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Book ; Online: Seawater carbonate chemistry and carbon allocation, growth and morphology of the coccolithophore Emiliania huxleyi (calcifying strain CCMP 371) during experiments, 2011, supplementary data to: Lefebvre, Staphane C; Benner, Ina; Stillman, Jonathon H; Parker, Alexander E; Drake, Michelle K; Rossignol, Pascale E; Okimura, Kristine M; Komada, Tomoko; Capenter, Edward J (2012): Nitrogen source and pCO2 synergistically affect carbon allocation, growth and morphology of the coccolithophore Emiliania huxleyi: potential implications of ocean acidification for the carbon cycle. Global Change Biology, 18(2), 493-503

Lefebvre, Staphane C / Benner, Ina / Carpenter, E J / Drake, Michelle K / Komada, Tomoko / Okimura, Kristine M / Parker, Alexander E / Rossignol, Pascale E / Stillman, Jonathon H

2012

Abstract: ... on the combined effect of elevated pCO2 and increased NH4 to nitrate (NO3) ratio (NH4/NO3) on E. huxleyi, maintained ...

Abstract	Coccolithophores are unicellular phytoplankton that produce calcium carbonate coccoliths as an exoskeleton. Emiliania huxleyi, the most abundant coccolithophore in the world's ocean, plays a major role in the global carbon cycle by regulating the exchange of CO2 across the ocean-atmosphere interface through photosynthesis and calcium carbonate precipitation. As CO2 concentration is rising in the atmosphere, the ocean is acidifying and ammonium (NH4) concentration of future ocean water is expected to rise. The latter is attributed to increasing anthropogenic nitrogen (N) deposition, increasing rates of cyanobacterial N2 fixation due to warmer and more stratified oceans, and decreased rates of nitrification due to ocean acidification. Thus future global climate change will cause oceanic phytoplankton to experience changes in multiple environmental parameters including CO2, pH, temperature and nitrogen source. This study reports on the combined effect of elevated pCO2 and increased NH4 to nitrate (NO3) ratio (NH4/NO3) on E. huxleyi, maintained in continuous cultures for more than 200 generations under two pCO2 levels and two different N sources. Here we show that NH4 assimilation under N-replete conditions depresses calcification at both low and high pCO2, alters coccolith morphology, and increases primary production. We observed that N source and pCO2 synergistically drive growth rates, cell size and the ratio of inorganic to organic carbon. These responses to N source suggest that, compared to increasing CO2 alone, a greater disruption of the organic carbon pump could be expected in response to the combined effect of increased NH4/NO3 ratio and CO2 level in the future acidified ocean. Additional experiments conducted under lower nutrient conditions are needed prior to extrapolating our findings to the global oceans. Nonetheless, our results emphasize the need to assess combined effects of multiple environmental parameters on phytoplankton biology in order to develop accurate predictions of phytoplankton responses to ocean acidification.
Language	English
Dates of publication	2012-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1111/j.1365-2486.2011.02575.x
DOI	10.1594/PANGAEA.771910
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Neurologic Complications of the Central Nervous System after Allogeneic Stem Cell Transplantation: The Role of Transplantation-Associated Thrombotic Microangiopathy as a Potential Underreported Cause.

Sala, Elisa / Neagoie, Adela M / Lewerenz, Jan / Saadati, Maral / Benner, Axel / Gantner, Andrea / Wais, Verena / Döhner, Hartmut / Bunjes, Donald

Transplantation and cellular therapy

2024

Abstract: Neurologic complications (NCs), especially those of the central nervous system (CNS), represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and are associated with relevant morbidity and mortality. We aimed to ... ...

