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  1. Article ; Online: Initial characterisation of ELISA assays and the immune response of the clinically correlated SARS-CoV-2 biobank SERO-BL-COVID-19 collected during the pandemic onset in Switzerland

    Kaltenbach, H.-M. / Rudolf, F. / Linnik, J. / Deichmann, J. / Ruf, T. / Altamura, R. / Kapetanovic, E. / Mason, D. / Wagner, B. / Goetz, T. / Mundorff, L. / Stoll-Rudin, K. / Krebs, C. / Renz, T. / Hochueli, T. / Haymoz, S. / Hosch, M. / Periat, N. / Richert, M. /
    Sesia, S. / Paris, D. / Quinto, C. B. / Probst-Hensch, N. / Niederhauser, C. / Reddy, S. / Nickel, B. / Savic, M.

    Abstract: ... CoV-2 pandemic in Switzerland. Methods: Two laboratory ELISA assays measuring IgA & IgG (Euroimmun ...

    Abstract Background: To accurately measure seroprevalance in the population, boththe expected immune response as well as the assay performances have to be well characterised. Here, we describe the collection and initial characterisation of a blood and saliva biobank obtained after the initial peak of the SARS-CoV-2 pandemic in Switzerland. Methods: Two laboratory ELISA assays measuring IgA & IgG (Euroimmun), and IgM & IgG (Epitope Diagnostics) were used to characterise the biobank collected from 349 re- and convalescent patients from the canton of Basel-Landschaft. Findings: The antibody response in terms of recognized epitopes is diverse, especially in oligosymptomatic patients, while the average strength of the antibody response of the population does correlate with the severity of the disease at each time point. Interpretation: The diverse immune response presents a challenge when conducting epidemiological studies as the used assays only detect 90% of the oligosymptomatic cases. This problem cannot be rectified by using more sensitive assays or lower cut-offs as they concomitantly reduce specificity. Funding Funding was obtained from the Amt fur Gesundheit of the canton Basel-Landschaft, Switzerland.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.07.05.20145888
    Database COVID19

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  2. Book ; Thesis: Mental health of refugees - Addressing and overcoming challenges in the identification and treatment of mental health problems

    Kaltenbach, Elisa

    2019  

    Abstract: ... Kaltenbach, E., Härdtner, E., Hermenau, K., Schauer, M. & Elbert, T. (2017). Efficient identification ... of Psychotraumatology, 8:1389205. DOI: 10.1080/20008198.2017.1389205 (2) Kaltenbach, E., Schauer, M., Hermenau, K ... Frontiers in Psychiatry, 9:352. DOI: 10.3389/fpsyt.2018.00352 (3) Kaltenbach, E., Elbert, T., Hermenau, K ...

