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Article: Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.

Haines, Seline / Caccamo, Amy / Chan, Fonda / Galaso, German / Catinchi, Alexis / Gupta, Puneet K

2020 Volume 60, Issue 2, Page(s) 78–95

Abstract: The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, which has resulted in a spike in the anxiety of the frontline ... ...

Abstract	The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, which has resulted in a spike in the anxiety of the frontline healthcare workers. News reports and information about the virus are rapidly changing. We present a case of a patient with COVID-19 who had a seizure-like spell for which an EEG was performed. In early to mid-March, there were no clear guidelines or recommendations available from neurodiagnostic-related organizations or hospitals on how to adapt procedure workflow to those with COVID-19. When caring for COVID-19 patients, as when caring for any patient with an infectious disease, it is hospital protocol to follow contact, droplet/airborne precautions by wearing appropriate PPE. However, because we knew very little about the coronavirus, this case was different. In this article, we discuss our experience with our EEG workflow and concerns for staff exposure. We then discuss our adaptations and modifications to our standard procedures and protocols. A time analysis comparing our standard EEG protocol with our modified COVID-19 protocol revealed a significant decrease in technologist exposure time (99 minutes versus 51 minutes), which theoretically would reduce the chance of virus transmission to our technologist. At this critical moment in time, we hope such modifications will allow us to continue delivering high quality patient care while optimizing resource utilization and above all keeping our technologists safe.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/transmission ; Electroencephalography/methods ; Health Personnel ; Humans ; Infection Control/methods ; Male ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/transmission ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2663639-6
ISSN	2375-8627 ; 2164-6821
ISSN (online)	2375-8627
ISSN	2164-6821
DOI	10.1080/21646821.2020.1756132
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Article ; Online: Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases

Haines, Seline / Caccamo, Amy / Chan, Fonda / Galaso, German / Catinchi, Alexis / Gupta, Puneet K.

The Neurodiagnostic Journal

2020 Volume 60, Issue 2, Page(s) 78–95

Keywords	Medical Laboratory Technology ; Clinical Neurology ; covid19
Language	English
Publisher	Informa UK Limited
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2663639-6
ISSN	2375-8627 ; 2164-6821
ISSN (online)	2375-8627
ISSN	2164-6821
DOI	10.1080/21646821.2020.1756132
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases

Haines, Seline / Caccamo, Amy / Chan, Fonda / Galaso, German / Catinchi, Alexis / Gupta, Puneet K

Neurodiagn J

Abstract	The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, which has resulted in a spike in the anxiety of the frontline healthcare workers. News reports and information about the virus are rapidly changing. We present a case of a patient with COVID-19 who had a seizure-like spell for which an EEG was performed. In early to mid-March, there were no clear guidelines or recommendations available from neurodiagnostic-related organizations or hospitals on how to adapt procedure workflow to those with COVID-19. When caring for COVID-19 patients, as when caring for any patient with an infectious disease, it is hospital protocol to follow contact, droplet/airborne precautions by wearing appropriate PPE. However, because we knew very little about the coronavirus, this case was different. In this article, we discuss our experience with our EEG workflow and concerns for staff exposure. We then discuss our adaptations and modifications to our standard procedures and protocols. A time analysis comparing our standard EEG protocol with our modified COVID-19 protocol revealed a significant decrease in technologist exposure time (99 minutes versus 51 minutes), which theoretically would reduce the chance of virus transmission to our technologist. At this critical moment in time, we hope such modifications will allow us to continue delivering high quality patient care while optimizing resource utilization and above all keeping our technologists safe.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #186389
Database	COVID19

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Article: Veterinary leadership: Time for us to step into our own power.

Wilson, Jeff / Rivers, Jocelyn / Anholt, Michele / Onawola, Dauda / Lantos, Gabor / Speicher, David J / De Monte, Sal / Kasab-Bachi, Hind / Haines, Treasure / Noor, Sanna / Gillam, Will / Suganda, Erin / Aramini, Jeff

The Canadian veterinary journal = La revue veterinaire canadienne

2022 Volume 63, Issue 6, Page(s) 647–648

MeSH term(s)	Animals ; Education, Veterinary ; Leadership
Language	English
Publishing date	2022-07-02
Publishing country	Canada
Document type	Journal Article
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
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Article ; Online: Global health burden of ambient PM2.5 and the contribution of anthropogenic black carbon and organic aerosols

Sourangsu Chowdhury / Andrea Pozzer / Andy Haines / Klaus Klingmüller / Thomas Münzel / Pauli Paasonen / Arushi Sharma / Chandra Venkataraman / Jos Lelieveld

Environment International, Vol 159, Iss , Pp 107020- (2022)

2022

Abstract: ... than other PM2.5 compounds such as soluble salts, related to their high potential to inflict oxidative stress ...