Abstract	Neurologic complications (NCs), especially those of the central nervous system (CNS), represent a severe complication after allogeneic stem cell transplantation (allo-HSCT) and are associated with relevant morbidity and mortality. We aimed to characterize the potential risk factors for the development of CNS-NC, with a special focus on the role of calcineurin inhibitors (CNIs) as a predisposing factor. For this purpose, we compared cyclosporin A (CsA) versus tacrolimus (TAC) with respect to their influence on the incidence and type of CNS-NC after allo-HSCT. We retrospectively analyzed the incidence, risk factors, and impact on outcomes of CNS-NC diagnosed during the post-transplantation follow-up in patients with different high-risk hematologic malignancies who underwent allo-HSCT at our institution over a 20-year period. All patients included in the analysis received CNI (CsA or TAC) as graft-versus-host disease (GVHD) prophylaxis. We evaluated a total of 739 consecutive patients who underwent transplantation between December 1999 and April 2019. During a median follow-up of 6.8 years, we observed a CNS-NC incidence of 17%. The development of CNS-NC was associated with decreased overall survival (OS) and increased transplantation-related mortality (TRM). The most frequent CNS-NCs were infections (30%) and neurologic adverse events related to the administration of CNI, TAC, or CsA as GVHD prophylaxis (42%). In the multivariable analysis, age, total body irradiation (TBI), and severe acute GVHD and chronic GVHD were significant risk factors in the development of CNS-NCs. TAC compared with CsA emerged as an independent predisposing factor for CNS-NCs. The TAC-associated risk of CNS-NCs was related mostly to the occurrence of transplantation-associated thrombotic microangiopathy (TA-TMA) with neurologic manifestations (neuro-TA-TMA), although the general TA-TMA incidence was comparable in the 2 CNI subgroups. CNS-NCs are associated with poor prognosis after allo-HSCT, with TAC emerging as a potential yet insufficiently characterized predisposing factor.
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2024.03.017
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Article ; Online: Endophytic ancestors of modern leaf miners may have evolved in the Late Carboniferous.

Knecht, Richard J / Swain, Anshuman / Benner, Jacob S / Emma, Steve L / Pierce, Naomi E / Labandeira, Conrad C

The New phytologist

2023 Volume 240, Issue 5, Page(s) 2050–2057

Abstract: Endophytic feeding behaviors, including stem borings and galling, have been observed in the fossil record from as early as the Devonian and involve the consumption of a variety of plant (and fungal) tissues. Historically, the exploitation of internal ... ...

Abstract	Endophytic feeding behaviors, including stem borings and galling, have been observed in the fossil record from as early as the Devonian and involve the consumption of a variety of plant (and fungal) tissues. Historically, the exploitation of internal stem tissues through galling has been well documented as emerging during the Pennsylvanian (c. 323-299 million years ago (Ma)), replaced during the Permian by galling of foliar tissues. However, leaf mining, a foliar endophytic behavior that today is exhibited exclusively by members of the four hyperdiverse holometabolous insect orders, has been more sparsely documented, with confirmed examples dating back only to the Early Triassic (c. 252-250 Ma). Here, we describe a trace fossil on seed-fern foliage from the Rhode Island Formation of Massachusetts, USA, representing the earliest indication of a general, endophytic type of feeding damage and dating from the Middle Pennsylvanian (c. 312 Ma). Although lacking the full features of Mesozoic leaf mines, this specimen provides evidence of how endophytic mining behavior may have originated. It sheds light on the evolutionary transition to true foliar endophagy, contributes to our understanding of the behaviors of early holometabolous insects, and enhances our knowledge of macroevolutionary patterns of plant-insect interactions.
MeSH term(s)	Animals ; Biological Evolution ; Plants ; Fossils ; Insecta ; Herbivory
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19266
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Article ; Online: Catalytic Synthesis of Polyribonucleic Acid on Prebiotic Rock Glasses.

Jerome, Craig A / Kim, Hyo-Joong / Mojzsis, Stephen J / Benner, Steven A / Biondi, Elisa

Astrobiology

2022 Volume 22, Issue 6, Page(s) 629–636

Abstract: Reported here are experiments that show that ribonucleoside triphosphates are converted to polyribonucleic acid when incubated with rock glasses similar to those likely present 4.3-4.4 billion years ago on the Hadean Earth surface, where they were formed ...

Abstract	Reported here are experiments that show that ribonucleoside triphosphates are converted to polyribonucleic acid when incubated with rock glasses similar to those likely present 4.3-4.4 billion years ago on the Hadean Earth surface, where they were formed by impacts and volcanism. This polyribonucleic acid averages 100-300 nucleotides in length, with a substantial fraction of 3',-5'-dinucleotide linkages. Chemical analyses, including classical methods that were used to prove the structure of natural RNA, establish a polyribonucleic acid structure for these products. The polyribonucleic acid accumulated and was stable for months, with a synthesis rate of 2 × 10
MeSH term(s)	Catalysis ; Earth, Planet ; Glass ; RNA/chemistry
Chemical Substances	RNA (63231-63-0)
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2047736-3
ISSN	1557-8070 ; 1531-1074
ISSN (online)	1557-8070
ISSN	1531-1074
DOI	10.1089/ast.2022.0027
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Article ; Online: A phase IV study evaluating QT interval, pharmacokinetics, and safety following fractionated dosing of gemtuzumab ozogamicin in patients with relapsed/refractory CD33-positive acute myeloid leukemia.

