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  1. Article: Jerome G. Rozen, Jr.: a biographical sketch and summary of scientific contributions

    Engel, M.S / Rightmyer, M.G

    Journal of the Kansas Entomological Society. 2003 Apr., v. 76, no. 2

    2003  

    Language English
    Dates of publication 2003-04
    Size p. 84-91.
    Document type Article
    Note In the special issue dedicated to Jerome G. Rozen, Jr. / edited by M.G. Rightmyer and M.S. Engel.
    ZDB-ID 2210268-1
    ISSN 0022-8567
    ISSN 0022-8567
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Phenotyping of Review-of-Systems Responses to Differentiate Functional Seizures From Epilepsy.

    Kerr, Wesley T / Allas, Corinne H / Sreenivasan, Siddhika S / Janio, Emily A / Karimi, Amir H / Dubey, Ishita / Braesch, Chelsea T / Le, Justine M / Hori, Jessica M / Patel, Akash B / Gallardo, Norma L / Bauirjan, Janar / Jr, Jerome Engel / Stern, John M / Feusner, Jamie D

    The primary care companion for CNS disorders

    2022  Volume 24, Issue 2

    Abstract: Objective:: Methods:: Results:: Discussion: ...

    Abstract Objective:
    Methods:
    Results:
    Discussion:
    MeSH term(s) Diagnosis, Differential ; Electroencephalography/methods ; Epilepsy/diagnosis ; Humans ; Seizures/diagnosis ; Surveys and Questionnaires
    Language English
    Publishing date 2022-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7780
    ISSN (online) 2155-7780
    ISSN 2155-7780
    DOI 10.4088/PCC.21m03049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: High-frequency oscillations – Where we are and where we need to go

    Engel, Jerome, Jr / da Silva, Fernando Lopes

    Progress in neurobiology. 2012 Sept., v. 98, no. 3

    2012  

    Abstract: High-frequency oscillations (HFOs) are EEG field potentials with frequencies higher than 30Hz; commonly the frequency band between 30 and 70Hz is denominated the gamma band, but with the discovery of activities at frequencies higher than 70Hz a variety ... ...

    Abstract High-frequency oscillations (HFOs) are EEG field potentials with frequencies higher than 30Hz; commonly the frequency band between 30 and 70Hz is denominated the gamma band, but with the discovery of activities at frequencies higher than 70Hz a variety of terms have been proposed to describe the latter (Gotman and Crone, 2011). In general we may consider that the term HFO encompasses activities from 30 to 600Hz. The best practice is to indicate always explicitly the frequency range of the HFOs in any specific study. There are numerous types of HFOs: those in normal brain appear to facilitate synchronization and information transfer necessary for cognitive processes and memory, while a particular class of HFOs in the brain of animals and people with epilepsy appears to reflect fundamental mechanisms of epileptic phenomena and could serve as biomarkers of epileptogenesis and epileptogenicity in abnormal conditions such as epilepsy. A better understanding of the significance of HFOs depends on a deeper analysis of the mechanisms of generation of different kinds of HFOs, that typically are at the crossroads between intrinsic membrane properties and neuronal interactions, both chemical and electrical. There is still a lack of understanding of how specific information is carried by HFOs and can be operational in normal cognitive processes such as in working and long-term memory and abnormal conditions such as epilepsy. The complexity of these processes makes the development of relevant computational models of dynamical neuronal networks most compelling.
    Keywords animals ; biomarkers ; brain ; cognition ; dynamic models ; electroencephalography ; epilepsy ; memory ; neural networks ; people
    Language English
    Dates of publication 2012-09
    Size p. 316-318.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 185535-9
    ISSN 1873-5118 ; 0301-0082
    ISSN (online) 1873-5118
    ISSN 0301-0082
    DOI 10.1016/j.pneurobio.2012.02.001
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Network analysis of the default mode network using functional connectivity mri in temporal lobe epilepsy

    Haneef, Zulfi / Lenartowicz, Agatha / Yeh, Hsiang J / Engel Jr., Jerome / Stern, John M

    Journal of visualized experiments. 2014 Aug. 05, , no. 90

    2014  

    Abstract: Functional connectivity MRI (fcMRI) is an fMRI method that examines the connectivity of different brain areas based on the correlation of BOLD signal fluctuations over time. Temporal Lobe Epilepsy (TLE) is the most common type of adult epilepsy and ... ...

