abstract Mixed states address the relationships between episodes and the course of an illness, presenting significant clinical challenges. Recurrent affective disorders were described thousands of years ago as dimensional disturbances of the basic elements of behavior, combining the characteristics of what we would now consider manic and depressive episodes. It was recognized from the beginning that combinations of depressive and manic features are associated with a severe illness course, including increased suicide risk. Early descriptions of affective disorders formulated them as systemic illnesses, a concept supported by more recent data. Descriptions of affective disorders and their course, including mixed states, became more systematic during the 19th century. Structured criteria achieved importance with evidence that, in addition to early onset, frequent recurrence, and comorbid problems, mixed states had worse treatment outcomes than other episodes. In contrast to 2000 years of literature on recurrent affective episodes and mixed states, the unipolar-bipolar disorder distinction was formalized in the mid-20th century. Mixed-state criteria, initially developed for bipolar disorder, ranged from fully combined depression and mania to the DSM-5 criteria, no longer limited to bipolar disorder, of a primary depressive or manic episode with at least three symptoms of the other episode type. The challenges involved in understanding and identifying mixed states center largely on what drives them, including (1) their formulation as either categorical or dimensional constructs, (2) the specificity of their relationships to depressive or manic episodes, and (3) specificity for bipolar versus major depressive disorder. Their existence challenges the distinction between bipolar and major depressive disorders. The challenges involved in identifying the underlying physiological mechanisms go to the heart of these questions.
    MeSH term(s) Affect/drug effects ; Antidepressive Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/classification ; Bipolar Disorder/diagnosis ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Depressive Disorder, Major/classification ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/drug therapy ; Depressive Disorder, Major/psychology ; Drug Therapy, Combination ; Humans ; Lithium Carbonate/therapeutic use ; Treatment Outcome
    Chemical Substances Antidepressive Agents ; Antipsychotic Agents ; Lithium Carbonate (2BMD2GNA4V)
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852916000882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Mixed States: Beyond Depression and Mania.

    Sani, Gabriele / Swann, Alan C

    The Psychiatric clinics of North America

    2019  Volume 43, Issue 1, Page(s) xv–xvii

    MeSH term(s) Bipolar Disorder ; Depression ; Depressive Disorder ; Humans
    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2019.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Suicide Risk in a National VA Sample: Roles of Psychiatric Diagnosis, Behavior Regulation, Substance Use, and Smoking.

    Swann, Alan C / Graham, David P / Wilkinson, Anna V / Kosten, Thomas R

    The Journal of clinical psychiatry

    2022  Volume 83, Issue 3

    Abstract: Background:: Methods:: Results:: ... ...

    Abstract Background:
    Methods:
    Results:
    Discussion
    MeSH term(s) Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/epidemiology ; Humans ; Mental Disorders/diagnosis ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Smoking/adverse effects ; Smoking/epidemiology ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/psychology ; Suicidal Ideation ; Suicide/psychology ; Veterans/psychology
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.21m14123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 247: Show issues

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  6. Article ; Online: Mixed States: Historical Impact and Evolution of the Concept.

    Sani, Gabriele / Swann, Alan C

    The Psychiatric clinics of North America

    2019  Volume 43, Issue 1, Page(s) 1–13

    Abstract: Mixed states have been discussed for more than 2 millennia. The theoretic conception of the coexistence of presumably opposite symptoms of mood or of different psychic domains is well established, although obscured by the presumed separation between ... ...

    Abstract Mixed states have been discussed for more than 2 millennia. The theoretic conception of the coexistence of presumably opposite symptoms of mood or of different psychic domains is well established, although obscured by the presumed separation between bipolar and depressive disorders. Moreover, the lack of response to treatments and severe psychopathology raise important issues requiring urgent solution. The aim of this article was to review the development of the concept of mixed states from the classic literature to modern nosologic systems and to claim for the need of a new paradigm to address the still-open issues about mixed states.
    MeSH term(s) Bipolar Disorder/diagnosis ; Depressive Disorder, Major/diagnosis ; Diagnosis, Differential ; History, 18th Century ; History, 19th Century ; History, 20th Century ; History, Ancient ; History, Medieval ; Humans ; Psychopathology
    Language English
    Publishing date 2019-11-27
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2019.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Non-pharmacological and pharmacological treatments act on the same brain.

    Swann, Alan C

    World psychiatry : official journal of the World Psychiatric Association (WPA)

    2014  Volume 13, Issue 3, Page(s) 262–264

    Language English
    Publishing date 2014-10-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2236130-3
    ISSN 2051-5545 ; 1723-8617
    ISSN (online) 2051-5545
    ISSN 1723-8617
    DOI 10.1002/wps.20166
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  8. Article ; Online: CANMAT Guidelines commentary: where does the evidence come from, and how can we use it for our patients?