Montesinos, Pau / Kota, Vamsi / Brandwein, Joseph / Bousset, Pierre / Benner, Rebecca J / Vandendries, Erik / Chen, Ying / McMullin, Mary Frances

Cancer chemotherapy and pharmacology

2023 Volume 91, Issue 5, Page(s) 441–446

Abstract: Purpose: Gemtuzumab ozogamicin (GO) is indicated for treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML). The QT interval, pharmacokinetics (PK), and immunogenicity following the fractionated GO dosing regimen have not been previously ... ...

Abstract	Purpose: Gemtuzumab ozogamicin (GO) is indicated for treatment of relapsed/refractory (R/R) acute myeloid leukemia (AML). The QT interval, pharmacokinetics (PK), and immunogenicity following the fractionated GO dosing regimen have not been previously assessed. This phase IV study was designed to obtain this information in patients with R/R AML. Methods: Patients aged ≥ 18 years with R/R AML received the fractionated dosing regimen of GO 3 mg/m Results: Fifty patients received ≥ 1 dose of GO during Cycle 1. The upper limit of the 2-sided 90% confidence interval for least squares mean differences in QTc using Fridericia's formula (QTcF) was < 10 ms for all time points during Cycle 1. No patients had a post-baseline QTcF > 480 ms or a change from baseline > 60 ms. Treatment-emergent adverse events (TEAEs) occurred in 98% of patients; 54% were grade 3-4. The most common grade 3-4 TEAEs were febrile neutropenia (36%) and thrombocytopenia (18%). The PK profiles of both conjugated and unconjugated calicheamicin mirror that of total hP67.6 antibody. The incidence of antidrug antibodies (ADAs) and neutralizing antibodies was 12% and 2%, respectively. Conclusion: Fractionated GO dosing regimen (3 mg/m Trial registry: Clinicaltrials.gov ID: NCT03727750 (November 1, 2018).
MeSH term(s)	Humans ; Gemtuzumab/adverse effects ; Gemtuzumab/pharmacokinetics ; Sialic Acid Binding Ig-like Lectin 3/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy ; Calicheamicins ; Aminoglycosides/adverse effects
Chemical Substances	Gemtuzumab (93NS566KF7) ; Sialic Acid Binding Ig-like Lectin 3 ; Calicheamicins ; Aminoglycosides ; CD33 protein, human
Language	English
Publishing date	2023-03-09
Publishing country	Germany
Document type	Clinical Trial, Phase IV ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-023-04516-9
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Article ; Online: Aural search & rescue: Techniques for ear foreign body removal in the emergency department.

Hudock, S / Hysell, M / Luna, M / Dixon, E / Mangione, M / Holsinger, H / Zamarripa, A / Benner, C / Ouellette, L / Jones, J S

The American journal of emergency medicine

2023 Volume 75, Page(s) 167–168

MeSH term(s)	Humans ; Ear/surgery ; Emergency Service, Hospital ; Foreign Bodies/diagnostic imaging ; Foreign Bodies/surgery ; Retrospective Studies
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.10.048
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Article ; Online: The impact of early remission on disease trajectory and patient outcomes in major depression disorder (MDD): A targeted literature review and microsimulation modeling approach based on the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study.

Arnaud, Alix / Benner, Jennifer / Suthoff, Ellison / Werneburg, Brian / Reinhart, Marcia / Sussman, Matthew / Kessler, Ronald C

Journal of affective disorders

2023 Volume 325, Page(s) 264–272

Abstract: ... DTM were instead derived using parametric extrapolation methods (i.e., exponential, Weibull, log ... including long-term outcomes (i.e., 5-year follow-up, lifetime follow-up), efforts by clinicians to increase ...