    Abstract Functional connectivity MRI (fcMRI) is an fMRI method that examines the connectivity of different brain areas based on the correlation of BOLD signal fluctuations over time. Temporal Lobe Epilepsy (TLE) is the most common type of adult epilepsy and involves multiple brain networks. The default mode network (DMN) is involved in conscious, resting state cognition and is thought to be affected in TLE where seizures cause impairment of consciousness. The DMN in epilepsy was examined using seed based fcMRI. The anterior and posterior hubs of the DMN were used as seeds in this analysis. The results show a disconnection between the anterior and posterior hubs of the DMN in TLE during the basal state. In addition, increased DMN connectivity to other brain regions in left TLE along with decreased connectivity in right TLE is revealed. The analysis demonstrates how seed-based fcMRI can be used to probe cerebral networks in brain disorders such as TLE.
    Keywords adults ; cerebral cortex ; consciousness ; epilepsy ; magnetic resonance imaging ; seizures
    Language English
    Dates of publication 2014-0805
    Size p. e51442.
    Publishing place Journal of Visualized Experiments
    Document type Article
    ZDB-ID 2259946-0
    ISSN 1940-087X
    ISSN 1940-087X
    DOI 10.3791/51442
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Regional cortical thickness changes accompanying generalized tonic-clonic seizures

    Jennifer A. Ogren / Raghav Tripathi / Paul M. Macey / Rajesh Kumar / John M. Stern / Dawn S. Eliashiv / Luke A. Allen / Beate Diehl / Jerome Engel, Jr / M.R. Sandhya Rani / Samden D. Lhatoo / Ronald M. Harper

    NeuroImage: Clinical, Vol 20, Iss , Pp 205-

    2018  Volume 215

    Abstract: Objective: Generalized tonic-clonic seizures are accompanied by cardiovascular and respiratory sequelae that threaten survival. The frequency of these seizures is a major risk factor for sudden unexpected death in epilepsy (SUDEP), a leading cause of ... ...

    Abstract Objective: Generalized tonic-clonic seizures are accompanied by cardiovascular and respiratory sequelae that threaten survival. The frequency of these seizures is a major risk factor for sudden unexpected death in epilepsy (SUDEP), a leading cause of untimely death in epilepsy. The circumstances accompanying such fatal events suggest a cardiovascular or respiratory failure induced by unknown neural processes rather than an inherent cardiac or lung deficiency. Certain cortical regions, especially the insular, cingulate, and orbitofrontal cortices, are key structures that integrate sensory input and influence diencephalic and brainstem regions regulating blood pressure, cardiac rhythm, and respiration; output from those cortical regions compromised by epilepsy-associated injury may lead to cardiorespiratory dysregulation. The aim here was to assess changes in cortical integrity, reflected as cortical thickness, relative to healthy controls. Cortical alterations in areas that influence cardiorespiratory action could contribute to SUDEP mechanisms. Methods: High-resolution T1-weighted images were collected with a 3.0-Tesla MRI scanner from 53 patients with generalized tonic-clonic seizures (Mean age ± SD: 37.1 ± 12.6 years, 22 male) at Case Western Reserve University, University College London, and the University of California at Los Angeles. Control data included 530 healthy individuals (37.1 ± 12.6 years; 220 male) from UCLA and two open access databases (OASIS and IXI). Cortical thickness group differences were assessed at all non-cerebellar brain surface locations (P < 0.05 corrected). Results: Increased cortical thickness appeared in post-central gyri, insula, and subgenual, anterior, posterior, and isthmus cingulate cortices. Post-central gyri increases were greater in females, while males showed more extensive cingulate increases. Frontal and temporal cortex, lateral orbitofrontal, frontal pole, and lateral parietal and occipital cortices showed thinning. The extents of thickness changes were sex- and ...
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurology. Diseases of the nervous system ; RC346-429
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Hand posture as localizing sign in adult focal epileptic seizures.

    Ferando, Isabella / Soss, Jason R / Elder, Christopher / Shah, Vishal / Lo Russo, Giorgio / Tassi, Laura / Tassinari, Carlo Alberto / Engel, Jerome

    Annals of neurology

    2019  Volume 86, Issue 5, Page(s) 793–800

    Abstract: Objective: The aim of this study was to identify specific ictal hand postures (HPs) as localizing signs of the epileptogenic zone (EZ) in patients with frontal or temporal lobe epilepsy.: Methods: In this study, we retrospectively analyzed ictal ... ...

