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  1. Article ; Online: A novel tetragonal T-C

    Xue, Zhe / Tan, Rui / Wang, Hongxia / Tian, Jinzhong / Wei, Xiaolin / Hou, Hua / Zhao, Yuhong

    Journal of colloid and interface science

    2023  Volume 651, Page(s) 149–158

    Abstract: ... nitride T-C ...

    Abstract Single-atom catalysts with particular electronic structures and precisely regulated coordination environments delivering excellent activity for oxygen-evolution reaction (OER) and oxygen-reduction reaction (ORR) are highly desirable for renewable energy applications. In this work, a novel tetragonal carbon nitride T-C
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2023.07.128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 71/707: Show issues

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  2. Article ; Online: C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell homeostasis and response to acute liver injury.

    Niemietz, Patricia / Peiseler, Moritz / Kohlhepp, Marlene / Horn, Paul / Matchett, Kylie / Wang, Yuting / Haas, Leon / Zhang, Tianjiao / Bruneau, Alix / Guillot, Adrien / Berger, Hilmar / Liepelt, Anke / Warzecha, Klaudia / Demske, Catharina / Möckel, Diana / Lammers, Twan / Henderson, Neil / Heymann, Felix / Tacke, Frank

    Hepatology (Baltimore, Md.)

    2024  

    Abstract: ... hepatic T cell infiltration as a prominent feature in human ALF. CD8 + T cells were characterized ... induced liver injury, intravital microscopy revealed zonation of CD8 + but not CD4 + T cells at necrotic ... areas. Gene expression analysis exposed upregulated C-C chemokine receptor 7 (CCR7) and its ligand CCL21 ...

    Abstract Background and aims: Acute liver failure (ALF) is a rare but life-threatening condition, and DILI, particularly acetaminophen toxicity, is the leading cause of ALF. Innate immune mechanisms further perpetuate liver injury, while the role of the adaptive immune system in DILI-related ALF is unclear.
    Approach and results: We analyzed liver tissue from 2 independent patient cohorts with ALF and identified hepatic T cell infiltration as a prominent feature in human ALF. CD8 + T cells were characterized by zonation toward necrotic regions and an activated gene expression signature. In murine acetaminophen-induced liver injury, intravital microscopy revealed zonation of CD8 + but not CD4 + T cells at necrotic areas. Gene expression analysis exposed upregulated C-C chemokine receptor 7 (CCR7) and its ligand CCL21 in the liver as well as a broadly activated phenotype of hepatic CD8 + T cells. In 2 mouse models of ALF, Ccr7-/- mice had significantly aggravated early-phase liver damage. Functionally, CCR7 was not involved in the recruitment of CD8 + T cells, but regulated their activation profile potentially through egress to lymphatics. Ccr7-/- CD8 + T cells were characterized by elevated expression of activation, effector, and exhaustion profiles. Adoptive transfer revealed preferential homing of CCR7-deficient CD8 + T cells to the liver, and depletion of CD8 + T cells attenuated liver damage in mice.
    Conclusions: Our study demonstrates the involvement of the adaptive immune system in ALF in humans and mice. We identify the CCR7-CCL21 axis as an important regulatory pathway, providing downstream protection against T cell-mediated liver injury.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000757
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Case Report: A Novel Variant c.2262+3A>T of the

    Yin, Jie / Zhou, Jia / Chen, Jinlong / Xu, Ting / Zhang, Zhongman / Zhang, Han / Yuan, Chang / Cheng, Xueying / Qin, Yuming / Zheng, Bixia / Wang, Chunli / Yang, Shiwei / Jia, Zhanjun

    Frontiers in medicine

    2021  Volume 8, Page(s) 659119

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-08-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.659119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A nonsense mutation PARN (c.382C>T) in a patient with idiopathic pulmonary fibrosis.

    Wang, Chen-Yu / Liu, Lv / Peng, Hong / Luo, Hong

    QJM : monthly journal of the Association of Physicians

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcae069
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Anti-allergic effect of vitamin C through inhibiting degranulation and regulating T

    Li, Qian / Tang, Xinlei / Huang, Lu / Wang, Tao / Huang, Yutong / Jiang, Songsong

    Journal of the science of food and agriculture

    2024  

    Abstract: ... the possible anti-allergic effect of vitamin C (VC). A rat basophilic leukemia (RBL)-2H3 cell degranulation ... c mouse allergy model was used to assess the anti-allergy effect of VC in vivo.: Results ... through inhibiting degranulation and regulating T ...

    Abstract Background: Food allergy has become a global public health problem. This study aimed to explore the possible anti-allergic effect of vitamin C (VC). A rat basophilic leukemia (RBL)-2H3 cell degranulation model was used to assess the effect of VC on degranulation in vitro, and an ovalbumin (OVA)-induced BALB/c mouse allergy model was used to assess the anti-allergy effect of VC in vivo.
    Results: In vitro, VC significantly attenuated the release of β-hexosaminidase, tryptase and histamine, and also reduced cytokine production (interleukins 4 and 6, tumor necrosis factor α) significantly (P < 0.05), with the inhibitory effect demonstrating a positive correlation with VC dose. In vivo, compared with the OVA group, the levels of serum immunoglobulins E and G
    Conclusion: VC exerted an anti-allergic effect through inhibiting degranulation and regulating T
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 184116-6
    ISSN 1097-0010 ; 0022-5142
    ISSN (online) 1097-0010
    ISSN 0022-5142
    DOI 10.1002/jsfa.13419
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 808: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The rs2227481 C>T Polymorphism in the

    Chai, Long Long / Xiao, Ying Xuan / Meng, Ling Han / Wang, Huan / Feng, Xian Hong / Gu, Xiu Li / Li, Qi Chang / Xiong, Qian Tao / Chen, Bi Feng