Abstract	Background: While literature has suggested that the duration of a major depressive episode (MDE) may affect both symptomatic and functional outcomes in major depressive disorder (MDD), study designs are limited in their ability to isolate a causal relationship. Methods: A targeted literature review was conducted using the MEDLINE database to assess whether there was an association between (1) shorter duration of an MDE, or (2) increased rapidity of symptom improvement, and MDD outcomes in adult patients. Given findings from the literature, we hypothesized that rapid symptom improvement could be associated with other longer-term clinical outcomes and used a previously-developed microsimulation model to test this hypothesis. The base case of the model replicated step-therapy treatment patterns, for 10,000 simulated patients, based on lines of therapy related to standard of care, observed remission rates, and observed time to relapse from the STARD study. In alternative scenario analyses, the step 1 remission rate was varied by +25 % and +50 % from the base case value to simulate the potential impact of improved earlier remission on disease trajectory and patient-level clinical outcomes. Results:* The literature review (N = 35 studies) suggests a statistically significant relationship between the duration of MDE or early symptom improvement and MDD outcomes. The microsimulation model corroborated these findings and demonstrated that increasing the rate of remission in step 1 results in patients experiencing decreased number of treatment steps, faster time to remission, decreased rate of reaching treatment-resistant depression, and delayed time to relapse. Limitations: Rates of relapse in STARD were deemed unreliable due to the high-loss of follow-up; rates of relapse for the MDD DTM were instead derived using parametric extrapolation methods (i.e., exponential, Weibull, log-logistic, Gaussian, log-normal, logistic). Adherence to treatment was assumed to be 100 %; however, non-adherence is expected to result in lower cumulative remission rates. Conclusion:* Findings from the literature, coupled with quantification through a novel microsimulation model, demonstrate the potential impact of increased remission on disease trajectory and patient outcomes in MDD. While additional analyses with the model may be warranted to explore the impact of novel interventions on population health, including long-term outcomes (i.e., 5-year follow-up, lifetime follow-up), efforts by clinicians to increase remission early in the disease trajectory may improve long-term outcomes.
MeSH term(s)	Adult ; Humans ; Depressive Disorder, Major/epidemiology ; Depressive Disorder, Major/therapy ; Depressive Disorder, Major/diagnosis ; Treatment Outcome ; Depression ; Chronic Disease ; Recurrence
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.12.147
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Article ; Online: Endophytic ancestors of modern leaf miners may have evolved in the Late Carboniferous

Knecht, Richard J. / Swain, Anshuman / Benner, Jacob S. / Emma, Steve L. / Pierce, Naomi E. / Labandeira, Conrad C.

New Phytologist. 2023 Dec., v. 240, no. 5 p.2050-2057

2023

Abstract	Endophytic feeding behaviors, including stem borings and galling, have been observed in the fossil record from as early as the Devonian and involve the consumption of a variety of plant (and fungal) tissues. Historically, the exploitation of internal stem tissues through galling has been well documented as emerging during the Pennsylvanian (c. 323–299 million years ago (Ma)), replaced during the Permian by galling of foliar tissues. However, leaf mining, a foliar endophytic behavior that today is exhibited exclusively by members of the four hyperdiverse holometabolous insect orders, has been more sparsely documented, with confirmed examples dating back only to the Early Triassic (c. 252–250 Ma). Here, we describe a trace fossil on seed‐fern foliage from the Rhode Island Formation of Massachusetts, USA, representing the earliest indication of a general, endophytic type of feeding damage and dating from the Middle Pennsylvanian (c. 312 Ma). Although lacking the full features of Mesozoic leaf mines, this specimen provides evidence of how endophytic mining behavior may have originated. It sheds light on the evolutionary transition to true foliar endophagy, contributes to our understanding of the behaviors of early holometabolous insects, and enhances our knowledge of macroevolutionary patterns of plant–insect interactions.
Keywords	Devonian period ; Middle Pennsylvanian epoch ; Permian period ; Triassic period ; endophytes ; fossils ; fungi ; insects ; leaves ; Massachusetts ; Rhode Island
Language	English
Dates of publication	2023-12
Size	p. 2050-2057.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.19266
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Thromboembolic Complications in the First Year After Acute Pancreatitis Diagnosis.