    Title translation Psychische Gesundheit von Flüchtlingen - Angehen und Überwinden von Herausforderungen bei der Erkennung und Behandlung von psychischen Problemen (DeepL)
    Abstract The present thesis addresses the challenge of identifying and treating mental health problems in refugees and aims to close some of the current research gaps of this field to contribute to a better provision of care. The following objectives will be addressed in detail: (1) to assess the extent of mental health problems in a sample of refugees in Germany as well as to examine the feasibility, validity, and reliability of the mental health screening instrument Refugee Health Screener (RHS) as a self-rating and interview instrument; (2) to analyze the course of mental health symptoms in refugees not undergoing psychological treatment over one year and to find influencing factors; (3) to investigate PTSD symptom trajectories of refugees receiving trauma-focused therapy, namely Narrative Exposure Therapy (NET), as well as the influence of imaginal exposure to traumatic experiences and of therapy-unrelated life events; (4) to examine the feasibility of the preventive approach Interaction Competencies with Children (ICC) which aims to reduce violent disciplining in highly burdened populations - tested on a sample of Tanzanian teachers inflicting corporal punishment on a regular basis. Article 1 found mental health problems to be prevalent in a refugee sample in Germany, with clinically significant PTSD, depression, anxiety, and somatization symptoms being present in 35% of the same population. Furthermore, article 1 shows a good feasibility, validity, and reliability of the RHS in detecting common mental health problems for refugees residing in Germany. A shorter version, the RHS-13, shows equally good psychometric properties and is easier to administer. In addition, the RHS can be used both as a self-rating and an interview instrument. In Article 2 the course of mental health symptoms in refugees was examined by combining monthly assisted self-reports on the phone with half-yearly clinical interviews. Over the course of one year, the average of symptoms did not systematically change. However, on the individual level, about 40% showed a significant symptom improvement or worsening. Higher PTSD symptoms were related to more experiences of past traumatic stress, while a worsening of PTSD symptoms over time was associated with reporting more current postmigrational stressors (PMS). Furthermore, current emotional distress was associated with negative life events, unemployment, and frequent visits to physicians. Article 3 analyzed symptom trajectories during NET on the basis of the PTSD Checklist, which was filled in before each therapy session as well as during follow-up interviews. Overall, symptoms decreased during and after treatment - with some showing fast (27%), slow (31%), or no immediate symptom response (42%) during therapy. Persistent symptom worsening was not observed. Imaginal exposure to the most distressing traumatic experiences was not associated with symptom aggravation. However, therapy-unrelated negative life events were related to increases in PTSD symptoms. Aiming to reduce additional ongoing and potentially traumatic stressors that could contribute to a high trauma load, Article 4 describes the preventive approach ICC which intends to reduce violent disciplining. This approach was tested on a Tanzanian teacher sample, showing a good feasibility and acceptance despite challenging conditions. Future studies should test adapted versions in other affected populations such as refugee families. The current thesis highlights the need to provide better care for refugees presenting mental health problems. It further discusses a potential mental health care model by incorporating the findings of this thesis into the currently suggested scalable care approaches. Given that mental health problems in refugees are prevalent and often persistent, we recommend the inclusion of a mental health screening, such as the RHS for all refugees. Refugees with a positive screening result should be referred to appropriate mental health services, which can range from low-threshold interventions conducted by supervised peer counselors up to specialized mental health professionals for those with a complex symptomatology. The collaboration with other professionals working with refugees such as medical staff, social workers, teachers, and potentially also volunteers should be strengthened to identify mental health problems that arise at later stages and warrant a timely referral. Furthermore, training centers that offer qualifications, training, and regular supervision for the different actors within such a care system are vital to provide good care. Training for evidence-based treatments for PTSD such as NET should be offered, with therapists' concerns of symptom aggravation and dropout being addressed and resolved. Such an integrative mental health care model has not yet been tested nor been implemented into the mental health care system - future studies should accordingly examine its feasibility and efficacy with the aim to reduce the mental health burden of refugees in order to improve their quality of life and functionality, thereby facilitating integration. - Contents: (1) Kaltenbach, E., Härdtner, E., Hermenau, K., Schauer, M. & Elbert, T. (2017). Efficient identification of mental health problems in refugees in Germany: The Refugee Health Screener. European Journal of Psychotraumatology, 8:1389205. DOI: 10.1080/20008198.2017.1389205 (2) Kaltenbach, E., Schauer, M., Hermenau, K., Elbert, T. & Schalinski, I. (2018). Course of mental health in refugees - A one year panel survey. Frontiers in Psychiatry, 9:352. DOI: 10.3389/fpsyt.2018.00352 (3) Kaltenbach, E., Elbert, T., Hermenau, K., Schauer, M. & Schalinski, I. (n. d.). Trajectories of posttraumatic stress symptoms during and after Narrative Exposure Therapy in refugees. Unpublished manuscript. (4) Kaltenbach, E., Hermenau, K., Nkuba, M., Goessmann, K. & Hecker, T. (2018). Improving interaction competencies with children - A pilot feasibility study to reduce school corporal punishment. Journal of Aggression, Maltreatment & Trauma, 27, 35-53. DOI: 10.1080/10926771.2017.1357060
    Keywords Expositionstherapie ; Exposure Therapy ; Flüchtlinge ; Mental Health ; Narrative Therapie ; Narrative Therapy ; Posttraumatic Stress Disorder ; Posttraumatische Belastungsstörung ; Psychische Gesundheit ; Refugees ; Screening Tests ; Therapie ; Treatment
    Language English
    Size 184 pp., 14 pp. appendix
    Publisher Universität, Mathematisch-Naturwissenschaftliche Sektion
    Publishing place Konstanz
    Document type Book ; Thesis
    Note Kumulative Dissertation
    Database PSYNDEX

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  3. Book ; Online ; Thesis: Mental health of refugees

    Kaltenbach, Elisa [Verfasser]

    addressing and overcoming challenges in the identification and treatment of mental health problems

    2019  

    Author's details Elisa Kaltenbach
    Keywords Psychologie ; Psychology
    Subject code sg150
    Language English
    Publisher KOPS Universität Konstanz
    Publishing place Konstanz
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: The influence of social support on posttraumatic stress symptoms among children and adolescents: a scoping review and meta-analysis.