Abstract	Chronic exposure to fine particulate matter (PM2.5) poses a major global health risk, commonly assessed by assuming equivalent toxicity for different PM2.5 constituents. We used a data-informed global atmospheric model and recent exposure–response functions to calculate the health burden of ambient PM2.5 from ten source categories. We estimate 4.23 (95% confidence interval 3.0–6.14) million excess deaths annually from the exposure to ambient PM2.5. We distinguished contributions and major sources of black carbon (BC), primary organic aerosols (POA) and anthropogenic secondary organic aerosols (aSOA). These components make up to ∼20% of the total PM2.5 in South and East Asia and East Africa. We find that domestic energy use by the burning of solid biofuels is the largest contributor to ambient BC, POA and aSOA globally. Epidemiological and toxicological studies indicate that these compounds may be relatively more hazardous than other PM2.5 compounds such as soluble salts, related to their high potential to inflict oxidative stress. We performed sensitivity analyses by considering these species to be more harmful compared to other compounds in PM2.5, as suggested by their oxidative potential using a range of potential relative risks. These analyses show that domestic energy use emerges as the leading cause of excess mortality attributable to ambient PM2.5, notably in Asia and Africa. We acknowledge the uncertainties inherent in our assumed enhanced toxicity of the anthropogenic organic and BC aerosol components, which suggest the need to better understand the mechanisms and magnitude of the associated health risks and the consequences for regulatory policies. However our assessment of the importance of emissions from domestic energy use as a cause of premature mortality is robust to a range of assumptions about the magnitude of the excess risk.
Keywords	PM2.5 ; BC ; aSOA ; POA ; Excess mortality ; Source sectors ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Global health burden of ambient PM2.5 and the contribution of anthropogenic black carbon and organic aerosols

Chowdhury, Sourangsu / Pozzer, Andrea / Haines, Andy / Klingmüller, Klaus / Münzel, Thomas / Paasonen, Pauli / Sharma, Arushi / Venkataraman, Chandra / Lelieveld, Jos

Environment international. 2022 Jan. 15, v. 159

2022

Abstract: ... than other PM₂.₅ compounds such as soluble salts, related to their high potential to inflict oxidative stress ...

Abstract	Chronic exposure to fine particulate matter (PM₂.₅) poses a major global health risk, commonly assessed by assuming equivalent toxicity for different PM₂.₅ constituents. We used a data-informed global atmospheric model and recent exposure–response functions to calculate the health burden of ambient PM₂.₅ from ten source categories. We estimate 4.23 (95% confidence interval 3.0–6.14) million excess deaths annually from the exposure to ambient PM₂.₅. We distinguished contributions and major sources of black carbon (BC), primary organic aerosols (POA) and anthropogenic secondary organic aerosols (aSOA). These components make up to ∼20% of the total PM₂.₅ in South and East Asia and East Africa. We find that domestic energy use by the burning of solid biofuels is the largest contributor to ambient BC, POA and aSOA globally. Epidemiological and toxicological studies indicate that these compounds may be relatively more hazardous than other PM₂.₅ compounds such as soluble salts, related to their high potential to inflict oxidative stress. We performed sensitivity analyses by considering these species to be more harmful compared to other compounds in PM₂.₅, as suggested by their oxidative potential using a range of potential relative risks. These analyses show that domestic energy use emerges as the leading cause of excess mortality attributable to ambient PM₂.₅, notably in Asia and Africa. We acknowledge the uncertainties inherent in our assumed enhanced toxicity of the anthropogenic organic and BC aerosol components, which suggest the need to better understand the mechanisms and magnitude of the associated health risks and the consequences for regulatory policies. However our assessment of the importance of emissions from domestic energy use as a cause of premature mortality is robust to a range of assumptions about the magnitude of the excess risk.
Keywords	aerosols ; biofuels ; carbon ; chronic exposure ; confidence interval ; energy ; environment ; models ; mortality ; oxidative stress ; particulates ; toxicity ; toxicology ; East Asia ; Eastern Africa
Language	English
Dates of publication	2022-0115
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2021.107020
Database	NAL-Catalogue (AGRICOLA)

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Article: Quantitation of Total Vanadium in Rodent Plasma and Urine by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS).

Harrington, James M / Haines, Laura G / Essader, Amal S / Liyanapatirana, Chamindu / Poitras, Eric A / Weber, Frank X / Levine, Keith E / Fernando, Reshan A / Robinson, Veronica G / Waidyanatha, Suramya

Analytical letters

2021 Volume 54, Issue 17, Page(s) 2777–2788

Abstract: ... to limited data on soluble V salts, the National Toxicology Program is investigating the toxicity in rodents ...