Robbins, Alexandria J / Lusczek, Elizabeth / Bellin, Melena D / Benner, Ashley / Alwan, Fatima S / Beilman, Gregory J

Pancreas

2021 Volume 50, Issue 5, Page(s) 751–755

Abstract: Objectives: This study aimed to quantify the prevalence of venous thromboembolic (VTE) events in patients with pancreatitis requiring hospitalization and its impact on outcomes.: Methods: Adult patients admitted from 2011 to 2018 for pancreatitis ... ...

Abstract	Objectives: This study aimed to quantify the prevalence of venous thromboembolic (VTE) events in patients with pancreatitis requiring hospitalization and its impact on outcomes. Methods: Adult patients admitted from 2011 to 2018 for pancreatitis were identified. Every admission for pancreatitis in the first year after diagnosis was evaluated for a VTE (pulmonary embolism, deep vein thrombosis, or mesenteric vessel thrombosis) within 30 days of discharge. Characteristics of patients who developed a thromboembolic event were compared with those who did not. Results: There were 4613 patients with pancreatitis identified, 301 of whom developed a VTE (6.5%). Patients who developed a VTE were more likely to be male (P < 0.01), older (P = 0.03), and have an underlying coagulopathy (P < 0.01). Those with VTEs were more likely to die (27% vs 13%, P < 0.01), have more readmissions for pancreatitis (1.7 vs 1.3, P < 0.01), longer length of stay (16 vs 5.5 days, P < 0.01), and be discharged to acute or long-term rehabilitation rather than home (P < 0.01). Conclusions: Acute pancreatitis requiring hospitalization is associated with high risk of VTE in the first year after diagnosis. Thromboembolic disease is associated with worse morbidity and mortality.
MeSH term(s)	Adult ; Aged ; Clinical Decision-Making ; Female ; Hospitalization ; Humans ; Male ; Middle Aged ; Minnesota/epidemiology ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/mortality ; Pancreatitis/therapy ; Prevalence ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/mortality ; Venous Thromboembolism/therapy
Language	English
Publishing date	2021-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001827
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Article ; Online: 20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis.

Chao, Agnes S / Matak, Pavle / Pegram, Kelly / Powers, James / Hutson, Collin / Jo, Rebecca / Dubois, Laura / Thompson, J Will / Smith, P Brian / Jain, Vaibhav / Liu, Chunlei / Younge, Noelle E / Rikard, Blaire / Reyes, Estefany Y / Shinohara, Mari L / Gregory, Simon G / Goldberg, Ronald N / Benner, Eric J

Cell stem cell

2023 Volume 30, Issue 8, Page(s) 1054–1071.e8

Abstract: White matter injuries (WMIs) are the leading cause of neurologic impairment in infants born premature. There are no treatment options available. The most common forms of WMIs in infants occur prior to the onset of normal myelination, making its ... ...

Abstract	White matter injuries (WMIs) are the leading cause of neurologic impairment in infants born premature. There are no treatment options available. The most common forms of WMIs in infants occur prior to the onset of normal myelination, making its pathophysiology distinctive, thus requiring a tailored approach to treatment. Neonates present a unique opportunity to repair WMIs due to a transient abundance of neural stem/progenitor cells (NSPCs) present in the germinal matrix with oligodendrogenic potential. We identified an endogenous oxysterol, 20-αHydroxycholesterol (20HC), in human maternal breast milk that induces oligodendrogenesis through a sonic hedgehog (shh), Gli-dependent mechanism. Following WMI in neonatal mice, injection of 20HC induced subventricular zone-derived oligodendrogenesis and improved myelination in the periventricular white matter, resulting in improved motor outcomes. Targeting the oligodendrogenic potential of postnatal NSPCs in neonates with WMIs may be further developed into a novel approach to mitigate this devastating complication of preterm birth.
MeSH term(s)	Female ; Humans ; Animals ; Mice ; Infant, Newborn ; White Matter/metabolism ; Milk, Human/metabolism ; Hedgehog Proteins/metabolism ; Premature Birth ; Cerebral Ventricles/metabolism ; Brain Injuries ; Oligodendroglia/physiology
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2375354-7
ISSN	1875-9777 ; 1934-5909
ISSN (online)	1875-9777
ISSN	1934-5909
DOI	10.1016/j.stem.2023.07.010
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