    Xiong, Ting / Milios, Athena / McGrath, Patrick J / Kaltenbach, Elisa

    European journal of psychotraumatology

    2022  Volume 13, Issue 1, Page(s) 2011601

    Abstract: Background: Several risk and protective factors play a role in the development of posttraumatic stress symptoms (PTSS) in children and youth. The evidence for social support (SS) as a protective factor is rising; however, a review of the evidence is ... ...

    Abstract Background: Several risk and protective factors play a role in the development of posttraumatic stress symptoms (PTSS) in children and youth. The evidence for social support (SS) as a protective factor is rising; however, a review of the evidence is lacking.
    Objective: This scoping review and meta-analysis aims to map out and synthesize the present research on the influence of social support on PTSS in children and adolescents.
    Method: The literature searched through PubMed, MEDLINE, Embase, PsycInfo, and CINAHL identified 3629 abstracts. Ninety articles published from 1999 to 2020 were selected, including a total of 77,439 participants.
    Results: Most papers focused on social and emotional support from family members (36/88) and peers (26/88); other types of support (e.g., informational support and support from professionals) were not widely reported. The cross-sectional studies illustrated an overall significant, but weak, negative correlation between global social support and PTSS. A similar weak negative association was found between family support and PTSS. The association between peer support and PTSS was not significant. For longitudinal studies, 4 of 5 indicated that SS was a significant negative predictor of PTSS.
    Conclusions: There was conceptual, methodological, and statistical heterogeneity of the identified studies. This review suggests a weak negative relationship between global SS and PTSS in children and adolescents. Higher global SS was related to less PTSS. The evidence regarding family support revealed a more stable negative relationship with PTSS than that for peer support. Investigating social support without specifying the form of support confounds the effect. Studies on informational, teacher, or professional support seem to be lacking. More studies are needed on the longitudinal effects of SS on PTSS.
    MeSH term(s) Adolescent ; Child ; Cross-Sectional Studies ; Family ; Humans ; Problem Behavior ; Social Support ; Stress Disorders, Post-Traumatic/diagnosis
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008198.2021.2011601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A systematic review of socio-ecological factors contributing to risk and protection of the mental health of refugee children and adolescents.

    Scharpf, Florian / Kaltenbach, Elisa / Nickerson, Angela / Hecker, Tobias

    Clinical psychology review

    2020  Volume 83, Page(s) 101930

    Abstract: In the past decade, millions of children and adolescents have been forced to flee from protracted or newly erupted violent conflicts. Forcibly displaced children are particularly vulnerable for developing mental health problems. However, a timely and ... ...

    Abstract In the past decade, millions of children and adolescents have been forced to flee from protracted or newly erupted violent conflicts. Forcibly displaced children are particularly vulnerable for developing mental health problems. However, a timely and systematic review of the current evidence is lacking. We conducted a systematic review of factors contributing to the mental health of refugee children across different socio-ecological levels (individual, family, community, sociocultural). We systematically searched the databases Medline, PsycINFO, Web of Science, and Cochrane for English studies published in peer-reviewed journals between August 2010 and May 2020. Of the 2413 identified studies, 63 were included in the analyses. Only 24 studies were considered to be of high quality. Pre-migration individual (risk: exposure to war-related trauma, female gender) and post-migration family factors (risk: parental mental health problems and impaired parenting, protective: family cohesion) currently have the best evidence base. Post-migration community (protective: school connectedness, support by peers) and sociocultural factors (risk: discrimination and acculturative stress, protective: integrative acculturation) have gained some support in high-income settings. Prevention and intervention approaches should integrate factors across different socio-ecological levels. More longitudinal studies and research in low- and middle-income countries are needed to advance our knowledge on causal mechanisms behind factors contributing to refugee youth's mental health.
    MeSH term(s) Adolescent ; Child ; Female ; Humans ; Longitudinal Studies ; Mental Health ; Refugees ; Schools
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 604577-7
    ISSN 1873-7811 ; 0272-7358
    ISSN (online) 1873-7811
    ISSN 0272-7358
    DOI 10.1016/j.cpr.2020.101930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Practical guidelines for online Narrative Exposure Therapy (e-NET) - a short-term treatment for posttraumatic stress disorder adapted for remote delivery.

