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  1. Article ; Online: De-escalation versus shortening of DAPT.

    Galli, Mattia / Costa, Francesco / Navarese, Eliano Pio

    European heart journal. Cardiovascular pharmacotherapy

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvae019
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  2. Article ; Online: REPLY: ITT (intrepret and test to effectively treat) approach for no-reflow.

    Navarese, Eliano Pio / Kandzari, David E

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2020  Volume 99, Issue 1, Page(s) E44–E45

    MeSH term(s) Humans ; No-Reflow Phenomenon/diagnostic imaging ; No-Reflow Phenomenon/etiology ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2020-09-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.29278
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1226: Show issues Location:
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  3. Article: Clinical application of virtual reality in patients with cardiovascular disease: state of the art.

    Micheluzzi, Valentina / Navarese, Eliano Pio / Merella, Pierluigi / Talanas, Giuseppe / Viola, Graziana / Bandino, Stefano / Idini, Chiara / Burrai, Francesco / Casu, Gavino

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1356361

    Abstract: Virtual reality offers a multisensory experience to patients, allowing them to hear, watch, and interact in a virtual environment. Immersive virtual reality is particularly suitable for the purpose of completely isolating patients from the external ... ...

    Abstract Virtual reality offers a multisensory experience to patients, allowing them to hear, watch, and interact in a virtual environment. Immersive virtual reality is particularly suitable for the purpose of completely isolating patients from the external environment to transport them away from the suffering related to the disease. On this state of the art, we summarize the available literature on the effectiveness of virtual reality on various physical and psychological outcomes in patients with atherosclerotic cardiovascular disease. Virtual reality has been employed in the cardiovascular field in various settings such as cardiac rehabilitation, interventional cardiology, and cardiac surgery. This technology offers promising opportunities to improve several outcomes related to cardiovascular disease, but further research is needed to entirely capture its benefits and to standardize the intervention.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1356361
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  4. Article ; Online: Role of percutaneous coronary intervention in the modern-day management of chronic coronary syndrome.

    Cartlidge, Timothy / Kovacevic, Mila / Navarese, Eliano Pio / Werner, Gerald / Kunadian, Vijay

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 19, Page(s) 1429–1435

    Abstract: Contemporary randomised trials of percutaneous coronary intervention (PCI) in chronic coronary syndrome (CCS) demonstrate no difference between patients treated with a conservative or invasive strategy with respect to all-cause mortality or myocardial ... ...

    Abstract Contemporary randomised trials of percutaneous coronary intervention (PCI) in chronic coronary syndrome (CCS) demonstrate no difference between patients treated with a conservative or invasive strategy with respect to all-cause mortality or myocardial infarction, although trials lack power to test for individual endpoints and long-term follow-up data are needed. Open-label trials consistently show greater improvement in symptoms and quality of life among patients with stable angina treated with PCI. Further studies are awaited to clarify this finding. In patients with severe left ventricular (LV) systolic dysfunction and obstructive coronary artery disease in the Revascularization for Ischemic Ventricular Dysfunction trial, PCI has not been found to improve all-cause mortality, heart failure hospitalisation or recovery of LV function when compared with medical therapy. PCI was, however, performed without additional hazard and so remains a treatment option when there are favourable patient characteristics. The majority of patients reported no angina, and the low burden of angina in many of the randomised PCI trials is a widely cited limitation. Despite contentious evidence, elective PCI for CCS continues to play a significant role in UK clinical practice. While PCI for urgent indications has more than doubled since 2006, the rate of elective PCI remains unchanged. PCI remains an important strategy when symptoms are not well controlled, and we should maximise its value with appropriate patient selection. In this review, we provide a framework to assist in critical interpretation of findings from most recent trials and meta-analysis evidence.
    MeSH term(s) Humans ; Angina, Stable/therapy ; Coronary Artery Disease/therapy ; Myocardial Infarction/etiology ; Percutaneous Coronary Intervention/adverse effects ; Quality of Life ; Treatment Outcome ; Ventricular Dysfunction, Left/etiology
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321870
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.40: Show issues Location:
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    Zs.MO 112: Show issues

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  5. Article ; Online: Implantable Cardioverter-Defibrillators for Primary Prevention in Patients With Ischemic or Nonischemic Cardiomyopathy.

    Kolodziejczak, Michalina / Andreotti, Felicita / Navarese, Eliano Pio

    Annals of internal medicine

    2018  Volume 168, Issue 3, Page(s) 234–235

    MeSH term(s) Cardiomyopathies ; Defibrillators, Implantable ; Humans ; Primary Prevention
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L17-0692
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
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  6. Article ; Online: Safety and Efficacy of DOACs in Patients with Advanced and End-Stage Renal Disease.

    Rogula, Sylwester / Gąsecka, Aleksandra / Mazurek, Tomasz / Navarese, Eliano Pio / Szarpak, Łukasz / Filipiak, Krzysztof J

    International journal of environmental research and public health

    2022  Volume 19, Issue 3

    Abstract: The prevalence of chronic kidney disease (CKD) is increasing due to the aging of the population and multiplication of risk factors, such as hypertension, arteriosclerosis and obesity. Impaired renal function increases both the risk of bleeding and ... ...