    Abstract Objective: The aim of this study was to identify specific ictal hand postures (HPs) as localizing signs of the epileptogenic zone (EZ) in patients with frontal or temporal lobe epilepsy.
    Methods: In this study, we retrospectively analyzed ictal semiology of 489 temporal lobe or frontal lobe seizures recorded over a 6-year period at the Seizure Disorder Center at University of California, Los Angeles in the USA (45 patients) or at the C. Munari Epilepsy Surgery Center at Niguarda Hospital in Milan, Italy (34 patients). Our criterion for EZ localization was at least 2 years of seizure freedom after surgery. We analyzed presence and latency of ictal HP. We then examined whether specific initial HPs are predictive for EZ localization.
    Results: We found that ictal HPs were present in 72.5% of patients with frontal and 54.5% of patients with temporal lobe seizures. We divided HPs into 6 classes depending on the reciprocal position of the fingers ("fist," "cup," "politician's fist," "pincer," "extended hand," "pointing"). We found a striking correlation between EZ localization and ictal HP. In particular, fist and pointing HPs are strongly predictive of frontal lobe EZ; cup, politician's fist, and pincer are strongly predictive of temporal lobe EZ.
    Interpretation: Our study offers simple ictal signs that appear to clarify differential diagnosis of temporal versus frontal lobe EZ localization. These results are meant to be used as a novel complementary tool during presurgical evaluation for epilepsy. At the same time, they give us important insight into the neurophysiology of hand movements. ANN NEUROL 2019;86:793-800.
    MeSH term(s) Adult ; Diagnosis, Differential ; Epilepsy, Frontal Lobe/diagnosis ; Epilepsy, Temporal Lobe/diagnosis ; Female ; Hand ; Humans ; Male ; Middle Aged ; Posture ; Retrospective Studies ; Seizures
    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.25589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: High-frequency oscillations

    Frauscher, Birgit / Bartolomei, Fabrice / Kobayashi, Katsuhiro / Cimbalnik, Jan / Van't Klooster, Maryse A. / Rampp, Stefan / Otsubo, Hiroshi / Höller, Yvonne / Wu, Joyce Y. / Asano, Eishi / Engel, Jerome, Jr. / Kahane, Philippe / Jacobs, Julia / Gotman, Jean

    Epilepsia

    The state of clinical research

    2017  Volume 58, Issue 8, Page(s) 1316–1329

    Abstract: Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal ... ...

    Title translation Hochfrequente Schwingungen: Der Stand der klinischen Forschung (DeepL)
    Abstract Modern electroencephalographic (EEG) technology contributed to the appreciation that the EEG signal outside the classical Berger frequency band contains important information. In epilepsy, research of the past decade focused particularly on interictal high-frequency oscillations (HFOs) > 80 Hz. The first large application of HFOs was in the context of epilepsy surgery. This is now followed by other applications such as assessment of epilepsy severity and monitoring of antiepileptic therapy. This article reviews the evidence on the clinical use of HFOs in epilepsy with an emphasis on the latest developments. It highlights the growing literature on the association betweenHFOs and postsurgical seizure outcome. A recent meta-analysis confirmed a higher resection ratio for HFOs in seizure-free versus non-seizure-free patients. Residual HFOs in the postoperative electrocorticogram were shown to predict epilepsy surgery outcome better than preoperative HFOrates. The review further discusses the different attempts to separate physiological from epileptic HFOs, as this might increase the specificity of HFOs. As an example, analysis of sleep microstructure demonstrated a different coupling between HFOs inside and outside the epileptogenic zone. Moreover, there is increasing evidence that HFOs are useful to measure disease activity and assess treatment response using noninvasive EEG and magnetoencephalography. This approach is particularly promising in children, because they show high scalp HFO rates. HFO rates in West syndrome decrease after adrenocorticotropic hormone treatment. Presence of HFOs at the time of rolandic spikes correlates with seizure frequency. The time-consuming visual assessment of HFOs, which prevented their clinical application in the past, is now overcome by validated computer-assisted algorithms. HFO research has considerably advanced over the past decade, and use of noninvasive methods will make HFOs accessible to large numbers of patients. Prospective multicenter trials are awaited to gather information over long recording periods in large patient samples.
    Keywords Anticonvulsive Drugs ; Antikonvulsiva ; Drug Therapy ; Electroencephalography ; Elektroenzephalographie ; Epilepsie ; Epilepsy ; Epileptic Seizures ; Epileptische Anfälle ; Medikamentöse Therapie ; Neurochirurgie ; Neurosurgery ; Therapieergebnisse ; Treatment Outcomes
    Language English
    Document type Article
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.13829
    Database PSYNDEX

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  8. Article ; Online: Contribution of combined carbohydrates to dissolved and particulate organic carbon after the spring bloom in the northern Bay of Biscay (North-Eastern Atlantic Ocean)

    Engel, Anja / Harlay, Jérôme / Piontek, Judith / Chou, Lei

    2012  

    Abstract: Two cruises were conducted after the diatom spring bloom in the northern Bay of Biscay (2006, 2007), to assess the contribution of combined carbohydrates to organic carbon partitioning. Partitioning of total organic carbon (TOC) into particulate organic ... ...

