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  1. Article ; Online: Epidemiology of idiopathic pulmonary fibrosis: opportunities and hurdles for population-level studies of rare disease.

    Marinescu, Daniel-Costin / Wong, Alyson W

    Thorax

    2024  

    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Editorial
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2024-221581
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  2. Article ; Online: The Fatigue Severity Scale in Interstitial Lung Disease: An Energizing Endpoint.

    Wong, Alyson W / Johannson, Kerri A

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 2, Page(s) 128–129

    MeSH term(s) Humans ; Reproducibility of Results ; Lung Diseases, Interstitial/diagnosis ; Fatigue/etiology
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202305-0919ED
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  3. Article ; Online: The Genomic Classifier and Our Quest for Diagnostic Certainty in Interstitial Lung Disease.

    Wong, Alyson W / Fisher, Jolene H

    Annals of the American Thoracic Society

    2022  Volume 19, Issue 5, Page(s) 725–727

    MeSH term(s) Genomics ; Humans ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/genetics
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202107-873ED
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  4. Article ; Online: Providing Patient-Centered Care in Interstitial Lung Disease.

    Wong, Alyson W / Danoff, Sonye K

    Clinics in chest medicine

    2021  Volume 42, Issue 2, Page(s) 337–346

    Abstract: There have been growing interest in and emphasis on health systems adopting a patient-centered care (PCC) approach, which focuses on providing care that is respectful and responsive to patient preferences, needs, and values. The features of PCC can fall ... ...

    Abstract There have been growing interest in and emphasis on health systems adopting a patient-centered care (PCC) approach, which focuses on providing care that is respectful and responsive to patient preferences, needs, and values. The features of PCC can fall into 3 domains: structure, process, and outcomes. These domains encompass the necessary infrastructure and culture required to facilitate respectful and compassionate care and patient engagement. This review discusses the features that characterize each of these PCC domains and how they can be applied specifically to clinical care and research within the field of interstitial lung disease.
    MeSH term(s) Delivery of Health Care ; Humans ; Lung Diseases, Interstitial/therapy ; Patient-Centered Care
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 447455-7
    ISSN 1557-8216 ; 0272-5231
    ISSN (online) 1557-8216
    ISSN 0272-5231
    DOI 10.1016/j.ccm.2021.03.003
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  5. Article ; Online: Diagnostic Features in Combined Pulmonary Fibrosis and Emphysema: A Systematic Review.

    Wong, Alyson W / Liang, Jiaming / Cottin, Vincent / Ryerson, Christopher J

    Annals of the American Thoracic Society

    2021  Volume 17, Issue 10, Page(s) 1333–1336

    MeSH term(s) Emphysema ; Humans ; Pulmonary Emphysema/complications ; Pulmonary Emphysema/diagnosis ; Pulmonary Fibrosis/complications ; Pulmonary Fibrosis/diagnosis
    Language English
    Publishing date 2021-02-15
    Publishing country United States
    Document type Letter ; Systematic Review
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202002-122RL
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  6. Article ; Online: A systematic review on the economic burden of interstitial lung disease and the cost-effectiveness of current therapies.

    Wong, Alyson W / Koo, John / Ryerson, Christopher J / Sadatsafavi, Mohsen / Chen, Wenjia

    BMC pulmonary medicine

    2022  Volume 22, Issue 1, Page(s) 148

    Abstract: Background: The economic burden of interstitial lung disease (ILD) is unknown, limiting informed resource allocation and planning. We sought to conduct the first systematic review on the direct, indirect, and overall costs associated with ILD and to ... ...

    Abstract Background: The economic burden of interstitial lung disease (ILD) is unknown, limiting informed resource allocation and planning. We sought to conduct the first systematic review on the direct, indirect, and overall costs associated with ILD and to evaluate the cost-effectiveness of current therapies globally.
    Methods: We conducted systematic reviews of ILD disease cost studies and cost-effectiveness analyses (CEAs) using MEDLINE, Embase, and Web of Science databases between 2000 and 2020. We compared ILD costs between countries according to the share of costs towards each country's respective gross domestic product (GDP) per capita. Costs are reported in 2020 USD.
    Results: We identified 25 disease cost studies and 7 CEAs. The direct medical costs ranged between $1824 and $116,927 annually per patient (median $32,834; 14-180% of GDP per capita in Western countries). The leading drivers of direct costs were inpatient (55%), outpatient (22%), and medication costs (18%), based on pooled estimates. Annual indirect costs ranged from $7149 to $10,902 per employed patient (median $9607; 12-23% of GDP per capita). Among the 7 CEAs, only 1 study (14%) showed an ILD therapy (ambulatory oxygen) was cost-effective compared to best supportive care.
    Conclusion: The direct and indirect costs associated with ILD are consistently high in all countries with available data, with cost-effectiveness profiles of new therapies generally undesirable. Globally, the median total direct cost for ILD equates to 51% of a country's GDP per capita and has been increasing over time.
    MeSH term(s) Cost of Illness ; Cost-Benefit Analysis ; Drug Costs ; Financial Stress ; Health Care Costs ; Humans ; Lung Diseases, Interstitial/therapy
    Language English
    Publishing date 2022-04-20
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2059871-3
    ISSN 1471-2466 ; 1471-2466
    ISSN (online) 1471-2466
    ISSN 1471-2466
    DOI 10.1186/s12890-022-01922-2
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  7. Article ; Online: Update in Interstitial Lung Disease 2020.