Abstract	Human exposure to vanadium (V) is anticipated because it is a drinking water contaminant. Due to limited data on soluble V salts, the National Toxicology Program is investigating the toxicity in rodents following drinking water exposure. Measurement of internal V dose allows for interpretation of toxicology data. The objective of this study was to develop and validate an inductively coupled plasma-mass spectrometric method to quantitate total V in rat plasma. The method was linear (r ≥ 0.99) from 5.00 - 1,000 ng V/mL. Intra- and inter-day relative error (% RE) and relative standard deviation (% RSD) of spiked plasma samples were 8.5% - 15.6% RE and ≤ 1.8% RSD and 7.3% - 11.7% RE and ≤ 3.1% RSD, respectively. The limit of detection was 0.268 ng V/mL plasma and absolute percent recovery was 113%. Standards up to 7,500 ng V/mL plasma were diluted into the validated range (5.6% RE, 0.9% RSD). V in extracted plasma samples over 15 days at ambient and refrigerated conditions was from 97.7 - 126% of day 0. Determined plasma V concentrations after three freeze-thaw cycles and after frozen storage for up to 63 days ranged from 100 - 106% and 100 - 122% of day 0, respectively. The method was extended to rat urine (accuracy and precision -2.0 - 0.3% RE and <0.6% RSD, respectively for same linear range). These data demonstrate that the method is suitable to quantitate V in rat plasma and urine.
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	391022-2
ISSN	0003-2719
ISSN	0003-2719
DOI	10.1080/00032719.2021.1890107
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Article ; Online: Anionic salts in the prepartum diet and addition of sodium bicarbonate to colostrum replacer, and their effects on immunoglobulin G absorption in the neonate.

Morrill, K M / Marston, S P / Whitehouse, N L / Van Amburgh, M E / Schwab, C G / Haines, D M / Erickson, P S

Journal of dairy science

2010 Volume 93, Issue 5, Page(s) 2067–2075

Abstract: The objectives of this experiment were to determine whether feeding anionic salts to prepartum ... on 1 of 2 treatments: a diet without anionic salts (dietary cation-anion difference of +77 mEq/kg) or ... a diet with anionic salts (dietary cation-anion difference of -100 mEq/kg). Within 45 min after birth ...

Abstract	The objectives of this experiment were to determine whether feeding anionic salts to prepartum Holstein cows affected their calf's colostral IgG passive transfer and whether adding sodium bicarbonate to a colostrum replacer (CR) would increase the efficiency of IgG absorption. Forty Holstein cows and their resulting calves were assigned to a 2 x 2 factorial arrangement of treatments in a randomized complete block design based on expected date of calving. Three weeks before the projected due date, cows were placed on 1 of 2 treatments: a diet without anionic salts (dietary cation-anion difference of +77 mEq/kg) or a diet with anionic salts (dietary cation-anion difference of -100 mEq/kg). Within 45 min after birth, all calves received 1 dose of a commercially available CR (132g of IgG) without or with supplemental sodium bicarbonate (19.5 g/dose). A half-dose of CR (66g of IgG) and sodium bicarbonate (9.75g) was fed at 6h of age. Calves received milk replacer at 12, 24, 36, and 48h. Blood samples were obtained from calves at 0, 6, 12, 24, and 48h and were analyzed for IgG concentration. Cows fed the diet supplemented with anionic salts had lower DMI on d 8, 5, 4, and 1 and lower urine pH 2 and 1 wk before parturition compared with cows fed the diet without supplemental anionic salts. Calves born from dams receiving anionic salts had similar IgG concentrations (15.1 vs. 14.4g/L) and apparent efficiency of absorption values (29.2 vs. 28.2%) compared with calves born from dams not fed anionic salts. Calves receiving supplemental sodium bicarbonate in the CR had higher serum IgG concentrations at 12 (14.4 vs. 12.0g/L), 24 (16.3 vs. 13.2g/L), and 48h (14.6 vs. 11.2g/L) and higher apparent efficiency of absorption values (31.2 vs. 26.1%) than calves that did not receive sodium bicarbonate in the CR. Calves receiving sodium bicarbonate also had greater area under the curve values for IgG absorption compared with calves not receiving sodium bicarbonate. There was a trend for an interaction with calves born from dams fed anionic salts having a greater area under the curve when fed supplemental sodium bicarbonate. Of the 40 calves in the study, 90% obtained adequate passive transfer (serum IgG > or = 10g/L). This study indicates that feeding anionic salts to the dam has no effect on passive transfer, whereas adding sodium bicarbonate to the CR increased IgG uptake in calves.
MeSH term(s)	Animals ; Animals, Newborn/immunology ; Cattle/immunology ; Colostrum/immunology ; Diet/veterinary ; Eating/drug effects ; Female ; Hydrogen-Ion Concentration ; Immunity, Maternally-Acquired/drug effects ; Immunity, Maternally-Acquired/immunology ; Immunoglobulin G/blood ; Immunoglobulin G/immunology ; Milk Substitutes/chemistry ; Pregnancy ; Random Allocation ; Sodium Bicarbonate/administration & dosage ; Sodium Bicarbonate/pharmacology ; Time Factors ; Urine/chemistry
Chemical Substances	Immunoglobulin G ; Sodium Bicarbonate (8MDF5V39QO)
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
DOI	10.3168/jds.2009-2622
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Article: Anionic salts in the prepartum diet and addition of sodium bicarbonate to colostrum replacer, and their effects on immunoglobulin G absorption in the neonate

