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  1. Article ; Online: DiPOLE: a 10 J, 10 Hz cryogenic gas cooled multi-slab nanosecond Yb:YAG laser.

    Banerjee, Saumyabrata / Ertel, Klaus / Mason, Paul D / Phillips, P Jonathan / De Vido, Mariastefania / Smith, Jodie M / Butcher, Thomas J / Hernandez-Gomez, Cristina / Greenhalgh, R Justin S / Collier, John L

    Optics express

    2015  Volume 23, Issue 15, Page(s) 19542–19551

    Abstract: ... 10.8 J of energy in a 10 ns pulse at 1029.5 nm when pumped by 48 J of diode energy at 940 nm ... stability of 0.85% rms for the system operated at 7 J, 10 Hz during several runs lasting up to 6 hours ...

    Abstract The Diode Pumped Optical Laser for Experiments (DiPOLE) project at the Central Laser Facility aims to develop a scalable, efficient high pulse energy diode pumped laser amplifier system based on cryogenic gas cooled, multi-slab ceramic Yb:YAG technology. We present recent results obtained from a scaled down prototype laser system designed for operation at 10 Hz pulse repetition rate. At 140 K, the system generated 10.8 J of energy in a 10 ns pulse at 1029.5 nm when pumped by 48 J of diode energy at 940 nm, corresponding to an optical to optical conversion efficiency of 22.5%. To our knowledge, this represents the highest pulse energy obtained from a cryo cooled Yb laser to date and the highest efficiency achieved by a multi-Joule diode pumped solid state laser system. Additionally, we demonstrated shot-to-shot energy stability of 0.85% rms for the system operated at 7 J, 10 Hz during several runs lasting up to 6 hours, with more than 50 hours in total. We also demonstrated pulse shaping capability and report on beam, wavefront and focal spot quality.
    Language English
    Publishing date 2015-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.23.019542
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  2. Article ; Online: Imaging of Subcellular Distribution of Platinum in Single Cells Using Laser Ablation Inductively Coupled Plasma Mass Spectrometry.

    Managh, Amy J / Greenhalgh, Calum J

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2752, Page(s) 215–226

    Abstract: Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) is a well-established and sensitive analytical technique, which provides high-resolution imaging of endogenous elements, element tagged-markers, metal-containing nanoparticles, and ... ...

    Abstract Laser ablation inductively coupled plasma-mass spectrometry (LA-ICP-MS) is a well-established and sensitive analytical technique, which provides high-resolution imaging of endogenous elements, element tagged-markers, metal-containing nanoparticles, and metallodrugs within cells. Here we describe a protocol for imaging the subcellular distribution of platinum within A549 cells, following their incubation with the platinum-based anticancer agent, Oxaliplatin. We outline the essential steps in sample preparation and instrumental setup and discuss how the current generation of low-dispersion instruments facilitates new approaches to data acquisition and image processing. The protocol described herein can be easily adapted for other cell lines and metal-containing labeling agents.
    MeSH term(s) Diagnostic Imaging ; Spectrum Analysis ; Image Processing, Computer-Assisted ; Laser Therapy ; Platinum ; Mass Spectrometry
    Chemical Substances Platinum (49DFR088MY)
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3621-3_14
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  3. Article ; Online: Understanding the complexities of collecting and using PRO data in a primary care context.

    Greenhalgh, Joanne

    BMJ quality & safety

    2021  Volume 31, Issue 3, Page(s) 175–178

    MeSH term(s) Humans ; Patient Reported Outcome Measures ; Primary Health Care ; Quality Improvement
    Language English
    Publishing date 2021-09-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2592909-4
    ISSN 2044-5423 ; 2044-5415
    ISSN (online) 2044-5423
    ISSN 2044-5415
    DOI 10.1136/bmjqs-2021-013315
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    Zs.A 3754: Show issues Location:
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  4. Article: Re: Mehta T, Venkata Subramaniam A, Chetter I, McCollum P. Assessing the validity and responsiveness of disease-specific quality of life instruments in intermittent claudication. Eur J Vasc Endovasc Surg 2006;31:46-52.