    Podolanczuk, Anna J / Wong, Alyson W / Saito, Shigeki / Lasky, Joseph A / Ryerson, Christopher J / Eickelberg, Oliver

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 11, Page(s) 1343–1352

    MeSH term(s) Humans ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/etiology ; Lung Diseases, Interstitial/therapy
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202103-0559UP
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  8. Article ; Online: Malignancy Risk Associated With Mycophenolate Mofetil or Azathioprine in Patients With Fibrotic Interstitial Lung Disease.

    Lok, Stacey D / Wong, Alyson W / Khor, Yet H / Ryerson, Christopher J / Johannson, Kerri A

    Chest

    2021  Volume 161, Issue 6, Page(s) 1594–1597

    MeSH term(s) Azathioprine/adverse effects ; Humans ; Immunosuppressive Agents/adverse effects ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/epidemiology ; Mycophenolic Acid/adverse effects ; Neoplasms
    Chemical Substances Immunosuppressive Agents ; Mycophenolic Acid (HU9DX48N0T) ; Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.12.636
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  9. Article ; Online: Progression of fibrosing interstitial lung disease.

    Wong, Alyson W / Ryerson, Christopher J / Guler, Sabina A

    Respiratory research

    2020  Volume 21, Issue 1, Page(s) 32

    Abstract: Fibrotic interstitial lung diseases (ILDs) are often challenging to diagnose and classify, but an accurate diagnosis has significant implications for both treatment and prognosis. A subset of patients with fibrotic ILD experience progressive ... ...

    Abstract Fibrotic interstitial lung diseases (ILDs) are often challenging to diagnose and classify, but an accurate diagnosis has significant implications for both treatment and prognosis. A subset of patients with fibrotic ILD experience progressive deterioration in lung function, physical performance, and quality of life. Several risk factors for ILD progression have been reported, such as male sex, older age, lower baseline pulmonary function, and a radiological or pathological pattern of usual interstitial pneumonia. Morphological similarities, common underlying pathobiologic mechanisms, and the consistently progressive worsening of these patients support the concept of a progressive fibrosing (PF)-ILD phenotype that can be applied to a variety of ILD subtypes. The conventional approach has been to use antifibrotic medications in patients with idiopathic pulmonary fibrosis (IPF) and immunosuppressive medications in patients with other fibrotic ILD subtypes; however, recent clinical trials have suggested a favourable treatment response to antifibrotic therapy in a wider variety of fibrotic ILDs. This review summarizes the literature on the evaluation and management of patients with PF-ILD, and discusses questions relevant to applying recent clinicial trial findings to real-world practice.
    MeSH term(s) Disease Progression ; Fibrosis ; Humans ; Immunosuppressive Agents/therapeutic use ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/therapy ; Oxygen Inhalation Therapy/methods ; Randomized Controlled Trials as Topic/methods ; Risk Factors
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2020-01-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-020-1296-3
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  10. Article ; Online: Validation of a Dyspnea Visual Analogue Scale in Fibrotic Interstitial Lung Disease.

    Bevanda, Luka / Mok, Valerie / Lin, Kenny / Assayag, Deborah / Fisher, Jolene H / Johannson, Kerri A / Khalil, Nasreen / Kolb, Martin / Manganas, Helene / Marcoux, Veronica / Sadatsafavi, Mohsen / Wong, Alyson W / Ryerson, Christopher J

    Annals of the American Thoracic Society

    2024  

    Abstract: Rationale: A visual analogue scale (VAS) is a simple and easily administered tool for measuring impact of disease; however, little is known about the use of a Dyspnea VAS in interstitial lung disease (ILD).: Objective: To validate the use of a ... ...

    Abstract Rationale: A visual analogue scale (VAS) is a simple and easily administered tool for measuring impact of disease; however, little is known about the use of a Dyspnea VAS in interstitial lung disease (ILD).
    Objective: To validate the use of a Dyspnea VAS in a large and heterogenous cohort of patients with fibrotic ILD, including its minimal clinically important difference (MCID), responsiveness to change, and prognostic significance.
    Methods: Patients with fibrotic ILD were identified from a large prospective registry. Validity of a 100mm Dyspnea VAS was assessed by testing its correlation in change score with other measures of ILD severity, including the University of California San Diego Shortness of Breath Questionnaire (UCSDSOBQ), King's Brief Interstitial Lung Disease quality of life questionnaire Breathlessness and Activities Domain (KBILD-B), European Quality of Life visual analogue scale (EQ-VAS), forced vital capacity (FVC), and diffusion capacity of the lung for carbon monoxide (DLCO). Responsiveness of the Dyspnea VAS was qualitatively confirmed based on there being an observable difference in the change in Dyspnea VAS across tertiles of change in anchor variables. The minimum clinically important difference (MCID) in Dyspnea VAS was calculated using both anchor (linear regression) and distribution (one-half standard deviation) approaches, with anchors including the above variables that had a correlation with Dyspnea VAS (|r|0.30). The association of Dyspnea VAS with time to death or transplant was determined.
    Results: The cohort included 826 patients with fibrotic ILD, including 127 patients with follow-up measurements at 6 months. Mean baseline Dyspnea VAS was 5324mm. Dyspnea VAS change scores were moderately correlated with UCSDSOBQ (|r|=0.55) and KBILD-B (|r|=0.44), and weakly correlated with EQ-VAS (|r|=0.19), FVC% (|r|=0.21) and DLCO% (|r|=0.05). MCID was 2.7 to 4.5 using the more reliable anchor-based methods and 12.0 based on distribution-based methods. Dyspnea VAS was associated with time to death or transplant in unadjusted models and after adjustment for age and sex (hazard ratio 1.16 and 1.15 respectively, p<0.05 for both).
    Conclusion: This study provides support for the use of Dyspnea VAS in patients with fibrotic ILD, with an estimated anchor-based MCID of 5mm.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202307-658OC
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