    Biomedical and environmental sciences : BES

    2021  Volume 34, Issue 7, Page(s) 572–576

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Female ; Humans ; Interleukins/genetics ; Interleukins/metabolism ; Liver Neoplasms/epidemiology ; Liver Neoplasms/genetics ; Lung Neoplasms/epidemiology ; Lung Neoplasms/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Risk Factors ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/genetics ; Young Adult ; Interleukin-22
    Chemical Substances Interleukins
    Language English
    Publishing date 2021-08-02
    Publishing country China
    Document type Letter
    ZDB-ID 645083-0
    ISSN 2214-0190 ; 0895-3988
    ISSN (online) 2214-0190
    ISSN 0895-3988
    DOI 10.3967/bes2021.079
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2459: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A novel RHD allele caused by c.767 C>T mutation was identified in a Chinese individual.

    Lyu, Hongjuan / Wang, Kun / Feng, Zhihui / Xu, Tao

    Transfusion

    2024  

    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208417-x
    ISSN 1537-2995 ; 0041-1132
    ISSN (online) 1537-2995
    ISSN 0041-1132
    DOI 10.1111/trf.17820
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 284: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A novel T-C

    Zhou, Jia-Qi / Li, Lei / Fu, Cong / Wang, Jian / Fu, Peng / Kong, Chui-Peng / Bai, Fu-Quan / Eglitis, Roberts I / Zhang, Hong-Xing / Jia, Ran

    Nanoscale

    2020  Volume 12, Issue 8, Page(s) 5055–5066

    Abstract: ... calculations. This carbonitride consists of C3N tetrahedra, and is similar to T-carbon and thus named T-C3N ... properties reveal that bulk and 2D T-C3N are insulators with a 5.542 eV indirect band gap and a 5.741 eV ... direct band gap, respectively. However, the monolayer T-C3N exhibits an excellent uniform porosity. Its 5 ...

    Abstract A structurally stable stacked multilayer carbonitride is predicted with the aid of ab initio calculations. This carbonitride consists of C3N tetrahedra, and is similar to T-carbon and thus named T-C3N. Its 2-dimensional (2D) monolayer is also carefully investigated in this work. The studies on electronic properties reveal that bulk and 2D T-C3N are insulators with a 5.542 eV indirect band gap and a 5.741 eV direct band gap, respectively. However, the monolayer T-C3N exhibits an excellent uniform porosity. Its 5.50 Å pore size is perfect for water nanofiltration. The adsorption and permeation of water molecules on the monolayer T-C3N are investigated. Its promising potential application in highly efficient nanofiltration membranes for seawater desalination is discussed.
    Language English
    Publishing date 2020-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c9nr08108a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study.

    Li, Honge / Wang, Raorao / Wei, Xueyan / Zhang, Chunyan / Pei, Wenhui / Zhang, Xuhui / Yang, Zhen / Li, Zhi / Zhang, Yuhuan / Shi, Yanli / Wang, Yunchao / Wang, Xinhua

    International journal of chronic obstructive pulmonary disease

    2024  Volume 19, Page(s) 489–500

    Abstract: ... C polymorphism is linked to elevated COPD susceptibility, with the T allele heightening the risk ... Province to evaluate the correlation between GSTP1 (rs4147581C>G and rs1695A>G) and NLRP3 (rs3806265T>C and ... rs10754558G>C) polymorphisms and the susceptibility to COPD.: Results: The presence of the GSTP1 rs4147581G ...

    Abstract Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in the pulmonary system. The activation of the NOD-like receptor thermal protein domain (NLRP3) inflammatory vesicle can trigger an inflammatory response. Several investigations have implicated GSTP1 and NLRP3 in the progression of COPD; nonetheless, there remains debate regarding this mechanism.
    Methods: Employing a case-control study design, 312 individuals diagnosed with COPD and 314 healthy controls were recruited from Gansu Province to evaluate the correlation between GSTP1 (rs4147581C>G and rs1695A>G) and NLRP3 (rs3806265T>C and rs10754558G>C) polymorphisms and the susceptibility to COPD.
    Results: The presence of the GSTP1 rs4147581G allele substantially elevated the susceptibility to COPD (CGvs.CC:OR=3.11,95% CI=1.961-4.935,
    Conclusion: In summary, this study ascertained that the GSTP1 rs4147581C>G polymorphism is associated with increased COPD susceptibility, with the G allele elevating the risk of COPD. Similarly, the NLRP3 rs3806265T>C polymorphism is linked to elevated COPD susceptibility, with the T allele heightening the risk of COPD.
    MeSH term(s) Humans ; Antioxidants ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Glutathione S-Transferase pi/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Polymorphism, Single Nucleotide ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/genetics ; Risk Factors
    Chemical Substances Antioxidants ; Glutathione S-Transferase pi (EC 2.5.1.18) ; GSTP1 protein, human (EC 2.5.1.18) ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
    Language English
    Publishing date 2024-02-22
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S445680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The regulatory function of the d-orbital structure in TM@g-t-C

    Wang, Zhenduo / Wu, Meichen / Huang, Yuhong / Zhang, Jianmin / Wei, Xiumei

    Physical chemistry chemical physics : PCCP

    2023  Volume 26, Issue 1, Page(s) 558–568

    Abstract: ... principles investigations are performed to explore the catalytic performance of graphitic C ...

    Abstract Highly efficient catalysts for the oxygen evolution/reduction reaction (OER/ORR) have attracted great attention in research for energy devices with high conversion efficiency. Herein, systematic first-principles investigations are performed to explore the catalytic performance of graphitic C
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04249a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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