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  1. Book ; Thesis: Risikoabschätzung einer atopischen Erkrankung beim Neugeborenen mit Hilfe von IgE- und T-Zell-Screening im Nabelschnurblut und die Auswirkung unterschiedlicher Fütterungsarten auf die Atopieentwicklung während des ersten Lebensjahres

    Grübl, Armin

    1989  

    Author's details Armin Grübl
    Size 133 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis München, Techn. Univ., Diss., 1990
    HBZ-ID HT003673218
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: A Two-Stage Automatic Color Thresholding Technique.

    Pootheri, Shamna / Ellam, Daniel / Grübl, Thomas / Liu, Yang

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 6

    Abstract: Thresholding is a prerequisite for many computer vision algorithms. By suppressing the background in an image, one can remove unnecessary information and shift one's focus to the object of inspection. We propose a two-stage histogram-based background ... ...

    Abstract Thresholding is a prerequisite for many computer vision algorithms. By suppressing the background in an image, one can remove unnecessary information and shift one's focus to the object of inspection. We propose a two-stage histogram-based background suppression technique based on the chromaticity of the image pixels. The method is unsupervised, fully automated, and does not need any training or ground-truth data. The performance of the proposed method was evaluated using a printed circuit assembly (PCA) board dataset and the University of Waterloo skin cancer dataset. Accurately performing background suppression in PCA boards facilitates the inspection of digital images with small objects of interest, such as text or microcontrollers on a PCA board. The segmentation of skin cancer lesions will help doctors to automate skin cancer detection. The results showed a clear and robust background-foreground separation across various sample images under different camera or lighting conditions, which the naked implementation of existing state-of-the-art thresholding methods could not achieve.
    Language English
    Publishing date 2023-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23063361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Education of schoolchildren in cardiopulmonary resuscitation - overview of the current literature.

    Schroeder, Daniel C / Finke, Simon-Richard / Grübl, Tobias / Jänig, Christoph W / Böttiger, Bernd W

    Current opinion in critical care

    2023  Volume 29, Issue 6, Page(s) 616–620

    Abstract: Purpose of review: Recognition of cardiac arrest and initiation of cardiopulmonary resuscitation (CPR) can be learned and adequately replicated by schoolchildren. Regular instruction of schoolchildren in CPR is therefore a core element to increase low ... ...

    Abstract Purpose of review: Recognition of cardiac arrest and initiation of cardiopulmonary resuscitation (CPR) can be learned and adequately replicated by schoolchildren. Regular instruction of schoolchildren in CPR is therefore a core element to increase low bystander CPR rates. Thereby, schoolchildren CPR training evolved as own scientific field within the last decade. Aim was to describe current evidence in terms of epidemiology, teaching approaches and political aspects.
    Recent findings: Schoolchildren demonstrate a high motivation to be trained in CPR. Teaching approaches that combine theoretical and practical learning sessions guarantee a sustainable learning effect. Schoolchildren can adequately perform chest compressions and mouth-to-mouth ventilation from the age of 12 years. Use of digital media is a highly promising teaching approach. CPR training conducted by teachers from the own school is effective and guarantees continuous development of CPR skills. Integration of schoolchildren CPR training into school curricula is the foundation for a sustainable increase of lay resuscitation rates in the population. Scientific and political promotion of schoolchildren CPR training is needed to sensitize the population and move bystander CPR in the social focus.
    Summary: While bystander CPR rates are low in Europe comprehensive establishment of schoolchildren CPR training may sustainably increase survival after cardiac arrest.
    MeSH term(s) Humans ; Child ; Cardiopulmonary Resuscitation ; Internet ; Out-of-Hospital Cardiac Arrest/therapy ; Schools ; Europe
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prähospitaler Kreislaufstillstand im Lockdown: Auswirkungen der übergreifenden Infektionspräventionsmaßnahmen während der ersten SARS-CoV-2-Welle.

    Grübl, T / Plöger, B / Sassen, M C / Jerrentrup, A / Schieffer, B / Betz, S

    Notfall & rettungsmedizin

    2021  , Page(s) 1–6

    Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Consequences of infection prevention measures during such contagion events can cause disadvantages especially for patients in out-of-hospital cardiac arrest ( ... ...