Morrill, K.M / Marston, S.P / Whitehouse, N.L / Van Amburgh, M.E / Schwab, C.G / Haines, D.M / Erickson, P.S

Journal of dairy science. 2010 May, v. 93, no. 5

2010

Abstract	The objectives of this experiment were to determine whether feeding anionic salts to prepartum Holstein cows affected their calf's colostral IgG passive transfer and whether adding sodium bicarbonate to a colostrum replacer (CR) would increase the efficiency of IgG absorption. Forty Holstein cows and their resulting calves were assigned to a 2 × 2 factorial arrangement of treatments in a randomized complete block design based on expected date of calving. Three weeks before the projected due date, cows were placed on 1 of 2 treatments: a diet without anionic salts (dietary cation-anion difference of +77 mEq/kg) or a diet with anionic salts (dietary cation-anion difference of −100 mEq/kg). Within 45min after birth, all calves received 1 dose of a commercially available CR (132g of IgG) without or with supplemental sodium bicarbonate (19.5 g/dose). A half-dose of CR (66g of IgG) and sodium bicarbonate (9.75g) was fed at 6h of age. Calves received milk replacer at 12, 24, 36, and 48h. Blood samples were obtained from calves at 0, 6, 12, 24, and 48h and were analyzed for IgG concentration. Cows fed the diet supplemented with anionic salts had lower DMI on d 8, 5, 4, and 1 and lower urine pH 2 and 1 wk before parturition compared with cows fed the diet without supplemental anionic salts. Calves born from dams receiving anionic salts had similar IgG concentrations (15.1 vs. 14.4g/L) and apparent efficiency of absorption values (29.2 vs. 28.2%) compared with calves born from dams not fed anionic salts. Calves receiving supplemental sodium bicarbonate in the CR had higher serum IgG concentrations at 12 (14.4 vs. 12.0g/L), 24 (16.3 vs. 13.2g/L), and 48h (14.6 vs. 11.2g/L) and higher apparent efficiency of absorption values (31.2 vs. 26.1%) than calves that did not receive sodium bicarbonate in the CR. Calves receiving sodium bicarbonate also had greater area under the curve values for IgG absorption compared with calves not receiving sodium bicarbonate. There was a trend for an interaction with calves born from dams fed anionic salts having a greater area under the curve when fed supplemental sodium bicarbonate. Of the 40 calves in the study, 90% obtained adequate passive transfer (serum IgG >or=10g/L). This study indicates that feeding anionic salts to the dam has no effect on passive transfer, whereas adding sodium bicarbonate to the CR increased IgG uptake in calves.
Keywords	ruminant nutrition ; anions ; prepartum period ; sodium bicarbonate ; cow colostrum ; immunoglobulin G ; intestinal absorption ; neonates ; calf feeding ; milk replacer ; calves ; maternal nutrition ; dry matter intake
Language	English
Dates of publication	2010-05
Size	p. 2067-2075.
Document type	Article
ZDB-ID	242499-x
ISSN	1525-3198 ; 0022-0302
ISSN (online)	1525-3198
ISSN	0022-0302
Database	NAL-Catalogue (AGRICOLA)

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Article: Synthesis of the Dipotassium Salts of Methyl α-D-Mannopyranoside 6-Phosphorothioate and D-Mannose 6-Phosphorothioate

Haines, Alan H. / Massy, D. James R.

Synthesis

1996 Volume 1996, Issue 12, Page(s) 1422–1424

Keywords	carbohydrates ; mannose ; phosphitylation ; phosphorothioates ; inhibitors
Language	English
Publishing date	1996-01-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2033062-5
ISSN	1437-210X ; 0039-7881
ISSN (online)	1437-210X
ISSN	0039-7881
DOI	10.1055/s-1996-4421
Database	Thieme publisher's database

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