    Abstract The prevalence of chronic kidney disease (CKD) is increasing due to the aging of the population and multiplication of risk factors, such as hypertension, arteriosclerosis and obesity. Impaired renal function increases both the risk of bleeding and thrombosis. There are two groups of orally administered drugs to prevent thromboembolic events in patients with CKD who require anticoagulation: vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). Although VKAs remain the first-line treatment in patients with advanced CKD, treatment with VKAs is challenging due to difficulties in maintaining the appropriate anticoagulation level, tendency to accelerate vascular calcification and faster progression of CKD in patients treated with VKAs. On the other hand, the pleiotropic effect of DOACs, including vascular protection and anti-inflammatory properties along with comparable efficacy and safety of treatment with DOACs, compared to VKAs observed in preliminary reports encourages the use of DOACs in patients with CKD. This review summarizes the available data on the efficacy and safety of DOACs in patients with CKD and provides recommendations regarding the choice of the optimal drug and dosage depending on the CKD stage.
    MeSH term(s) Administration, Oral ; Anticoagulants/adverse effects ; Hemorrhage ; Humans ; Kidney Failure, Chronic/chemically induced ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/drug therapy ; Vitamin K
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19031436
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  7. Article ; Online: Safety and Efficacy of DOACs in Patients with Advanced and End-Stage Renal Disease

    Sylwester Rogula / Aleksandra Gąsecka / Tomasz Mazurek / Eliano Pio Navarese / Łukasz Szarpak / Krzysztof J. Filipiak

    International Journal of Environmental Research and Public Health, Vol 19, Iss 1436, p

    2022  Volume 1436

    Abstract: The prevalence of chronic kidney disease (CKD) is increasing due to the aging of the population and multiplication of risk factors, such as hypertension, arteriosclerosis and obesity. Impaired renal function increases both the risk of bleeding and ... ...

    Abstract The prevalence of chronic kidney disease (CKD) is increasing due to the aging of the population and multiplication of risk factors, such as hypertension, arteriosclerosis and obesity. Impaired renal function increases both the risk of bleeding and thrombosis. There are two groups of orally administered drugs to prevent thromboembolic events in patients with CKD who require anticoagulation: vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs). Although VKAs remain the first-line treatment in patients with advanced CKD, treatment with VKAs is challenging due to difficulties in maintaining the appropriate anticoagulation level, tendency to accelerate vascular calcification and faster progression of CKD in patients treated with VKAs. On the other hand, the pleiotropic effect of DOACs, including vascular protection and anti-inflammatory properties along with comparable efficacy and safety of treatment with DOACs, compared to VKAs observed in preliminary reports encourages the use of DOACs in patients with CKD. This review summarizes the available data on the efficacy and safety of DOACs in patients with CKD and provides recommendations regarding the choice of the optimal drug and dosage depending on the CKD stage.
    Keywords direct oral anticoagulants ; chronic kidney disease ; end-stage renal disease ; anticoagulation ; hemodialysis ; DOAC ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Prolonged endogenous fibrinolysis predicts reduced survival after acute coronary syndromes.

    Andreotti, Felicita / Navarese, Eliano Pio / Crea, Filippo

    European heart journal

    2018  Volume 39, Issue 13, Page(s) 1086–1088

    MeSH term(s) Acute Coronary Syndrome ; Fibrin ; Fibrinolysis ; Humans ; Thrombosis
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2018-04-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehy118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 640: Show issues

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  9. Article ; Online: Andexanet alfa - Recommendations for clinical use. Multidisciplinary experts' standpoint.

    Kubica, Jacek / Adamski, Piotr / Gajda, Robert / Gąsior, Mariusz / Gierlotka, Marek / Gil, Robert / Jaguszewski, Miłosz / Kubica, Aldona / Kuliczkowski, Wiktor / Kurek, Krzysztof / Ładny, Jerzy Robert / Michalski, Piotr / Navarese, Eliano Pio / Niezgoda, Piotr / Ostrowska, Małgorzata / Tycińska, Agnieszka

    Cardiology journal

    2023  Volume 30, Issue 4, Page(s) 502–505

    MeSH term(s) Humans ; Blood Coagulation ; Anticoagulants/adverse effects ; Factor Xa/pharmacology
    Chemical Substances PRT064445 ; Anticoagulants ; Factor Xa (EC 3.4.21.6)
    Language English
    Publishing date 2023-07-04
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2488680-4
    ISSN 1898-018X ; 1897-5593
    ISSN (online) 1898-018X
    ISSN 1897-5593
    DOI 10.5603/CJ.a2023.0043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6770: Show issues Location:
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  10. Article: Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes.

    Andreotti, Felicita / Iervolino, Adelaide / Navarese, Eliano Pio / Maggioni, Aldo Pietro / Crea, Filippo / Scambia, Giovanni

    Journal of clinical medicine

    2021  Volume 10, Issue 8

    Abstract: Acute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, ... ...

    Abstract Acute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, translating the acquired data into improved personalised interventions. Current precision treatments of ACS include immediate coronary revascularisation driven by ECG ST-segment elevation, early coronary angiography based on elevated blood cardiac troponins in patients without ST-segment elevation, and duration of intensified antithrombotic therapy according to bleeding risk scores. Phenotypically stratified analyses of multi-omic datasets are urgently needed to further refine and couple the diagnosis and treatment of these potentially life-threatening conditions. We provide definitions, examples and possible ways to advance precision treatments of ACS.
    Language English
    Publishing date 2021-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10081755
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