    Title translation Out-of-hospital cardiac arrest during lockdown.
    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Consequences of infection prevention measures during such contagion events can cause disadvantages especially for patients in out-of-hospital cardiac arrest (OHCA).
    Methods: Retrospective analysis of OHCAs in one county from January-May in 2018, 2019 and 2020, with the first appearance of the SARS-CoV‑2 pandemic in 2020 and a high incidence of the influenza virus in 2018.
    Results: A total of 497 OHCAs were investigated (2018
    Discussion: The lockdown during the first wave of SARS-CoV‑2 pandemic does not seem to have affected the outcome of OHCA patients without coronavirus disease 2019 (COVID-19) in the end.
    Language German
    Publishing date 2021-08-24
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 1424737-9
    ISSN 1436-0578 ; 1434-6222
    ISSN (online) 1436-0578
    ISSN 1434-6222
    DOI 10.1007/s10049-021-00932-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Demonstrating BrainScaleS-2 Inter-Chip Pulse-Communication using EXTOLL

    Thommes, Tobias / Bordukat, Sven / Grübl, Andreas / Karasenko, Vitali / Müller, Eric / Schemmel, Johannes

    2022  

    Abstract: The BrainScaleS-2 (BSS-2) Neuromorphic Computing System currently consists of multiple single-chip setups, which are connected to a compute cluster via Gigabit-Ethernet network technology. This is convenient for small experiments, where the neural ... ...

    Abstract The BrainScaleS-2 (BSS-2) Neuromorphic Computing System currently consists of multiple single-chip setups, which are connected to a compute cluster via Gigabit-Ethernet network technology. This is convenient for small experiments, where the neural networks fit into a single chip. When modeling networks of larger size, neurons have to be connected across chip boundaries. We implement these connections for BSS-2 using the EXTOLL networking technology. This provides high bandwidths and low latencies, as well as high message rates. Here, we describe the targeted pulse-routing implementation and required extensions to the BSS-2 software stack. We as well demonstrate feed-forward pulse-routing on BSS-2 using a scaled-down version without temporal merging.

    Comment: 3 pages, 2 figures, submitted to the Neuro Inspired Computational Elements 2022 (NICE'2022) conference, accepted and presented as a lightning-talk in March 2022; 1st replacement: version to be published in the conference proceedings
    Keywords Computer Science - Hardware Architecture ; Computer Science - Neural and Evolutionary Computing ; Computer Science - Networking and Internet Architecture
    Publishing date 2022-02-24
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book ; Thesis: Analysis of the PAT1a binding motif in APP/APLPs and identification of novel PAT1a binding partners affecting APP endocytosis and processing

    Grübl, Tomas

    2007  

    Author's details Tomas Grübl
    Language English
    Size 144 S., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Heidelberg, 2007
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Article ; Online: A singleplex IgE test to a mixture of molecules from multiple airborne allergen sources: Innovating in vitro screening of respiratory allergies.

    Potapova, Ekaterina / Panetta, Valentina / Grabenhenrich, Linus / Icke, Katja / Grübl, Armin / Müller, Christoph / Zepp, Fred / Schuster, Antje / Wahn, Ulrich / Lau, Susanne / Keil, Thomas / Matricardi, Paolo Maria

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2022  Volume 33, Issue 11, Page(s) e13867

    Abstract: Background: In vitro immunoglobulin E (IgE) tests can be better standardized if based on molecules rather than extracts. However, singleplex screening tests for respiratory or food allergies are still based on extracts only.: Target: To validate a ... ...

    Abstract Background: In vitro immunoglobulin E (IgE) tests can be better standardized if based on molecules rather than extracts. However, singleplex screening tests for respiratory or food allergies are still based on extracts only.
    Target: To validate a novel singleplex IgE screening test for respiratory allergies, based on a mix of major allergenic molecules Der p 1, Der p 2, Fel d 1, Can f 1, Can f 2, Can f 3, Can f 5, Bet v 1, Phl p 1, and Art v 1 (Molecular SX01, NOVEOS, HYCOR, USA), and requiring only four microliters (μl) of serum.
    Methods: We examined six subsets of sera from participants of the German Multicenter Allergy Study (MAS) birth cohort enrolling 1314 newborns during 1990: (1) monosensitized (n = 58); (2) polysensitized (n = 24); (3) nonsensitized, with total IgE levels above (n = 24) or (4) below (n = 24) 300 kU/L; (5) sensitized to milk and/or egg but not to airborne allergens (n = 24); and (6) sera of children aged ≤5 years at their earliest IgE monosensitization to airborne allergens (n = 41). Sera were analyzed with the novel molecular SX01 test (NOVEOS) and with three categories of comparators: ImmunoCAP Phadiatop SX01, extracts, and molecules of D. pteronyssinus, cat, dog, grass, and birch. Sensitivity, specificity, positive and negative predictive values were calculated. Quantitative interrelationships were determined using Spearman's rank-order correlation coefficient and Bland-Altmann plots.
    Results: The molecular SX01 test predicted the outcome of IgE tests based on molecules, extracts, or Phadiatop in 188 (96.4%), 171 (87.7%), and 171 (87.7%) of the 195 sera, respectively. Accordingly, sensitivity was 93.5%, 89.0%, and 82.4%, whereas specificity was 100%, 97.6%, and 96.1% when compared with molecular, extract, and Phadiatop tests, respectively. Inconsistent outcomes were largely confined to sera with IgE-Ab levels around the cutoff value of 0.35 kU/L, except for 5/195 (2.5%) sera, containing high levels of IgE to Phl p 5 and/or Alt a 1 only. IgE levels measured by the molecular SX01 test and with IgE tests to molecules, extracts, and Phadiatop were highly correlated (rho 0.90; p < .001), (rho 0.87, p < .001), (rho 0.84, p < .001), respectively. The novel molecular SX01 test detected IgE-Ab in 27/28 (sensitivity 96.4%) of the sera of preschool children at their earliest IgE sensitization to the same molecules.
    Discussion: Our study validates the prototype of a novel category of IgE test, based on molecular mixes. The test's rather good precision and accuracy in early screening IgE sensitization to airborne allergens in German children may be further improved by adding a few other molecules, such as Phl p 5 and Alt a 1.
    MeSH term(s) Humans ; Dogs ; Animals ; Allergens ; Immunoglobulin E ; Respiratory Hypersensitivity ; Food Hypersensitivity ; Dermatophagoides pteronyssinus
    Chemical Substances Allergens ; Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2022-11-22
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Prähospitaler Kreislaufstillstand unter einem seltenen Umstand