    Abstract Two cruises were conducted after the diatom spring bloom in the northern Bay of Biscay (2006, 2007), to assess the contribution of combined carbohydrates to organic carbon partitioning. Partitioning of total organic carbon (TOC) into particulate organic carbon (POC) and dissolved organic carbon (DOC) differed between the two years, particularly for depths above 60 m, and was related to the vernal development of the system: a post spring-bloom system in 2007, and a more stratified summer system with higher coccolithophore abundance in 2006. In general, contribution of POC to TOC ranged between 4% and 28% and decreased with depth. Concentration of high-molecular-weight (HMW;>1 kDa) dissolved combined carbohydrates (dCCHO) ranged from 0.6 to 1.4 μmol L−1 and contributed between 4% and 11% to DOC. Concentration of particulate combined carbohydrates (pCCHO) varied between 0.03 and 1.3 μmol L−1. A high contribution of pCCHO to POC was observed in 2007, i.e. 22–60% C compared to 3–10% C in 2006, and coincided with a higher abundance of transparent exopolymer particles (TEP). TEP accounted for 0.4–2.0 μmol C L−1 in 2007 and 0.5–1.5 μmol C L−1 in 2006. Above 60 m, differences in contribution of TEP-C to POC were most pronounced yielding 15.4±3.0% in 2007 compared to relatively low 4.8±1.4%, in 2006. TEP-C could explain about 60% in 2007 and about 40% of pCCHO-C in 2006. Hence, TEP were identified as a substantial component of pCCHO and POC, particularly in the wake of the spring bloom. Molecular composition of CCHO, i.e. HMW−dCCHO+pCCHO, revealed little difference between the years but strong variation over depth. Uronic acids (URA) were identified as a major component of CCHO (20–40%). Our study indicates that the distribution and composition of CCHO in surface seawater are determined by biogeochemical processes on a seasonal scale. A better knowledge of CCHO cycling and molecular signature has therefore a high potential for a better tracing of carbon dynamics in shelf sea ecosystems. Highlights: ► Role of combined ...
    Subject code 551 ; 550
    Language English
    Publisher Elsevier
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Functional and Anatomic Correlates of Two Frequently Observed Temporal Lobe Seizure-Onset Patterns

    Ana Luisa Velascol / Charles L. Wilson / Thomas L. Babb / Jerome Engel Jr

    Neural Plasticity, Vol 7, Iss 1-2, Pp 49-

    2000  Volume 63

    Keywords Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2000-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation

    Shennan Aibel Weiss / Ali A Asadi-Pooya / Sitaram Vangala / Stephanie Moy / Dale H Wyeth / Iren Orosz / Michael Gibbs / Lara Schrader / Jason Lerner / Christopher K Cheng / Edward Chang / Rajsekar Rajaraman / Inna Keselman / Perdro Churchman / Christine Bower-Baca / Adam L Numis / Michael G Ho / Lekha Rao / Annapoorna Bhat /
    Joanna Suski / Marjan Asadollahi / Timothy Ambrose / Andres Fernandez / Maromi Nei / Christopher Skidmore / Scott Mintzer / Dawn S Eliashiv / Gary W Mathern / Marc R Nuwer / Michael Sperling / Jerome Engel Jr / John M Stern

    F1000Research, Vol

    Validation and comparison of performance with commercially available software [version 2; referees: 2 approved]

    2017  Volume 6

    Abstract: Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to ... ...

    Abstract Objective: To develop a novel software method (AR2) for reducing muscle contamination of ictal scalp electroencephalogram (EEG), and validate this method on the basis of its performance in comparison to a commercially available software method (AR1) to accurately depict seizure-onset location. Methods: A blinded investigation used 23 EEG recordings of seizures from 8 patients. Each recording was uninterpretable with digital filtering because of muscle artifact and processed using AR1 and AR2 and reviewed by 26 EEG specialists. EEG readers assessed seizure-onset time, lateralization, and region, and specified confidence for each determination. The two methods were validated on the basis of the number of readers able to render assignments, confidence, the intra-class correlation (ICC), and agreement with other clinical findings. Results: Among the 23 seizures, two-thirds of the readers were able to delineate seizure-onset time in 10 of 23 using AR1, and 15 of 23 using AR2 (p<0.01). Fewer readers could lateralize seizure-onset (p<0.05). The confidence measures of the assignments were low (probable-unlikely), but increased using AR2 (p<0.05). The ICC for identifying the time of seizure-onset was 0.15 (95% confidence interval (CI), 0.11-0.18) using AR1 and 0.26 (95% CI 0.21-0.30) using AR2. The EEG interpretations were often consistent with behavioral, neurophysiological, and neuro-radiological findings, with left sided assignments correct in 95.9% (CI 85.7-98.9%, n=4) of cases using AR2, and 91.9% (77.0-97.5%) (n=4) of cases using AR1. Conclusions: EEG artifact reduction methods for localizing seizure-onset does not result in high rates of interpretability, reader confidence, and inter-reader agreement. However, the assignments by groups of readers are often congruent with other clinical data. Utilization of the AR2 software method may improve the validity of ictal EEG artifact reduction.
    Keywords Neuroimaging ; Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2017-04-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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