    Chong, P F S / Garratt, A M / Greenhalgh, R M / Davies, A H

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

    2006  Volume 32, Issue 1, Page(s) 110–1; author reply 110

    MeSH term(s) Angioplasty, Balloon ; Humans ; Intermittent Claudication/psychology ; Intermittent Claudication/therapy ; Pain Measurement ; Quality of Life ; Severity of Illness Index ; Surveys and Questionnaires ; Walking/psychology
    Language English
    Publishing date 2006-07
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 1225869-6
    ISSN 1532-2165 ; 1078-5884
    ISSN (online) 1532-2165
    ISSN 1078-5884
    DOI 10.1016/j.ejvs.2006.02.006
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    Zs.MO 381: Show issues

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  5. Article ; Online: J/ psi longitudinal polarization from pi N interactions.

    Biino / Greenhalgh / Kaaret / Louis / McDonald / Palestini / Shoemaker / Smith / Adolphsen / Alexander / Anderson / Conway / Heinrich / Pilcher / Possoz / Rosenberg

    Physical review letters

    1987  Volume 58, Issue 24, Page(s) 2523–2526

    Language English
    Publishing date 1987-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.58.2523
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  6. Article ; Online: Telepsychiatry: learning from the pandemic.

    Greenhalgh, Trisha / Wherton, Joseph

    The British journal of psychiatry : the journal of mental science

    2022  , Page(s) 1–5

    Abstract: This article draws on research and clinical experience to discuss how and when to use video consultations in mental health settings. The appropriateness and impact of virtual consultations are influenced by the patient's clinical needs and social context, ...

    Abstract This article draws on research and clinical experience to discuss how and when to use video consultations in mental health settings. The appropriateness and impact of virtual consultations are influenced by the patient's clinical needs and social context, as well as by service-level socio-technical and logistical factors.
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 218103-4
    ISSN 1472-1465 ; 0007-1250
    ISSN (online) 1472-1465
    ISSN 0007-1250
    DOI 10.1192/bjp.2021.224
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  7. Article ; Online: Medical Masks Versus N95 Respirators for Preventing COVID-19 Among Health Care Workers.

    Greenhalgh, Trisha / Cane, Danielle J / Oliver, Matthew

    Annals of internal medicine

    2023  Volume 176, Issue 7, Page(s) eL230072

    MeSH term(s) Humans ; COVID-19/prevention & control ; N95 Respirators ; Masks ; Health Personnel ; SARS-CoV-2 ; Occupational Exposure/prevention & control
    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L23-0072
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  8. Article ; Online: How current law and policy supports providers of NHS healthcare in England to respond to patient harm: A scoping review protocol.

    Assame, Naomi / Greenhalgh, Susan / Tingle, John / Wright, Julie / Yeowell, Gillian

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299121

    Abstract: Introduction: Harm arising from National Health Service (NHS) healthcare results in significant human cost for the patient, those who care for them, and the medical staff involved. Furthermore, patient harm results in substantial financial costs to the ... ...

    Abstract Introduction: Harm arising from National Health Service (NHS) healthcare results in significant human cost for the patient, those who care for them, and the medical staff involved. Furthermore, patient harm results in substantial financial costs to the public purse. Improving how NHS providers in England respond to patient harm could reduce the number of claims for clinical negligence brought against NHS. Doing so will ensure those affected receive the justice they deserve and protect the public purse. Law and policy are key to supporting providers of NHS healthcare to respond to patient harm but are not necessarily understood and therefore can be challenging to apply to practice. Research exploring how law and policy supports this understanding is limited. The purpose of this scoping review is to address this knowledge gap and improve understanding by critically evaluating how law and policy supports providers of NHS healthcare in England to respond to patient harm.
    Methods and analysis: The review will use the methodological framework proposed by Arskey and O'Malley, Levac et al and the Joanna Briggs Institute. Search strategies will be developed using selected key words and index terms. MEDLINE, CINAHL, and Westlaw and reference lists of relevant publications will be searched to identify relevant grey literature. Two reviewers will independently assess the extracted data against the eligibility criteria. All studies identified will be charted and the results presented as a narrative synthesis.
    MeSH term(s) Humans ; State Medicine ; Patient Harm ; Delivery of Health Care ; Policy ; England ; Research Design ; Review Literature as Topic
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299121
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  9. Article ; Online: Diel variation in insect‐dominated temperate pond soundscapes and guidelines for survey design