    Swann, Alan C

    Bipolar disorders

    2013  Volume 15, Issue 1, Page(s) 45–49

    MeSH term(s) Antidepressive Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Canada ; Clinical Trials as Topic/methods ; Clinical Trials as Topic/standards ; Evidence-Based Medicine ; Guidelines as Topic ; Humans
    Chemical Substances Antidepressive Agents
    Language English
    Publishing date 2013-02
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.12037
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  9. Article ; Online: Nicotine Inhalation and Suicide: Clinical Correlates and Behavioral Mechanisms.

    Swann, Alan C / Graham, David P / Wilkinson, Anna V / Kosten, Thomas R

    The American journal on addictions

    2021  Volume 30, Issue 4, Page(s) 316–329

    Abstract: Background and objectives: Extensive evidence links smoking and suicide independently of psychiatric diagnoses, but there are questions about the pathophysiology and specificity of this relationship. We examined characteristics of this linkage to ... ...

    Abstract Background and objectives: Extensive evidence links smoking and suicide independently of psychiatric diagnoses, but there are questions about the pathophysiology and specificity of this relationship. We examined characteristics of this linkage to identify potential transdiagnostic mechanisms in suicide and its prevention.
    Methods: We reviewed literature that associated suicide with smoking and e-cigarettes, including the temporal sequence of smoking and suicide risk and their shared behavioral risk factors of sensitization and impulsivity.
    Results: Smoking is associated with increased suicide across psychiatric diagnoses and in the general population, proportionately to the number of cigarettes smoked per day. Rapid nicotine uptake into the brain through inhalation of conventional cigarettes, electronic cigarettes (e-cigarette), or even second-hand smoke can facilitate long-term sensitization and short-term impulsivity. Both impair action regulation and predispose to negative affect, continued smoking, and suicidal behavior. Intermittent hypoxia, induced by cigarettes or e-cigarettes, synergistically promotes impulsivity and sensitization, exacerbating suicidality. Two other shared behavioral risks also develop negative urgency (combined impulsivity and negative affect) and cross-sensitization to stressors or to other addictive stimuli. Finally, early smoking onset, promoted by e-cigarettes in never-smokers, increases subsequent suicide risk.
    Conclusion and scientific significance: Prevention or cessation of nicotine inhalation can strategically prevent suicidality and other potentially lethal behavior regardless of psychiatric diagnoses. Medications for reducing smoking and suicidality, especially in younger smokers, should consider the neurobehavioral mechanisms for acute impulsivity and longer-term sensitization, potentially modulated more effectively through glutamate antagonism rather than nicotine substitution. (Am J Addict 2021;30:316-329).
    MeSH term(s) Administration, Inhalation ; Humans ; Nicotine/administration & dosage ; Randomized Controlled Trials as Topic ; Risk Factors ; Smoking/psychology ; Suicide/statistics & numerical data
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1141440-6
    ISSN 1521-0391 ; 1055-0496
    ISSN (online) 1521-0391
    ISSN 1055-0496
    DOI 10.1111/ajad.13171
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  10. Article ; Online: Activated depression: mixed bipolar disorder or agitated unipolar depression?

    Swann, Alan C

    Current psychiatry reports

    2013  Volume 15, Issue 8, Page(s) 376

    Abstract: The combination of depression and activation presents clinical and diagnostic challenges. It can occur, in either bipolar disorder or major depressive disorder, as increased agitation as a dimension of depression. What is called agitation can consist of ... ...

    Abstract The combination of depression and activation presents clinical and diagnostic challenges. It can occur, in either bipolar disorder or major depressive disorder, as increased agitation as a dimension of depression. What is called agitation can consist of expressions of painful inner tension or as disinhibited goal-directed behavior and thought. In bipolar disorder, elements of depression can be combined with those of mania. In this case, the agitation, in addition to increased motor activity and painful inner tension, must include symptoms of mania that are related to goal-directed behavior or manic cognition. These diagnostic considerations are important, as activated depression potentially carries increased behavioral risk, especially for suicidal behavior, and optimal treatments for depressive episodes differ between bipolar disorder and major depressive disorder.
    MeSH term(s) Bipolar Disorder/psychology ; Depressive Disorder/psychology ; Humans ; Psychomotor Agitation/psychology
    Language English
    Publishing date 2013-07-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055376-6
    ISSN 1535-1645 ; 1523-3812
    ISSN (online) 1535-1645
    ISSN 1523-3812
    DOI 10.1007/s11920-013-0376-1
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