    Kaltenbach, Elisa / McGrath, Patrick J / Schauer, Maggie / Kaiser, Elisabeth / Crombach, Anselm / Robjant, Katy

    European journal of psychotraumatology

    2021  Volume 12, Issue 1, Page(s) 1881728

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2586642-4
    ISSN 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008198.2021.1881728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: How to measure barriers in accessing mental healthcare? Psychometric evaluation of a screening tool in parents of children with intellectual and developmental disabilities.

    Xiong, Ting / Kaltenbach, Elisa / Yakovenko, Igor / Lebsack, Jeanine / McGrath, Patrick J

    BMC health services research

    2022  Volume 22, Issue 1, Page(s) 1383

    Abstract: Caring for children with intellectual and developmental disabilities (IDD) can cause an enormous physical and emotional burden, and therefore these parents have an elevated risk to experience mental health problems. The characteristics of current ... ...

    Abstract Caring for children with intellectual and developmental disabilities (IDD) can cause an enormous physical and emotional burden, and therefore these parents have an elevated risk to experience mental health problems. The characteristics of current healthcare systems and parents' responsibilities to care for their children seem to impede their access to mental healthcare. There is so far a lack of instruments to screen for such obstacles. The aim of this study was to develop and validate a scale for measuring barriers to accessing mental healthcare. The Parental Healthcare Barriers Scale (PHBS) was developed on the basis of an extensive literature research, input and discussion from experts and parents with lived experience. A cross-sectional survey was used to collect data from 456 parents of children with IDD. Physical health, mental health, social support, and parenting were measured for concurrent and discriminant validity of the PHBS. The PHBS scale revealed acceptable to good reliability and validity. It consists of four subscales (i.e., support accessibility, personal belief, emotional readiness, and resource availability). The PHBS found parents prioritized their children's treatments over their own mental health challenges (93.4%), did not have enough time (90.4%), and had financial concerns (85.8%). Parents in rural and remote areas had more limited resources. Findings from our study suggest increasing financial support for the parents seeking mental health services, introducing evidence-based treatments, increasing the availability of healthcare services for parents, and adjusting current services to their needs.
    MeSH term(s) Child ; Humans ; Cross-Sectional Studies ; Developmental Disabilities/diagnosis ; Developmental Disabilities/therapy ; Mental Health Services ; Parents/psychology ; Psychometrics ; Reproducibility of Results ; Health Services Accessibility ; Caregivers/psychology
    Language English
    Publishing date 2022-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050434-2
    ISSN 1472-6963 ; 1472-6963
    ISSN (online) 1472-6963
    ISSN 1472-6963
    DOI 10.1186/s12913-022-08762-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Parenting-related trauma exposure among parents of children with intellectual and developmental disorders: Development and validation of the Parenting Trauma Checklist.

    Xiong, Ting / McGrath, Patrick J / Yakovenko, Igor / Thomson, Donna / Kaltenbach, Elisa

    Journal of traumatic stress

    2022  Volume 35, Issue 2, Page(s) 759–770

    Abstract: Parents of children with intellectual and developmental disorders (IDDs) often encounter parenting-related traumatic events. Trauma exposure is a risk factor for mental health problems, including posttraumatic stress disorder (PTSD). Little is known ... ...

    Abstract Parents of children with intellectual and developmental disorders (IDDs) often encounter parenting-related traumatic events. Trauma exposure is a risk factor for mental health problems, including posttraumatic stress disorder (PTSD). Little is known regarding the types of traumatic events that parents commonly experience and how to best assess parenting-related trauma exposure. To address this gap, we developed the Parenting Trauma Checklist (PTC) and tested its psychometric properties. The PTC was created based on an extensive literature review and consultation with stakeholders, which led to the creation of a 17-item instrument. Participants (N = 424) were Canadian parents of children with IDDs who completed an online test battery that included the PTC and several questionnaires to assess PTSD symptoms, global mental and physical health, lifetime trauma exposure, and functional impairment, which were included to test the validity of the new instrument. The PTC demonstrated good construct validity. Ninety four percent of the sample reported parenting-related trauma exposure. Parents reported having experienced an average of 5.79 parenting-related traumatic events, with seeing their child undergo a medical procedure the most frequently endorsed event (68.6%). Experiencing more parenting-related traumatic events was positively associated with higher PTSD symptom levels, r = .35, p < .001. The PTC is a promising instrument that can be used to examine parenting-related trauma exposure. The measure can be used as a screening tool to detect parents' risk of traumatic stress disorders, evaluate traumatic experiences, and assess whether trauma-focused treatment is warranted.
    MeSH term(s) Canada ; Checklist ; Child ; Developmental Disabilities ; Humans ; Parenting/psychology ; Parents ; Stress Disorders, Post-Traumatic/diagnosis ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639478-4
    ISSN 1573-6598 ; 0894-9867
    ISSN (online) 1573-6598
    ISSN 0894-9867
    DOI 10.1002/jts.22779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Risk and protective factors for posttraumatic stress and posttraumatic growth in parents of children with intellectual and developmental disorders.