    Greenhalgh, Jack A. / Genner, Martin J. / Jones, Gareth

    Freshwater Biology. 2023 July, v. 68, no. 7 p.1148-1160

    2023  

    Abstract: Passive acoustic monitoring has been used for decades as a non‐invasive tool for quantifying biodiversity in terrestrial and marine ecosystems. Recently, there has been increased interest in the potential for the method to survey freshwater biodiversity. ...

    Abstract Passive acoustic monitoring has been used for decades as a non‐invasive tool for quantifying biodiversity in terrestrial and marine ecosystems. Recently, there has been increased interest in the potential for the method to survey freshwater biodiversity. Fundamental aspects of freshwater soundscape phenology, however, often remain poorly understood, despite their importance for suitable survey design. To gain a greater understanding of daily acoustic variation in aquatic insect‐dominated temperate pond soundscapes, 840 hr of underwater sound recordings were collected from five ponds in the southwest of the U.K. We calculated six commonly used acoustic indices to investigate diel trends and evaluated the suitability of each acoustic index to identify biologically complex pond soundscapes. In addition, macroinvertebrates were collected from each pond to investigate potential drivers of diel soundscape variation. The ponds studied possessed clear patterns of daily acoustic variation, with acoustic activity typically peaking between 02:00 and 04:00 and around the solar noon. Acoustic Entropy showed the greatest variation between day and night soundscapes and was best suited for detecting overall daily acoustic variation in the study ponds. However, the Normalised Difference Soundscape Index and the Bioacoustic Index captured strong diel variation in aquatic insect‐dominated soundscapes. Furthermore, we calculated that a minimum hydrophone deployment time of 24 hr is required to ensure that soundscape variation is adequately captured. This study provides an increased understanding of daily acoustic variation in insect‐dominated temperate pond soundscapes, enabling us to provide guidelines for the design and implementation of future passive acoustic monitoring surveys. We suggest that a minimum of 24 hr is required to adequately capture pond soundscape variation. This will increase the chance of detecting key soniferous species in the soundscape and enable more accurate assessments of temperate pond soundscapes.
    Keywords bioacoustics ; biodiversity ; entropy ; freshwater ; limnology ; macroinvertebrates ; phenology ; surveys
    Language English
    Dates of publication 2023-07
    Size p. 1148-1160.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 121180-8
    ISSN 0046-5070
    ISSN 0046-5070
    DOI 10.1111/fwb.14092
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Face coverings for the public: Laying straw men to rest

    Greenhalgh, Trisha

    J Eval Clin Pract

    Abstract: Background This article responds to one by Graham Martin and colleagues, who offered a critique of my previous publications on face coverings for the lay public in the Covid-19 pandemic. Their paper reflects criticisms that have been made of face ... ...

    Abstract Background This article responds to one by Graham Martin and colleagues, who offered a critique of my previous publications on face coverings for the lay public in the Covid-19 pandemic. Their paper reflects criticisms that have been made of face coverings policies more generally. Method Narrative rebuttal. Results I address charges that my coauthors and I had misapplied the precautionary principle; drawn conclusions that were not supported by empirical research; and failed to take account of potential harms But before that, I remind my critics that the evidence on face coverings goes beyond the contested trials and observational studies they place centre stage. I set out some key findings from basic science, epidemiology, mathematical modelling, case studies, and natural experiments, and use this rich and diverse body of evidence as the backdrop for my rebuttal of their narrowly framed objections. I challenge my critics' apparent assumption that a particular kind of systematic review should be valorised over narrative and real-world evidence, since stories are crucial to both our scientific understanding and our moral imagination. Conclusion I conclude by thanking my academic adversaries for the intellectual sparring match, but exhort them to remember our professional accountability to a society in crisis. It is time to lay straw men to rest and embrace the full range of evidence in the context of the perilous threat the world is now facing.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #378284
    Database COVID19

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