    Grübl, Tobias / Günnewig, Sebastian / Schulte, Holger / Weller, Norbert / Schmidbauer, Willi / Jänig, Christoph Walter / Müller, Gunnar

    NOTARZT

    2022  Volume 39, Issue 03, Page(s) 145–149

    Abstract: Es wird der Fall eines jungen Patienten mit Kreislaufstillstand nach suizidaler Inkorporation von Natriumnitrat beschrieben. Während der Reanimation sind reversible Ursachen zu suchen und schnell zu therapieren. Intoxikationen sind dabei oft nur schwer ... ...

    Abstract Es wird der Fall eines jungen Patienten mit Kreislaufstillstand nach suizidaler Inkorporation von Natriumnitrat beschrieben. Während der Reanimation sind reversible Ursachen zu suchen und schnell zu therapieren. Intoxikationen sind dabei oft nur schwer detektierbar. Nitroverbindungen führen zur Bildung von Methämoglobin und so zur Hypoxie. Anhand mobiler Laborgeräte kann dies bereits prähospital diagnostiziert werden. Therapeutisch ist zunächst ein symptomatisches Vorgehen mit Oxygenierung und Kreislaufunterstützung sowie ggf. erweiterten Maßnahmen angezeigt. Auch für seltene Intoxikationen sollten spezifische Antidota zumindest zentral vorgehalten werden. Notfallmediziner müssen die Zugriffs- und alternative Behandlungsmöglichkeiten bis zu deren Verfügbarkeit kennen. Im Falle eines Kreislaufstillstands können Systeme zur extrakorporalen Kreislaufunterstützung diesen Zeitraum überbrücken.
    Keywords Intoxikation ; Nitrit ; Antidot ; Reanimation ; H´s und HITS ; poisons ; nitrite ; antidotes ; resuscitation ; H´s and T´s
    Language German
    Publishing date 2022-09-05
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2039417-2
    ISSN 1438-8693 ; 0177-2309
    ISSN (online) 1438-8693
    ISSN 0177-2309
    DOI 10.1055/a-1903-1016
    Database Thieme publisher's database

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  9. Article: Atemwegsmanagement im Notfall

    Feth, Maximilian / Fritz, Stephanie / Grübl, Tobias / Gliwitzky, Bernhard / Düsterwald, Stephan / Bathe, Janina / Bernhard, Michael / Hossfeld, Björn

    NOTARZT

    2022  Volume 38, Issue 05, Page(s) 269–280

    Keywords Atemwegsmanagement ; chirurgischer Atemweg ; Teamarbeit ; Supraglottische Atemwegshilfen ; Endotracheale Intubation ; Notfallmedizin ; Airwaymanagement ; surgical airway ; team approach ; supraglottic airway device ; endotracheal intubation ; emergency medicine ; rapid sequence induction
    Language German
    Publishing date 2022-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2039417-2
    ISSN 1438-8693 ; 0177-2309
    ISSN (online) 1438-8693
    ISSN 0177-2309
    DOI 10.1055/a-1662-9630
    Database Thieme publisher's database

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  10. Book ; Thesis: Risikoabschätzung einer atopischen Erkrankung beim Neugeborenen mit Hilfe von IgE- und T-Zell-Screening im Nabelschnurblut und die Auswirkung unterschiedlicher Fütterungsarten auf die Atopieentwicklung während des ersten Lebensjahres

    Grübl, Armin

    1989  

    Author's details Armin Grübl
    Language Undetermined
    Size [6], 133 S, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @München, Techn. Univ., Diss. : 1990
    Database Former special subject collection: coastal and deep sea fishing

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