    Xiong, Ting / McGrath, Patrick J / Stewart, Sherry H / Bagnell, Alexa / Kaltenbach, Elisa

    European journal of psychotraumatology

    2022  Volume 13, Issue 1, Page(s) 2087979

    Abstract: Background: Parents of children with intellectual and developmental disorders often experience potentially traumatic events while caring for their children. Heightened posttraumatic stress (PTS) and posttraumatic growth (PTG) have been found in this ... ...

    Abstract Background: Parents of children with intellectual and developmental disorders often experience potentially traumatic events while caring for their children. Heightened posttraumatic stress (PTS) and posttraumatic growth (PTG) have been found in this population.
    Objective: We aimed to explore risk and protective factors for their PTS and PTG.
    Method: A cross-sectional study was conducted with 385 parents (average age M = 43.14 years, SD = 7.40; 95.3% mothers).
    Results: Parenting trauma showed an adverse effect on developing PTS (beta = 0.25, p < .01) and a positive role in promoting PTG (beta = 0.16, p < .01). Social support was protective in its correlation with lower levels of PTS (beta = -0.12, p < .01) and higher levels of PTG (beta = 0.22, p < .01). Barriers to care were associated with increased PTS (beta = 0.23, p < .01), but unrelated to PTG (beta = .01, p = .855). Negative parenting showed a significant, but small, correlation with more severe PTS (beta = 0.11, p < .05), and was unrelated to PTG (beta = -0.09, p = .065).
    Conclusions: Our study increases the understanding of posttraumatic reactions in parents, predominantly mothers, of children with IDD and identified parenting-related trauma, social support, and barriers to mental health care as predictive factors of the reactions. More research is needed to confirm and validate the effects of the discussed factors. Although causation can not be inferred, prompt and adequate screening and therapeutic resources should be provided to those mothers who were exposed to multiple stressful caregiving events and had limited healthcare access and less support from their spouses, peers, and caregiving partners.
    Highlights: Parents of a child with Intellectual and Developmental Disorders with parenting trauma had higher posttraumatic stress (PTS) and posttraumatic growth (PTG).Social support was related to lower PTS and higher PTG.Barriers to care were related to higher PTS but unrelated to PTG.
    MeSH term(s) Adaptation, Psychological ; Adult ; Child ; Cross-Sectional Studies ; Developmental Disabilities ; Humans ; Parenting ; Parents/psychology ; Posttraumatic Growth, Psychological ; Protective Factors ; Stress Disorders, Post-Traumatic/diagnosis
    Language English
    Publishing date 2022-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008198.2022.2087979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A systematic review of socio-ecological factors contributing to risk and protection of the mental health of refugee children and adolescents

    Scharpf, Florian / Kaltenbach, Elisa / Nickerson, Angela / Hecker, Tobias

    Clinical Psychology Review

    2021  

    Abstract: Abstract not released by ... ...

    Title translation Eine systematische Übersicht zu den sozio-ökologischen Faktoren, die zum Risiko und Schutz der psychischen Gesundheit von Flüchtlingskindern und -jugendlichen beitragen (DeepL)
    Abstract Abstract not released by publisher
    Keywords Flüchtlinge ; Mental Health ; Protective Factors ; Protektive Faktoren ; Psychische Gesundheit ; Refugees ; Risikofaktoren ; Risk Factors ; Sociocultural Factors ; Soziokulturelle Faktoren
    Language English
    Document type Article
    ZDB-ID 604577-7
    ISSN 1873-7811 ; 0272-7358
    ISSN (online) 1873-7811
    ISSN 0272-7358
    DOI 10.1016/j.cpr.2020.101930
    Database PSYNDEX

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